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PNMA5 PNMA family member 5 [ Homo sapiens (human) ]

Gene ID: 114824, updated on 5-Jan-2022

Summary

Official Symbol
PNMA5provided by HGNC
Official Full Name
PNMA family member 5provided by HGNC
Primary source
HGNC:HGNC:18743
See related
Ensembl:ENSG00000198883 MIM:300916
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
This gene encodes a member of the paraneoplastic Ma antigen protein family. These proteins have been implicated in the development of paraneoplastic disorders resulting from an immune response directed against them. Paraneoplastic disorders are the result of an abnormal immune response to a tumor. Multiple alternatively spliced variants, encoding the same protein, have been identified. [provided by RefSeq, Oct 2011]
Expression
Biased expression in testis (RPKM 6.1) and brain (RPKM 2.5) See more
Orthologs
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Genomic context

See PNMA5 in Genome Data Viewer
Location:
Xq28
Exon count:
5
Annotation release Status Assembly Chr Location
109.20211119 current GRCh38.p13 (GCF_000001405.39) X NC_000023.11 (152988824..152994458, complement)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) X NC_000023.10 (152157368..152162660, complement)

Chromosome X - NC_000023.11Genomic Context describing neighboring genes Neighboring gene NAD(P) dependent steroid dehydrogenase-like Neighboring gene zinc finger protein 185 with LIM domain Neighboring gene uncharacterized LOC105373372 Neighboring gene paraneoplastic antigen Ma6F-like Neighboring gene high mobility group nucleosomal binding domain 2 pseudogene 48

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Homology

Clone Names

  • KIAA1934

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables identical protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
involved_in positive regulation of apoptotic process ISS
Inferred from Sequence or Structural Similarity
more info
 

General protein information

Preferred Names
paraneoplastic antigen-like protein 5
Names
paraneoplastic Ma antigen family member 5
tumor antigen BJ-HCC-25

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_021341.2 RefSeqGene

    Range
    6915..10304
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001103150.1NP_001096620.1  paraneoplastic antigen-like protein 5

    See identical proteins and their annotated locations for NP_001096620.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) represents the longest transcript. All four variants encode the same protein.
    Source sequence(s)
    AA732768, AY121806, BP213790
    Consensus CDS
    CCDS14718.1
    UniProtKB/Swiss-Prot
    Q96PV4
    Related
    ENSP00000388850.1, ENST00000439251.3
    Conserved Domains (1) summary
    pfam14893
    Location:1321
    PNMA; PNMA
  2. NM_001103151.1NP_001096621.1  paraneoplastic antigen-like protein 5

    See identical proteins and their annotated locations for NP_001096621.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) differs in the 5' UTR compared to variant 2. All four variants encode the same protein.
    Source sequence(s)
    AA732768, AY121806, BP213790, DC329825
    Consensus CDS
    CCDS14718.1
    UniProtKB/Swiss-Prot
    Q96PV4
    Related
    ENSP00000392342.1, ENST00000452693.5
    Conserved Domains (1) summary
    pfam14893
    Location:1321
    PNMA; PNMA
  3. NM_001184924.2NP_001171853.1  paraneoplastic antigen-like protein 5

    See identical proteins and their annotated locations for NP_001171853.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) differs in the 5' UTR compared to variant 2. All four variants encode the same protein.
    Source sequence(s)
    AA732768, AY121806, DC401753
    Consensus CDS
    CCDS14718.1
    UniProtKB/Swiss-Prot
    Q96PV4
    Related
    ENSP00000445775.1, ENST00000535214.6
    Conserved Domains (1) summary
    pfam14893
    Location:1321
    PNMA; PNMA
  4. NM_052926.3NP_443158.1  paraneoplastic antigen-like protein 5

    See identical proteins and their annotated locations for NP_443158.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR compared to variant 2. All four variants encode the same protein.
    Source sequence(s)
    AA732768, AY121806, U82671
    Consensus CDS
    CCDS14718.1
    UniProtKB/Swiss-Prot
    Q96PV4
    Related
    ENSP00000354834.5, ENST00000361887.5
    Conserved Domains (1) summary
    pfam14893
    Location:1321
    PNMA; PNMA

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20211119

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000023.11 Reference GRCh38.p13 Primary Assembly

    Range
    152988824..152994458 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017029252.1XP_016884741.1  paraneoplastic antigen-like protein 5 isoform X1

    UniProtKB/Swiss-Prot
    Q96PV4
    Conserved Domains (1) summary
    pfam14893
    Location:1321
    PNMA; PNMA
  2. XM_017029253.1XP_016884742.1  paraneoplastic antigen-like protein 5 isoform X1

    UniProtKB/Swiss-Prot
    Q96PV4
    Conserved Domains (1) summary
    pfam14893
    Location:1321
    PNMA; PNMA
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