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Adcy6 adenylate cyclase 6 [ Mus musculus (house mouse) ]

Gene ID: 11512, updated on 22-Nov-2020

Summary

Official Symbol
Adcy6provided by MGI
Official Full Name
adenylate cyclase 6provided by MGI
Primary source
MGI:MGI:87917
See related
Ensembl:ENSMUSG00000022994
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
AC; AC6; mKIAA0422
Expression
Ubiquitous expression in colon adult (RPKM 45.5), thymus adult (RPKM 39.6) and 27 other tissues See more
Orthologs

Genomic context

See Adcy6 in Genome Data Viewer
Location:
15; 15 F1
Exon count:
27
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 15 NC_000081.7 (98484982..98508173, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 15 NC_000081.6 (98589978..98610287, complement)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 15 NC_000081.5 (98420409..98438064, complement)

Chromosome 15 - NC_000081.7Genomic Context describing neighboring genes Neighboring gene KAT8 regulatory NSL complex subunit 2 Neighboring gene small nucleolar RNA, H/ACA box 2B Neighboring gene cyclin T1 Neighboring gene RIKEN cDNA 9330020H09 gene Neighboring gene testis expressed 49 Neighboring gene calcium channel, voltage-dependent, beta 3 subunit Neighboring gene DEAD box helicase 23

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
ATP binding IEA
Inferred from Electronic Annotation
more info
 
SNARE binding ISO
Inferred from Sequence Orthology
more info
 
adenylate cyclase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
adenylate cyclase activity IDA
Inferred from Direct Assay
more info
PubMed 
adenylate cyclase activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
adenylate cyclase activity ISO
Inferred from Sequence Orthology
more info
 
calcium- and calmodulin-responsive adenylate cyclase activity IDA
Inferred from Direct Assay
more info
PubMed 
calcium- and calmodulin-responsive adenylate cyclase activity ISO
Inferred from Sequence Orthology
more info
 
lyase activity IEA
Inferred from Electronic Annotation
more info
 
metal ion binding IEA
Inferred from Electronic Annotation
more info
 
nucleotide binding IEA
Inferred from Electronic Annotation
more info
 
phosphorus-oxygen lyase activity IEA
Inferred from Electronic Annotation
more info
 
protein kinase C binding ISO
Inferred from Sequence Orthology
more info
 
protein kinase binding ISO
Inferred from Sequence Orthology
more info
 
scaffold protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
signaling receptor binding ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
adenylate cyclase-activating G protein-coupled receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
adenylate cyclase-activating G protein-coupled receptor signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
adenylate cyclase-activating G protein-coupled receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
 
adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
blood vessel diameter maintenance ISO
Inferred from Sequence Orthology
more info
 
cAMP biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cAMP biosynthetic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
cAMP biosynthetic process ISO
Inferred from Sequence Orthology
more info
 
cellular response to catecholamine stimulus ISO
Inferred from Sequence Orthology
more info
 
cellular response to forskolin IMP
Inferred from Mutant Phenotype
more info
PubMed 
cellular response to forskolin ISO
Inferred from Sequence Orthology
more info
 
cellular response to prostaglandin E stimulus ISO
Inferred from Sequence Orthology
more info
 
cellular response to vasopressin IMP
Inferred from Mutant Phenotype
more info
PubMed 
cyclic nucleotide biosynthetic process IEA
Inferred from Electronic Annotation
more info
 
dopamine receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
 
intracellular signal transduction IEA
Inferred from Electronic Annotation
more info
 
maintenance of protein location in plasma membrane ISO
Inferred from Sequence Orthology
more info
 
negative regulation of neuron projection development IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of neuron projection development ISO
Inferred from Sequence Orthology
more info
 
negative regulation of urine volume IMP
Inferred from Mutant Phenotype
more info
PubMed 
renal water homeostasis IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
cell projection IEA
Inferred from Electronic Annotation
more info
 
cilium IEA
Inferred from Electronic Annotation
more info
 
endosome ISO
Inferred from Sequence Orthology
more info
 
integral component of membrane IEA
Inferred from Electronic Annotation
more info
 
integral component of plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
intrinsic component of plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
membrane ISO
Inferred from Sequence Orthology
more info
 
