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Add1 adducin 1 (alpha) [ Mus musculus (house mouse) ]

Gene ID: 11518, updated on 7-Apr-2019

Summary

Official Symbol
Add1provided by MGI
Official Full Name
adducin 1 (alpha)provided by MGI
Primary source
MGI:MGI:87918
See related
Ensembl:ENSMUSG00000029106
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
AI256389
Expression
Ubiquitous expression in colon adult (RPKM 54.1), cortex adult (RPKM 53.6) and 28 other tissues See more
Orthologs

Genomic context

See Add1 in Genome Data Viewer
Location:
5 B2; 5 17.9 cM
Exon count:
20
Annotation release Status Assembly Chr Location
106 current GRCm38.p4 (GCF_000001635.24) 5 NC_000071.6 (34573714..34632305)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 5 NC_000071.5 (34916363..34974954)

Chromosome 5 - NC_000071.6Genomic Context describing neighboring genes Neighboring gene TNFAIP3 interacting protein 2 Neighboring gene SH3-domain binding protein 2 Neighboring gene microRNA 7036b Neighboring gene major facilitator superfamily domain containing 10 Neighboring gene NOP14 nucleolar protein Neighboring gene predicted gene 15522

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from BioSystems

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
T cell receptor binding ISO
Inferred from Sequence Orthology
more info
 
actin binding IEA
Inferred from Electronic Annotation
more info
 
actin filament binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
actin filament binding ISO
Inferred from Sequence Orthology
more info
 
calmodulin binding IEA
Inferred from Electronic Annotation
more info
 
protein heterodimerization activity ISO
Inferred from Sequence Orthology
more info
 
protein homodimerization activity ISO
Inferred from Sequence Orthology
more info
 
spectrin binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
spectrin binding ISO
Inferred from Sequence Orthology
more info
 
structural molecule activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
structural molecule activity IDA
Inferred from Direct Assay
more info
PubMed 
transcription factor binding ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
actin filament bundle assembly IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
actin filament bundle assembly ISO
Inferred from Sequence Orthology
more info
 
barbed-end actin filament capping IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
barbed-end actin filament capping ISO
Inferred from Sequence Orthology
more info
 
cell morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
cell volume homeostasis IMP
Inferred from Mutant Phenotype
more info
PubMed 
cellular response to calcium ion IDA
Inferred from Direct Assay
more info
PubMed 
cellular response to calcium ion ISO
Inferred from Sequence Orthology
more info
 
cellular response to retinoic acid ISO
Inferred from Sequence Orthology
more info
 
erythrocyte differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
hemoglobin metabolic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
homeostasis of number of cells within a tissue IMP
Inferred from Mutant Phenotype
more info
PubMed 
in utero embryonic development IMP
Inferred from Mutant Phenotype
more info
PubMed 
multicellular organism growth IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of actin filament polymerization ISO
Inferred from Sequence Orthology
more info
 
positive regulation of adherens junction organization IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
positive regulation of adherens junction organization IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of adherens junction organization ISO
Inferred from Sequence Orthology
more info
 
positive regulation of angiogenesis ISO
Inferred from Sequence Orthology
more info
 
positive regulation of endocytosis ISO
Inferred from Sequence Orthology
more info
 
positive regulation of establishment of endothelial barrier IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
positive regulation of establishment of endothelial barrier IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of establishment of endothelial barrier ISO
Inferred from Sequence Orthology
more info
 
positive regulation of protein binding ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
F-actin capping protein complex ISO
Inferred from Sequence Orthology
more info
 
cell-cell adherens junction IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cell-cell adherens junction IMP
Inferred from Mutant Phenotype
more info
PubMed 
cell-cell adherens junction ISO
Inferred from Sequence Orthology
more info
 
cytoplasm ISO
Inferred from Sequence Orthology
more info
 
cytoskeleton IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cytoskeleton IDA
Inferred from Direct Assay
more info
PubMed 
dendrite ISO
Inferred from Sequence Orthology
more info
 
dendritic spine ISO
Inferred from Sequence Orthology
more info
 
membrane IDA
Inferred from Direct Assay
more info
PubMed 
nuclear body ISO
Inferred from Sequence Orthology
more info
 
nucleoplasm ISO
Inferred from Sequence Orthology
more info
 
nucleus ISO
Inferred from Sequence Orthology
more info
 
perinuclear region of cytoplasm ISO
Inferred from Sequence Orthology
more info
 
colocalizes_with plasma membrane IMP
Inferred from Mutant Phenotype
more info
PubMed 
plasma membrane ISO
Inferred from Sequence Orthology
more info
 
colocalizes_with plasma membrane ISO
Inferred from Sequence Orthology
more info
 
plasma membrane raft IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
postsynaptic density IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
postsynaptic density ISO
Inferred from Sequence Orthology
more info
 
synapse ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
alpha-adducin
Names
erythrocyte adducin subunit alpha

