BATF2 basic leucine zipper ATF-like transcription factor 2 [Homo sapiens (human)] - Gene

Summary

Official Symbol: BATF2provided by HGNC
Official Full Name: basic leucine zipper ATF-like transcription factor 2provided by HGNC
Primary source: HGNC:HGNC:25163
See related: Ensembl:ENSG00000168062 MIM:614983; AllianceGenome:HGNC:25163
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: SARI
Summary: Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in defense response to protozoan; myeloid dendritic cell differentiation; and regulation of transcription by RNA polymerase II. Part of RNA polymerase II transcription regulator complex. [provided by Alliance of Genome Resources, Jul 2025]
Expression: Broad expression in spleen (RPKM 7.0), appendix (RPKM 4.9) and 23 other tissues See more
Orthologs: mouse all
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Genomic context

Location:: 11q13.1

Exon count:: 4

Annotation release	Status	Assembly	Chr	Location
RS_2025_08	current	GRCh38.p14 (GCF_000001405.40)	11	NC_000011.10 (64987945..64996971, complement)
RS_2025_08	current	T2T-CHM13v2.0 (GCF_009914755.1)	11	NC_060935.1 (64981187..64990214, complement)
RS_2024_09	previous assembly	GRCh37.p13 (GCF_000001405.25)	11	NC_000011.9 (64755417..64764443, complement)

Chromosome 11 - NC_000011.10 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Tissue-specific circular RNA induction during human fetal development
Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
BioProject: PRJNA270632
Publication: PMID 26076956
Analysis date: Mon Apr 2 22:54:59 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Exosomal miR-361-3p promotes the viability of breast cancer cells by targeting ETV7 and BATF2 to upregulate the PAI-1/ERK pathway.
Title: Exosomal miR-361-3p promotes the viability of breast cancer cells by targeting ETV7 and BATF2 to upregulate the PAI-1/ERK pathway.
BATF2 inhibits PD-L1 expression and regulates CD8+ T-cell infiltration in non-small cell lung cancer.
Title: BATF2 inhibits PD-L1 expression and regulates CD8+ T-cell infiltration in non-small cell lung cancer.
Nuclear export of BATF2 enhances colorectal cancer proliferation through binding to CRM1.
Title: Nuclear export of BATF2 enhances colorectal cancer proliferation through binding to CRM1.
Loss of the Immunomodulatory Transcription Factor BATF2 in Humans Is Associated with a Neurological Phenotype.
Title: Loss of the Immunomodulatory Transcription Factor BATF2 in Humans Is Associated with a Neurological Phenotype.
m6A modification-mediated BATF2 suppresses metastasis and angiogenesis of tongue squamous cell carcinoma through inhibiting VEGFA.
Title: m6A modification-mediated BATF2 suppresses metastasis and angiogenesis of tongue squamous cell carcinoma through inhibiting VEGFA.
SARI inhibits growth and reduces survival of oral squamous cell carcinomas (OSCC) by inducing endoplasmic reticulum stress.
Title: SARI inhibits growth and reduces survival of oral squamous cell carcinomas (OSCC) by inducing endoplasmic reticulum stress.
Expression and clinical implications of basic leucine zipper ATF-like transcription factor 2 in breast cancer.
Title: Expression and clinical implications of basic leucine zipper ATF-like transcription factor 2 in breast cancer.
BATF2 prevents glioblastoma multiforme progression by inhibiting recruitment of myeloid-derived suppressor cells.
Title: BATF2 prevents glioblastoma multiforme progression by inhibiting recruitment of myeloid-derived suppressor cells.
BATF2 expression as a novel marker for invasive phenotype in malignant melanoma.
Title: BATF2 expression as a novel marker for invasive phenotype in malignant melanoma.
miRNA-765 mediates multidrug resistance via targeting BATF2 in gastric cancer cells.
Title: miRNA-765 mediates multidrug resistance via targeting BATF2 in gastric cancer cells.

