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Lyve1 lymphatic vessel endothelial hyaluronan receptor 1 [ Mus musculus (house mouse) ]

Gene ID: 114332, updated on 4-Jun-2024

Summary

Official Symbol
Lyve1provided by MGI
Official Full Name
lymphatic vessel endothelial hyaluronan receptor 1provided by MGI
Primary source
MGI:MGI:2136348
See related
Ensembl:ENSMUSG00000030787 AllianceGenome:MGI:2136348
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Xlkd1; Lyve-1; Crsbp-1; 1200012G08Rik
Summary
Enables hyaluronic acid binding activity and transmembrane signaling receptor activity. Acts upstream of or within glycosaminoglycan catabolic process. Located in plasma membrane. Is expressed in several structures, including cardiovascular system; gut; hemolymphoid system; meninges; and metanephros. Orthologous to human LYVE1 (lymphatic vessel endothelial hyaluronan receptor 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in lung adult (RPKM 22.3), liver E18 (RPKM 15.1) and 15 other tissues See more
Orthologs
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Genomic context

See Lyve1 in Genome Data Viewer
Location:
7 E3; 7 57.89 cM
Exon count:
6
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (110449814..110462160, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (110850607..110862953, complement)

Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene adenosine monophosphate deaminase 3 Neighboring gene predicted gene, 39069 Neighboring gene ring finger protein 141 Neighboring gene STARR-positive B cell enhancer ABC_E2250 Neighboring gene STARR-seq mESC enhancer starr_19833 Neighboring gene inositol 1,4,5-triphosphate receptor associated 1 Neighboring gene STARR-seq mESC enhancer starr_19834 Neighboring gene predicted gene 16336 Neighboring gene STARR-seq mESC enhancer starr_19835 Neighboring gene STARR-seq mESC enhancer starr_19836 Neighboring gene STARR-positive B cell enhancer ABC_E9701 Neighboring gene CTR9 homolog, Paf1/RNA polymerase II complex component

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

General gene information

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables cargo receptor activity IDA
Inferred from Direct Assay
more info
PubMed 
enables cargo receptor activity ISO
Inferred from Sequence Orthology
more info
PubMed 
enables hyaluronic acid binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables hyaluronic acid binding IDA
Inferred from Direct Assay
more info
PubMed 
enables hyaluronic acid binding ISO
Inferred from Sequence Orthology
more info
 
enables transmembrane signaling receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables transmembrane signaling receptor activity IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
located_in cell periphery IDA
Inferred from Direct Assay
more info
PubMed 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
lymphatic vessel endothelial hyaluronic acid receptor 1
Names
cell surface retention sequence binding protein-1
extra cellular link domain-containing 1
extracellular link domain-containing protein 1
lymphatic vessel endothelial HA receptor-1
lymphatic vessel endothelial HA recptor-1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_053247.4NP_444477.2  lymphatic vessel endothelial hyaluronic acid receptor 1 precursor

    See identical proteins and their annotated locations for NP_444477.2

    Status: PROVISIONAL

    Source sequence(s)
    AC184052
    Consensus CDS
    CCDS21748.1
    UniProtKB/Swiss-Prot
    Q3TUC1, Q8BHC0, Q99NE4
    Related
    ENSMUSP00000033050.4, ENSMUST00000033050.5
    Conserved Domains (1) summary
    cd03516
    Location:33176
    Link_domain_CD44_like; This domain is a hyaluronan (HA)-binding domain. It is found in CD44 receptor and mediates adhesive interactions during inflammatory leukocyte homing and tumor metastasis. It also plays an important role in arteriogenesis. The functional HA-binding ...

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000073.7 Reference GRCm39 C57BL/6J

    Range
    110449814..110462160 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)