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Plin2 perilipin 2 [ Mus musculus (house mouse) ]

Gene ID: 11520, updated on 2-Nov-2024

Summary

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Official Symbol
Plin2provided by MGI
Official Full Name
perilipin 2provided by MGI
Primary source
MGI:MGI:87920
See related
Ensembl:ENSMUSG00000028494 AllianceGenome:MGI:87920
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
ADPH; Adfp; Adrp
Summary
Acts upstream of or within lipid storage and long-chain fatty acid transport. Located in several cellular components, including cytosol; lipid droplet; and nucleus. Is expressed in hindlimb tendon and pancreas epithelium. Orthologous to human PLIN2 (perilipin 2). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Broad expression in subcutaneous fat pad adult (RPKM 153.8), liver adult (RPKM 106.9) and 24 other tissues See more
Orthologs
human all
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Genomic context

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See Plin2 in Genome Data Viewer
Location:
4 C4; 4 40.69 cM
Exon count:
12
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 4 NC_000070.7 (86545147..86588518, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 4 NC_000070.6 (86626910..86670217, complement)

Chromosome 4 - NC_000070.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer mm9_chr4:86225970-86226270 Neighboring gene Ras-related GTP binding A Neighboring gene HAUS augmin-like complex, subunit 6 Neighboring gene small Cajal body-specific RNA 8 Neighboring gene STARR-positive B cell enhancer ABC_E2115 Neighboring gene STARR-seq mESC enhancer starr_10694 Neighboring gene perilipin 2 pseudogene Neighboring gene STARR-seq mESC enhancer starr_10695 Neighboring gene STARR-seq mESC enhancer starr_10697 Neighboring gene STARR-seq mESC enhancer starr_10698 Neighboring gene CapStarr-seq enhancer MGSCv37_chr4:86358735-86358844 Neighboring gene predicted gene, 42312 Neighboring gene STARR-positive B cell enhancer ABC_E7973 Neighboring gene DENN domain containing 4C Neighboring gene predicted gene 6521

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Loss of perilipin 2 in cultured myotubes enhances lipolysis and redirects the metabolic energy balance from glucose oxidation towards fatty acid oxidation. Feng YZ, et al. J Lipid Res, 2017 Nov. PMID 28822960, Free PMC Article
  2. Cardiac overexpression of perilipin 2 induces atrial steatosis, connexin 43 remodeling, and atrial fibrillation in aged mice. Sato S, et al. Am J Physiol Endocrinol Metab, 2019 Dec 1. PMID 31661297, Free PMC Article
  3. Delayed liver regeneration after partial hepatectomy in adipose differentiation related protein-null mice. Kohjima M, et al. J Hepatol, 2013 Dec. PMID 23928401, Free PMC Article
  4. Plin2-deficiency reduces lipophagy and results in increased lipid accumulation in the heart. Mardani I, et al. Sci Rep, 2019 May 6. PMID 31061399, Free PMC Article
  5. Metformin prevents hepatic steatosis by regulating the expression of adipose differentiation-related protein. Liu F, et al. Int J Mol Med, 2014 Jan. PMID 24253218, Free PMC Article

See all (161) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Altered hepatic lipid droplet morphology and lipid metabolism in fasted Plin2-null mice.
    Title: Altered hepatic lipid droplet morphology and lipid metabolism in fasted Plin2-null mice.
  2. Lysine tRNA fragments and miR-194-5p co-regulate hepatic steatosis via beta-Klotho and perilipin 2.
    Title: Lysine tRNA fragments and miR-194-5p co-regulate hepatic steatosis via β-Klotho and perilipin 2.
  3. Alcoholic Setdb1 suppression promotes hepatosteatosis in mice by strengthening Plin2.
    Title: Alcoholic Setdb1 suppression promotes hepatosteatosis in mice by strengthening Plin2.
  4. Inhibition of perilipin 2 attenuates cerebral ischemia/reperfusion injury by blocking NLRP3 inflammasome activation both in vivo and in vitro.
    Title: Inhibition of perilipin 2 attenuates cerebral ischemia/reperfusion injury by blocking NLRP3 inflammasome activation both in vivo and in vitro.
  5. Perilipin 2 downregulation in beta cells impairs insulin secretion under nutritional stress and damages mitochondria.
    Title: Perilipin 2 downregulation in β cells impairs insulin secretion under nutritional stress and damages mitochondria.
  6. Perilipin 2 Impacts Acute Kidney Injury via Regulation of PPARalpha.
    Title: Perilipin 2 Impacts Acute Kidney Injury via Regulation of PPARα.
  7. Dietary excess regulates absorption and surface of gut epithelium through intestinal PPARalpha.
    Title: Dietary excess regulates absorption and surface of gut epithelium through intestinal PPARα.
  8. The role of perilipin 2 in Pseudomonas aeruginosa pulmonary infection.
    Title: The role of perilipin 2 in Pseudomonas aeruginosa pulmonary infection.
  9. Rab18 binds PLIN2 and ACSL3 to mediate lipid droplet dynamics.
    Title: Rab18 binds PLIN2 and ACSL3 to mediate lipid droplet dynamics.
  10. Lipid droplets are both highly oxidized and Plin2-covered in hepatocytes of diet-induced obese mice.
    Title: Lipid droplets are both highly oxidized and Plin2-covered in hepatocytes of diet-induced obese mice.
Submit: New GeneRIF Correction See all GeneRIFs (90)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (3) 
  • Gene trapped (1) 
  • Targeted (5)  1 citation

