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Tle6 transducin-like enhancer of split 6 [ Mus musculus (house mouse) ]

Gene ID: 114606, updated on 9-May-2024

Summary

Official Symbol
Tle6provided by MGI
Official Full Name
transducin-like enhancer of split 6provided by MGI
Primary source
MGI:MGI:2149593
See related
Ensembl:ENSMUSG00000034758 AllianceGenome:MGI:2149593
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Grg6; 1810057E06Rik
Summary
Predicted to enable transcription corepressor activity. Involved in several processes, including cytoskeleton organization; positive regulation of embryonic development; and spermatogonial cell division. Acts upstream of or within positive regulation of neurogenesis and positive regulation of neuron differentiation. Located in cell cortex and nucleus. Part of subcortical maternal complex. Is expressed in several structures, including brain; early conceptus; foregut-midgut junction; gonad; and metanephric mesenchyme. Human ortholog(s) of this gene implicated in infertility. Orthologous to human TLE6 (TLE family member 6, subcortical maternal complex member). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in ovary adult (RPKM 24.8), adrenal adult (RPKM 10.1) and 17 other tissues See more
Orthologs
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Genomic context

See Tle6 in Genome Data Viewer
Location:
10 C1; 10 39.72 cM
Exon count:
17
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 10 NC_000076.7 (81426738..81437021, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 10 NC_000076.6 (81590904..81601185, complement)

Chromosome 10 - NC_000076.7Genomic Context describing neighboring genes Neighboring gene TLE family member 5, transcriptional modulator Neighboring gene STARR-positive B cell enhancer ABC_E3902 Neighboring gene predicted gene, 31936 Neighboring gene transducin-like enhancer of split 2 Neighboring gene STARR-positive B cell enhancer ABC_E9796 Neighboring gene STARR-positive B cell enhancer ABC_E2953 Neighboring gene STARR-positive B cell enhancer ABC_E464 Neighboring gene zinc finger protein pseudogene Neighboring gene STARR-seq mESC enhancer starr_27345 Neighboring gene STARR-positive B cell enhancer ABC_E6888 Neighboring gene sirtuin 6

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (2) 
  • Targeted (2)  1 citation

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables transcription corepressor activity IBA
Inferred from Biological aspect of Ancestor
more info
 
Component Evidence Code Pubs
located_in cell cortex IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in cytosol ISO
Inferred from Sequence Orthology
more info
PubMed 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in nucleus IDA
Inferred from Direct Assay
more info
PubMed 
part_of protein-containing complex IDA
Inferred from Direct Assay
more info
 
part_of protein-containing complex ISO
Inferred from Sequence Orthology
more info
 
part_of subcortical maternal complex IDA
Inferred from Direct Assay
more info
PubMed 
part_of subcortical maternal complex ISO
Inferred from Sequence Orthology
more info
 
part_of transcription regulator complex IBA
Inferred from Biological aspect of Ancestor
more info
 

General protein information

Preferred Names
transducin-like enhancer protein 6
Names
Groucho-related protein 6
transducin-like enhancer of split 6, homolog of Drosophila E(spl)

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001346695.1NP_001333624.1  transducin-like enhancer protein 6 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC153919
    Consensus CDS
    CCDS83737.1
    UniProtKB/TrEMBL
    D3Z5E1
    Related
    ENSMUSP00000117287.2, ENSMUST00000142948.8
    Conserved Domains (2) summary
    sd00039
    Location:289331
    7WD40; WD40 repeat [structural motif]
    cl29593
    Location:277563
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
  2. NM_001359134.1NP_001346063.1  transducin-like enhancer protein 6 isoform 3

    Status: VALIDATED

    Source sequence(s)
    BC048832
    UniProtKB/TrEMBL
    Q80XH3
    Related
    ENSMUST00000128278.8
    Conserved Domains (2) summary
    sd00039
    Location:226268
    7WD40; WD40 repeat [structural motif]
    cl29593
    Location:214500
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
  3. NM_001359135.1NP_001346064.1  transducin-like enhancer protein 6 isoform 3

    Status: VALIDATED

    Source sequence(s)
    BC048832, BY236020
    UniProtKB/TrEMBL
    Q80XH3
    Conserved Domains (2) summary
    sd00039
    Location:226268
    7WD40; WD40 repeat [structural motif]
    cl29593
    Location:214500
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
  4. NM_053254.2NP_444484.1  transducin-like enhancer protein 6 isoform 1

    See identical proteins and their annotated locations for NP_444484.1

    Status: VALIDATED

    Source sequence(s)
    AC153919
    Consensus CDS
    CCDS24064.1
    UniProtKB/Swiss-Prot
    Q9WVB3
    Related
    ENSMUSP00000071905.3, ENSMUST00000072020.9
    Conserved Domains (2) summary
    sd00039
    Location:299341
    7WD40; WD40 repeat [structural motif]
    cl29593
    Location:287573
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000076.7 Reference GRCm39 C57BL/6J

