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GPR146 G protein-coupled receptor 146 [ Homo sapiens (human) ]

Gene ID: 115330, updated on 21-Dec-2019

Summary

Official Symbol
GPR146provided by HGNC
Official Full Name
G protein-coupled receptor 146provided by HGNC
Primary source
HGNC:HGNC:21718
See related
Ensembl:ENSG00000164849
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
PGR8
Expression
Broad expression in fat (RPKM 14.9), lung (RPKM 4.6) and 18 other tissues See more
Orthologs

Genomic context

See GPR146 in Genome Data Viewer
Location:
7p22.3
Exon count:
4
Annotation release Status Assembly Chr Location
109.20191205 current GRCh38.p13 (GCF_000001405.39) 7 NC_000007.14 (1044546..1059261)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 7 NC_000007.13 (1084218..1098905)

Chromosome 7 - NC_000007.14Genomic Context describing neighboring genes Neighboring gene chromosome 7 open reading frame 50 Neighboring gene nonconserved acetylation island sequence 100 enhancer Neighboring gene microRNA 339 Neighboring gene uncharacterized LOC107986755 Neighboring gene Sharpr-MPRA regulatory region 11358 Neighboring gene uncharacterized LOC105375120

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Phenotypes

NHGRI GWAS Catalog

Description
Discovery and refinement of loci associated with lipid levels.
NHGRI GWA Catalog

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
G protein-coupled receptor activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
G protein-coupled receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
integral component of membrane IEA
Inferred from Electronic Annotation
more info
 
plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
probable G-protein coupled receptor 146
Names
G-protein coupled receptor PGR8

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001303473.2NP_001290402.1  probable G-protein coupled receptor 146

    See identical proteins and their annotated locations for NP_001290402.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR compared to variant 1. Variants 1, 2 and 3 encode the same protein.
    Source sequence(s)
    AC073957, AK300166, BC014241, BI910046, CD676083
    Consensus CDS
    CCDS5321.1
    UniProtKB/Swiss-Prot
    Q96CH1
    UniProtKB/TrEMBL
    A4D2Q3, B4DTD6
    Related
    ENSP00000410743.2, ENST00000444847.2
    Conserved Domains (1) summary
    cd14990
    Location:39307
    7tmA_GPR146; G protein-coupled receptor 146, member of the class A family of seven-transmembrane G protein-coupled receptors
  2. NM_001303474.2NP_001290403.1  probable G-protein coupled receptor 146

    See identical proteins and their annotated locations for NP_001290403.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript. Variants 1, 2 and 3 encode the same protein.
    Source sequence(s)
    AK300166, BC014241, DA169774
    Consensus CDS
    CCDS5321.1
    UniProtKB/Swiss-Prot
    Q96CH1
    UniProtKB/TrEMBL
    A4D2Q3, B4DTD6
    Conserved Domains (1) summary
    cd14990
    Location:39307
    7tmA_GPR146; G protein-coupled receptor 146, member of the class A family of seven-transmembrane G protein-coupled receptors
  3. NM_138445.4NP_612454.1  probable G-protein coupled receptor 146

    See identical proteins and their annotated locations for NP_612454.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an exon in the 5' UTR compared to variant 1. Variants 1, 2 and 3 encode the same protein.
    Source sequence(s)
    AK300166, AK313171, BC014241
    Consensus CDS
    CCDS5321.1
    UniProtKB/Swiss-Prot
    Q96CH1
    UniProtKB/TrEMBL
    A4D2Q3, B4DTD6
    Related
    ENSP00000380283.1, ENST00000397095.2
    Conserved Domains (1) summary
    cd14990
    Location:39307
    7tmA_GPR146; G protein-coupled receptor 146, member of the class A family of seven-transmembrane G protein-coupled receptors

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20191205

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000007.14 Reference GRCh38.p13 Primary Assembly

    Range
    1044546..1059261
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006715642.2XP_006715705.1  probable G-protein coupled receptor 146 isoform X1

    See identical proteins and their annotated locations for XP_006715705.1

    Conserved Domains (1) summary
    pfam00001
    Location:63314
    7tm_1; 7 transmembrane receptor (rhodopsin family)
  2. XM_006715643.2XP_006715706.1  probable G-protein coupled receptor 146 isoform X2

    See identical proteins and their annotated locations for XP_006715706.1

    UniProtKB/Swiss-Prot
    Q96CH1
    UniProtKB/TrEMBL
    A4D2Q3
    Conserved Domains (1) summary
    cd14990
    Location:39307
    7tmA_GPR146; G protein-coupled receptor 146, member of the class A family of seven-transmembrane G protein-coupled receptors
  3. XM_005249613.3XP_005249670.2  probable G-protein coupled receptor 146 isoform X2

    Conserved Domains (1) summary
    cd14990
    Location:39307
    7tmA_GPR146; G protein-coupled receptor 146, member of the class A family of seven-transmembrane G protein-coupled receptors
  4. XM_011515116.3XP_011513418.1  probable G-protein coupled receptor 146 isoform X1

    See identical proteins and their annotated locations for XP_011513418.1

    Conserved Domains (1) summary
    pfam00001
    Location:63314
    7tm_1; 7 transmembrane receptor (rhodopsin family)
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