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Asic1 acid-sensing ion channel 1 [ Mus musculus (house mouse) ]

Gene ID: 11419, updated on 20-Feb-2024

Summary

Official Symbol
Asic1provided by MGI
Official Full Name
acid-sensing ion channel 1provided by MGI
Primary source
MGI:MGI:1194915
See related
Ensembl:ENSMUSG00000023017 AllianceGenome:MGI:1194915
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
ASIC; Accn2; BNaC2; ASIC1a; ASIC1b; B530003N02Rik
Summary
Enables acid-sensing ion channel activity and ion gated channel activity. Acts upstream of or within several processes, including behavioral fear response; learning or memory; and response to amphetamine. Located in synapse. Is integral component of plasma membrane. Is expressed in several structures, including brain. Orthologous to human ASIC1 (acid sensing ion channel subunit 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in whole brain E14.5 (RPKM 11.2), CNS E18 (RPKM 10.4) and 7 other tissues See more
Orthologs
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Genomic context

See Asic1 in Genome Data Viewer
Location:
15 F1; 15 56.13 cM
Exon count:
14
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 15 NC_000081.7 (99568090..99599011)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 15 NC_000081.6 (99670197..99701130)

Chromosome 15 - NC_000081.7Genomic Context describing neighboring genes Neighboring gene Rac GTPase-activating protein 1 Neighboring gene STARR-positive B cell enhancer mm9_chr15:99481947-99482248 Neighboring gene predicted gene, 34880 Neighboring gene STARR-seq mESC enhancer starr_39720 Neighboring gene predicted gene, 34939 Neighboring gene SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 1 Neighboring gene ribosomal protein S27 pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables inorganic cation transmembrane transporter activity ISO
Inferred from Sequence Orthology
more info
 
enables ligand-gated sodium channel activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables ligand-gated sodium channel activity IEA
Inferred from Electronic Annotation
more info
 
enables monoatomic cation channel activity IDA
Inferred from Direct Assay
more info
PubMed 
enables monoatomic cation channel activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
enables monoatomic ion channel activity ISO
Inferred from Sequence Orthology
more info
 
enables monoatomic ion-gated channel activity IDA
Inferred from Direct Assay
more info
PubMed 
enables monoatomic ion-gated channel activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
enables pH-gated monoatomic ion channel activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables pH-gated monoatomic ion channel activity IDA
Inferred from Direct Assay
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables sodium channel activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
acts_upstream_of_or_within associative learning IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within behavioral fear response IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within calcium ion transmembrane transport IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within calcium ion transport IEA
Inferred from Electronic Annotation
more info
 
involved_in cellular response to pH ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within establishment of localization in cell IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within inorganic cation transmembrane transport ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within memory IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within monoatomic cation transmembrane transport IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within monoatomic cation transport IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within monoatomic cation transport IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within monoatomic ion transmembrane transport IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within monoatomic ion transmembrane transport IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in monoatomic ion transmembrane transport ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within monoatomic ion transport IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within negative regulation of neurotransmitter secretion IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of neurotransmitter secretion IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within regulation of membrane potential IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within response to acidic pH IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within response to acidic pH IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within response to amphetamine IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in sensory perception of sour taste ISO
Inferred from Sequence Orthology
more info
 
involved_in sodium ion transmembrane transport IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in sodium ion transmembrane transport ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within sodium ion transport IEA
Inferred from Electronic Annotation
more info
 
involved_in sodium ion transport IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
located_in Golgi apparatus ISO
Inferred from Sequence Orthology
more info
 
located_in cell surface ISO
Inferred from Sequence Orthology
more info
 
located_in dendritic shaft ISO
Inferred from Sequence Orthology
more info
 
located_in dendritic spine ISO
Inferred from Sequence Orthology
more info
 
located_in membrane ISO
Inferred from Sequence Orthology
more info
 
located_in plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in plasma membrane ISO
Inferred from Sequence Orthology
more info
 
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
 
located_in synapse IDA
Inferred from Direct Assay
more info
PubMed 
located_in synapse ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
acid-sensing ion channel 1
Names
acid-sensing (proton-gated) ion channel 1
amiloride-sensitive cation channel 2, neuronal
brain sodium channel 2
degenerin 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001289791.2NP_001276720.1  acid-sensing ion channel 1 isoform 2

    See identical proteins and their annotated locations for NP_001276720.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR and represents use of an alternate promoter, compared to variant 1. It encodes isoform 2 which has a distinct N-terminus compared to isoform 1.
    Source sequence(s)
    AC134548
    Consensus CDS
    CCDS88841.1
    UniProtKB/Swiss-Prot
    Q6NXK8
    Related
    ENSMUSP00000154379.2, ENSMUST00000228185.2
    Conserved Domains (1) summary
    cl02990
    Location:63541
    ASC; Amiloride-sensitive sodium channel
  2. NM_009597.2NP_033727.1  acid-sensing ion channel 1 isoform 1

    See identical proteins and their annotated locations for NP_033727.1

    Status: VALIDATED

    Source sequence(s)
    AI850572, BC067025, CB527867
    Consensus CDS
    CCDS27826.1
    UniProtKB/Swiss-Prot
    Q50K97, Q6NXK8
    Related
    ENSMUSP00000023758.8, ENSMUST00000023758.9
    Conserved Domains (1) summary
    TIGR00859
    Location:19508
    ENaC; sodium channel transporter

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000081.7 Reference GRCm39 C57BL/6J

    Range
    99568090..99599011
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006520297.5XP_006520360.1  acid-sensing ion channel 1 isoform X1

    See identical proteins and their annotated locations for XP_006520360.1

    Conserved Domains (1) summary
    TIGR00859
    Location:19509
    ENaC; sodium channel transporter
  2. XM_006520298.4XP_006520361.1  acid-sensing ion channel 1 isoform X1

    See identical proteins and their annotated locations for XP_006520361.1

    Conserved Domains (1) summary
    TIGR00859
    Location:19509
    ENaC; sodium channel transporter
  3. XM_036159074.1XP_036014967.1  acid-sensing ion channel 1 isoform X2

    UniProtKB/Swiss-Prot
    Q50K97, Q6NXK8
    Conserved Domains (1) summary
    TIGR00859
    Location:19508
    ENaC; sodium channel transporter