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in cellular response to glucose starvation ISO
Inferred from Sequence Orthology
more info
  
involved_in cellular response to glucose starvation ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in lipid droplet disassembly ISO
Inferred from Sequence Orthology
more info
  
involved_in lipid droplet disassembly ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in lipid storage IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within lipid storage IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in lipid storage ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within long-chain fatty acid transport IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in positive regulation of sequestering of triglyceride IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in response to organic cyclic compound IEA
Inferred from Electronic Annotation
more info
  
involved_in response to xenobiotic stimulus IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytosol IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytosol TAS
Traceable Author Statement
more info
  
is_active_in lipid droplet IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in lipid droplet IDA
Inferred from Direct Assay
more info
 PubMed 
located_in lipid droplet ISO
Inferred from Sequence Orthology
more info
  
located_in lipid droplet TAS
Traceable Author Statement
more info
  
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 
located_in plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
perilipin-2
Names
adipophilin
adipose differentiation-related protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001403711.1 → NP_001390640.1  perilipin-2 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AL824707
    UniProtKB/Swiss-Prot
    P43883, Q8K3Q8

  2. NM_001403712.1 → NP_001390641.1  perilipin-2 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AL824707
    UniProtKB/Swiss-Prot
    P43883, Q8K3Q8

  3. NM_001403713.1 → NP_001390642.1  perilipin-2 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AL824707
    UniProtKB/Swiss-Prot
    P43883, Q8K3Q8

  4. NM_001403714.1 → NP_001390643.1  perilipin-2 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AL824707
    UniProtKB/Swiss-Prot
    P43883, Q8K3Q8

  5. NM_001403715.1 → NP_001390644.1  perilipin-2 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AL824707
    UniProtKB/Swiss-Prot
    P43883, Q8K3Q8

  6. NM_001403716.1 → NP_001390645.1  perilipin-2 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AL824707

  7. NM_001403717.1 → NP_001390646.1  perilipin-2 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AL824707

  8. NM_001403718.1 → NP_001390647.1  perilipin-2 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AL824707

  9. NM_001403719.1 → NP_001390648.1  perilipin-2 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AL824707

  10. NM_001403720.1 → NP_001390649.1  perilipin-2 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AL824707

  11. NM_001403721.1 → NP_001390650.1  perilipin-2 isoform 3

    Status: VALIDATED

    Source sequence(s)
    AL824707

  12. NM_001403722.1 → NP_001390651.1  perilipin-2 isoform 3

    Status: VALIDATED

    Source sequence(s)
    AL824707

  13. NM_007408.4 → NP_031434.3  perilipin-2 isoform 1

    See identical proteins and their annotated locations for NP_031434.3

    Status: VALIDATED

    Source sequence(s)
    AL824707
    Consensus CDS
    CCDS18308.1
    UniProtKB/Swiss-Prot
    P43883, Q8K3Q8
    UniProtKB/TrEMBL
    Q3U711, Q541S0
    Related
    ENSMUSP00000000466.7, ENSMUST00000000466.13
    Conserved Domains (1) summary
    pfam03036
    Location:6 → 392
    Perilipin; Perilipin family

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000070.7 Reference GRCm39 C57BL/6J

    Range
    86545147..86588518 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011249907.4 → XP_011248209.1  perilipin-2 isoform X2

    UniProtKB/TrEMBL
    Q3U711, Q541S0
    Conserved Domains (1) summary
    pfam03036
    Location:6 → 392
    Perilipin; Perilipin family
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P43883.2 GenPept UniProtKB/Swiss-Prot:P43883

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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