    Range
    81426738..81437021 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006513083.4XP_006513146.1  transducin-like enhancer protein 6 isoform X1

    See identical proteins and their annotated locations for XP_006513146.1

    Conserved Domains (2) summary
    sd00039
    Location:299369
    7WD40; WD40 repeat [structural motif]
    cl29593
    Location:287601
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
  2. XM_036155507.1XP_036011400.1  transducin-like enhancer protein 6 isoform X4

    UniProtKB/TrEMBL
    D3Z5E1
    Conserved Domains (2) summary
    sd00039
    Location:289331
    7WD40; WD40 repeat [structural motif]
    cl29593
    Location:277563
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
  3. XM_036155506.1XP_036011399.1  transducin-like enhancer protein 6 isoform X3

    UniProtKB/Swiss-Prot
    Q9WVB3
    Conserved Domains (2) summary
    sd00039
    Location:299341
    7WD40; WD40 repeat [structural motif]
    cl29593
    Location:287573
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
  4. XM_006513085.5XP_006513148.1  transducin-like enhancer protein 6 isoform X2

    Conserved Domains (2) summary
    sd00039
    Location:289359
    7WD40; WD40 repeat [structural motif]
    cl29593
    Location:277591
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
  5. XM_006513081.5XP_006513144.1  transducin-like enhancer protein 6 isoform X1

    See identical proteins and their annotated locations for XP_006513144.1

    Conserved Domains (2) summary
    sd00039
    Location:299369
    7WD40; WD40 repeat [structural motif]
    cl29593
    Location:287601
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
  6. XM_017313766.3XP_017169255.1  transducin-like enhancer protein 6 isoform X5

    Conserved Domains (2) summary
    COG2319
    Location:198560
    WD40; WD40 repeat [General function prediction only]
    sd00039
    Location:259329
    7WD40; WD40 repeat [structural motif]
  7. XM_036155512.1XP_036011405.1  transducin-like enhancer protein 6 isoform X8

    Conserved Domains (2) summary
    sd00039
    Location:216258
    7WD40; WD40 repeat [structural motif]
    cl29593
    Location:204490
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
  8. XM_036155511.1XP_036011404.1  transducin-like enhancer protein 6 isoform X9

    UniProtKB/TrEMBL
    Q80XH3
    Conserved Domains (2) summary
    sd00039
    Location:226268
    7WD40; WD40 repeat [structural motif]
    cl29593
    Location:214500
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
  9. XM_036155513.1XP_036011406.1  transducin-like enhancer protein 6 isoform X8

    Conserved Domains (2) summary
    sd00039
    Location:216258
    7WD40; WD40 repeat [structural motif]
    cl29593
    Location:204490
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
  10. XM_036155508.1XP_036011401.1  transducin-like enhancer protein 6 isoform X6

    Conserved Domains (2) summary
    COG2319
    Location:165527
    WD40; WD40 repeat [General function prediction only]
    sd00039
    Location:226296
    7WD40; WD40 repeat [structural motif]
  11. XM_036155509.1XP_036011402.1  transducin-like enhancer protein 6 isoform X7

    Conserved Domains (2) summary
    COG2319
    Location:155517
    WD40; WD40 repeat [General function prediction only]
    sd00039
    Location:216286
    7WD40; WD40 repeat [structural motif]
  12. XM_006513088.4XP_006513151.1  transducin-like enhancer protein 6 isoform X6

    See identical proteins and their annotated locations for XP_006513151.1

    Conserved Domains (2) summary
    COG2319
    Location:165527
    WD40; WD40 repeat [General function prediction only]
    sd00039
    Location:226296
    7WD40; WD40 repeat [structural motif]
  13. XM_030244827.2XP_030100687.1  transducin-like enhancer protein 6 isoform X6

    Conserved Domains (2) summary
    COG2319
    Location:165527
    WD40; WD40 repeat [General function prediction only]
    sd00039
    Location:226296
    7WD40; WD40 repeat [structural motif]
  14. XM_030244828.2XP_030100688.1  transducin-like enhancer protein 6 isoform X7

    Conserved Domains (2) summary
    COG2319
    Location:155517
    WD40; WD40 repeat [General function prediction only]
    sd00039
    Location:216286
    7WD40; WD40 repeat [structural motif]
  15. XM_036155510.1XP_036011403.1  transducin-like enhancer protein 6 isoform X8

    Related
    ENSMUST00000137631.8
    Conserved Domains (2) summary
    sd00039
    Location:216258
    7WD40; WD40 repeat [structural motif]
    cl29593
    Location:204490
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...