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Adam22 a disintegrin and metallopeptidase domain 22 [ Mus musculus (house mouse) ]

Gene ID: 11496, updated on 7-Apr-2019

Summary

Official Symbol
Adam22provided by MGI
Official Full Name
a disintegrin and metallopeptidase domain 22provided by MGI
Primary source
MGI:MGI:1340046
See related
Ensembl:ENSMUSG00000040537
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
MDC2; AI854032; 2900022I03Rik
Summary
This gene encodes a member of a disintegrin and metalloprotease (ADAM) family of endoproteases that play important roles in various biological processes including cell signaling, adhesion and migration. The encoded preproprotein undergoes proteolytic processing to generate a mature, functional protein. The protein encoded by this gene is believed to lack metalloproteinase activity due to the lack of a critical catalytic motif. Mice lacking the encoded protein exhibit severe ataxia, hypomyelination and premature death. Alternative splicing results in multiple transcript variants encoding different isoforms, some of which may undergo similar processing. [provided by RefSeq, May 2016]
Expression
Biased expression in cerebellum adult (RPKM 18.0), cortex adult (RPKM 14.5) and 7 other tissues See more
Orthologs

Genomic context

See Adam22 in Genome Data Viewer
Location:
5 A1; 5 3.39 cM
Exon count:
35
Annotation release Status Assembly Chr Location
106 current GRCm38.p4 (GCF_000001635.24) 5 NC_000071.6 (8072347..8368270, complement)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 5 NC_000071.5 (8072352..8368081, complement)

Chromosome 5 - NC_000071.6Genomic Context describing neighboring genes Neighboring gene predicted gene 15731 Neighboring gene 60S ribosomal protein L27 pseudogene Neighboring gene sorcin Neighboring gene predicted gene, 21759 Neighboring gene ribosomal protein L19 pseudogene Neighboring gene DBF4 zinc finger Neighboring gene solute carrier family 25, member 40

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from BioSystems

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
metalloendopeptidase activity IEA
Inferred from Electronic Annotation
more info
 
metallopeptidase activity IEA
Inferred from Electronic Annotation
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
Schwann cell differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
adult locomotory behavior IMP
Inferred from Mutant Phenotype
more info
PubMed 
gliogenesis IGI
Inferred from Genetic Interaction
more info
PubMed 
myelination in peripheral nervous system IMP
Inferred from Mutant Phenotype
more info
PubMed 
neurotransmitter receptor localization to postsynaptic specialization membrane EXP
Inferred from Experiment
more info
PubMed 
proteolysis IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
axon IDA
Inferred from Direct Assay
more info
PubMed 
cell projection IEA
Inferred from Electronic Annotation
more info
 
glutamatergic synapse EXP
Inferred from Experiment
more info
PubMed 
glutamatergic synapse IDA
Inferred from Direct Assay
more info
PubMed 
integral component of membrane IDA
Inferred from Direct Assay
more info
PubMed 
integral component of postsynaptic density membrane EXP
Inferred from Experiment
more info
PubMed 
integral component of postsynaptic density membrane IDA
Inferred from Direct Assay
more info
PubMed 
membrane EXP
Inferred from Experiment
more info
PubMed 
plasma membrane ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
disintegrin and metalloproteinase domain-containing protein 22
Names
a disintegrin and metalloprotease domain (ADAM) 22

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001007220.3NP_001007221.1  disintegrin and metalloproteinase domain-containing protein 22 isoform a precursor

    See identical proteins and their annotated locations for NP_001007221.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1, also known as alpha or A04) encodes isoform a. This isoform (a) may undergo protein processing similar to isoform 5.
    Source sequence(s)
    AB009674, BY732321
    Consensus CDS
    CCDS19080.1
    UniProtKB/Swiss-Prot
    Q9R1V6
    Related
    ENSMUSP00000049120.7, ENSMUST00000046838.13
    Conserved Domains (5) summary
    smart00608
    Location:528669
    ACR; ADAM Cysteine-Rich Domain
    cd04269
    Location:237434
    ZnMc_adamalysin_II_like; Zinc-dependent metalloprotease; adamalysin_II_like subfamily. Adamalysin II is a snake venom zinc endopeptidase. This subfamily contains other snake venom metalloproteinases, as well as membrane-anchored metalloproteases belonging to the ADAM family. ...
    pfam00200
    Location:451525
    Disintegrin; Disintegrin
    pfam01421
    Location:237436
    Reprolysin; Reprolysin (M12B) family zinc metalloprotease
    pfam01562
    Location:73185
    Pep_M12B_propep; Reprolysin family propeptide
  2. NM_001007221.3NP_001007222.1  disintegrin and metalloproteinase domain-containing protein 22 isoform b precursor

