Dag1 dystroglycan 1 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Dag1provided by RGD
Official Full Name: dystroglycan 1provided by RGD
Primary source: RGD:621890
See related: EnsemblRapid:ENSRNOG00000019400 AllianceGenome:RGD:621890
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Enables laminin-1 binding activity. Involved in several processes, including calcium-dependent cell-matrix adhesion; cellular response to cholesterol; and nervous system development. Located in several cellular components, including basolateral plasma membrane; costamere; and focal adhesion. Part of dystrophin-associated glycoprotein complex. Is active in glutamatergic synapse and postsynaptic cytosol. Used to study myocardial infarction. Biomarker of muscular atrophy; primary biliary cholangitis; and type 2 diabetes mellitus. Human ortholog(s) of this gene implicated in Duchenne muscular dystrophy; autosomal recessive limb-girdle muscular dystrophy type 2D; autosomal recessive limb-girdle muscular dystrophy type 2P; congenital muscular dystrophy-dystroglycanopathy type A9; and inclusion body myositis. Orthologous to human DAG1 (dystroglycan 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in Lung (RPKM 675.3), Heart (RPKM 576.3) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 8q32

Exon count:: 5

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	8	NC_086026.1 (117769517..117834347, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	8	NC_051343.1 (108890926..108955611, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	8	NC_005107.4 (116980501..116993182, complement)

Chromosome 8 - NC_086026.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The cell adhesion protein dystroglycan affects the structural remodeling of dendritic spines.
Title: The cell adhesion protein dystroglycan affects the structural remodeling of dendritic spines.
MiR-132 down-regulates high glucose-induced beta-dystroglycan degradation through Matrix Metalloproteinases-9 up-regulation in primary neurons.
Title: MiR-132 down-regulates high glucose-induced β-dystroglycan degradation through Matrix Metalloproteinases-9 up-regulation in primary neurons.
The alteration of DG expression could regulate that of AQP4 expression after Traumatic Brain Injury .
Title: Lost Polarization of Aquaporin4 and Dystroglycan in the Core Lesion after Traumatic Brain Injury Suggests Functional Divergence in Evolution.
a role for beta-dystroglycan in targeting and stabilizing AQP4 channel in astrocytic cells, which may be critical for water homeostasis in brain.
Title: Loss of AQP4 polarized localization with loss of β-dystroglycan immunoreactivity may induce brain edema following intracerebral hemorrhage.
Dystroglycan binding to alpha-neurexin competes with neurexophilin-1 and neuroligin in the brain.
Title: Dystroglycan binding to α-neurexin competes with neurexophilin-1 and neuroligin in the brain.
These results suggest that dystroglycan-Lm interactions influence oligodendroglial process dynamics and therefore may regulate the myelination capacity of individual oligodendroglia.
Title: Dystroglycan promotes filopodial formation and process branching in differentiating oligodendroglia.
Alterations in the immunoreactivities and expressions of beta-dystroglycan, utrophin, and laminin seem to correlate with angiogenesis rather than BBB disruption during cerebral hypoperfusion.
Title: Dynamics of dystroglycan complex proteins and laminin changes due to angiogenesis in rat cerebral hypoperfusion.
we identified and examined a connection between dystroglycan and the ability of insulin-like growth factor-1 (IGF-1) to promote oligodendrocyte differentiation
Title: Dystroglycan modulates the ability of insulin-like growth factor-1 to promote oligodendrocyte differentiation.
Findings demonstrate the interdependence between laminin binding to dystroglycan and GM1-containing lipid raft reorganization and provide novel insight into the dystrophin complex regulation of AQP4 polarization in astrocytes.
Title: Interdependence of laminin-mediated clustering of lipid rafts and the dystrophin complex in astrocytes.
These results suggest that exposure to cyclic stretch activates the metabolic sensing pathway AMPK in the lung epithelium and supports a novel role for dystroglycan in this mechanotransduction.
Title: Stretch-induced activation of AMP kinase in the lung requires dystroglycan.

