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etv6 ETS variant transcription factor 6 [ Danio rerio (zebrafish) ]

Gene ID: 114444, updated on 12-Sep-2024

Summary

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Official Symbol
etv6provided by ZNC
Official Full Name
ETS variant transcription factor 6provided by ZNC
Primary source
ZFIN:ZDB-GENE-010727-1
See related
AllianceGenome:ZFIN:ZDB-GENE-010727-1
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
tel; id:ibd2308
Summary
Predicted to enable DNA-binding transcription factor activity and sequence-specific DNA binding activity. Acts upstream of or within embryonic hemopoiesis. Predicted to be located in nucleus. Is expressed in several structures, including brain; germ ring; intermediate cell mass of mesoderm; mesoderm; and renal system. Human ortholog(s) of this gene implicated in hematologic cancer (multiple) and thrombocytopenia. Orthologous to human ETV6 (ETS variant transcription factor 6). [provided by Alliance of Genome Resources, Apr 2022]
Annotation information
Annotation category: partial on reference assembly
Orthologs
all
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Genomic context

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Location:
chromosome: Un
Exon count:
1
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCz11 (GCF_000002035.6) Unplaced Scaffold NW_003337254.2 (5152..5447, complement)
105 previous assembly GRCz10 (GCF_000002035.5) Unplaced Scaffold NW_003337254.2 (5152..5447, complement)

NW_003337254.2Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Functional analysis of truncated forms of ETV6. Rasighaemi P, et al. Br J Haematol, 2015 Nov. PMID 25850516
  2. Analysis of the conservation of synteny between Fugu and human chromosome 12. Montpetit A, et al. BMC Genomics, 2003 Jul 23. PMID 12877756, Free PMC Article
  3. Control of endothelial sprouting by a Tel-CtBP complex. Roukens MG, et al. Nat Cell Biol, 2010 Oct. PMID 20835243
  4. Hematopoietic perturbation in zebrafish expressing a tel-jak2a fusion. Onnebo SM, et al. Exp Hematol, 2005 Feb. PMID 15676212
  5. Alternative TEL-JAK2 fusions associated with T-cell acute lymphoblastic leukemia and atypical chronic myelogenous leukemia dissected in zebrafish. Onnebo SM, et al. Haematologica, 2012 Dec. PMID 22733019, Free PMC Article

See all (13) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables DNA binding IEA
Inferred from Electronic Annotation
more info
  
enables DNA-binding transcription factor activity IEA
Inferred from Electronic Annotation
more info
  
enables sequence-specific DNA binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within embryonic hemopoiesis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within regulation of DNA-templated transcription IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within regulation of transcription by RNA polymerase II IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
transcription factor ETV6
Names
ets variant gene 6 (TEL oncogene)
ztel

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_131832.2 → NP_571907.2  transcription factor ETV6

    See identical proteins and their annotated locations for NP_571907.2

    Status: PROVISIONAL

    Source sequence(s)
    BC045451
    UniProtKB/TrEMBL
    Q7ZU22
    Conserved Domains (2) summary
    cd08535
    Location:56 → 123
    SAM_PNT-Tel_Yan; Sterile alpha motif (SAM)/Pointed domain of Tel/Yan protein
    smart00413
    Location:331 → 417
    ETS; erythroblast transformation specific domain

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NW_003337254.2 Reference GRCz11 Primary Assembly

    Range
    5152..5447 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version

Gene LinkOut

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Molecular Biology Databases
Research Materials