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Adam22 a disintegrin and metallopeptidase domain 22 [ Mus musculus (house mouse) ]

Gene ID: 11496, updated on 8-Feb-2024

Summary

Official Symbol
Adam22provided by MGI
Official Full Name
a disintegrin and metallopeptidase domain 22provided by MGI
Primary source
MGI:MGI:1340046
See related
Ensembl:ENSMUSG00000040537 AllianceGenome:MGI:1340046
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
MDC2; 2900022I03Rik
Summary
This gene encodes a member of a disintegrin and metalloprotease (ADAM) family of endoproteases that play important roles in various biological processes including cell signaling, adhesion and migration. The encoded preproprotein undergoes proteolytic processing to generate a mature, functional protein. The protein encoded by this gene is believed to lack metalloproteinase activity due to the lack of a critical catalytic motif. Mice lacking the encoded protein exhibit severe ataxia, hypomyelination and premature death. Alternative splicing results in multiple transcript variants encoding different isoforms, some of which may undergo similar processing. [provided by RefSeq, May 2016]
Expression
Biased expression in cerebellum adult (RPKM 18.0), cortex adult (RPKM 14.5) and 7 other tissues See more
Orthologs
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

See Adam22 in Genome Data Viewer
Location:
5 A1; 5 3.39 cM
Exon count:
35
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 5 NC_000071.7 (8122353..8418312, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 5 NC_000071.6 (8072347..8368312, complement)

Chromosome 5 - NC_000071.7Genomic Context describing neighboring genes Neighboring gene predicted gene 15731 Neighboring gene predicted gene, 52802 Neighboring gene 60S ribosomal protein L27 pseudogene Neighboring gene STARR-seq mESC enhancer starr_12380 Neighboring gene sorcin Neighboring gene STARR-seq mESC enhancer starr_12381 Neighboring gene predicted gene, 21759 Neighboring gene STARR-seq mESC enhancer starr_12382 Neighboring gene STARR-seq mESC enhancer starr_12383 Neighboring gene predicted gene, 23993 Neighboring gene STARR-seq mESC enhancer starr_12384 Neighboring gene ribosomal protein L19 pseudogene Neighboring gene STARR-seq mESC enhancer starr_12387 Neighboring gene solute carrier family 25, member 40 Neighboring gene DBF4 zinc finger Neighboring gene STARR-positive B cell enhancer mm9_chr5:8489752-8490052 Neighboring gene STARR-seq mESC enhancer starr_12390 Neighboring gene RUN domain containing 3B Neighboring gene ATP-binding cassette, sub-family B member 1A

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables metalloendopeptidase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables metalloendopeptidase activity IEA
Inferred from Electronic Annotation
more info
 
enables metallopeptidase activity IEA
Inferred from Electronic Annotation
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Component Evidence Code Pubs
located_in axon IDA
Inferred from Direct Assay
more info
PubMed 
located_in axon initial segment ISO
Inferred from Sequence Orthology
more info
 
located_in cell projection IEA
Inferred from Electronic Annotation
more info
 
is_active_in glutamatergic synapse IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in glutamatergic synapse IMP
Inferred from Mutant Phenotype
more info
PubMed 
is_active_in glutamatergic synapse IPI
Inferred from Physical Interaction
more info
PubMed 
located_in membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
 
is_active_in postsynaptic density membrane IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in postsynaptic density membrane IMP
Inferred from Mutant Phenotype
more info
PubMed 
is_active_in postsynaptic density membrane IPI
Inferred from Physical Interaction
more info
PubMed 

General protein information

Preferred Names
disintegrin and metalloproteinase domain-containing protein 22
Names
a disintegrin and metalloprotease domain (ADAM) 22

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001007220.4NP_001007221.1  disintegrin and metalloproteinase domain-containing protein 22 isoform a precursor