Submit: New GeneRIF Correction See all GeneRIFs (15)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

BG378140 (e-PCR)
- UniSTS:245056

RH135177 (e-PCR)
- UniSTS:218454

D3S3337 (e-PCR)
- UniSTS:5975

Dag1 (e-PCR), detects polymorphism
- UniSTS:142828

RH125695 (e-PCR)
- UniSTS:142830

SSC24F05 (e-PCR)
- UniSTS:253436

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables SH2 domain binding	ISO Inferred from Sequence Orthology more info
enables actin binding	ISO Inferred from Sequence Orthology more info
enables alpha-actinin binding	ISO Inferred from Sequence Orthology more info
enables calcium ion binding	IEA Inferred from Electronic Annotation more info
enables dystroglycan binding	ISO Inferred from Sequence Orthology more info
enables laminin binding	IBA Inferred from Biological aspect of Ancestor more info
enables laminin binding	IDA Inferred from Direct Assay more info	PubMed
enables laminin binding	ISO Inferred from Sequence Orthology more info
enables laminin-1 binding	IDA Inferred from Direct Assay more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein-containing complex binding	ISO Inferred from Sequence Orthology more info
enables structural constituent of muscle	ISO Inferred from Sequence Orthology more info
enables tubulin binding	ISO Inferred from Sequence Orthology more info
enables vinculin binding	ISO Inferred from Sequence Orthology more info
enables virus receptor activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in Schwann cell development	ISO Inferred from Sequence Orthology more info
involved_in Schwann cell differentiation	IEP Inferred from Expression Pattern more info	PubMed
involved_in angiogenesis involved in wound healing	IEP Inferred from Expression Pattern more info	PubMed
involved_in axon guidance	IBA Inferred from Biological aspect of Ancestor more info
involved_in axon regeneration	IEP Inferred from Expression Pattern more info	PubMed
acts_upstream_of_or_within basement membrane organization	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within branching involved in salivary gland morphogenesis	ISO Inferred from Sequence Orthology more info
involved_in calcium-dependent cell-matrix adhesion	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cellular response to cholesterol	IEP Inferred from Expression Pattern more info	PubMed
involved_in cellular response to mechanical stimulus	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within cellular response to organic cyclic compound	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within commissural neuron axon guidance	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within epithelial tube branching involved in lung morphogenesis	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within heart development	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within heart morphogenesis	ISO Inferred from Sequence Orthology more info
involved_in membrane protein ectodomain proteolysis	ISO Inferred from Sequence Orthology more info
involved_in microtubule anchoring	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within morphogenesis of an epithelial sheet	ISO Inferred from Sequence Orthology more info
involved_in morphogenesis of an epithelium	IBA Inferred from Biological aspect of Ancestor more info
involved_in muscle attachment	IBA Inferred from Biological aspect of Ancestor more info
involved_in myelination in peripheral nervous system	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of MAPK cascade	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of cell migration	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction	ISO Inferred from Sequence Orthology more info
involved_in nerve development	IBA Inferred from Biological aspect of Ancestor more info
involved_in nerve development	IEP Inferred from Expression Pattern more info	PubMed
involved_in nerve maturation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of basement membrane assembly involved in embryonic body morphogenesis	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of cell-matrix adhesion	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of myelination	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of oligodendrocyte differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of protein kinase activity	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within protein transport	ISO Inferred from Sequence Orthology more info
involved_in regulation of epithelial to mesenchymal transition	ISO Inferred from Sequence Orthology more info
involved_in regulation of gastrulation	ISO Inferred from Sequence Orthology more info
involved_in regulation of neurotransmitter receptor localization to postsynaptic specialization membrane	ISO Inferred from Sequence Orthology more info
involved_in regulation of synapse organization	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within regulation of synaptic plasticity	ISO Inferred from Sequence Orthology more info
involved_in response to denervation involved in regulation of muscle adaptation	IEP Inferred from Expression Pattern more info	PubMed
acts_upstream_of_or_within response to muscle activity	ISO Inferred from Sequence Orthology more info
involved_in response to peptide hormone	IEP Inferred from Expression Pattern more info	PubMed
involved_in retrograde trans-synaptic signaling by trans-synaptic protein complex	ISO Inferred from Sequence Orthology more info
involved_in skeletal muscle tissue regeneration	IEP Inferred from Expression Pattern more info	PubMed
involved_in symbiont entry into host cell	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
is_active_in GABA-ergic synapse	ISO Inferred from Sequence Orthology more info
located_in adherens junction	IDA Inferred from Direct Assay more info	PubMed
is_active_in basement membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in basement membrane	ISO Inferred from Sequence Orthology more info
located_in basolateral plasma membrane	IDA Inferred from Direct Assay more info	PubMed
is_active_in cell surface	ISO Inferred from Sequence Orthology more info
located_in cell-cell junction	ISO Inferred from Sequence Orthology more info
located_in contractile ring	ISO Inferred from Sequence Orthology more info
located_in costamere	IDA Inferred from Direct Assay more info	PubMed
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in cytoskeleton	IEA Inferred from Electronic Annotation more info
part_of dystroglycan complex	IBA Inferred from Biological aspect of Ancestor more info
part_of dystroglycan complex	ISO Inferred from Sequence Orthology more info
part_of dystrophin-associated glycoprotein complex	IDA Inferred from Direct Assay more info	PubMed
part_of dystrophin-associated glycoprotein complex	ISO Inferred from Sequence Orthology more info
located_in external side of plasma membrane	ISO Inferred from Sequence Orthology more info
located_in extracellular region	TAS Traceable Author Statement more info
is_active_in extracellular space	IBA Inferred from Biological aspect of Ancestor more info
located_in extracellular space	IDA Inferred from Direct Assay more info	PubMed
located_in extracellular space	ISO Inferred from Sequence Orthology more info
located_in filopodium	ISO Inferred from Sequence Orthology more info
located_in focal adhesion	IDA Inferred from Direct Assay more info	PubMed
located_in focal adhesion	ISO Inferred from Sequence Orthology more info
is_active_in glutamatergic synapse	IDA Inferred from Direct Assay more info	PubMed
located_in intracellular membrane-bounded organelle	ISO Inferred from Sequence Orthology more info
located_in lamellipodium	ISO Inferred from Sequence Orthology more info
located_in membrane	ISO Inferred from Sequence Orthology more info
located_in membrane raft	ISO Inferred from Sequence Orthology more info
located_in node of Ranvier	ISO Inferred from Sequence Orthology more info
located_in nuclear periphery	IDA Inferred from Direct Assay more info	PubMed
located_in nucleoplasm	IEA Inferred from Electronic Annotation more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
is_active_in photoreceptor ribbon synapse	ISO Inferred from Sequence Orthology more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info
located_in plasma membrane	TAS Traceable Author Statement more info
located_in plasma membrane raft	IDA Inferred from Direct Assay more info	PubMed
is_active_in postsynapse	ISO Inferred from Sequence Orthology more info
is_active_in postsynaptic cytosol	IDA Inferred from Direct Assay more info	PubMed
located_in postsynaptic membrane	IEA Inferred from Electronic Annotation more info
is_active_in sarcolemma	IBA Inferred from Biological aspect of Ancestor more info
located_in sarcolemma	IDA Inferred from Direct Assay more info	PubMed
located_in sarcolemma	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: dystroglycan 1

