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Adk adenosine kinase [ Mus musculus (house mouse) ]

Gene ID: 11534, updated on 8-Nov-2022

Summary

Official Symbol
Adkprovided by MGI
Official Full Name
adenosine kinaseprovided by MGI
Primary source
MGI:MGI:87930
See related
Ensembl:ENSMUSG00000039197 AllianceGenome:MGI:87930
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Ak; 2310026J05Rik; 5033405D03Rik
Summary
Enables adenosine kinase activity and deoxyadenosine kinase activity. Involved in AMP salvage; GMP salvage; and dAMP salvage. Acts upstream of or within dATP biosynthetic process and purine ribonucleoside salvage. Located in cytosol and nucleus. Is expressed in several structures, including alimentary system; brain; genitourinary system; sensory organ; and skeleton. Used to study fatty liver disease. Human ortholog(s) of this gene implicated in hypermethioninemia due to adenosine kinase deficiency. Orthologous to human ADK (adenosine kinase). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in liver adult (RPKM 33.3), liver E18 (RPKM 24.2) and 21 other tissues See more
Orthologs
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Genomic context

See Adk in Genome Data Viewer
Location:
14; 14 A3
Exon count:
14
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 14 NC_000080.7 (21102622..21498637)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 14 NC_000080.6 (21052574..21448569)

Chromosome 14 - NC_000080.7Genomic Context describing neighboring genes Neighboring gene vinculin Neighboring gene uncharacterized protein C3orf14 homolog pseudogene Neighboring gene adaptor-related protein complex 3, mu 1 subunit Neighboring gene VISTA enhancer mm1738 Neighboring gene predicted gene, 30363 Neighboring gene K(lysine) acetyltransferase 6B

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Gene trapped (1) 
  • Targeted (3)  1 citation
  • Endonuclease-mediated (4) 

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC6593

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
 
enables adenosine kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables adenosine kinase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables adenosine kinase activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
enables adenosine kinase activity ISO
Inferred from Sequence Orthology
more info
 
enables deoxyadenosine kinase activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
enables kinase activity IEA
Inferred from Electronic Annotation
more info
 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
 
enables phosphotransferase activity, alcohol group as acceptor IEA
Inferred from Electronic Annotation
more info
 
enables transferase activity IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
 
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
is_active_in cytosol IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytosol IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytosol ISO
Inferred from Sequence Orthology
more info
 
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in nucleus IDA
Inferred from Direct Assay
more info
PubMed 
located_in nucleus ISO
Inferred from Sequence Orthology
more info
 
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
adenosine kinase
Names
adenosine 5'-phosphotransferase
NP_001229970.1
NP_598840.1
XP_006518503.1
XP_006518504.1
XP_030103470.1
XP_030103471.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001243041.1NP_001229970.1  adenosine kinase isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR, lacks a portion of the 5' coding region, and initiates translation at an alternate start codon, compared to variant 1. The encoded isoform (2) has a distinct N-terminus and is shorter than isoform 1.
    Source sequence(s)
    AI194759, AK151863
    Consensus CDS
    CCDS88589.1
    UniProtKB/Swiss-Prot
    P55264
    UniProtKB/TrEMBL
    A0A6P5R0Z0
    Related
    ENSMUSP00000153089.2, ENSMUST00000224069.2
    Conserved Domains (1) summary
    cl00192
    Location:12344
    ribokinase_pfkB_like; ribokinase/pfkB superfamily: Kinases that accept a wide variety of substrates, including carbohydrates and aromatic small molecules, all are phosphorylated at a hydroxyl group. The superfamily includes ribokinase, fructokinase, ketohexokinase, ...
  2. NM_134079.4NP_598840.1  adenosine kinase isoform 1

    See identical proteins and their annotated locations for NP_598840.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longer isoform (1).
    Source sequence(s)
    AC163681, AI194759, AK032871, AK160264, AY540996
    Consensus CDS
    CCDS26862.1
    UniProtKB/Swiss-Prot
    P55264, Q91VJ3
    UniProtKB/TrEMBL
    A0A6P5R3N2, Q8BMC5
    Related
    ENSMUSP00000047665.10, ENSMUST00000045376.11
    Conserved Domains (1) summary
    cl00192
    Location:28360
    ribokinase_pfkB_like; ribokinase/pfkB superfamily: Kinases that accept a wide variety of substrates, including carbohydrates and aromatic small molecules, all are phosphorylated at a hydroxyl group. The superfamily includes ribokinase, fructokinase, ketohexokinase, ...

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000080.7 Reference GRCm39 C57BL/6J

    Range
    21102622..21498637
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006518441.4XP_006518504.1  adenosine kinase isoform X3

    Conserved Domains (1) summary
    cl00192
    Location:28241
    ribokinase_pfkB_like; ribokinase/pfkB superfamily: Kinases that accept a wide variety of substrates, including carbohydrates and aromatic small molecules, all are phosphorylated at a hydroxyl group. The superfamily includes ribokinase, fructokinase, ketohexokinase, ...
  2. XM_006518440.5XP_006518503.1  adenosine kinase isoform X1

    Conserved Domains (1) summary
    cl00192
    Location:28241
    ribokinase_pfkB_like; ribokinase/pfkB superfamily: Kinases that accept a wide variety of substrates, including carbohydrates and aromatic small molecules, all are phosphorylated at a hydroxyl group. The superfamily includes ribokinase, fructokinase, ketohexokinase, ...
  3. XM_030247610.2XP_030103470.1  adenosine kinase isoform X2

    Conserved Domains (1) summary
    cl00192
    Location:12225
    ribokinase_pfkB_like; ribokinase/pfkB superfamily: Kinases that accept a wide variety of substrates, including carbohydrates and aromatic small molecules, all are phosphorylated at a hydroxyl group. The superfamily includes ribokinase, fructokinase, ketohexokinase, ...
  4. XM_030247611.1XP_030103471.1  adenosine kinase isoform X4

    Conserved Domains (1) summary
    cl00192
    Location:12225
    ribokinase_pfkB_like; ribokinase/pfkB superfamily: Kinases that accept a wide variety of substrates, including carbohydrates and aromatic small molecules, all are phosphorylated at a hydroxyl group. The superfamily includes ribokinase, fructokinase, ketohexokinase, ...