    See identical proteins and their annotated locations for NP_001007221.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1, also known as alpha or A04) encodes isoform a. This isoform (a) may undergo protein processing similar to isoform 5.
    Source sequence(s)
    AC140364, AC152165, AC156022
    Consensus CDS
    CCDS19080.1
    UniProtKB/TrEMBL
    A4FUT9
    Related
    ENSMUSP00000049120.8, ENSMUST00000046838.14
    Conserved Domains (5) summary
    smart00608
    Location:528669
    ACR; ADAM Cysteine-Rich Domain
    cd04269
    Location:237434
    ZnMc_adamalysin_II_like; Zinc-dependent metalloprotease; adamalysin_II_like subfamily. Adamalysin II is a snake venom zinc endopeptidase. This subfamily contains other snake venom metalloproteinases, as well as membrane-anchored metalloproteases belonging to the ADAM family. ...
    pfam00200
    Location:451525
    Disintegrin; Disintegrin
    pfam01421
    Location:237436
    Reprolysin; Reprolysin (M12B) family zinc metalloprotease
    pfam01562
    Location:73185
    Pep_M12B_propep; Reprolysin family propeptide
  2. NM_001007221.4NP_001007222.1  disintegrin and metalloproteinase domain-containing protein 22 isoform b precursor

    See identical proteins and their annotated locations for NP_001007222.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2, also known as beta or A05) lacks an alternate in-frame exon in the 3' coding region, compared to variant 1. The encoded isoform (b) is shorter than isoform a. This isoform (b) may undergo protein processing similar to isoform 5.
    Source sequence(s)
    AC140364, AC152165, AC156022
    UniProtKB/TrEMBL
    A4FUT9
    Conserved Domains (5) summary
    smart00608
    Location:528669
    ACR; ADAM Cysteine-Rich Domain
    cd04269
    Location:237434
    ZnMc_adamalysin_II_like; Zinc-dependent metalloprotease; adamalysin_II_like subfamily. Adamalysin II is a snake venom zinc endopeptidase. This subfamily contains other snake venom metalloproteinases, as well as membrane-anchored metalloproteases belonging to the ADAM family. ...
    pfam00200
    Location:451525
    Disintegrin; Disintegrin
    pfam01421
    Location:237436
    Reprolysin; Reprolysin (M12B) family zinc metalloprotease
    pfam01562
    Location:73185
    Pep_M12B_propep; Reprolysin family propeptide
  3. NM_001098225.3NP_001091695.1  disintegrin and metalloproteinase domain-containing protein 22 isoform c precursor

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3, also known as G03) contains multiple differences in the 3' coding region and differs in the 3' UTR compared variant 1. The encoded isoform (c) has a distinct C-terminus and is longer than isoform a. This isoform (c) may undergo protein processing similar to isoform 5.
    Source sequence(s)
    AC140364, AC152165, AC156022
    Consensus CDS
    CCDS51411.1
    UniProtKB/TrEMBL
    A4FUT9
    Related
    ENSMUSP00000055000.8, ENSMUST00000050166.14
    Conserved Domains (5) summary
    smart00608
    Location:528669
    ACR; ADAM Cysteine-Rich Domain
    cd04269
    Location:237434
    ZnMc_adamalysin_II_like; Zinc-dependent metalloprotease; adamalysin_II_like subfamily. Adamalysin II is a snake venom zinc endopeptidase. This subfamily contains other snake venom metalloproteinases, as well as membrane-anchored metalloproteases belonging to the ADAM family. ...
    pfam00200
    Location:451525
    Disintegrin; Disintegrin
    pfam01421
    Location:237436
    Reprolysin; Reprolysin (M12B) family zinc metalloprotease
    pfam01562
    Location:73185
    Pep_M12B_propep; Reprolysin family propeptide
  4. NM_001310439.2NP_001297368.1  disintegrin and metalloproteinase domain-containing protein 22 isoform 4 precursor