Names: alpha-dystroglycan; beta-dystroglycan; dystroglycan 1 (dystrophin-associated glycoprotein 1)

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_053697.1 → NP_446149.1 dystroglycan 1 precursor

Status: VALIDATED

Source sequence(s)

JAXUCZ010000008

UniProtKB/TrEMBL

F1M8K0

Related

ENSRNOP00000026327.4, ENSRNOT00000026327.9

Conserved Domains (4) summary

cd11303
Location:60 → 161

Dystroglycan_repeat; Cadherin-like repeat domain of alpha dystroglycan

PRK14971
Location:311 → 402

PRK14971; DNA polymerase III subunit gamma/tau

pfam05454
Location:604 → 893

DAG1; Dystroglycan (Dystrophin-associated glycoprotein 1)

pfam18424
Location:180 → 302

a_DG1_N2; Alpha-Dystroglycan N-terminal domain 2

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086026.1 Reference GRCr8

Range

117769517..117834347 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_039080666.2 → XP_038936594.1 dystroglycan 1 isoform X1

UniProtKB/TrEMBL

F1M8K0

Conserved Domains (4) summary

cd11303
Location:60 → 161

Dystroglycan_repeat; Cadherin-like repeat domain of alpha dystroglycan

PRK14971
Location:311 → 402

PRK14971; DNA polymerase III subunit gamma/tau

pfam05454
Location:604 → 893

DAG1; Dystroglycan (Dystrophin-associated glycoprotein 1)

pfam18424
Location:180 → 302

a_DG1_N2; Alpha-Dystroglycan N-terminal domain 2
XM_039080670.2 → XP_038936598.1 dystroglycan 1 isoform X1