    See identical proteins and their annotated locations for NP_001007222.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2, also known as beta or A05) lacks an alternate in-frame exon in the 3' coding region, compared to variant 1. The encoded isoform (b) is shorter than isoform a. This isoform (b) may undergo protein processing similar to isoform 5.
    Source sequence(s)
    AB009674, BY732321
    UniProtKB/Swiss-Prot
    Q9R1V6
    Conserved Domains (5) summary
    smart00608
    Location:528669
    ACR; ADAM Cysteine-Rich Domain
    cd04269
    Location:237434
    ZnMc_adamalysin_II_like; Zinc-dependent metalloprotease; adamalysin_II_like subfamily. Adamalysin II is a snake venom zinc endopeptidase. This subfamily contains other snake venom metalloproteinases, as well as membrane-anchored metalloproteases belonging to the ADAM family. ...
    pfam00200
    Location:451525
    Disintegrin; Disintegrin
    pfam01421
    Location:237436
    Reprolysin; Reprolysin (M12B) family zinc metalloprotease
    pfam01562
    Location:73185
    Pep_M12B_propep; Reprolysin family propeptide
  3. NM_001098225.2NP_001091695.1  disintegrin and metalloproteinase domain-containing protein 22 isoform c precursor

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3, also known as G03) contains multiple differences in the 3' coding region and differs in the 3' UTR compared variant 1. The encoded isoform (c) has a distinct C-terminus and is longer than isoform a. This isoform (c) may undergo protein processing similar to isoform 5.
    Source sequence(s)
    AC140364, AK034528, BY732321, HM004095
    Consensus CDS
    CCDS51411.1
    UniProtKB/Swiss-Prot
    Q9R1V6
    UniProtKB/TrEMBL
    D6QSS8
    Related
    ENSMUSP00000055000.7, ENSMUST00000050166.13
    Conserved Domains (5) summary
    smart00608
    Location:528669
    ACR; ADAM Cysteine-Rich Domain
    cd04269
    Location:237434
    ZnMc_adamalysin_II_like; Zinc-dependent metalloprotease; adamalysin_II_like subfamily. Adamalysin II is a snake venom zinc endopeptidase. This subfamily contains other snake venom metalloproteinases, as well as membrane-anchored metalloproteases belonging to the ADAM family. ...
    pfam00200
    Location:451525
    Disintegrin; Disintegrin
    pfam01421
    Location:237436
    Reprolysin; Reprolysin (M12B) family zinc metalloprotease
    pfam01562
    Location:73185
    Pep_M12B_propep; Reprolysin family propeptide
  4. NM_001310439.1NP_001297368.1  disintegrin and metalloproteinase domain-containing protein 22 isoform 4 precursor

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4, also known as G07) contains multiple differences in the 3' coding region and differs in the 3' UTR compared variant 1. The encoded isoform (c) has a distinct C-terminus and is longer than isoform a. This isoform (4) may undergo protein processing similar to isoform 5.
    Source sequence(s)
    AB179845, AC140364, BY732321, HM004095
    Consensus CDS
    CCDS80205.1
    UniProtKB/Swiss-Prot
    Q9R1V6
    UniProtKB/TrEMBL
    D6QSS8
    Related
    ENSMUSP00000111046.2, ENSMUST00000115388.8
    Conserved Domains (5) summary
    smart00608
    Location:528669
    ACR; ADAM Cysteine-Rich Domain
    cd04269
    Location:237434
    ZnMc_adamalysin_II_like; Zinc-dependent metalloprotease; adamalysin_II_like subfamily. Adamalysin II is a snake venom zinc endopeptidase. This subfamily contains other snake venom metalloproteinases, as well as membrane-anchored metalloproteases belonging to the ADAM family. ...
    pfam00200
    Location:451525
    Disintegrin; Disintegrin
    pfam01421
    Location:237436
    Reprolysin; Reprolysin (M12B) family zinc metalloprotease
    pfam01562
    Location:73185
    Pep_M12B_propep; Reprolysin family propeptide
  5. NM_001310440.1NP_001297369.1  disintegrin and metalloproteinase domain-containing protein 22 isoform 5 preproprotein