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4, also known as G07) contains multiple differences in the 3' coding region and differs in the 3' UTR compared variant 1. The encoded isoform (c) has a distinct C-terminus and is longer than isoform a. This isoform (4) may undergo protein processing similar to isoform 5.
    Source sequence(s)
    AC140364, AC152165, AC156022
    Consensus CDS
    CCDS80205.1
    UniProtKB/TrEMBL
    A4FUT9
    Related
    ENSMUSP00000111046.3, ENSMUST00000115388.9
    Conserved Domains (5) summary
    smart00608
    Location:528669
    ACR; ADAM Cysteine-Rich Domain
    cd04269
    Location:237434
    ZnMc_adamalysin_II_like; Zinc-dependent metalloprotease; adamalysin_II_like subfamily. Adamalysin II is a snake venom zinc endopeptidase. This subfamily contains other snake venom metalloproteinases, as well as membrane-anchored metalloproteases belonging to the ADAM family. ...
    pfam00200
    Location:451525
    Disintegrin; Disintegrin
    pfam01421
    Location:237436
    Reprolysin; Reprolysin (M12B) family zinc metalloprotease
    pfam01562
    Location:73185
    Pep_M12B_propep; Reprolysin family propeptide
  5. NM_001310440.2NP_001297369.1  disintegrin and metalloproteinase domain-containing protein 22 isoform 5 preproprotein

    See identical proteins and their annotated locations for NP_001297369.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (5, also known as G01) differs in the 3' coding region and 3' UTR compared to variant 1. The encoded isoform (c) has a longer C-terminus than isoform a.
    Source sequence(s)
    AC140364, AC152165, AC156022
    Consensus CDS
    CCDS80207.1
    UniProtKB/Swiss-Prot
    Q5TLI8, Q5TLI9, Q5TLJ0, Q5TLJ1, Q5TLJ2, Q5TLJ3, Q5TLJ4, Q5TLJ5, Q5TLJ6, Q5TLJ7, Q5TLJ8, Q5TLJ9, Q5TLK0, Q5TLK1, Q5TLK2, Q5TLK3, Q5TLK4, Q5TLK5, Q5TLK6, Q5TLK7, Q5TLK8, Q8BSF2, Q9R1V5, Q9R1V6
    UniProtKB/TrEMBL
    A4FUT9, D6QSS8
    Related
    ENSMUSP00000086139.5, ENSMUST00000088761.11
    Conserved Domains (5) summary
    smart00608
    Location:528669
    ACR; ADAM Cysteine-Rich Domain
    cd04269
    Location:237434
    ZnMc_adamalysin_II_like; Zinc-dependent metalloprotease; adamalysin_II_like subfamily. Adamalysin II is a snake venom zinc endopeptidase. This subfamily contains other snake venom metalloproteinases, as well as membrane-anchored metalloproteases belonging to the ADAM family. ...
    pfam00200
    Location:451525
    Disintegrin; Disintegrin
    pfam01421
    Location:237436
    Reprolysin; Reprolysin (M12B) family zinc metalloprotease
    pfam01562
    Location:73185
    Pep_M12B_propep; Reprolysin family propeptide
  6. NM_001418085.1NP_001405014.1  disintegrin and metalloproteinase domain-containing protein 22 isoform 6 precursor

    Status: REVIEWED

    Source sequence(s)
    AC140364, AC152165, AC156022
    UniProtKB/TrEMBL
    A4FUT9
  7. NM_001418086.1NP_001405015.1  disintegrin and metalloproteinase domain-containing protein 22 isoform 7 precursor

    Status: REVIEWED

    Source sequence(s)
    AC140364, AC152165, AC156022
    UniProtKB/TrEMBL
    A4FUT9
  8. NM_001418087.1NP_001405016.1  disintegrin and metalloproteinase domain-containing protein 22 isoform 8 precursor

    Status: REVIEWED

    Source sequence(s)
    AC140364, AC152165, AC156022
    UniProtKB/TrEMBL
    D3YUQ0
    Related
    ENSMUSP00000111043.2, ENSMUST00000115385.2

