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Rasa2 RAS p21 protein activator 2 [ Mus musculus (house mouse) ]

Gene ID: 114713, updated on 5-Mar-2024

Summary

Official Symbol
Rasa2provided by MGI
Official Full Name
RAS p21 protein activator 2provided by MGI
Primary source
MGI:MGI:2149960
See related
Ensembl:ENSMUSG00000032413 AllianceGenome:MGI:2149960
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
GAP1m; 5430433H21Rik
Summary
Predicted to enable GTPase activator activity. Predicted to be involved in intracellular signal transduction; negative regulation of Ras protein signal transduction; and regulation of GTPase activity. Predicted to be located in plasma membrane. Is expressed in brain and retina. Orthologous to human RASA2 (RAS p21 protein activator 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in frontal lobe adult (RPKM 4.5), limb E14.5 (RPKM 2.3) and 26 other tissues See more
Orthologs
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Genomic context

See Rasa2 in Genome Data Viewer
Location:
9 E3.3; 9 50.66 cM
Exon count:
27
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 9 NC_000075.7 (96421353..96513665, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 9 NC_000075.6 (96539300..96631612, complement)

Chromosome 9 - NC_000075.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_24959 Neighboring gene predicted gene 28729 Neighboring gene STARR-seq mESC enhancer starr_24962 Neighboring gene STARR-seq mESC enhancer starr_24963 Neighboring gene ubiquitin domain containing 2 pseudogene Neighboring gene STARR-positive B cell enhancer mm9_chr9:96473690-96473991 Neighboring gene STARR-seq mESC enhancer starr_24966 Neighboring gene protein transport protein Sec61 subunit gamma-like Neighboring gene STARR-seq mESC enhancer starr_24967 Neighboring gene CapStarr-seq enhancer MGSCv37_chr9:96570433-96570620 Neighboring gene STARR-seq mESC enhancer starr_24971 Neighboring gene zinc finger and BTB domain containing 38 Neighboring gene RIKEN cDNA E030011O05 gene Neighboring gene STARR-positive B cell enhancer ABC_E9333 Neighboring gene STARR-seq mESC enhancer starr_24975 Neighboring gene STARR-positive B cell enhancer mm9_chr9:96654988-96655289 Neighboring gene STARR-positive B cell enhancer mm9_chr9:96659582-96659882 Neighboring gene RIKEN cDNA C430002N11 gene Neighboring gene STARR-positive B cell enhancer ABC_E11752

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (3) 

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables GTPase activator activity ISO
Inferred from Sequence Orthology
more info
 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables phospholipid binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
involved_in intracellular signal transduction IEA
Inferred from Electronic Annotation
more info
 
involved_in negative regulation of Ras protein signal transduction IEA
Inferred from Electronic Annotation
more info
 
involved_in regulation of GTPase activity IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
located_in membrane IEA
Inferred from Electronic Annotation
more info
 
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
ras GTPase-activating protein 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_053268.2NP_444498.2  ras GTPase-activating protein 2

    See identical proteins and their annotated locations for NP_444498.2

    Status: VALIDATED

    Source sequence(s)
    AC144935, AC161257
    Consensus CDS
    CCDS23416.1
    UniProtKB/Swiss-Prot
    G3X918, P58069
    UniProtKB/TrEMBL
    Q3U405
    Related
    ENSMUSP00000034984.7, ENSMUST00000034984.8
    Conserved Domains (7) summary
    smart00107
    Location:706741
    BTK; Bruton's tyrosine kinase Cys-rich motif
    cd04010
    Location:171313
    C2B_RasA3; C2 domain second repeat present in RAS p21 protein activator 3 (RasA3)
    cd08401
    Location:38158
    C2A_RasA2_RasA3; C2 domain first repeat present in RasA2 and RasA3
    smart00323
    Location:300640
    RasGAP; GTPase-activator protein for Ras-like GTPases
    cd13370
    Location:589721
    PH_GAP1m_mammal-like; GTPase activating protein 1 m pleckstrin homology (PH) domain
    pfam00169
    Location:606704
    PH; PH domain
    cl02569
    Location:322592
    RasGAP; Ras GTPase Activating Domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000075.7 Reference GRCm39 C57BL/6J