    See identical proteins and their annotated locations for NP_001297369.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (5, also known as G01) differs in the 3' coding region and 3' UTR compared to variant 1. The encoded isoform (c) has a longer C-terminus than isoform a.
    Source sequence(s)
    AC140364, BY732321, HM004095
    Consensus CDS
    CCDS80207.1
    UniProtKB/Swiss-Prot
    Q9R1V6
    UniProtKB/TrEMBL
    D6QSS8
    Related
    ENSMUSP00000086139.4, ENSMUST00000088761.10
    Conserved Domains (5) summary
    smart00608
    Location:528669
    ACR; ADAM Cysteine-Rich Domain
    cd04269
    Location:237434
    ZnMc_adamalysin_II_like; Zinc-dependent metalloprotease; adamalysin_II_like subfamily. Adamalysin II is a snake venom zinc endopeptidase. This subfamily contains other snake venom metalloproteinases, as well as membrane-anchored metalloproteases belonging to the ADAM family. ...
    pfam00200
    Location:451525
    Disintegrin; Disintegrin
    pfam01421
    Location:237436
    Reprolysin; Reprolysin (M12B) family zinc metalloprotease
    pfam01562
    Location:73185
    Pep_M12B_propep; Reprolysin family propeptide

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm38.p4 C57BL/6J

Genomic

  1. NC_000071.6 Reference GRCm38.p4 C57BL/6J

    Range
    8072347..8368270 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006503528.3XP_006503591.1  disintegrin and metalloproteinase domain-containing protein 22 isoform X1

    Conserved Domains (5) summary
    smart00608
    Location:528669
    ACR; ADAM Cysteine-Rich Domain
    cd04269
    Location:237434
    ZnMc_adamalysin_II_like; Zinc-dependent metalloprotease; adamalysin_II_like subfamily. Adamalysin II is a snake venom zinc endopeptidase. This subfamily contains other snake venom metalloproteinases, as well as membrane-anchored metalloproteases belonging to the ADAM family. ...
    pfam00200
    Location:451525
    Disintegrin; Disintegrin
    pfam01421
    Location:237436
    Reprolysin; Reprolysin (M12B) family zinc metalloprotease
    pfam01562
    Location:73185
    Pep_M12B_propep; Reprolysin family propeptide
  2. XM_006503529.3XP_006503592.1  disintegrin and metalloproteinase domain-containing protein 22 isoform X2

    UniProtKB/Swiss-Prot
    Q9R1V6
    Conserved Domains (5) summary
    smart00608
    Location:528669
    ACR; ADAM Cysteine-Rich Domain
    cd04269
    Location:237434
    ZnMc_adamalysin_II_like; Zinc-dependent metalloprotease; adamalysin_II_like subfamily. Adamalysin II is a snake venom zinc endopeptidase. This subfamily contains other snake venom metalloproteinases, as well as membrane-anchored metalloproteases belonging to the ADAM family. ...
    pfam00200
    Location:451525
    Disintegrin; Disintegrin
    pfam01421
    Location:237436
    Reprolysin; Reprolysin (M12B) family zinc metalloprotease
    pfam01562
    Location:73185
    Pep_M12B_propep; Reprolysin family propeptide
  3. XM_006503534.3XP_006503597.1  disintegrin and metalloproteinase domain-containing protein 22 isoform X7

    Conserved Domains (5) summary
    smart00608
    Location:528669
    ACR; ADAM Cysteine-Rich Domain
    cd04269
    Location:237434
    ZnMc_adamalysin_II_like; Zinc-dependent metalloprotease; adamalysin_II_like subfamily. Adamalysin II is a snake venom zinc endopeptidase. This subfamily contains other snake venom metalloproteinases, as well as membrane-anchored metalloproteases belonging to the ADAM family. ...
    pfam00200
    Location:451525
    Disintegrin; Disintegrin
    pfam01421
    Location:237436
    Reprolysin; Reprolysin (M12B) family zinc metalloprotease
    pfam01562
    Location:73185
    Pep_M12B_propep; Reprolysin family propeptide
  4. XM_006503532.3XP_006503595.1  disintegrin and metalloproteinase domain-containing protein 22 isoform X5

