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Angpt1 angiopoietin 1 [ Mus musculus (house mouse) ]

Gene ID: 11600, updated on 1-Mar-2024

Summary

Official Symbol
Angpt1provided by MGI
Official Full Name
angiopoietin 1provided by MGI
Primary source
MGI:MGI:108448
See related
Ensembl:ENSMUSG00000022309 AllianceGenome:MGI:108448
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Ang1; Ang-1; 1110046O21Rik
Summary
This gene encodes a secreted glycoprotein that belongs to the angiopoietin family of vascular growth factors. The encoded protein is a ligand in the vascular tyrosine kinase signaling pathway and regulates the formation and stabilization of blood vessels. This protein also functions in striated muscles by promoting proliferation, migration and differentiation of skeletal myoblasts and plays an essential role in the vascular response to tissue injury. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2013]
Expression
Broad expression in heart adult (RPKM 3.3), lung adult (RPKM 2.4) and 18 other tissues See more
Orthologs
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Genomic context

See Angpt1 in Genome Data Viewer
Location:
15 B3.1; 15 16.69 cM
Exon count:
11
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 15 NC_000081.7 (42288063..42540373, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 15 NC_000081.6 (42424667..42676977, complement)

Chromosome 15 - NC_000081.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 52226 Neighboring gene ribosomal protein L5 pseudogene Neighboring gene predicted gene, 41313 Neighboring gene predicted gene, 17473 Neighboring gene STARR-seq mESC enhancer starr_38545 Neighboring gene predicted gene, 46505 Neighboring gene STARR-seq mESC enhancer starr_38546 Neighboring gene STARR-seq mESC enhancer starr_38547 Neighboring gene STARR-seq mESC enhancer starr_38548 Neighboring gene predicted gene, 41315 Neighboring gene R-spondin 2

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (7)  1 citation
  • Endonuclease-mediated (1) 

Pathways from PubChem

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables receptor tyrosine kinase binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables receptor tyrosine kinase binding ISO
Inferred from Sequence Orthology
more info
 
enables signaling receptor binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables vascular endothelial growth factor receptor binding TAS
Traceable Author Statement
more info
PubMed 
Process Evidence Code Pubs
involved_in Tie signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in Tie signaling pathway ISO
Inferred from Sequence Orthology
more info
 
involved_in Tie signaling pathway TAS
Traceable Author Statement
more info
PubMed 
involved_in activation of transmembrane receptor protein tyrosine kinase activity ISO
Inferred from Sequence Orthology
more info
 
involved_in angiogenesis IBA
Inferred from Biological aspect of Ancestor
more info
 
acts_upstream_of_or_within angiogenesis IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within angiogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in branching involved in blood vessel morphogenesis TAS
Traceable Author Statement
more info
PubMed 
involved_in cardiac muscle tissue morphogenesis TAS
Traceable Author Statement
more info
PubMed 
acts_upstream_of_or_within cell differentiation IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within cell-substrate adhesion IDA
Inferred from Direct Assay
more info
PubMed 
involved_in endocardium morphogenesis TAS
Traceable Author Statement
more info
PubMed 
acts_upstream_of_or_within endoderm development TAS
Traceable Author Statement
more info
PubMed 
acts_upstream_of_or_within glomerulus vasculature development IDA
Inferred from Direct Assay
more info
PubMed 
involved_in glomerulus vasculature development ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within hemopoiesis IDA
Inferred from Direct Assay
more info
PubMed 
involved_in heparin biosynthetic process ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within in utero embryonic development IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within in utero embryonic development IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within multicellular organism development IEA
Inferred from Electronic Annotation
more info
 
involved_in negative regulation of apoptotic process ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of cell adhesion ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within negative regulation of cytokine production involved in immune response IDA
Inferred from Direct Assay
more info
PubMed 
involved_in negative regulation of endothelial cell apoptotic process ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within negative regulation of neuron apoptotic process IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within negative regulation of neuron apoptotic process IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within negative regulation of protein import into nucleus IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within negative regulation of protein phosphorylation IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within negative regulation of vascular permeability IDA
Inferred from Direct Assay
more info
PubMed 
involved_in negative regulation of vascular permeability ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of neuron apoptotic process IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of neuron apoptotic process IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in ovarian follicle development ISO
Inferred from Sequence Orthology
more info
 
