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BATF2 basic leucine zipper ATF-like transcription factor 2 [ Homo sapiens (human) ]

Gene ID: 116071, updated on 2-Nov-2024

Summary

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Official Symbol
BATF2provided by HGNC
Official Full Name
basic leucine zipper ATF-like transcription factor 2provided by HGNC
Primary source
HGNC:HGNC:25163
See related
Ensembl:ENSG00000168062 MIM:614983; AllianceGenome:HGNC:25163
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
SARI
Summary
Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in defense response to protozoan; myeloid dendritic cell differentiation; and regulation of transcription by RNA polymerase II. Part of RNA polymerase II transcription regulator complex. [provided by Alliance of Genome Resources, Nov 2024]
Expression
Broad expression in spleen (RPKM 7.0), appendix (RPKM 4.9) and 23 other tissues See more
Orthologs
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Genomic context

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See BATF2 in Genome Data Viewer
Location:
11q13.1
Exon count:
4
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 11 NC_000011.10 (64987945..64996971, complement)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 11 NC_060935.1 (64981187..64990214, complement)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 11 NC_000011.9 (64755417..64764443, complement)

Chromosome 11 - NC_000011.10Genomic Context describing neighboring genes Neighboring gene protein phosphatase 2 regulatory subunit B'beta Neighboring gene glycoprotein hormone subunit alpha 2 Neighboring gene membrane anchored junction protein Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:64757136-64757663 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:64763842-64764342 Neighboring gene CRISPRi-validated cis-regulatory element chr11.3163 Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr11:64773912-64775111 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3504 Neighboring gene ARL2-SNX15 readthrough (NMD candidate) Neighboring gene microRNA 6879 Neighboring gene ARF like GTPase 2 Neighboring gene eukaryotic translation elongation factor 1 alpha 1 pseudogene 18

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Decreased SARI expression predicts poor prognosis of Chinese patients with non-small cell lung cancer. Zhou RJ, et al. Int J Clin Exp Pathol, 2013. PMID 24133583, Free PMC Article
  2. BATF2 in human colorectal cancer. Liu Z, et al. Aging (Albany NY), 2015 May. PMID 26022579, Free PMC Article
  3. The tumor-suppressive role of BATF2 in esophageal squamous cell carcinoma. Han T, et al. Oncol Rep, 2015 Sep. PMID 26135942
  4. Expression and mechanism of action of the SARI tumor suppressor in prostate cancer. Chen Q, et al. Int J Clin Exp Pathol, 2015. PMID 26339361, Free PMC Article
  5. SARI, a novel target gene of glucocorticoid receptor, plays an important role in dexamethasone-mediated killing of B lymphoma cells. Huang Y, et al. Cancer Lett, 2016 Apr 1. PMID 26808579

See all (49) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Exosomal miR-361-3p promotes the viability of breast cancer cells by targeting ETV7 and BATF2 to upregulate the PAI-1/ERK pathway.
    Title: Exosomal miR-361-3p promotes the viability of breast cancer cells by targeting ETV7 and BATF2 to upregulate the PAI-1/ERK pathway.
  2. BATF2 inhibits PD-L1 expression and regulates CD8+ T-cell infiltration in non-small cell lung cancer.
    Title: BATF2 inhibits PD-L1 expression and regulates CD8+ T-cell infiltration in non-small cell lung cancer.
  3. Nuclear export of BATF2 enhances colorectal cancer proliferation through binding to CRM1.
    Title: Nuclear export of BATF2 enhances colorectal cancer proliferation through binding to CRM1.
  4. Loss of the Immunomodulatory Transcription Factor BATF2 in Humans Is Associated with a Neurological Phenotype.
    Title: Loss of the Immunomodulatory Transcription Factor BATF2 in Humans Is Associated with a Neurological Phenotype.
  5. m6A modification-mediated BATF2 suppresses metastasis and angiogenesis of tongue squamous cell carcinoma through inhibiting VEGFA.
    Title: m6A modification-mediated BATF2 suppresses metastasis and angiogenesis of tongue squamous cell carcinoma through inhibiting VEGFA.
  6. SARI inhibits growth and reduces survival of oral squamous cell carcinomas (OSCC) by inducing endoplasmic reticulum stress.
    Title: SARI inhibits growth and reduces survival of oral squamous cell carcinomas (OSCC) by inducing endoplasmic reticulum stress.
  7. Expression and clinical implications of basic leucine zipper ATF-like transcription factor 2 in breast cancer.
    Title: Expression and clinical implications of basic leucine zipper ATF-like transcription factor 2 in breast cancer.
  8. BATF2 prevents glioblastoma multiforme progression by inhibiting recruitment of myeloid-derived suppressor cells.
    Title: BATF2 prevents glioblastoma multiforme progression by inhibiting recruitment of myeloid-derived suppressor cells.
  9. BATF2 expression as a novel marker for invasive phenotype in malignant melanoma.
    Title: BATF2 expression as a novel marker for invasive phenotype in malignant melanoma.
  10. miRNA-765 mediates multidrug resistance via targeting BATF2 in gastric cancer cells.
    Title: miRNA-765 mediates multidrug resistance via targeting BATF2 in gastric cancer cells.
Submit: New GeneRIF Correction See all GeneRIFs (34)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • MGC20410