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001024458.4NP_001019629.2  alpha-adducin isoform 1

    See identical proteins and their annotated locations for NP_001019629.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes isoform 1.
    Source sequence(s)
    AC115695, AF096839, AF189771, AK054558, CD349465, CF531553
    Consensus CDS
    CCDS19216.1
    UniProtKB/Swiss-Prot
    Q9QYC0
    Related
    ENSMUSP00000109979.2, ENSMUST00000114340.8
    Conserved Domains (2) summary
    pfam15310
    Location:595701
    VAD1-2; Vitamin A-deficiency (VAD) rat model signalling
    cl00214
    Location:145391
    Aldolase_II; Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II). ...
  2. NM_001102444.2NP_001095914.1  alpha-adducin isoform 3

    See identical proteins and their annotated locations for NP_001095914.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) uses an alternate in-frame splice junction at the end of an exon and has an alternate exon compared to variant 1 that contains an in-frame stop codon. The resulting isoform (3) contains an internal 31 aa segment not found in isoform 1, but it is still shorter and has a distinct C-terminus compared to isoform 1.
    Source sequence(s)
    AC115695, AF096839, AK054558, CF531553
    Consensus CDS
    CCDS51471.1
    UniProtKB/Swiss-Prot
    Q9QYC0
    UniProtKB/TrEMBL
    F8WGR0
    Related
    ENSMUSP00000001108.4, ENSMUST00000001108.10
    Conserved Domains (1) summary
    cl00214
    Location:145391
    Aldolase_II; Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II). ...
  3. NM_001331080.1NP_001318009.1  alpha-adducin isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC115695
    Consensus CDS
    CCDS19216.1
    UniProtKB/Swiss-Prot
    Q9QYC0
    Conserved Domains (2) summary
    pfam15310
    Location:595701
    VAD1-2; Vitamin A-deficiency (VAD) rat model signalling
    cl00214
    Location:145391
    Aldolase_II; Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II). ...
  4. NM_001331081.1NP_001318010.1  alpha-adducin isoform 4

    Status: VALIDATED

    Source sequence(s)
    AC115695
  5. NM_001331082.1NP_001318011.1  alpha-adducin isoform 5

    Status: VALIDATED

    Source sequence(s)
    AC115695
  6. NM_001331083.1NP_001318012.1  alpha-adducin isoform 6

    Status: VALIDATED

    Source sequence(s)
    AC115695
  7. NM_001331084.1NP_001318013.1  alpha-adducin isoform 7

    Status: VALIDATED

    Source sequence(s)
    AC115695
  8. NM_001331085.1NP_001318014.1  alpha-adducin isoform 8

    Status: VALIDATED

    Source sequence(s)
    AC115695
  9. NM_001331086.1NP_001318015.1  alpha-adducin isoform 9

    Status: VALIDATED

    Source sequence(s)
    AC115695
  10. NM_001331087.1NP_001318016.1  alpha-adducin isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC115695
    UniProtKB/Swiss-Prot
    Q9QYC0
  11. NM_013457.4NP_038485.1  alpha-adducin isoform 2

    See identical proteins and their annotated locations for NP_038485.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) has an alternate exon compared to variant 1 that contains an in-frame stop codon. The resulting isoform (2) is shorter and has a distinct C-terminus compared to isoform 1.
    Source sequence(s)
    AC115695, AF096839, AK054558, CD349465, CF531553
    Consensus CDS
    CCDS39069.1
    UniProtKB/Swiss-Prot
    Q9QYC0
    Related
    ENSMUSP00000109977.2, ENSMUST00000114338.8
    Conserved Domains (1) summary
    cl00214
    Location:145391
    Aldolase_II; Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II). ...

