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Afg3l1 AFG3-like AAA ATPase 1 [ Mus musculus (house mouse) ]

Gene ID: 114896, updated on 12-May-2024

Summary

Official Symbol
Afg3l1provided by MGI
Official Full Name
AFG3-like AAA ATPase 1provided by MGI
Primary source
MGI:MGI:1928277
See related
Ensembl:ENSMUSG00000031967 AllianceGenome:MGI:1928277
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
1700047G05Rik; 3110061K15Rik
Summary
Predicted to enable metalloendopeptidase activity. Involved in protein processing. Acts upstream of or within cristae formation; mitochondrial fusion; and mitochondrial protein processing. Located in mitochondrial inner membrane. Part of m-AAA complex. Orthologous to human AFG3L1P (AFG3 like matrix AAA peptidase subunit 1, pseudogene). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in placenta adult (RPKM 13.4), kidney adult (RPKM 12.5) and 28 other tissues See more
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Genomic context

See Afg3l1 in Genome Data Viewer
Location:
8 E1; 8 72.1 cM
Exon count:
17
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 8 NC_000074.7 (124204601..124230655)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 8 NC_000074.6 (123477862..123503916)

Chromosome 8 - NC_000074.7Genomic Context describing neighboring genes Neighboring gene differentially expressed in FDCP 8 Neighboring gene predicted gene, 39275 Neighboring gene dysbindin domain containing 1 Neighboring gene STARR-positive B cell enhancer ABC_E6700 Neighboring gene growth arrest specific 8

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
 
enables ATP hydrolysis activity IEA
Inferred from Electronic Annotation
more info
 
enables ATP-dependent peptidase activity IEA
Inferred from Electronic Annotation
more info
 
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables metalloendopeptidase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables metalloendopeptidase activity ISA
Inferred from Sequence Alignment
more info
PubMed 
enables metallopeptidase activity IEA
Inferred from Electronic Annotation
more info
 
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
 
enables peptidase activity IEA
Inferred from Electronic Annotation
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables zinc ion binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
acts_upstream_of_or_within cristae formation IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within mitochondrial fusion IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in mitochondrial protein processing IBA
Inferred from Biological aspect of Ancestor
more info
 
acts_upstream_of_or_within mitochondrial protein processing IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within mitochondrial protein processing IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within mitochondrion organization IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in protein processing IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within proteolysis IEA
Inferred from Electronic Annotation
more info
 
involved_in proteolysis IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
part_of m-AAA complex IBA
Inferred from Biological aspect of Ancestor
more info
 
part_of m-AAA complex IDA
Inferred from Direct Assay
more info
PubMed 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 
located_in mitochondrial inner membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in mitochondrion HDA PubMed 
located_in mitochondrion IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
AFG3-like protein 1
Names
AFG3(ATPase family gene 3)-like 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_054070.3NP_473411.2  AFG3-like protein 1

    See identical proteins and their annotated locations for NP_473411.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript.
    Source sequence(s)
    AC158362, AK159647, BC056978
    Consensus CDS
    CCDS22760.1
    UniProtKB/Swiss-Prot
    Q3THK2, Q6PGJ7, Q920A7, Q9CZN2
    Related
    ENSMUSP00000001520.8, ENSMUST00000001520.13
    Conserved Domains (4) summary
    TIGR01241
    Location:281738
    FtsH_fam; ATP-dependent metalloprotease FtsH
    pfam00004
    Location:337468
    AAA; ATPase family associated with various cellular activities (AAA)
    pfam01434
    Location:554736
    Peptidase_M41; Peptidase family M41
    pfam06480
    Location:142233
    FtsH_ext; FtsH Extracellular

RNA

  1. NR_028260.1 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks one alternate, internal exon compared to variant 1. This variant is represented as non-coding because use of the 5'-most expected translational start codon as used in variant 1 renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AC158362, BC056978, BC060064
    Related
    ENSMUST00000098320.6

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000074.7 Reference GRCm39 C57BL/6J

    Range
    124204601..124230655
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011248276.3XP_011246578.1  AFG3-like protein 1 isoform X1

    See identical proteins and their annotated locations for XP_011246578.1

    UniProtKB/Swiss-Prot
    Q920A7
    Conserved Domains (2) summary
    TIGR01241
    Location:155612
    FtsH_fam; ATP-dependent metalloprotease FtsH
    pfam06480
    Location:16107
    FtsH_ext; FtsH Extracellular