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000071.7 Reference GRCm39 C57BL/6J

    Range
    8122353..8418312 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006503534.5XP_006503597.1  disintegrin and metalloproteinase domain-containing protein 22 isoform X7

    UniProtKB/TrEMBL
    A4FUT9
    Conserved Domains (5) summary
    smart00608
    Location:528669
    ACR; ADAM Cysteine-Rich Domain
    pfam07974
    Location:677709
    EGF_2; EGF-like domain
    pfam00200
    Location:451524
    Disintegrin
    pfam01421
    Location:237436
    Reprolysin; Reprolysin (M12B) family zinc metalloprotease
    pfam01562
    Location:48186
    Pep_M12B_propep; Reprolysin family propeptide
  2. XM_006503540.5XP_006503603.1  disintegrin and metalloproteinase domain-containing protein 22 isoform X12

    UniProtKB/TrEMBL
    A4FUT9, D3YUP9
    Related
    ENSMUSP00000111044.2, ENSMUST00000115386.8
    Conserved Domains (5) summary
    smart00608
    Location:528669
    ACR; ADAM Cysteine-Rich Domain
    pfam07974
    Location:677709
    EGF_2; EGF-like domain
    pfam00200
    Location:451524
    Disintegrin
    pfam01421
    Location:237436
    Reprolysin; Reprolysin (M12B) family zinc metalloprotease
    pfam01562
    Location:48186
    Pep_M12B_propep; Reprolysin family propeptide
  3. XM_006503536.5XP_006503599.1  disintegrin and metalloproteinase domain-containing protein 22 isoform X10

    UniProtKB/TrEMBL
    A4FUT9
    Conserved Domains (5) summary
    smart00608
    Location:528669
    ACR; ADAM Cysteine-Rich Domain
    pfam07974
    Location:677709
    EGF_2; EGF-like domain
    pfam00200
    Location:451524
    Disintegrin
    pfam01421
    Location:237436
    Reprolysin; Reprolysin (M12B) family zinc metalloprotease
    pfam01562
    Location:48186
    Pep_M12B_propep; Reprolysin family propeptide
  4. XM_006503537.5XP_006503600.1  disintegrin and metalloproteinase domain-containing protein 22 isoform X11

    UniProtKB/TrEMBL
    A4FUT9
    Conserved Domains (5) summary
    smart00608
    Location:528669
    ACR; ADAM Cysteine-Rich Domain
    pfam07974
    Location:677709
    EGF_2; EGF-like domain
    pfam00200
    Location:451524
    Disintegrin
    pfam01421
    Location:237436
    Reprolysin; Reprolysin (M12B) family zinc metalloprotease
    pfam01562
    Location:48186
    Pep_M12B_propep; Reprolysin family propeptide
  5. XM_006503532.5XP_006503595.1  disintegrin and metalloproteinase domain-containing protein 22 isoform X5

    UniProtKB/TrEMBL
    A4FUT9
    Conserved Domains (5) summary
    smart00608
    Location:528669
    ACR; ADAM Cysteine-Rich Domain
    pfam07974
    Location:677709
    EGF_2; EGF-like domain
    pfam00200
    Location:451524
    Disintegrin
    pfam01421
    Location:237436
    Reprolysin; Reprolysin (M12B) family zinc metalloprotease
    pfam01562
    Location:48186
    Pep_M12B_propep; Reprolysin family propeptide
  6. XM_006503533.5XP_006503596.1  disintegrin and metalloproteinase domain-containing protein 22 isoform X6

    UniProtKB/TrEMBL
    A4FUT9
    Conserved Domains (5) summary
    smart00608
    Location:528669
    ACR; ADAM Cysteine-Rich Domain
    pfam07974
    Location:677709
    EGF_2; EGF-like domain
    pfam00200
    Location:451524
    Disintegrin
    pfam01421
    Location:237436
    Reprolysin; Reprolysin (M12B) family zinc metalloprotease
    pfam01562
    Location:48186
    Pep_M12B_propep; Reprolysin family propeptide
  7. XM_006503530.5XP_006503593.1  disintegrin and metalloproteinase domain-containing protein 22 isoform X3