UniProtKB/TrEMBL

F1M8K0

Conserved Domains (4) summary

cd11303
Location:60 → 161

Dystroglycan_repeat; Cadherin-like repeat domain of alpha dystroglycan

PRK14971
Location:311 → 402

PRK14971; DNA polymerase III subunit gamma/tau

pfam05454
Location:604 → 893

DAG1; Dystroglycan (Dystrophin-associated glycoprotein 1)

pfam18424
Location:180 → 302

a_DG1_N2; Alpha-Dystroglycan N-terminal domain 2
XM_039080664.2 → XP_038936592.1 dystroglycan 1 isoform X1

UniProtKB/TrEMBL

F1M8K0

Conserved Domains (4) summary

cd11303
Location:60 → 161

Dystroglycan_repeat; Cadherin-like repeat domain of alpha dystroglycan

PRK14971
Location:311 → 402

PRK14971; DNA polymerase III subunit gamma/tau

pfam05454
Location:604 → 893

DAG1; Dystroglycan (Dystrophin-associated glycoprotein 1)

pfam18424
Location:180 → 302

a_DG1_N2; Alpha-Dystroglycan N-terminal domain 2
XM_039080669.2 → XP_038936597.1 dystroglycan 1 isoform X1

UniProtKB/TrEMBL

F1M8K0

Conserved Domains (4) summary

cd11303
Location:60 → 161

Dystroglycan_repeat; Cadherin-like repeat domain of alpha dystroglycan

PRK14971
Location:311 → 402

PRK14971; DNA polymerase III subunit gamma/tau

pfam05454
Location:604 → 893

DAG1; Dystroglycan (Dystrophin-associated glycoprotein 1)

pfam18424
Location:180 → 302

a_DG1_N2; Alpha-Dystroglycan N-terminal domain 2
XM_039080665.2 → XP_038936593.1 dystroglycan 1 isoform X1

UniProtKB/TrEMBL

F1M8K0

Conserved Domains (4) summary

cd11303
Location:60 → 161

Dystroglycan_repeat; Cadherin-like repeat domain of alpha dystroglycan

PRK14971
Location:311 → 402

PRK14971; DNA polymerase III subunit gamma/tau

pfam05454
Location:604 → 893

DAG1; Dystroglycan (Dystrophin-associated glycoprotein 1)

pfam18424
Location:180 → 302

a_DG1_N2; Alpha-Dystroglycan N-terminal domain 2
XM_039080672.2 → XP_038936600.1 dystroglycan 1 isoform X1

UniProtKB/TrEMBL

F1M8K0

Conserved Domains (4) summary

cd11303
Location:60 → 161

Dystroglycan_repeat; Cadherin-like repeat domain of alpha dystroglycan

PRK14971
Location:311 → 402

PRK14971; DNA polymerase III subunit gamma/tau

pfam05454
Location:604 → 893

DAG1; Dystroglycan (Dystrophin-associated glycoprotein 1)

pfam18424
Location:180 → 302

a_DG1_N2; Alpha-Dystroglycan N-terminal domain 2
XM_039080668.2 → XP_038936596.1 dystroglycan 1 isoform X1

UniProtKB/TrEMBL

F1M8K0

Conserved Domains (4) summary

cd11303
Location:60 → 161

Dystroglycan_repeat; Cadherin-like repeat domain of alpha dystroglycan

PRK14971
Location:311 → 402

PRK14971; DNA polymerase III subunit gamma/tau

pfam05454
Location:604 → 893

DAG1; Dystroglycan (Dystrophin-associated glycoprotein 1)

pfam18424
Location:180 → 302

a_DG1_N2; Alpha-Dystroglycan N-terminal domain 2
XM_039080667.2 → XP_038936595.1 dystroglycan 1 isoform X1

UniProtKB/TrEMBL

F1M8K0

Conserved Domains (4) summary

cd11303
Location:60 → 161

Dystroglycan_repeat; Cadherin-like repeat domain of alpha dystroglycan

PRK14971
Location:311 → 402

PRK14971; DNA polymerase III subunit gamma/tau

pfam05454
Location:604 → 893

DAG1; Dystroglycan (Dystrophin-associated glycoprotein 1)

pfam18424
Location:180 → 302

a_DG1_N2; Alpha-Dystroglycan N-terminal domain 2