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LMTK3 lemur tyrosine kinase 3 [ Homo sapiens (human) ]

Gene ID: 114783, updated on 18-Aug-2020

Summary

Official Symbol
LMTK3provided by HGNC
Official Full Name
lemur tyrosine kinase 3provided by HGNC
Primary source
HGNC:HGNC:19295
See related
Ensembl:ENSG00000142235
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
LMR3; TYKLM3; PPP1R101
Expression
Biased expression in brain (RPKM 7.4), duodenum (RPKM 0.9) and 5 other tissues See more
Orthologs

Genomic context

See LMTK3 in Genome Data Viewer
Location:
19q13.33
Exon count:
17
Annotation release Status Assembly Chr Location
109.20200815 current GRCh38.p13 (GCF_000001405.39) 19 NC_000019.10 (48485271..48513926, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (48988528..49016446, complement)

Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene glutamate rich WD repeat containing 1 Neighboring gene potassium inwardly rectifying channel subfamily J member 14 Neighboring gene cytohesin 2 Neighboring gene Sharpr-MPRA regulatory regions 10218 and 12364 Neighboring gene sulfotransferase family 2B member 1 Neighboring gene family with sequence similarity 83 member E Neighboring gene sperm acrosome associated 4

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

Copy number response

Description
Copy number response
Triplosensitivity

No evidence available (Last evaluated (2018-07-25)

ClinGen Genome Curation Page
Haploinsufficency

Little evidence for dosage pathogenicity (Last evaluated (2018-07-25)

ClinGen Genome Curation PagePubMed

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • KIAA1883

Gene Ontology Provided by GOA

Function Evidence Code Pubs
ATP binding IEA
Inferred from Electronic Annotation
more info
 
metal ion binding IEA
Inferred from Electronic Annotation
more info
 
molecular_function ND
No biological Data available
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
protein serine/threonine kinase activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
negative regulation of phosphatase activity IDA
Inferred from Direct Assay
more info
PubMed 
protein phosphorylation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
Golgi membrane IEA
Inferred from Electronic Annotation
more info
 
axon IEA
Inferred from Electronic Annotation
more info
 
cellular_component ND
No biological Data available
more info
 
dendrite IEA
Inferred from Electronic Annotation
more info
 
integral component of membrane IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
serine/threonine-protein kinase LMTK3
Names
protein phosphatase 1, regulatory subunit 101
NP_001073903.1
XP_011524713.1
XP_011524714.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001080434.1NP_001073903.1  serine/threonine-protein kinase LMTK3

    Status: VALIDATED

    Source sequence(s)
    AC008403
    Consensus CDS
    CCDS46136.1
    UniProtKB/TrEMBL
    A0A0A0MQW5
    Related
    ENSP00000270238.3, ENST00000270238.3
    Conserved Domains (2) summary
    smart00221
    Location:162437
    STYKc; Protein kinase; unclassified specificity
    cd14206
    Location:164439
    PTKc_Aatyk3; Catalytic domain of the Protein Tyrosine Kinases, Apoptosis-associated tyrosine kinase 3

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20200815

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000019.10 Reference GRCh38.p13 Primary Assembly

    Range
    48485271..48513926 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011526412.2XP_011524714.1  serine/threonine-protein kinase LMTK3 isoform X2

    Conserved Domains (2) summary
    smart00221
    Location:148423
    STYKc; Protein kinase; unclassified specificity
    cd14206
    Location:150425
    PTKc_Aatyk3; Catalytic domain of the Protein Tyrosine Kinases, Apoptosis-associated tyrosine kinase 3
  2. XM_011526411.2XP_011524713.1  serine/threonine-protein kinase LMTK3 isoform X1

    Related
    ENSP00000497480.1, ENST00000650440.1
    Conserved Domains (2) summary
    smart00221
    Location:159434
    STYKc; Protein kinase; unclassified specificity
    cd14206
    Location:161436
    PTKc_Aatyk3; Catalytic domain of the Protein Tyrosine Kinases, Apoptosis-associated tyrosine kinase 3
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