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Acvr2a activin receptor IIA [ Mus musculus (house mouse) ]

Gene ID: 11480, updated on 11-Apr-2024

Summary

Official Symbol
Acvr2aprovided by MGI
Official Full Name
activin receptor IIAprovided by MGI
Primary source
MGI:MGI:102806
See related
Ensembl:ENSMUSG00000052155 AllianceGenome:MGI:102806
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Acvr2; ActrIIa; TactrII
Summary
Enables several functions, including BMP receptor activity; PDZ domain binding activity; and activin binding activity. Acts upstream of or within several processes, including Sertoli cell proliferation; copulation; and embryonic skeletal system development. Located in cell surface. Is expressed in several structures, including central nervous system; early conceptus; gonad; gut; and sensory organ. Used to study Weissenbacher-Zweymuller syndrome. Human ortholog(s) of this gene implicated in colon cancer. Orthologous to human ACVR2A (activin A receptor type 2A). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in CNS E18 (RPKM 16.6), whole brain E14.5 (RPKM 12.4) and 25 other tissues See more
Orthologs
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Genomic context

See Acvr2a in Genome Data Viewer
Location:
2 C1.1; 2 28.38 cM
Exon count:
12
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (48704121..48793276)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (48814109..48903264)

Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene predicted gene, 31324 Neighboring gene glyceraldehyde-3-phosphate dehydrogenase pseudogene Neighboring gene CapStarr-seq enhancer MGSCv37_chr2:48804892-48805001 Neighboring gene origin recognition complex, subunit 4 Neighboring gene methyl-CpG binding domain protein 5 Neighboring gene predicted gene 13510 Neighboring gene adaptor-related protein complex 2, mu 1 subunit, pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Gene trapped (1) 
  • Targeted (5)  1 citation
  • Endonuclease-mediated (5) 

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
 
enables BMP receptor activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
enables PDZ domain binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables activin binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables activin binding IPI
Inferred from Physical Interaction
more info
PubMed 
contributes_to activin binding ISO
Inferred from Sequence Orthology
more info
 
enables activin binding ISO
Inferred from Sequence Orthology
more info
 
enables activin receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables activin receptor activity IDA
Inferred from Direct Assay
more info
PubMed 
contributes_to activin receptor activity ISO
Inferred from Sequence Orthology
more info
 
enables activin receptor activity ISO
Inferred from Sequence Orthology
more info
 
enables coreceptor activity ISO
Inferred from Sequence Orthology
more info
 
enables growth factor binding IMP
Inferred from Mutant Phenotype
more info
PubMed 
enables growth factor binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables inhibin binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables inhibin binding ISO
Inferred from Sequence Orthology
more info
 
enables kinase activity IEA
Inferred from Electronic Annotation
more info
 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein kinase activity IEA
Inferred from Electronic Annotation
more info
 
enables protein serine/threonine kinase activity ISO
Inferred from Sequence Orthology
more info
 
enables protein serine/threonine kinase activity TAS
Traceable Author Statement
more info
 
enables transferase activity IEA
Inferred from Electronic Annotation
more info
 
enables transmembrane receptor protein serine/threonine kinase activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
acts_upstream_of_or_within BMP signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in BMP signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within BMP signaling pathway ISO
Inferred from Sequence Orthology
more info
PubMed 
involved_in BMP signaling pathway ISO
Inferred from Sequence Orthology
more info
 
involved_in SMAD protein signal transduction ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within Sertoli cell proliferation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in activin receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in activin receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within anterior/posterior pattern specification IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in autophagy ISO
Inferred from Sequence Orthology
more info
 
involved_in cell surface receptor protein serine/threonine kinase signaling pathway IEA
Inferred from Electronic Annotation
more info
 
involved_in cellular response to BMP stimulus ISO
Inferred from Sequence Orthology
more info
 
involved_in cellular response to growth factor stimulus IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in cellular response to oxygen-glucose deprivation ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within determination of left/right symmetry IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within embryonic skeletal system development IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within gastrulation with mouth forming second IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within male gonad development IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within mesoderm development IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within odontogenesis of dentin-containing tooth IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within penile erection IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within phosphorylation IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of SMAD protein signal transduction ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of activin receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of bone mineralization ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of erythrocyte differentiation ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of follicle-stimulating hormone secretion ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of osteoblast differentiation ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within positive regulation of protein phosphorylation ISO
Inferred from Sequence Orthology
more info
PubMed 
involved_in positive regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
 
involved_in protein phosphorylation IBA
Inferred from Biological aspect of Ancestor
more info
 
acts_upstream_of_or_within regulation of nitric oxide biosynthetic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within regulation of signal transduction IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within sperm ejaculation IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within spermatogenesis IGI
Inferred from Genetic Interaction
more info
PubMed 
Component Evidence Code Pubs
part_of activin receptor complex IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in cell surface IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
 
part_of inhibin-betaglycan-ActRII complex ISO
Inferred from Sequence Orthology
more info
 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
 
is_active_in plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in plasma membrane TAS
Traceable Author Statement
more info
 
part_of receptor complex ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
activin receptor type-2A
Names
ACTR-IIA
activin receptor type IIA
NP_031422.3
XP_006497686.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_007396.4NP_031422.3  activin receptor type-2A precursor

    See identical proteins and their annotated locations for NP_031422.3

    Status: VALIDATED

    Source sequence(s)
    AK041246, AK143186, BG066107, BY014959, CK340532
    Consensus CDS
    CCDS16021.1
    UniProtKB/Swiss-Prot
    P27038
    UniProtKB/TrEMBL
    A2AI38, Q8BRV4
    Related
    ENSMUSP00000067305.4, ENSMUST00000063886.4
    Conserved Domains (2) summary
    cd14141
    Location:196485
    STKc_ACVR2a; Catalytic domain of the Serine/Threonine Kinase, Activin Type IIA Receptor
    pfam01064
    Location:59114
    Activin_recp; Activin types I and II receptor domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000068.8 Reference GRCm39 C57BL/6J

    Range
    48704121..48793276
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006497623.5XP_006497686.1  activin receptor type-2A isoform X1

    See identical proteins and their annotated locations for XP_006497686.1

    UniProtKB/TrEMBL
    Q8BRV4
    Conserved Domains (2) summary
    cd14141
    Location:204493
    STKc_ACVR2a; Catalytic domain of the Serine/Threonine Kinase, Activin Type IIA Receptor
    pfam01064
    Location:59114
    Activin_recp; Activin types I and II receptor domain