membrane raft ISO
Inferred from Sequence Orthology
more info
 
microvillus membrane ISO
Inferred from Sequence Orthology
more info
 
plasma membrane ISO
Inferred from Sequence Orthology
more info
 
colocalizes_with sarcolemma ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
adenylate cyclase type 6
Names
ATP pyrophosphate-lyase 6
adenylate cyclase type VI
adenylyl cyclase 6
ca(2+)-inhibitable adenylyl cyclase
NP_001355342.1
NP_031431.2
XP_006520366.3
XP_006520369.3
XP_006520370.1
XP_006520377.1
XP_006520378.1
XP_030104139.1
XP_030104140.2
XP_030104141.1
XP_030104143.1
XP_036014968.1
XP_036014969.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001368413.1NP_001355342.1  adenylate cyclase type 6 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC138221
    Consensus CDS
    CCDS88833.1
    Related
    ENSMUSP00000154421.1, ENSMUST00000228566.1
    Conserved Domains (3) summary
    pfam00211
    Location:9681162
    Guanylate_cyc; Adenylate and Guanylate cyclase catalytic domain
    pfam16214
    Location:14366
    AC_N; Adenylyl cyclase N-terminal extracellular and transmembrane region
    pfam06327
    Location:580666
    DUF1053; Domain of Unknown Function (DUF1053)
  2. NM_007405.3NP_031431.2  adenylate cyclase type 6 isoform 1

    See identical proteins and their annotated locations for NP_031431.2

    Status: VALIDATED

    Source sequence(s)
    AC138221
    Consensus CDS
    CCDS27799.1
    UniProtKB/Swiss-Prot
    Q01341
    UniProtKB/TrEMBL
    F8VQ52
    Related
    ENSMUSP00000093939.4, ENSMUST00000096224.5
    Conserved Domains (4) summary
    smart00044
    Location:332529
    CYCc; Adenylyl- / guanylyl cyclase, catalytic domain
    pfam00211
    Location:9701164
    Guanylate_cyc; Adenylate and Guanylate cyclase catalytic domain
    pfam06327
    Location:582668
    DUF1053; Domain of Unknown Function (DUF1053)
    pfam16214
    Location:14366
    AC_N; Adenylyl cyclase N-terminal extracellular and transmembrane region

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000081.7 Reference GRCm39 C57BL/6J

    Range
    98484982..98508173 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006520303.5XP_006520366.3  adenylate cyclase type 6 isoform X1

  2. XM_030248283.2XP_030104143.1  adenylate cyclase type 6 isoform X5

    Conserved Domains (3) summary
    pfam00211
    Location:9681162
    Guanylate_cyc; Adenylate and Guanylate cyclase catalytic domain
    pfam16214
    Location:14366
    AC_N; Adenylyl cyclase N-terminal extracellular and transmembrane region
    pfam06327
    Location:580666
    DUF1053; Domain of Unknown Function (DUF1053)
  3. XM_006520307.4XP_006520370.1  adenylate cyclase type 6 isoform X6

  4. XM_006520306.5XP_006520369.3  adenylate cyclase type 6 isoform X4

  5. XM_036159076.1XP_036014969.1  adenylate cyclase type 6 isoform X5

    Conserved Domains (3) summary
    pfam00211
    Location:9681162
    Guanylate_cyc; Adenylate and Guanylate cyclase catalytic domain
    pfam16214
    Location:14366
    AC_N; Adenylyl cyclase N-terminal extracellular and transmembrane region
    pfam06327
    Location:580666
    DUF1053; Domain of Unknown Function (DUF1053)
  6. XM_006520315.2XP_006520378.1  adenylate cyclase type 6 isoform X5

    See identical proteins and their annotated locations for XP_006520378.1

    Conserved Domains (3) summary
    pfam00211
    Location:9681162
    Guanylate_cyc; Adenylate and Guanylate cyclase catalytic domain
    pfam16214
    Location:14366
    AC_N; Adenylyl cyclase N-terminal extracellular and transmembrane region
    pfam06327
    Location:580666
    DUF1053; Domain of Unknown Function (DUF1053)
  7. XM_030248281.2XP_030104141.1  adenylate cyclase type 6 isoform X8

  8. XM_030248280.2XP_030104140.2  adenylate cyclase type 6 isoform X7

  9. XM_006520314.5XP_006520377.1  adenylate cyclase type 6 isoform X5

    See identical proteins and their annotated locations for XP_006520377.1

    Conserved Domains (3) summary
    pfam00211
    Location:9681162
    Guanylate_cyc; Adenylate and Guanylate cyclase catalytic domain
    pfam16214
    Location:14366
    AC_N; Adenylyl cyclase N-terminal extracellular and transmembrane region
    pfam06327
    Location:580666
    DUF1053; Domain of Unknown Function (DUF1053)
  10. XM_030248279.2XP_030104139.1  adenylate cyclase type 6 isoform X3

  11. XM_036159075.1XP_036014968.1  adenylate cyclase type 6 isoform X2

RNA

  1. XR_004938786.1 RNA Sequence

  2. XR_001781491.3 RNA Sequence

  3. XR_004938785.1 RNA Sequence

  4. XR_383972.5 RNA Sequence

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