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
  
enables DNA-binding transcription factor activity, RNA polymerase II-specific ISA
Inferred from Sequence Alignment
more info
  
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in defense response to protozoan ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in integrated stress response signaling NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in myeloid dendritic cell differentiation ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of transcription by RNA polymerase II NAS
Non-traceable Author Statement
more info
 PubMed 
Component Evidence Code Pubs
part_of RNA polymerase II transcription regulator complex IPI
Inferred from Physical Interaction
more info
 PubMed 
located_in chromatin ISA
Inferred from Sequence Alignment
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus NAS
Non-traceable Author Statement
more info
 PubMed 

General protein information

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Preferred Names
basic leucine zipper transcriptional factor ATF-like 2
Names
B-ATF-2
basic leucine zipper transcription factor, ATF-like 2
suppressor of AP-1 regulated by IFN

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001300807.2 → NP_001287736.1  basic leucine zipper transcriptional factor ATF-like 2 isoform 2

    See identical proteins and their annotated locations for NP_001287736.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) has an alternate exon in place of the first two exons compared to variant 1. The resulting isoform (2) has a shorter and distinct N-terminus compared to isoform 1.
    Source sequence(s)
    AK300917, BP206576, HM134154
    Consensus CDS
    CCDS76429.1
    UniProtKB/TrEMBL
    B4DV37
    Related
    ENSP00000434915.1, ENST00000527716.1
    Conserved Domains (1) summary
    cl21462
    Location:23 → 50
    bZIP; Basic leucine zipper (bZIP) domain of bZIP transcription factors: a DNA-binding and dimerization domain

  2. NM_001300808.2 → NP_001287737.1  basic leucine zipper transcriptional factor ATF-like 2 isoform 3

    See identical proteins and their annotated locations for NP_001287737.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) has an alternate exon in place of the first two exons compared to variant 1. The resulting isoform (3) is shorter at the N-terminus compared to isoform 1.
    Source sequence(s)
    AK092453, BP206576, HM134154
    Consensus CDS
    CCDS73317.1
    UniProtKB/Swiss-Prot
    Q8N1L9
    Related
    ENSP00000398911.2, ENST00000435842.2

  3. NM_138456.4 → NP_612465.3  basic leucine zipper transcriptional factor ATF-like 2 isoform 1

    See identical proteins and their annotated locations for NP_612465.3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
    Source sequence(s)
    AK096702, BC012330
    Consensus CDS
    CCDS8087.1
    UniProtKB/Swiss-Prot
    D9IC56, Q8N1L9, Q8NAF4, Q8NAL8, Q96EH4
    Related
    ENSP00000301887.4, ENST00000301887.9
    Conserved Domains (1) summary
    cd14701
    Location:17 → 74
    bZIP_BATF; Basic leucine zipper (bZIP) domain of BATF proteins: a DNA-binding and dimerization domain

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000011.10 Reference GRCh38.p14 Primary Assembly

    Range
    64987945..64996971 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060935.1 Alternate T2T-CHM13v2.0

    Range
    64981187..64990214 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8N1L9.1 GenPept UniProtKB/Swiss-Prot:Q8N1L9

Gene LinkOut

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