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C1QTNF2 C1q and TNF related 2 [ Homo sapiens (human) ]

Gene ID: 114898, updated on 26-Oct-2022

Summary

Official Symbol
C1QTNF2provided by HGNC
Official Full Name
C1q and TNF related 2provided by HGNC
Primary source
HGNC:HGNC:14325
See related
Ensembl:ENSG00000145861 MIM:618647; AllianceGenome:HGNC:14325
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
CTRP2; zacrp2
Summary
Predicted to enable identical protein binding activity and signaling receptor binding activity. Predicted to be involved in regulation of lipid metabolic process. Predicted to act upstream of or within positive regulation of MAPK cascade; positive regulation of glucose import; and positive regulation of small molecule metabolic process. Predicted to be located in extracellular space. Predicted to be part of protein-containing complex. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in testis (RPKM 1.3), lung (RPKM 1.2) and 23 other tissues See more
Orthologs
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Genomic context

See C1QTNF2 in Genome Data Viewer
Location:
5q33.3
Exon count:
4
Annotation release Status Assembly Chr Location
110 current GRCh38.p14 (GCF_000001405.40) 5 NC_000005.10 (160347754..160370626, complement)
110 current T2T-CHM13v2.0 (GCF_009914755.1) 5 NC_060929.1 (160876282..160899121, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 5 NC_000005.9 (159774761..159797633, complement)

Chromosome 5 - NC_000005.10Genomic Context describing neighboring genes Neighboring gene cyclin J like Neighboring gene uncharacterized LOC105377691 Neighboring gene SNRPE pseudogene 1 Neighboring gene family with sequence similarity 200 member C Neighboring gene SLU7 homolog, splicing factor

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
involved_in regulation of lipid metabolic process ISS
Inferred from Sequence or Structural Similarity
more info
 
Component Evidence Code Pubs
part_of collagen trimer IEA
Inferred from Electronic Annotation
more info
 
located_in extracellular region IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
complement C1q tumor necrosis factor-related protein 2
Names
C1q and tumor necrosis factor related protein 2
complement-c1q tumor necrosis factor-related protein 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001366504.1NP_001353433.1  complement C1q tumor necrosis factor-related protein 2 isoform 2 precursor

    Status: VALIDATED

    Source sequence(s)
    AC091842, AC112191
    Conserved Domains (2) summary
    pfam01391
    Location:6185
    Collagen; Collagen triple helix repeat (20 copies)
    pfam00386
    Location:85207
    C1q; C1q domain
  2. NM_031908.6NP_114114.3  complement C1q tumor necrosis factor-related protein 2 isoform 1 precursor

    Status: VALIDATED

    Source sequence(s)
    AC112191, AY358839
    Consensus CDS
    CCDS4351.3
    UniProtKB/Swiss-Prot
    Q9BXJ5
    UniProtKB/TrEMBL
    A0A3B0INC0
    Related
    ENSP00000498651.1, ENST00000652664.2
    Conserved Domains (2) summary
    pfam01391
    Location:58108
    Collagen; Collagen triple helix repeat (20 copies)
    pfam00386
    Location:151275
    C1q; C1q domain

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 110 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000005.10 Reference GRCh38.p14 Primary Assembly

    Range
    160347754..160370626 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011534425.3XP_011532727.2  complement C1q tumor necrosis factor-related protein 2 isoform X1

  2. XM_047416691.1XP_047272647.1  complement C1q tumor necrosis factor-related protein 2 isoform X4

  3. XM_011534426.4XP_011532728.2  complement C1q tumor necrosis factor-related protein 2 isoform X2

  4. XM_011534427.3XP_011532729.2  complement C1q tumor necrosis factor-related protein 2 isoform X5

  5. XM_047416690.1XP_047272646.1  complement C1q tumor necrosis factor-related protein 2 isoform X3

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060929.1 Alternate T2T-CHM13v2.0

    Range
    160876282..160899121 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)