    Conserved Domains (5) summary
    smart00608
    Location:528669
    ACR; ADAM Cysteine-Rich Domain
    cd04269
    Location:237434
    ZnMc_adamalysin_II_like; Zinc-dependent metalloprotease; adamalysin_II_like subfamily. Adamalysin II is a snake venom zinc endopeptidase. This subfamily contains other snake venom metalloproteinases, as well as membrane-anchored metalloproteases belonging to the ADAM family. ...
    pfam00200
    Location:451525
    Disintegrin; Disintegrin
    pfam01421
    Location:237436
    Reprolysin; Reprolysin (M12B) family zinc metalloprotease
    pfam01562
    Location:73185
    Pep_M12B_propep; Reprolysin family propeptide
  5. XM_006503533.3XP_006503596.1  disintegrin and metalloproteinase domain-containing protein 22 isoform X6

    UniProtKB/Swiss-Prot
    Q9R1V6
    Conserved Domains (5) summary
    smart00608
    Location:528669
    ACR; ADAM Cysteine-Rich Domain
    cd04269
    Location:237434
    ZnMc_adamalysin_II_like; Zinc-dependent metalloprotease; adamalysin_II_like subfamily. Adamalysin II is a snake venom zinc endopeptidase. This subfamily contains other snake venom metalloproteinases, as well as membrane-anchored metalloproteases belonging to the ADAM family. ...
    pfam00200
    Location:451525
    Disintegrin; Disintegrin
    pfam01421
    Location:237436
    Reprolysin; Reprolysin (M12B) family zinc metalloprotease
    pfam01562
    Location:73185
    Pep_M12B_propep; Reprolysin family propeptide
  6. XM_006503530.3XP_006503593.1  disintegrin and metalloproteinase domain-containing protein 22 isoform X3

    UniProtKB/Swiss-Prot
    Q9R1V6
    Conserved Domains (5) summary
    smart00608
    Location:528669
    ACR; ADAM Cysteine-Rich Domain
    cd04269
    Location:237434
    ZnMc_adamalysin_II_like; Zinc-dependent metalloprotease; adamalysin_II_like subfamily. Adamalysin II is a snake venom zinc endopeptidase. This subfamily contains other snake venom metalloproteinases, as well as membrane-anchored metalloproteases belonging to the ADAM family. ...
    pfam00200
    Location:451525
    Disintegrin; Disintegrin
    pfam01421
    Location:237436
    Reprolysin; Reprolysin (M12B) family zinc metalloprotease
    pfam01562
    Location:73185
    Pep_M12B_propep; Reprolysin family propeptide
  7. XM_006503535.3XP_006503598.1  disintegrin and metalloproteinase domain-containing protein 22 isoform X8

    UniProtKB/Swiss-Prot
    Q9R1V6
    Conserved Domains (5) summary
    smart00608
    Location:528669
    ACR; ADAM Cysteine-Rich Domain
    cd04269
    Location:237434
    ZnMc_adamalysin_II_like; Zinc-dependent metalloprotease; adamalysin_II_like subfamily. Adamalysin II is a snake venom zinc endopeptidase. This subfamily contains other snake venom metalloproteinases, as well as membrane-anchored metalloproteases belonging to the ADAM family. ...
    pfam00200
    Location:451525
    Disintegrin; Disintegrin
    pfam01421
    Location:237436
    Reprolysin; Reprolysin (M12B) family zinc metalloprotease
    pfam01562
    Location:73185
    Pep_M12B_propep; Reprolysin family propeptide
  8. XM_006503531.3XP_006503594.1  disintegrin and metalloproteinase domain-containing protein 22 isoform X4

