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Ahcyl adenosylhomocysteinase like [ Mus musculus (house mouse) ]

Gene ID: 11615, updated on 8-Feb-2024

Summary

Official Symbol
Ahcylprovided by MGI
Official Full Name
adenosylhomocysteinase likeprovided by MGI
Primary source
MGI:MGI:3643647
See related
Ensembl:ENSMUSG00000048087 AllianceGenome:MGI:3643647
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Gm4737; EG11615; AL024110
Summary
Predicted to enable adenosylhomocysteinase activity; identical protein binding activity; and nucleotide binding activity. Predicted to be involved in several processes, including S-adenosylhomocysteine catabolic process; chronic inflammatory response to antigenic stimulus; and circadian sleep/wake cycle. Predicted to be located in cytosol; neuron projection; and nucleus. Human ortholog(s) of this gene implicated in hypermethioninemia with deficiency of S-adenosylhomocysteine hydrolase. Orthologous to human AHCY (adenosylhomocysteinase). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

See Ahcyl in Genome Data Viewer
Location:
16 B5; 16 30.45 cM
Exon count:
1
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 16 NC_000082.7 (45973348..45975440, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 16 NC_000082.6 (46152985..46155077, complement)

Chromosome 16 - NC_000082.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 31198 Neighboring gene CD96 antigen Neighboring gene STARR-seq mESC enhancer starr_40924 Neighboring gene CapStarr-seq enhancer MGSCv37_chr16:46104635-46104888 Neighboring gene zinc finger BED-type containing 2 Neighboring gene CapStarr-seq enhancer MGSCv37_chr16:46120234-46120417 Neighboring gene predicted gene, 26297 Neighboring gene nectin cell adhesion molecule 3

Genomic regions, transcripts, and products

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables NAD binding ISO
Inferred from Sequence Orthology
more info
 
enables adenosylhomocysteinase activity ISO
Inferred from Sequence Orthology
more info
 
enables adenyl nucleotide binding ISO
Inferred from Sequence Orthology
more info
 
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
involved_in S-adenosylhomocysteine catabolic process ISO
Inferred from Sequence Orthology
more info
 
involved_in chronic inflammatory response to antigenic stimulus ISO
Inferred from Sequence Orthology
more info
 
involved_in circadian sleep/wake cycle ISO
Inferred from Sequence Orthology
more info
 
involved_in response to nutrient ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
located_in cytosol ISO
Inferred from Sequence Orthology
more info
 

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001304528.1NP_001291457.1  Adenosylhomocysteinase

    See identical proteins and their annotated locations for NP_001291457.1

    Status: VALIDATED

    Source sequence(s)
    AC139039
    Consensus CDS
    CCDS84240.1
    UniProtKB/Swiss-Prot
    P50247, Q91WF1
    UniProtKB/TrEMBL
    Q3TF14, Q3U4D1, Q5M9P0
    Related
    ENSMUSP00000127198.2, ENSMUST00000059524.7
    Conserved Domains (1) summary
    smart00996
    Location:8431
    AdoHcyase; S-adenosyl-L-homocysteine hydrolase

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000082.7 Reference GRCm39 C57BL/6J

    Range
    45973348..45975440 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NG_004757.4: Suppressed sequence

    Description
    NG_004757.4: This RefSeq was permanently suppressed because it is now thought that this gene does encode a protein.