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm38.p4 C57BL/6J

Genomic

  1. NC_000071.6 Reference GRCm38.p4 C57BL/6J

    Range
    34573714..34632305
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006503669.3XP_006503732.1  alpha-adducin isoform X1

    See identical proteins and their annotated locations for XP_006503732.1

    Conserved Domains (2) summary
    pfam15310
    Location:655761
    VAD1-2; Vitamin A-deficiency (VAD) rat model signalling
    cl00214
    Location:145391
    Aldolase_II; Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II). ...
  2. XM_017320615.1XP_017176104.1  alpha-adducin isoform X15

    UniProtKB/Swiss-Prot
    Q9QYC0
    Conserved Domains (1) summary
    cl00214
    Location:145391
    Aldolase_II; Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II). ...
  3. XM_006503671.3XP_006503734.1  alpha-adducin isoform X3

    Conserved Domains (2) summary
    pfam15310
    Location:626732
    VAD1-2; Vitamin A-deficiency (VAD) rat model signalling
    cl00214
    Location:145391
    Aldolase_II; Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II). ...
  4. XM_006503673.3XP_006503736.1  alpha-adducin isoform X6

    Conserved Domains (1) summary
    cl00214
    Location:145391
    Aldolase_II; Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II). ...
  5. XM_006503675.3XP_006503738.1  alpha-adducin isoform X8

    See identical proteins and their annotated locations for XP_006503738.1

    Related
    ENSMUSP00000109974.1, ENSMUST00000114335.7
    Conserved Domains (1) summary
    cl00214
    Location:145391
    Aldolase_II; Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II). ...
  6. XM_006503668.3XP_006503731.1  alpha-adducin isoform X1

    Conserved Domains (2) summary
    pfam15310
    Location:655761
    VAD1-2; Vitamin A-deficiency (VAD) rat model signalling
    cl00214
    Location:145391
    Aldolase_II; Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II). ...
  7. XM_006503678.3XP_006503741.1  alpha-adducin isoform X11

    See identical proteins and their annotated locations for XP_006503741.1

    UniProtKB/TrEMBL
    F8WHZ9
    Related
    ENSMUSP00000052266.6, ENSMUST00000052836.13
    Conserved Domains (1) summary
    cl00214
    Location:145391
    Aldolase_II; Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II). ...
  8. XM_006503670.3XP_006503733.1  alpha-adducin isoform X2

    Conserved Domains (2) summary
    pfam15310
    Location:639745
    VAD1-2; Vitamin A-deficiency (VAD) rat model signalling
    cl00214
    Location:145391
    Aldolase_II; Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II). ...
  9. XM_006503672.3XP_006503735.1  alpha-adducin isoform X4

    Conserved Domains (2) summary
    pfam15310
    Location:624730
    VAD1-2; Vitamin A-deficiency (VAD) rat model signalling
    cl00214
    Location:145391
    Aldolase_II; Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II). ...
  10. XM_017320614.1XP_017176103.1  alpha-adducin isoform X13

  11. XM_017320616.1XP_017176105.1  alpha-adducin isoform X16

    Conserved Domains (1) summary
    cl00214
    Location:145391
    Aldolase_II; Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II). ...
  12. XM_017320617.1XP_017176106.1  alpha-adducin isoform X17

    Conserved Domains (1) summary
    cl00214
    Location:145391
    Aldolase_II; Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II). ...
  13. XM_006503677.2XP_006503740.1  alpha-adducin isoform X10

    See identical proteins and their annotated locations for XP_006503740.1

    UniProtKB/TrEMBL
    F8WGR0
    Conserved Domains (1) summary
    cl00214
    Location:145391
    Aldolase_II; Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II). ...
  14. XM_006503674.2XP_006503737.1  alpha-adducin isoform X7

    See identical proteins and their annotated locations for XP_006503737.1

    Conserved Domains (1) summary
    cl00214
    Location:145391
    Aldolase_II; Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II). ...
  15. XM_006503676.2XP_006503739.1  alpha-adducin isoform X9

    See identical proteins and their annotated locations for XP_006503739.1

    Conserved Domains (1) summary
    cl00214
    Location:145391
    Aldolase_II; Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II). ...
  16. XM_006503679.2XP_006503742.1  alpha-adducin isoform X12

    See identical proteins and their annotated locations for XP_006503742.1

    UniProtKB/TrEMBL
    F8WHZ9
    Conserved Domains (1) summary
    cl00214
    Location:145391
    Aldolase_II; Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II). ...
  17. XM_006503680.2XP_006503743.1  alpha-adducin isoform X14

    UniProtKB/TrEMBL
    E9Q1K3
    Conserved Domains (1) summary
    cl00214
    Location:145391
    Aldolase_II; Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II). ...
  18. XM_006503681.2XP_006503744.1  alpha-adducin isoform X18

    Conserved Domains (1) summary
    cl00214
    Location:145391
    Aldolase_II; Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II). ...
  19. XM_017320613.1XP_017176102.1  alpha-adducin isoform X5

    Conserved Domains (2) summary
    pfam15310
    Location:595701
    VAD1-2; Vitamin A-deficiency (VAD) rat model signalling
    cl00214
    Location:145391
    Aldolase_II; Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II). ...
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