    UniProtKB/Swiss-Prot
    Q9R1V6
    Conserved Domains (5) summary
    smart00608
    Location:528669
    ACR; ADAM Cysteine-Rich Domain
    cd04269
    Location:237434
    ZnMc_adamalysin_II_like; Zinc-dependent metalloprotease; adamalysin_II_like subfamily. Adamalysin II is a snake venom zinc endopeptidase. This subfamily contains other snake venom metalloproteinases, as well as membrane-anchored metalloproteases belonging to the ADAM family. ...
    pfam00200
    Location:451525
    Disintegrin; Disintegrin
    pfam01421
    Location:237436
    Reprolysin; Reprolysin (M12B) family zinc metalloprotease
    pfam01562
    Location:73185
    Pep_M12B_propep; Reprolysin family propeptide
  9. XM_006503540.3XP_006503603.1  disintegrin and metalloproteinase domain-containing protein 22 isoform X11

    UniProtKB/TrEMBL
    D3YUP9
    Related
    ENSMUSP00000111044.1, ENSMUST00000115386.7
    Conserved Domains (5) summary
    smart00608
    Location:528669
    ACR; ADAM Cysteine-Rich Domain
    cd04269
    Location:237434
    ZnMc_adamalysin_II_like; Zinc-dependent metalloprotease; adamalysin_II_like subfamily. Adamalysin II is a snake venom zinc endopeptidase. This subfamily contains other snake venom metalloproteinases, as well as membrane-anchored metalloproteases belonging to the ADAM family. ...
    pfam00200
    Location:451525
    Disintegrin; Disintegrin
    pfam01421
    Location:237436
    Reprolysin; Reprolysin (M12B) family zinc metalloprotease
    pfam01562
    Location:73185
    Pep_M12B_propep; Reprolysin family propeptide
  10. XM_006503536.3XP_006503599.1  disintegrin and metalloproteinase domain-containing protein 22 isoform X9

    Conserved Domains (5) summary
    smart00608
    Location:528669
    ACR; ADAM Cysteine-Rich Domain
    cd04269
    Location:237434
    ZnMc_adamalysin_II_like; Zinc-dependent metalloprotease; adamalysin_II_like subfamily. Adamalysin II is a snake venom zinc endopeptidase. This subfamily contains other snake venom metalloproteinases, as well as membrane-anchored metalloproteases belonging to the ADAM family. ...
    pfam00200
    Location:451525
    Disintegrin; Disintegrin
    pfam01421
    Location:237436
    Reprolysin; Reprolysin (M12B) family zinc metalloprotease
    pfam01562
    Location:73185
    Pep_M12B_propep; Reprolysin family propeptide
  11. XM_006503537.3XP_006503600.1  disintegrin and metalloproteinase domain-containing protein 22 isoform X10

    UniProtKB/Swiss-Prot
    Q9R1V6
    Conserved Domains (5) summary
    smart00608
    Location:528669
    ACR; ADAM Cysteine-Rich Domain
    cd04269
    Location:237434
    ZnMc_adamalysin_II_like; Zinc-dependent metalloprotease; adamalysin_II_like subfamily. Adamalysin II is a snake venom zinc endopeptidase. This subfamily contains other snake venom metalloproteinases, as well as membrane-anchored metalloproteases belonging to the ADAM family. ...
    pfam00200
    Location:451525
    Disintegrin; Disintegrin
    pfam01421
    Location:237436
    Reprolysin; Reprolysin (M12B) family zinc metalloprotease
    pfam01562
    Location:73185
    Pep_M12B_propep; Reprolysin family propeptide
  12. XM_006503542.3XP_006503605.1  disintegrin and metalloproteinase domain-containing protein 22 isoform X12

    UniProtKB/Swiss-Prot
    Q9R1V6
    Conserved Domains (5) summary
    smart00608
    Location:528669
    ACR; ADAM Cysteine-Rich Domain
    cd04269
    Location:237434
    ZnMc_adamalysin_II_like; Zinc-dependent metalloprotease; adamalysin_II_like subfamily. Adamalysin II is a snake venom zinc endopeptidase. This subfamily contains other snake venom metalloproteinases, as well as membrane-anchored metalloproteases belonging to the ADAM family. ...
    pfam00200
    Location:451525
    Disintegrin; Disintegrin
    pfam01421
    Location:237436
    Reprolysin; Reprolysin (M12B) family zinc metalloprotease
    pfam01562
    Location:73185
    Pep_M12B_propep; Reprolysin family propeptide

RNA

  1. XR_001784598.1 RNA Sequence

  2. XR_376691.3 RNA Sequence

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