    Range
    96421353..96513665 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006510776.5XP_006510839.1  ras GTPase-activating protein 2 isoform X2

    UniProtKB/TrEMBL
    Q3U405
    Conserved Domains (5) summary
    smart00107
    Location:649684
    BTK; Bruton's tyrosine kinase Cys-rich motif
    cd04010
    Location:114256
    C2B_RasA3; C2 domain second repeat present in RAS p21 protein activator 3 (RasA3)
    cd13370
    Location:532664
    PH_GAP1m_mammal-like; GTPase activating protein 1 m pleckstrin homology (PH) domain
    cl02569
    Location:265535
    RasGAP; Ras GTPase Activating Domain
    cl14603
    Location:1101
    C2; C2 domain
  2. XM_036154565.1XP_036010458.1  ras GTPase-activating protein 2 isoform X6

    Conserved Domains (3) summary
    smart00107
    Location:299334
    BTK; Bruton's tyrosine kinase Cys-rich motif
    cd13370
    Location:182314
    PH_GAP1m_mammal-like; GTPase activating protein 1 m pleckstrin homology (PH) domain
    cl02569
    Location:1185
    RasGAP; Ras GTPase Activating Domain
  3. XM_006510775.4XP_006510838.1  ras GTPase-activating protein 2 isoform X1

    UniProtKB/TrEMBL
    Q3U405
    Conserved Domains (5) summary
    smart00107
    Location:743778
    BTK; Bruton's tyrosine kinase Cys-rich motif
    cd04010
    Location:208350
    C2B_RasA3; C2 domain second repeat present in RAS p21 protein activator 3 (RasA3)
    cd08401
    Location:82195
    C2A_RasA2_RasA3; C2 domain first repeat present in RasA2 and RasA3
    cd13370
    Location:626758
    PH_GAP1m_mammal-like; GTPase activating protein 1 m pleckstrin homology (PH) domain
    cl02569
    Location:359629
    RasGAP; Ras GTPase Activating Domain
  4. XM_036154564.1XP_036010457.1  ras GTPase-activating protein 2 isoform X3

    Conserved Domains (3) summary
    cd04010
    Location:208350
    C2B_RasA3; C2 domain second repeat present in RAS p21 protein activator 3 (RasA3)
    cd08401
    Location:82195
    C2A_RasA2_RasA3; C2 domain first repeat present in RasA2 and RasA3
    cl02569
    Location:359620
    RasGAP; Ras GTPase Activating Domain
  5. XM_017313108.2XP_017168597.1  ras GTPase-activating protein 2 isoform X5

    Conserved Domains (3) summary
    cd04010
    Location:171313
    C2B_RasA3; C2 domain second repeat present in RAS p21 protein activator 3 (RasA3)
    cd08401
    Location:38158
    C2A_RasA2_RasA3; C2 domain first repeat present in RasA2 and RasA3
    cl02569
    Location:322557
    RasGAP; Ras GTPase Activating Domain
  6. XM_006510777.5XP_006510840.1  ras GTPase-activating protein 2 isoform X4

    Conserved Domains (3) summary
    cd04010
    Location:208350
    C2B_RasA3; C2 domain second repeat present in RAS p21 protein activator 3 (RasA3)
    cd08401
    Location:82195
    C2A_RasA2_RasA3; C2 domain first repeat present in RasA2 and RasA3
    cl02569
    Location:359594
    RasGAP; Ras GTPase Activating Domain

RNA

  1. XR_004935308.1 RNA Sequence

  2. XR_004935307.1 RNA Sequence

  3. XR_004935304.1 RNA Sequence

  4. XR_004935305.1 RNA Sequence

  5. XR_004935306.1 RNA Sequence