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C1QTNF2 C1q and TNF related 2 [ Homo sapiens (human) ]

Gene ID: 114898, updated on 11-Jun-2021

Summary

Official Symbol
C1QTNF2provided by HGNC
Official Full Name
C1q and TNF related 2provided by HGNC
Primary source
HGNC:HGNC:14325
See related
Ensembl:ENSG00000145861 MIM:618647
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
CTRP2; zacrp2
Expression
Broad expression in testis (RPKM 1.3), lung (RPKM 1.2) and 23 other tissues See more
Orthologs
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Genomic context

See C1QTNF2 in Genome Data Viewer
Location:
5q33.3
Exon count:
5
Annotation release Status Assembly Chr Location
109.20210514 current GRCh38.p13 (GCF_000001405.39) 5 NC_000005.10 (160347558..160370656, complement)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 5 NC_000005.9 (159774761..159797633, complement)

Chromosome 5 - NC_000005.10Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105377691 Neighboring gene cyclin J like Neighboring gene SNRPE pseudogene 1 Neighboring gene zinc finger BED-type containing 8 Neighboring gene SLU7 homolog, splicing factor

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Phenotypes

Associated conditions

Description Tests
Weight loss after gastric bypass is associated with a variant at 15q26.1.
GeneReviews: Not available

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
involved_in regulation of lipid metabolic process ISS
Inferred from Sequence or Structural Similarity
more info
 
Component Evidence Code Pubs
part_of collagen trimer IEA
Inferred from Electronic Annotation
more info
 
located_in extracellular region IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
complement C1q tumor necrosis factor-related protein 2
Names
C1q and tumor necrosis factor related protein 2
complement-c1q tumor necrosis factor-related protein 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001366504.1NP_001353433.1  complement C1q tumor necrosis factor-related protein 2 isoform 2 precursor

    Status: VALIDATED

    Source sequence(s)
    AC091842, AC112191
    Conserved Domains (2) summary
    pfam01391
    Location:6185
    Collagen; Collagen triple helix repeat (20 copies)
    pfam00386
    Location:85207
    C1q; C1q domain
  2. NM_031908.6NP_114114.3  complement C1q tumor necrosis factor-related protein 2 isoform 1 precursor

    Status: VALIDATED

    Source sequence(s)
    AC112191, AY358839
    Consensus CDS
    CCDS4351.2
    Related
    ENSP00000498651.1, ENST00000652664.2
    Conserved Domains (2) summary
    pfam01391
    Location:58108
    Collagen; Collagen triple helix repeat (20 copies)
    pfam00386
    Location:151275
    C1q; C1q domain

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210514

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000005.10 Reference GRCh38.p13 Primary Assembly

    Range
    160347558..160370656 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011534426.3XP_011532728.1  complement C1q tumor necrosis factor-related protein 2 isoform X2

    Conserved Domains (2) summary
    pfam01391
    Location:145169
    Collagen; Collagen triple helix repeat (20 copies)
    pfam00386
    Location:169291
    C1q; C1q domain
  2. XM_011534425.2XP_011532727.1  complement C1q tumor necrosis factor-related protein 2 isoform X1

    Related
    ENSP00000377545.3, ENST00000393975.4
    Conserved Domains (2) summary
    pfam01391
    Location:142192
    Collagen; Collagen triple helix repeat (20 copies)
    pfam00386
    Location:235359
    C1q; C1q domain
  3. XM_011534427.2XP_011532729.1  complement C1q tumor necrosis factor-related protein 2 isoform X4

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