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Ak1 adenylate kinase 1 [ Mus musculus (house mouse) ]

Gene ID: 11636, updated on 5-Mar-2024

Summary

Official Symbol
Ak1provided by MGI
Official Full Name
adenylate kinase 1provided by MGI
Primary source
MGI:MGI:87977
See related
Ensembl:ENSMUSG00000026817 AllianceGenome:MGI:87977
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Ak-1; B430205N08Rik
Summary
Enables adenylate kinase activity. Acts upstream of or within regulation of G1/S transition of mitotic cell cycle. Located in cytoplasm; outer dense fiber; and plasma membrane. Is expressed in several structures, including heart; lung; metanephros; nervous system; and nose. Human ortholog(s) of this gene implicated in congenital nonspherocytic hemolytic anemia and hemolytic anemia. Orthologous to human AK1 (adenylate kinase 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in heart adult (RPKM 107.3), testis adult (RPKM 39.2) and 15 other tissues See more
Orthologs
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Genomic context

See Ak1 in Genome Data Viewer
Location:
2 B; 2 22.09 cM
Exon count:
11
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (32511770..32525070)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (32621758..32635058)

Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 4 Neighboring gene predicted gene, 52551 Neighboring gene predicted gene, 23369 Neighboring gene ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 6 Neighboring gene STARR-positive B cell enhancer ABC_E10096 Neighboring gene STARR-seq mESC enhancer starr_04202 Neighboring gene STARR-seq mESC enhancer starr_04203 Neighboring gene STARR-seq mESC enhancer starr_04204 Neighboring gene endoglin Neighboring gene microRNA 1954 Neighboring gene predicted gene, 26236

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (2)  1 citation
  • Endonuclease-mediated (2) 

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
 
enables adenylate kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables adenylate kinase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables adenylate kinase activity ISO
Inferred from Sequence Orthology
more info
 
enables kinase activity IEA
Inferred from Electronic Annotation
more info
 
enables nucleobase-containing compound kinase activity IEA
Inferred from Electronic Annotation
more info
 
enables nucleoside diphosphate kinase activity ISO
Inferred from Sequence Orthology
more info
 
enables nucleoside triphosphate adenylate kinase activity IEA
Inferred from Electronic Annotation
more info
 
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
 
contributes_to phosphotransferase activity, phosphate group as acceptor ISO
Inferred from Sequence Orthology
more info
 
enables transferase activity IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
 
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in cytosol ISO
Inferred from Sequence Orthology
more info
 
located_in outer dense fiber IDA
Inferred from Direct Assay
more info
PubMed 
located_in perinuclear region of cytoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in sarcomere ISO
Inferred from Sequence Orthology
more info
 
located_in sperm flagellum IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
adenylate kinase isoenzyme 1
Names
cytosolic adenylate kinase
NP_001185719.1
NP_001185720.1
NP_001185721.1
NP_067490.1
XP_030102669.1
XP_036013552.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001198790.1NP_001185719.1  adenylate kinase isoenzyme 1 isoform 2

    See identical proteins and their annotated locations for NP_001185719.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs at the 5' UTR and 5' coding region, compared to variant 1. The encoded protein (isoform 2) has a shorter, distinct N-terminus compared to isoform 1. Variants 2, 3, and 4 encode the same protein (isoform 2).
    Source sequence(s)
    AK046613, BC014802
    Consensus CDS
    CCDS57167.1
    UniProtKB/Swiss-Prot
    A2AK80, Q542C5, Q9R0Y4, Q9R0Y5
    Related
    ENSMUSP00000108903.3, ENSMUST00000113278.9
    Conserved Domains (1) summary
    TIGR01360
    Location:6193
    aden_kin_iso1; adenylate kinase, isozyme 1 subfamily
  2. NM_001198791.1NP_001185720.1  adenylate kinase isoenzyme 1 isoform 2

    See identical proteins and their annotated locations for NP_001185720.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs at the 5' UTR and 5' coding region, compared to variant 1. The encoded protein (isoform 2) has a shorter, distinct N-terminus compared to isoform 1. Variants 2, 3, and 4 encode the same protein (isoform 2).
    Source sequence(s)
    BC014802, BY130582
    Consensus CDS
    CCDS57167.1
    UniProtKB/Swiss-Prot
    A2AK80, Q542C5, Q9R0Y4, Q9R0Y5
    Related
    ENSMUSP00000108902.2, ENSMUST00000113277.8
    Conserved Domains (1) summary
    TIGR01360
    Location:6193
    aden_kin_iso1; adenylate kinase, isozyme 1 subfamily
  3. NM_001198792.1NP_001185721.1  adenylate kinase isoenzyme 1 isoform 2

    See identical proteins and their annotated locations for NP_001185721.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) differs at the 5' UTR and 5' coding region, compared to variant 1. The encoded protein (isoform 2) has a shorter, distinct N-terminus compared to isoform 1. Variants 2, 3, and 4 encode the same protein (isoform 2).
    Source sequence(s)
    BC014802, BY333336
    Consensus CDS
    CCDS57167.1
    UniProtKB/Swiss-Prot
    A2AK80, Q542C5, Q9R0Y4, Q9R0Y5
    Conserved Domains (1) summary
    TIGR01360
    Location:6193
    aden_kin_iso1; adenylate kinase, isozyme 1 subfamily
  4. NM_021515.3NP_067490.1  adenylate kinase isoenzyme 1 isoform 1

    See identical proteins and their annotated locations for NP_067490.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longer protein (isoform 1).
    Source sequence(s)
    BC014802, CF950379
    Consensus CDS
    CCDS15924.1
    UniProtKB/Swiss-Prot
    Q9R0Y5
    Related
    ENSMUSP00000068479.5, ENSMUST00000068271.5
    Conserved Domains (1) summary
    TIGR01360
    Location:22209
    aden_kin_iso1; adenylate kinase, isozyme 1 subfamily

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000068.8 Reference GRCm39 C57BL/6J

    Range
    32511770..32525070
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_030246809.2XP_030102669.1  adenylate kinase isoenzyme 1 isoform X1

    UniProtKB/Swiss-Prot
    A2AK80, Q542C5, Q9R0Y4, Q9R0Y5
    Conserved Domains (1) summary
    TIGR01360
    Location:6193
    aden_kin_iso1; adenylate kinase, isozyme 1 subfamily
  2. XM_036157659.1XP_036013552.1  adenylate kinase isoenzyme 1 isoform X1

    UniProtKB/Swiss-Prot
    A2AK80, Q542C5, Q9R0Y4, Q9R0Y5
    Conserved Domains (1) summary
    TIGR01360
    Location:6193
    aden_kin_iso1; adenylate kinase, isozyme 1 subfamily