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Adsl adenylosuccinate lyase [ Mus musculus (house mouse) ]

Gene ID: 11564, updated on 5-Feb-2023

Summary

Official Symbol
Adslprovided by MGI
Official Full Name
adenylosuccinate lyaseprovided by MGI
Primary source
MGI:MGI:103202
See related
Ensembl:ENSMUSG00000022407 AllianceGenome:MGI:103202
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Adl; Asl
Summary
This gene encodes a protein that is involved in adenosine monophosphate (AMP) biosynthesis and maintaining AMP levels in the muscle. The encoded enzyme catalyzes the release of fumarate during AMP biosynthesis by cleaving the substrates succinylaminoimidazole carboxamide (SAICA) ribotide to give aminoimidazole carboxamide (AICA) ribotide, and adenylosuccinate to give adenylate. In humans, this gene is associated with adenylosuccinate deficiency, a rare autosomal disorder resulting in a spectrum of neurological symptoms. A pseudogene associated with this gene is located on the X chromosome. [provided by RefSeq, Jan 2013]
Expression
Ubiquitous expression in CNS E11.5 (RPKM 11.1), limb E14.5 (RPKM 10.5) and 28 other tissues See more
Orthologs
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Genomic context

See Adsl in Genome Data Viewer
Location:
15 E1; 15 37.95 cM
Exon count:
13
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 15 NC_000081.7 (80832691..80855148)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 15 NC_000081.6 (80948490..80970947)

Chromosome 15 - NC_000081.7Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA A430088P11 gene Neighboring gene family with sequence similarity 83, member F Neighboring gene trinucleotide repeat containing 6b Neighboring gene microRNA 5113 Neighboring gene predicted gene 6612 Neighboring gene small G protein signaling modulator 3 Neighboring gene myocardin related transcription factor A Neighboring gene predicted gene, 25131

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Gene trapped (1) 
  • Targeted (2) 
  • Endonuclease-mediated (1)  1 citation

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Process Evidence Code Pubs
involved_in 'de novo' AMP biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in 'de novo' AMP biosynthetic process IDA
Inferred from Direct Assay
more info
PubMed 
involved_in 'de novo' AMP biosynthetic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in 'de novo' IMP biosynthetic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in 'de novo' XMP biosynthetic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within AMP biosynthetic process ISA
Inferred from Sequence Alignment
more info
PubMed 
involved_in AMP biosynthetic process ISO
Inferred from Sequence Orthology
more info
 
involved_in AMP salvage IDA
Inferred from Direct Assay
more info
PubMed 
involved_in AMP salvage TAS
Traceable Author Statement
more info
PubMed 
involved_in GMP biosynthetic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in aerobic respiration ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within purine nucleotide biosynthetic process IEA
Inferred from Electronic Annotation
more info
 
involved_in purine nucleotide metabolic process ISO
Inferred from Sequence Orthology
more info
 
involved_in purine ribonucleotide biosynthetic process IEA
Inferred from Electronic Annotation
more info
 
involved_in response to nutrient ISO
Inferred from Sequence Orthology
more info
 
involved_in ribonucleoside monophosphate biosynthetic process ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in cytosol ISO
Inferred from Sequence Orthology
more info
 
located_in mitochondrion HDA PubMed 
part_of protein-containing complex ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
adenylosuccinate lyase
Names
ASase
adenylosuccinase
adenylosuccinate lyase 1
NP_033764.2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_009634.6NP_033764.2  adenylosuccinate lyase

    See identical proteins and their annotated locations for NP_033764.2

    Status: REVIEWED

    Source sequence(s)
    AC125540, AC141880, AK049372, BY032654
    Consensus CDS
    CCDS27664.1
    UniProtKB/Swiss-Prot
    P54822, Q8VCD4
    Related
    ENSMUSP00000023043.3, ENSMUST00000023043.10
    Conserved Domains (2) summary
    cd03302
    Location:17452
    Adenylsuccinate_lyase_2; Adenylsuccinate lyase (ASL)_subgroup 2
    TIGR00928
    Location:17460
    purB; adenylosuccinate lyase

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000081.7 Reference GRCm39 C57BL/6J

    Range
    80832691..80855148
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)