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Asic1 acid-sensing ion channel 1 [ Mus musculus (house mouse) ]

Gene ID: 11419, updated on 17-Jul-2024

Summary

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Official Symbol
Asic1provided by MGI
Official Full Name
acid-sensing ion channel 1provided by MGI
Primary source
MGI:MGI:1194915
See related
Ensembl:ENSMUSG00000023017 AllianceGenome:MGI:1194915
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
ASIC; Accn2; BNaC2; ASIC1a; ASIC1b; B530003N02Rik
Summary
Enables acid-sensing ion channel activity and ion gated channel activity. Acts upstream of or within several processes, including behavioral fear response; learning or memory; and response to amphetamine. Located in synapse. Is integral component of plasma membrane. Is expressed in several structures, including brain. Orthologous to human ASIC1 (acid sensing ion channel subunit 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in whole brain E14.5 (RPKM 11.2), CNS E18 (RPKM 10.4) and 7 other tissues See more
Orthologs
human all
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Genomic context

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See Asic1 in Genome Data Viewer
Location:
15 F1; 15 56.13 cM
Exon count:
14
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 15 NC_000081.7 (99568090..99599011)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 15 NC_000081.6 (99670197..99701130)

Chromosome 15 - NC_000081.7Genomic Context describing neighboring genes Neighboring gene Rac GTPase-activating protein 1 Neighboring gene STARR-positive B cell enhancer mm9_chr15:99481947-99482248 Neighboring gene predicted gene, 34880 Neighboring gene STARR-seq mESC enhancer starr_39720 Neighboring gene predicted gene, 34939 Neighboring gene SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 1 Neighboring gene ribosomal protein S27 pseudogene

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Acid-sensing ion channel 1a exacerbates renal ischemia-reperfusion injury through the NF-κB/NLRP3 inflammasome pathway. Yang Y, et al. J Mol Med (Berl), 2023 Jul. PMID 37246982, Free PMC Article
  2. Acid-sensing ion channel 1a activates IKCa/SKCa channels and contributes to endothelium-dependent dilation. Garcia SM, et al. J Gen Physiol, 2023 Feb 6. PMID 36484717, Free PMC Article
  3. Acid-sensitive ion channel 1a regulates TNF-α expression in LPS-induced acute lung injury via ERS-CHOP-C/EBPα signaling pathway. Liu Y, et al. Mol Immunol, 2023 Jan. PMID 36403431
  4. Knockdown of Acid-sensing Ion Channel 1a in the PVN Promotes Metabolic Disturbances in Male Mice. Wang W, et al. Endocrinology, 2022 Oct 1. PMID 35894166
  5. Pharmacological Validation of ASIC1a as a Druggable Target for Neuroprotection in Cerebral Ischemia Using an Intravenously Available Small Molecule Inhibitor. Qi X, et al. Front Pharmacol, 2022. PMID 35401212, Free PMC Article

See all (171) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Inhibition of ASIC1a Improves Behavioral Recovery after Stroke.
    Title: Inhibition of ASIC1a Improves Behavioral Recovery after Stroke.
  2. ASIC1a affects hypothalamic signaling and regulates the daily rhythm of body temperature in mice.
    Title: ASIC1a affects hypothalamic signaling and regulates the daily rhythm of body temperature in mice.
  3. Acid-sensing ion channel 1a exacerbates renal ischemia-reperfusion injury through the NF-kappaB/NLRP3 inflammasome pathway.
    Title: Acid-sensing ion channel 1a exacerbates renal ischemia-reperfusion injury through the NF-κB/NLRP3 inflammasome pathway.
  4. Acid-sensitive ion channel 1a regulates TNF-alpha expression in LPS-induced acute lung injury via ERS-CHOP-C/EBPalpha signaling pathway.
    Title: Acid-sensitive ion channel 1a regulates TNF-α expression in LPS-induced acute lung injury via ERS-CHOP-C/EBPα signaling pathway.
  5. Acid-sensing ion channel 1a activates IKCa/SKCa channels and contributes to endothelium-dependent dilation.
    Title: Acid-sensing ion channel 1a activates IKCa/SKCa channels and contributes to endothelium-dependent dilation.
  6. Knockdown of Acid-sensing Ion Channel 1a in the PVN Promotes Metabolic Disturbances in Male Mice.
    Title: Knockdown of Acid-sensing Ion Channel 1a in the PVN Promotes Metabolic Disturbances in Male Mice.
  7. Acid-sensing ion channel 1a regulates the specificity of reconsolidation of conditioned threat responses.
    Title: Acid-sensing ion channel 1a regulates the specificity of reconsolidation of conditioned threat responses.
  8. Activation of acid-sensing ion channels by carbon dioxide regulates amygdala synaptic protein degradation in memory reconsolidation.
    Title: Activation of acid-sensing ion channels by carbon dioxide regulates amygdala synaptic protein degradation in memory reconsolidation.
  9. C-Jun N-Terminal Kinase Post-Translational Regulation of Pain-Related Acid-Sensing Ion Channels 1b and 3.
    Title: C-Jun N-Terminal Kinase Post-Translational Regulation of Pain-Related Acid-Sensing Ion Channels 1b and 3.
  10. Acid-sensing ion channel 1 contributes to pulmonary arterial smooth muscle cell depolarization following hypoxic pulmonary hypertension.
    Title: Acid-sensing ion channel 1 contributes to pulmonary arterial smooth muscle cell depolarization following hypoxic pulmonary hypertension.
Submit: New GeneRIF Correction See all GeneRIFs (109)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables inorganic cation transmembrane transporter activity ISO
Inferred from Sequence Orthology
more info
  