involved_in positive chemotaxis ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within_positive_effect positive regulation of ERK1 and ERK2 cascade ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of blood vessel endothelial cell migration ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of blood-brain barrier permeability ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within positive regulation of cell adhesion IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of endothelial cell migration ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of endothelial cell migration TAS
Traceable Author Statement
more info
PubMed 
involved_in positive regulation of gene expression ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within positive regulation of peptidyl-serine phosphorylation IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within positive regulation of peptidyl-tyrosine phosphorylation IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of peptidyl-tyrosine phosphorylation ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within_positive_effect positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of protein phosphorylation ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of protein ubiquitination ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of receptor internalization ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of vascular endothelial growth factor receptor signaling pathway TAS
Traceable Author Statement
more info
PubMed 
involved_in protein localization to cell surface ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within regulation of canonical NF-kappaB signal transduction IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within regulation of macrophage migration inhibitory factor signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within regulation of protein binding IDA
Inferred from Direct Assay
more info
PubMed 
involved_in regulation of skeletal muscle satellite cell proliferation ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within regulation of tumor necrosis factor production IDA
Inferred from Direct Assay
more info
PubMed 
involved_in sprouting angiogenesis ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within transmembrane receptor protein tyrosine kinase signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
involved_in vasculogenesis TAS
Traceable Author Statement
more info
PubMed 
involved_in vasculogenesis involved in coronary vascular morphogenesis TAS
Traceable Author Statement
more info
PubMed 
Component Evidence Code Pubs
is_active_in collagen-containing extracellular matrix IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in extracellular region IEA
Inferred from Electronic Annotation
more info
 
is_active_in extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in extracellular space ISO
Inferred from Sequence Orthology
more info
 
located_in membrane raft ISO
Inferred from Sequence Orthology
more info
 
located_in microvillus ISO
Inferred from Sequence Orthology
more info
 
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
 

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001286062.1NP_001272991.1  angiopoietin-1 isoform 2 precursor

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) uses an alternate in-frame splice site in the coding region compared to variant 1. This encoded protein (isoform 2) is shorter than isoform 1.
    Source sequence(s)
    AC100734, AC101713, AC161347
    UniProtKB/TrEMBL
    Q8C2K6
    Conserved Domains (2) summary
    cd00087
    Location:280495
    FReD; Fibrinogen-related domains (FReDs); C terminal globular domain of fibrinogen. Fibrinogen is involved in blood clotting, being activated by thrombin to assemble into fibrin clots. The N-termini of 2 times 3 chains come together to form a globular ...
    cl23720
    Location:161272
    RILP-like; Rab interacting lysosomal protein-like 1 and 2 (Rilpl1 and Rilpl2)
  2. NM_009640.4NP_033770.2  angiopoietin-1 isoform 1 precursor

    See identical proteins and their annotated locations for NP_033770.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AC100734, AC101713, BC067410
    Consensus CDS
    CCDS27450.1
    UniProtKB/Swiss-Prot
    O08538, Q6NWV7
    UniProtKB/TrEMBL
    Q8C2K6
    Related
    ENSMUSP00000022921.6, ENSMUST00000022921.7
    Conserved Domains (2) summary
    cd00087
    Location:281496
    FReD; Fibrinogen-related domains (FReDs); C terminal globular domain of fibrinogen. Fibrinogen is involved in blood clotting, being activated by thrombin to assemble into fibrin clots. The N-termini of 2 times 3 chains come together to form a globular ...
    cl23720
    Location:133238
    RILP-like; Rab interacting lysosomal protein-like 1 and 2 (Rilpl1 and Rilpl2)

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000081.7 Reference GRCm39 C57BL/6J

    Range
    42288063..42540373 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006520323.3XP_006520386.1  angiopoietin-1 isoform X1

    UniProtKB/TrEMBL
    Q8C2K6
    Conserved Domains (2) summary
    cd00087
    Location:183398
    FReD; Fibrinogen-related domains (FReDs); C terminal globular domain of fibrinogen. Fibrinogen is involved in blood clotting, being activated by thrombin to assemble into fibrin clots. The N-termini of 2 times 3 chains come together to form a globular ...
    pfam09787
    Location:20173
    Golgin_A5; Golgin subfamily A member 5
  2. XM_036159078.1XP_036014971.1  angiopoietin-1 isoform X3

    Conserved Domains (2) summary
    cd00087
    Location:173388
    FReD; Fibrinogen-related domains (FReDs); C terminal globular domain of fibrinogen. Fibrinogen is involved in blood clotting, being activated by thrombin to assemble into fibrin clots. The N-termini of 2 times 3 chains come together to form a globular ...
    TIGR04523
    Location:29151
    Mplasa_alph_rch; helix-rich Mycoplasma protein
  3. XM_036159077.1XP_036014970.1  angiopoietin-1 isoform X2

    Conserved Domains (2) summary
    cd00087
    Location:174389
    FReD; Fibrinogen-related domains (FReDs); C terminal globular domain of fibrinogen. Fibrinogen is involved in blood clotting, being activated by thrombin to assemble into fibrin clots. The N-termini of 2 times 3 chains come together to form a globular ...
    TIGR04523
    Location:29151
    Mplasa_alph_rch; helix-rich Mycoplasma protein