    UniProtKB/TrEMBL
    A4FUT9
    Conserved Domains (5) summary
    smart00608
    Location:528669
    ACR; ADAM Cysteine-Rich Domain
    pfam07974
    Location:677709
    EGF_2; EGF-like domain
    pfam00200
    Location:451524
    Disintegrin
    pfam01421
    Location:237436
    Reprolysin; Reprolysin (M12B) family zinc metalloprotease
    pfam01562
    Location:48186
    Pep_M12B_propep; Reprolysin family propeptide
  8. XM_006503528.5XP_006503591.1  disintegrin and metalloproteinase domain-containing protein 22 isoform X1

    UniProtKB/TrEMBL
    A4FUT9
    Conserved Domains (5) summary
    smart00608
    Location:528669
    ACR; ADAM Cysteine-Rich Domain
    pfam07974
    Location:677709
    EGF_2; EGF-like domain
    pfam00200
    Location:451524
    Disintegrin
    pfam01421
    Location:237436
    Reprolysin; Reprolysin (M12B) family zinc metalloprotease
    pfam01562
    Location:48186
    Pep_M12B_propep; Reprolysin family propeptide
  9. XM_006503535.5XP_006503598.1  disintegrin and metalloproteinase domain-containing protein 22 isoform X8

    UniProtKB/TrEMBL
    A4FUT9
    Conserved Domains (4) summary
    smart00608
    Location:528669
    ACR; ADAM Cysteine-Rich Domain
    pfam00200
    Location:451524
    Disintegrin
    pfam01421
    Location:237436
    Reprolysin; Reprolysin (M12B) family zinc metalloprotease
    pfam01562
    Location:48186
    Pep_M12B_propep; Reprolysin family propeptide
  10. XM_006503531.5XP_006503594.1  disintegrin and metalloproteinase domain-containing protein 22 isoform X4

    UniProtKB/TrEMBL
    A4FUT9
    Conserved Domains (5) summary
    smart00608
    Location:528669
    ACR; ADAM Cysteine-Rich Domain
    pfam07974
    Location:677709
    EGF_2; EGF-like domain
    pfam00200
    Location:451524
    Disintegrin
    pfam01421
    Location:237436
    Reprolysin; Reprolysin (M12B) family zinc metalloprotease
    pfam01562
    Location:48186
    Pep_M12B_propep; Reprolysin family propeptide
  11. XM_006503529.5XP_006503592.1  disintegrin and metalloproteinase domain-containing protein 22 isoform X2

    UniProtKB/TrEMBL
    A4FUT9
    Conserved Domains (5) summary
    smart00608
    Location:528669
    ACR; ADAM Cysteine-Rich Domain
    pfam07974
    Location:677709
    EGF_2; EGF-like domain
    pfam00200
    Location:451524
    Disintegrin
    pfam01421
    Location:237436
    Reprolysin; Reprolysin (M12B) family zinc metalloprotease
    pfam01562
    Location:48186
    Pep_M12B_propep; Reprolysin family propeptide
  12. XM_030254064.2XP_030109924.1  disintegrin and metalloproteinase domain-containing protein 22 isoform X13

    UniProtKB/TrEMBL
    A4FUT9
    Conserved Domains (4) summary
    smart00608
    Location:528669
    ACR; ADAM Cysteine-Rich Domain
    pfam00200
    Location:451524
    Disintegrin
    pfam01421
    Location:237436
    Reprolysin; Reprolysin (M12B) family zinc metalloprotease
    pfam01562
    Location:48186
    Pep_M12B_propep; Reprolysin family propeptide

RNA

  1. XR_376691.4 RNA Sequence