Submit: New GeneRIF Correction See all GeneRIFs (34)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

L18080 (e-PCR)
- UniSTS:8994

MGC20410__7686 (e-PCR)
- UniSTS:468519

D11S3587 (e-PCR)
- UniSTS:152826

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables DNA binding	IEA Inferred from Electronic Annotation more info
enables DNA-binding transcription factor activity	IEA Inferred from Electronic Annotation more info
enables DNA-binding transcription factor activity, RNA polymerase II-specific	IBA Inferred from Biological aspect of Ancestor more info
enables DNA-binding transcription factor activity, RNA polymerase II-specific	ISA Inferred from Sequence Alignment more info
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in cell differentiation	IEA Inferred from Electronic Annotation more info
involved_in defense response to protozoan	IEA Inferred from Electronic Annotation more info
involved_in defense response to protozoan	ISS Inferred from Sequence or Structural Similarity more info
involved_in integrated stress response signaling	NAS Non-traceable Author Statement more info	PubMed
involved_in myeloid dendritic cell differentiation	IEA Inferred from Electronic Annotation more info
involved_in myeloid dendritic cell differentiation	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of DNA-templated transcription	IEA Inferred from Electronic Annotation more info
involved_in regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of transcription by RNA polymerase II	IEA Inferred from Electronic Annotation more info
involved_in regulation of transcription by RNA polymerase II	NAS Non-traceable Author Statement more info	PubMed

Component	Evidence Code	Pubs
part_of RNA polymerase II transcription regulator complex	IPI Inferred from Physical Interaction more info	PubMed
located_in chromatin	ISA Inferred from Sequence Alignment more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IEA Inferred from Electronic Annotation more info
located_in nucleus	NAS Non-traceable Author Statement more info	PubMed

General protein information

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Preferred Names: basic leucine zipper transcriptional factor ATF-like 2

Names: B-ATF-2; basic leucine zipper transcription factor, ATF-like 2; suppressor of AP-1 regulated by IFN

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001300807.2 → NP_001287736.1 basic leucine zipper transcriptional factor ATF-like 2 isoform 2

See identical proteins and their annotated locations for NP_001287736.1

Status: VALIDATED

Description

Transcript Variant: This variant (2) has an alternate exon in place of the first two exons compared to variant 1. The resulting isoform (2) has a shorter and distinct N-terminus compared to isoform 1.

Source sequence(s)

AK300917, BP206576, HM134154

Consensus CDS

CCDS76429.1

UniProtKB/TrEMBL

B4DV37

Related

ENSP00000434915.1, ENST00000527716.1

Conserved Domains (1) summary

cl21462
Location:23 → 50

bZIP; Basic leucine zipper (bZIP) domain of bZIP transcription factors: a DNA-binding and dimerization domain
NM_001300808.2 → NP_001287737.1 basic leucine zipper transcriptional factor ATF-like 2 isoform 3

See identical proteins and their annotated locations for NP_001287737.1

Status: VALIDATED

Description

Transcript Variant: This variant (3) has an alternate exon in place of the first two exons compared to variant 1. The resulting isoform (3) is shorter at the N-terminus compared to isoform 1.

Source sequence(s)

AK092453, BP206576, HM134154

Consensus CDS

CCDS73317.1

UniProtKB/Swiss-Prot

Q8N1L9

Related

ENSP00000398911.2, ENST00000435842.2
NM_138456.4 → NP_612465.3 basic leucine zipper transcriptional factor ATF-like 2 isoform 1

See identical proteins and their annotated locations for NP_612465.3

Status: VALIDATED

Description

Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).

Source sequence(s)

AK096702, BC012330

Consensus CDS

CCDS8087.1

UniProtKB/Swiss-Prot

D9IC56, Q8N1L9, Q8NAF4, Q8NAL8, Q96EH4

Related

ENSP00000301887.4, ENST00000301887.9

Conserved Domains (1) summary

cd14701
Location:17 → 74

bZIP_BATF; Basic leucine zipper (bZIP) domain of BATF proteins: a DNA-binding and dimerization domain