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Acp2 acid phosphatase 2, lysosomal [ Mus musculus (house mouse) ]

Gene ID: 11432, updated on 19-Jun-2024

Summary

Official Symbol
Acp2provided by MGI
Official Full Name
acid phosphatase 2, lysosomalprovided by MGI
Primary source
MGI:MGI:87882
See related
Ensembl:ENSMUSG00000002103 AllianceGenome:MGI:87882
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
LAP; Acp-2
Summary
The protein encoded by this gene belongs to the histidine acid phosphatase family, which hydrolyze orthophosphoric monoesters to alcohol and phosphate. This protein is localized to the lysosomal membrane, and is chemically and genetically distinct from the red cell acid phosphatase. Mice lacking this gene showed multiple defects, including bone structure alterations, lysosomal storage defects, and an increased tendency towards seizures. An enzymatically-inactive allele of this gene showed severe growth retardation, hair-follicle abnormalities, and an ataxia-like phenotype. Two isoforms are predicted to be produced from the same mRNA by the use of alternative in-frame translation termination codons via a stop codon readthrough mechanism. [provided by RefSeq, Oct 2017]
Expression
Ubiquitous expression in mammary gland adult (RPKM 14.6), ovary adult (RPKM 12.8) and 28 other tissues See more
Orthologs
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Genomic context

See Acp2 in Genome Data Viewer
Location:
2 E1; 2 50.54 cM
Exon count:
12
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (91033157..91044443)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (91202812..91214098)

Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene MAP-kinase activating death domain Neighboring gene STARR-positive B cell enhancer mm9_chr2:91023256-91023557 Neighboring gene STARR-positive B cell enhancer ABC_E4478 Neighboring gene nuclear receptor subfamily 1, group H, member 3 Neighboring gene STARR-positive B cell enhancer ABC_E9070 Neighboring gene predicted gene, 23390 Neighboring gene CapStarr-seq enhancer MGSCv37_chr2:91057269-91057452 Neighboring gene damage specific DNA binding protein 2 Neighboring gene RIKEN cDNA A330069E16 gene Neighboring gene STARR-positive B cell enhancer ABC_E8985 Neighboring gene predicted gene, 31054

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables acid phosphatase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables acid phosphatase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables acid phosphatase activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
enables acid phosphatase activity ISO
Inferred from Sequence Orthology
more info
 
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
 
enables phosphoprotein phosphatase activity ISO
Inferred from Sequence Orthology
more info
 
enables phosphotyrosine residue binding ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
involved_in autophagic cell death ISO
Inferred from Sequence Orthology
more info
 
involved_in dephosphorylation IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in lysosome organization IBA
Inferred from Biological aspect of Ancestor
more info
 
acts_upstream_of_or_within lysosome organization IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within skeletal system development IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
is_active_in lysosome IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in lysosome IDA
Inferred from Direct Assay
more info
PubMed 
located_in lysosome IMP
Inferred from Mutant Phenotype
more info
PubMed 
located_in lysosome ISO
Inferred from Sequence Orthology
more info
 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
lysosomal acid phosphatase
NP_001343996.1
NP_031413.1
XP_011237559.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001357067.1NP_001343996.1  lysosomal acid phosphatase isoform 1x precursor

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) encodes two isoforms, which result from the use of alternative in-frame translation termination codons. The shorter isoform (1) results from translation termination at the upstream UGA stop codon, while the longer isoform (1x) results from UGA stop codon readthrough to the downstream UAG termination codon. This RefSeq represents the longer isoform (1x). As the UGA stop codon has been reported to specify several alternative amino acids (tryptophan, cysteine, arginine and serine), its location in the longer isoform is denoted by an 'X'.
    Source sequence(s)
    AK128963, AK133756, AL691450, AW061158, BQ445129, CD741498
    Consensus CDS
    CCDS89516.1
    UniProtKB/TrEMBL
    A0A5F8MPS7, Q3U4F3
    Related
    ENSMUSP00000159089.2, ENSMUST00000238832.2
    Conserved Domains (1) summary
    cd07061
    Location:33330
    HP_HAP_like; Histidine phosphatase domain found in histidine acid phosphatases and phytases; contains a His residue which is phosphorylated during the reaction
  2. NM_007387.2NP_031413.1  lysosomal acid phosphatase isoform 1 precursor

    See identical proteins and their annotated locations for NP_031413.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) encodes two isoforms, which result from the use of alternative in-frame translation termination codons. The shorter isoform (1) results from translation termination at the upstream UGA stop codon, while the longer isoform (1x) results from UGA stop codon readthrough to the downstream UAG termination codon. This RefSeq represents the shorter isoform (1).
    Source sequence(s)
    AK128963, AK133756, AL691450, AW061158, BQ445129, CD741498
    Consensus CDS
    CCDS16427.1
    UniProtKB/Swiss-Prot
    P24638, Q8QZT5
    UniProtKB/TrEMBL
    Q3U4F3
    Related
    ENSMUSP00000159053.2, ENSMUST00000239169.2
    Conserved Domains (1) summary
    cd07061
    Location:33330
    HP_HAP_like; Histidine phosphatase domain found in histidine acid phosphatases and phytases; contains a His residue which is phosphorylated during the reaction

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000068.8 Reference GRCm39 C57BL/6J

    Range
    91033157..91044443
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011239257.3XP_011237559.1  lysosomal acid phosphatase isoform X1

    UniProtKB/TrEMBL
    Q3U4F3
    Conserved Domains (1) summary
    cd07061
    Location:18312
    HP_HAP_like; Histidine phosphatase domain found in histidine acid phosphatases and phytases; contains a His residue which is phosphorylated during the reaction

RNA

  1. XR_003950055.2 RNA Sequence