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Adk adenosine kinase [ Mus musculus (house mouse) ]

Gene ID: 11534, updated on 21-May-2019

Summary

Official Symbol
Adkprovided by MGI
Official Full Name
adenosine kinaseprovided by MGI
Primary source
MGI:MGI:87930
See related
Ensembl:ENSMUSG00000039197
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Ak; AI255373; AI987814; 2310026J05Rik; 5033405D03Rik
Expression
Broad expression in liver adult (RPKM 33.3), liver E18 (RPKM 24.2) and 21 other tissues See more
Orthologs

Genomic context

See Adk in Genome Data Viewer
Location:
14; 14 A3
Exon count:
14
Annotation release Status Assembly Chr Location
106 current GRCm38.p4 (GCF_000001635.24) 14 NC_000080.6 (21052574..21448569)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 14 NC_000080.5 (21871855..22267769)

Chromosome 14 - NC_000080.6Genomic Context describing neighboring genes Neighboring gene vinculin Neighboring gene predicted gene, 30274 Neighboring gene adaptor-related protein complex 3, mu 1 subunit Neighboring gene predicted gene, 30363 Neighboring gene K(lysine) acetyltransferase 6B

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from BioSystems

General gene information

Markers

Homology

Clone Names

  • MGC6593

Gene Ontology Provided by MGI

Function Evidence Code Pubs
ATP binding IEA
Inferred from Electronic Annotation
more info
 
adenosine kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
adenosine kinase activity IDA
Inferred from Direct Assay
more info
PubMed 
adenosine kinase activity ISO
Inferred from Sequence Orthology
more info
 
kinase activity IEA
Inferred from Electronic Annotation
more info
 
metal ion binding IEA
Inferred from Electronic Annotation
more info
 
nucleotide binding IEA
Inferred from Electronic Annotation
more info
 
phosphotransferase activity, alcohol group as acceptor IEA
Inferred from Electronic Annotation
more info
 
transferase activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
adenosine metabolic process ISO
Inferred from Sequence Orthology
more info
 
dATP biosynthetic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
phosphorylation IEA
Inferred from Electronic Annotation
more info
 
positive regulation of T cell proliferation ISO
Inferred from Sequence Orthology
more info
 
positive regulation of cardiac muscle hypertrophy ISO
Inferred from Sequence Orthology
more info
 
purine ribonucleoside salvage IDA
Inferred from Direct Assay
more info
PubMed 
type B pancreatic cell proliferation ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
cytoplasm ISO
Inferred from Sequence Orthology
more info
 
cytosol IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cytosol IDA
Inferred from Direct Assay
more info
PubMed 
cytosol ISO
Inferred from Sequence Orthology
more info
 
nucleoplasm ISO
Inferred from Sequence Orthology
more info
 
nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
nucleus IDA
Inferred from Direct Assay
more info
PubMed 
nucleus ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
adenosine kinase
Names
adenosine 5'-phosphotransferase
NP_001229970.1
NP_598840.1
XP_006518503.1
XP_006518504.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001243041.1NP_001229970.1  adenosine kinase isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR, lacks a portion of the 5' coding region, and initiates translation at an alternate start codon, compared to variant 1. The encoded isoform (2) has a distinct N-terminus and is shorter than isoform 1.
    Source sequence(s)
    AI194759, AK151863
    UniProtKB/Swiss-Prot
    P55264
    Related
    ENSMUSP00000153089.1, ENSMUST00000224069.1
    Conserved Domains (1) summary
    cl00192
    Location:12344
    ribokinase_pfkB_like; ribokinase/pfkB superfamily: Kinases that accept a wide variety of substrates, including carbohydrates and aromatic small molecules, all are phosphorylated at a hydroxyl group. The superfamily includes ribokinase, fructokinase, ketohexokinase, ...
  2. NM_134079.4NP_598840.1  adenosine kinase isoform 1

    See identical proteins and their annotated locations for NP_598840.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longer isoform (1).
    Source sequence(s)
    AC163681, AI194759, AK032871, AK160264, AY540996
    Consensus CDS
    CCDS26862.1
    UniProtKB/Swiss-Prot
    P55264
    UniProtKB/TrEMBL
    Q8BMC5
    Related
    ENSMUSP00000047665.9, ENSMUST00000045376.10
    Conserved Domains (1) summary
    cl00192
    Location:28360
    ribokinase_pfkB_like; ribokinase/pfkB superfamily: Kinases that accept a wide variety of substrates, including carbohydrates and aromatic small molecules, all are phosphorylated at a hydroxyl group. The superfamily includes ribokinase, fructokinase, ketohexokinase, ...

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm38.p4 C57BL/6J

Genomic

  1. NC_000080.6 Reference GRCm38.p4 C57BL/6J

    Range
    21052574..21448569
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006518440.3XP_006518503.1  adenosine kinase isoform X1

    Conserved Domains (1) summary
    cl00192
    Location:28241
    ribokinase_pfkB_like; ribokinase/pfkB superfamily: Kinases that accept a wide variety of substrates, including carbohydrates and aromatic small molecules, all are phosphorylated at a hydroxyl group. The superfamily includes ribokinase, fructokinase, ketohexokinase, ...
  2. XM_006518441.3XP_006518504.1  adenosine kinase isoform X2

    Conserved Domains (1) summary
    cl00192
    Location:28241
    ribokinase_pfkB_like; ribokinase/pfkB superfamily: Kinases that accept a wide variety of substrates, including carbohydrates and aromatic small molecules, all are phosphorylated at a hydroxyl group. The superfamily includes ribokinase, fructokinase, ketohexokinase, ...
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