enables ligand-gated sodium channel activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables monoatomic cation channel activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables monoatomic cation channel activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables monoatomic ion channel activity ISO
Inferred from Sequence Orthology
more info
  
enables monoatomic ion-gated channel activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables monoatomic ion-gated channel activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables pH-gated monoatomic ion channel activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables pH-gated monoatomic ion channel activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables pH-gated monoatomic ion channel activity ISO
Inferred from Sequence Orthology
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables sodium channel activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within associative learning IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within behavioral fear response IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within calcium ion transmembrane transport IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within calcium ion transport IEA
Inferred from Electronic Annotation
more info
  
involved_in cellular response to pH ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within establishment of localization in cell IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within inorganic cation transmembrane transport ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within memory IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within monoatomic cation transport IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within monoatomic cation transport IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within monoatomic ion transmembrane transport IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within monoatomic ion transmembrane transport IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in monoatomic ion transmembrane transport ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within monoatomic ion transport IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within negative regulation of neurotransmitter secretion IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of neurotransmitter secretion IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within regulation of membrane potential IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of postsynapse assembly IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in regulation of postsynapse assembly IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within response to acidic pH IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within response to acidic pH IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within response to amphetamine IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in sensory perception of sour taste ISO
Inferred from Sequence Orthology
more info
  
involved_in sodium ion transmembrane transport IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in sodium ion transmembrane transport ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within sodium ion transport IEA
Inferred from Electronic Annotation
more info
  
involved_in sodium ion transport IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in Golgi apparatus ISO
Inferred from Sequence Orthology
more info
  
located_in cell surface ISO
Inferred from Sequence Orthology
more info
  
located_in dendritic shaft ISO
Inferred from Sequence Orthology
more info
  
located_in dendritic spine ISO
Inferred from Sequence Orthology
more info
  
is_active_in glutamatergic synapse IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in glutamatergic synapse IMP
Inferred from Mutant Phenotype
more info
 PubMed 
located_in membrane ISO
Inferred from Sequence Orthology
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in plasma membrane ISO
Inferred from Sequence Orthology
more info
  
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
  
located_in synapse IDA
Inferred from Direct Assay
more info
 PubMed 
located_in synapse ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
acid-sensing ion channel 1
Names
acid-sensing (proton-gated) ion channel 1
amiloride-sensitive cation channel 2, neuronal
brain sodium channel 2
degenerin 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001289791.2 → NP_001276720.1  acid-sensing ion channel 1 isoform 2

    See identical proteins and their annotated locations for NP_001276720.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR and represents use of an alternate promoter, compared to variant 1. It encodes isoform 2 which has a distinct N-terminus compared to isoform 1.
    Source sequence(s)
    AC134548
    Consensus CDS
    CCDS88841.1
    UniProtKB/Swiss-Prot
    Q6NXK8
    Related
    ENSMUSP00000154379.2, ENSMUST00000228185.2
    Conserved Domains (1) summary
    cl02990
    Location:63 → 541
    ASC; Amiloride-sensitive sodium channel

  2. NM_009597.2 → NP_033727.1  acid-sensing ion channel 1 isoform 1

    See identical proteins and their annotated locations for NP_033727.1

    Status: VALIDATED

    Source sequence(s)
    AI850572, BC067025, CB527867
    Consensus CDS
    CCDS27826.1
    UniProtKB/Swiss-Prot
    Q50K97, Q6NXK8
    Related
    ENSMUSP00000023758.8, ENSMUST00000023758.9
    Conserved Domains (1) summary
    TIGR00859
    Location:19 → 508
    ENaC; sodium channel transporter

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000081.7 Reference GRCm39 C57BL/6J

    Range
    99568090..99599011
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006520297.5 → XP_006520360.1  acid-sensing ion channel 1 isoform X1

    See identical proteins and their annotated locations for XP_006520360.1

    Conserved Domains (1) summary
    TIGR00859
    Location:19 → 509
    ENaC; sodium channel transporter

  2. XM_006520298.4 → XP_006520361.1  acid-sensing ion channel 1 isoform X1

    See identical proteins and their annotated locations for XP_006520361.1

    Conserved Domains (1) summary
    TIGR00859
    Location:19 → 509
    ENaC; sodium channel transporter

  3. XM_036159074.1 → XP_036014967.1  acid-sensing ion channel 1 isoform X2

    UniProtKB/Swiss-Prot
    Q50K97, Q6NXK8
    Conserved Domains (1) summary
    TIGR00859
    Location:19 → 508
    ENaC; sodium channel transporter
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q6NXK8.1 GenPept UniProtKB/Swiss-Prot:Q6NXK8

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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