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Acox1 acyl-Coenzyme A oxidase 1, palmitoyl [ Mus musculus (house mouse) ]

Gene ID: 11430, updated on 24-Jan-2023

Summary

Official Symbol
Acox1provided by MGI
Official Full Name
acyl-Coenzyme A oxidase 1, palmitoylprovided by MGI
Primary source
MGI:MGI:1330812
See related
Ensembl:ENSMUSG00000020777 AllianceGenome:MGI:1330812
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
AOX; Acox; Paox; D130055E20Rik
Summary
This gene encodes a member of the acyl-coenzyme A oxidase family. The encoded protein is localized to peroxisomes and is the first enzyme of the fatty acid beta-oxidation pathway, which catalyzes the desaturation of acyl-coenzyme A to 2-trans-enoyl-coenzyme A. Disruption of this gene results in microvesicular steatohepatitis, spontaneous peroxisome proliferation, and the eventual development of hepatocellular carcinomas. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2012]
Expression
Broad expression in liver adult (RPKM 251.9), liver E18 (RPKM 159.5) and 21 other tissues See more
Orthologs
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Genomic context

See Acox1 in Genome Data Viewer
Location:
11; 11 E2
Exon count:
15
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (116062709..116089871, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (116171883..116199045, complement)

Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene mitochondrial ribosomal protein L38 Neighboring gene Fas (TNFRSF6) binding factor 1 Neighboring gene predicted gene, 26413 Neighboring gene TEN1 telomerase capping complex subunit Neighboring gene cyclin-dependent kinase 3 Neighboring gene envoplakin Neighboring gene predicted gene, 33250

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • D130055E20Rik

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables FAD binding ISO
Inferred from Sequence Orthology
more info
 
enables PDZ domain binding ISO
Inferred from Sequence Orthology
more info
PubMed 
enables acyl-CoA oxidase activity ISO
Inferred from Sequence Orthology
more info
 
enables acyl-CoA oxidase activity TAS
Traceable Author Statement
more info
PubMed 
enables fatty acid binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables fatty acid binding ISO
Inferred from Sequence Orthology
more info
 
enables flavin adenine dinucleotide binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables flavin adenine dinucleotide binding ISO
Inferred from Sequence Orthology
more info
 
enables oxidoreductase activity IEA
Inferred from Electronic Annotation
more info
 
enables oxidoreductase activity, acting on the CH-CH group of donors IEA
Inferred from Electronic Annotation
more info
 
enables palmitoyl-CoA oxidase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables palmitoyl-CoA oxidase activity ISO
Inferred from Sequence Orthology
more info
 
enables protein homodimerization activity ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
involved_in cholesterol homeostasis ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within fatty acid beta-oxidation TAS
Traceable Author Statement
more info
PubMed 
involved_in fatty acid beta-oxidation using acyl-CoA oxidase IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in fatty acid beta-oxidation using acyl-CoA oxidase ISO
Inferred from Sequence Orthology
more info
 
involved_in fatty acid catabolic process ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within fatty acid metabolic process IEA
Inferred from Electronic Annotation
more info
 
involved_in fatty acid metabolic process IEA
Inferred from Electronic Annotation
more info
 
involved_in fatty acid oxidation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in fatty acid oxidation ISO
Inferred from Sequence Orthology
more info
 
involved_in generation of precursor metabolites and energy ISO
Inferred from Sequence Orthology
more info
 
involved_in hydrogen peroxide biosynthetic process ISO
Inferred from Sequence Orthology
more info
 
involved_in lipid homeostasis IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in lipid homeostasis ISO
Inferred from Sequence Orthology
more info
 
involved_in lipid metabolic process ISO
Inferred from Sequence Orthology
more info
 
involved_in peroxisome fission ISO
Inferred from Sequence Orthology
more info
 
involved_in prostaglandin metabolic process ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within spermatogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in very long-chain fatty acid beta-oxidation ISO
Inferred from Sequence Orthology
more info
 
involved_in very long-chain fatty acid metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in very long-chain fatty acid metabolic process ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
located_in cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytosol TAS
Traceable Author Statement
more info
 
located_in mitochondrion HDA PubMed 
located_in peroxisomal membrane IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in peroxisome IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in peroxisome IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in peroxisome ISO
Inferred from Sequence Orthology
more info
 
located_in peroxisome ISO
Inferred from Sequence Orthology
more info
 
located_in peroxisome TAS
Traceable Author Statement
more info
PubMed 

General protein information

Preferred Names
peroxisomal acyl-coenzyme A oxidase 1
Names
palmitoyl-CoA oxidase
peroxisomal fatty acyl-CoA oxidase
peroxisomal fatty acyl-coenzyme A oxidase
peroxisomal straight-chain Acyl-CoA oxidase
straight-chain acyl-CoA oxidase
NP_001258827.1
NP_001364450.1
NP_001364451.1
NP_056544.2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001271898.2NP_001258827.1  peroxisomal acyl-coenzyme A oxidase 1 isoform 2

    See identical proteins and their annotated locations for NP_001258827.1

    Status: REVIEWED

    Source sequence(s)
    AL607108, AL669925
    Consensus CDS
    CCDS70354.1
    UniProtKB/Swiss-Prot
    Q8BYC3, Q9R0H0
    Related
    ENSMUSP00000072717.5, ENSMUST00000072948.11
    Conserved Domains (1) summary
    cd01150
    Location:3638
    AXO; Peroxisomal acyl-CoA oxidase
  2. NM_001377521.1NP_001364450.1  peroxisomal acyl-coenzyme A oxidase 1 isoform 3

    Status: REVIEWED

    Source sequence(s)
    AL607108, AL669925
    Related
    ENSMUSP00000122185.2, ENSMUST00000148601.2
    Conserved Domains (1) summary
    cd01150
    Location:23570
    AXO; Peroxisomal acyl-CoA oxidase
  3. NM_001377522.1NP_001364451.1  peroxisomal acyl-coenzyme A oxidase 1 isoform 4

    Status: REVIEWED

    Source sequence(s)
    AL607108, AL669925
    Conserved Domains (1) summary
    cl09933
    Location:3562
    ACAD; Acyl-CoA dehydrogenase
  4. NM_015729.4NP_056544.2  peroxisomal acyl-coenzyme A oxidase 1 isoform 1

    See identical proteins and their annotated locations for NP_056544.2

    Status: REVIEWED

    Source sequence(s)
    AL607108, AL669925
    Consensus CDS
    CCDS25660.1
    UniProtKB/Swiss-Prot
    Q9R0H0
    Related
    ENSMUSP00000063325.6, ENSMUST00000066587.12
    Conserved Domains (2) summary
    cd01150
    Location:3638
    AXO; Peroxisomal acyl-CoA oxidase
    PLN02443
    Location:5657
    PLN02443; acyl-coenzyme A oxidase

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000077.7 Reference GRCm39 C57BL/6J

    Range
    116062709..116089871 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)