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Acadm acyl-Coenzyme A dehydrogenase, medium chain [ Mus musculus (house mouse) ]

Gene ID: 11364, updated on 8-Feb-2024

Summary

Official Symbol
Acadmprovided by MGI
Official Full Name
acyl-Coenzyme A dehydrogenase, medium chainprovided by MGI
Primary source
MGI:MGI:87867
See related
Ensembl:ENSMUSG00000062908 AllianceGenome:MGI:87867
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
MCAD
Summary
This gene encodes a homotetrameric mitochondrial flavoprotein and is a member of the acyl-CoA dehydrogenase family. Members of this family catalyze the first step of fatty acid beta-oxidation, forming a C2-C3 trans-double bond in a FAD-dependent reaction. As beta-oxidation cycles through its four steps, each member of the acyl-CoA dehydrogenase family works at an optimum fatty acid chain-length. This enzyme has its optimum length between C6- and C12-acylCoA. In mice, deficiency of this gene can cause neonatal mortality as well as fasting and cold intolerance. This gene has multiple, intronless pseudogenes. [provided by RefSeq, Nov 2012]
Expression
Broad expression in heart adult (RPKM 179.5), liver E18 (RPKM 140.4) and 20 other tissues See more
Orthologs
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Genomic context

See Acadm in Genome Data Viewer
Location:
3 H3; 3 78.77 cM
Exon count:
12
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 3 NC_000069.7 (153627990..153650280, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 3 NC_000069.6 (153922353..153944643, complement)

Chromosome 3 - NC_000069.7Genomic Context describing neighboring genes Neighboring gene Rab geranylgeranyl transferase, b subunit Neighboring gene small nucleolar RNA, C/D box 45C Neighboring gene STARR-seq mESC enhancer starr_09325 Neighboring gene predicted gene, 24494 Neighboring gene STARR-positive B cell enhancer ABC_E6148 Neighboring gene STARR-seq mESC enhancer starr_09326 Neighboring gene STARR-seq mESC enhancer starr_09327 Neighboring gene solute carrier family 44, member 5 Neighboring gene STARR-seq mESC enhancer starr_09328 Neighboring gene predicted gene, 40185 Neighboring gene predicted gene 3076

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (3)  1 citation
  • Endonuclease-mediated (3) 

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables acyl-CoA dehydrogenase activity ISO
Inferred from Sequence Orthology
more info
 
enables fatty-acyl-CoA binding ISO
Inferred from Sequence Orthology
more info
 
enables flavin adenine dinucleotide binding ISO
Inferred from Sequence Orthology
more info
 
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
 
enables isomerase activity ISO
Inferred from Sequence Orthology
more info
 
enables medium-chain fatty acyl-CoA dehydrogenase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables medium-chain fatty acyl-CoA dehydrogenase activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
enables medium-chain fatty acyl-CoA dehydrogenase activity ISO
Inferred from Sequence Orthology
more info
 
enables oxidoreductase activity IEA
Inferred from Electronic Annotation
more info
 
enables oxidoreductase activity, acting on the CH-CH group of donors IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
acts_upstream_of_or_within cardiac muscle cell differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in carnitine biosynthetic process ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within carnitine metabolic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in carnitine metabolic process, CoA-linked IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in carnitine metabolic process, CoA-linked ISO
Inferred from Sequence Orthology
more info
 
involved_in fatty acid beta-oxidation ISO
Inferred from Sequence Orthology
more info
 
involved_in fatty acid beta-oxidation using acyl-CoA dehydrogenase IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in fatty acid beta-oxidation using acyl-CoA dehydrogenase ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within fatty acid metabolic process IEA
Inferred from Electronic Annotation
more info
 
involved_in glycogen biosynthetic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within heart development IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within lipid metabolic process IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within liver development IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in medium-chain fatty acid catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in medium-chain fatty acid catabolic process ISO
Inferred from Sequence Orthology
more info
 
involved_in medium-chain fatty acid metabolic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in medium-chain fatty acid metabolic process ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within organic acid metabolic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within post-embryonic development IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of gluconeogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within response to cold IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within response to starvation IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
located_in axon ISO
Inferred from Sequence Orthology
more info
 
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in mitochondrial matrix ISO
Inferred from Sequence Orthology
more info
 
located_in mitochondrial membrane ISO
Inferred from Sequence Orthology
more info
 
located_in mitochondrion HDA PubMed 
is_active_in mitochondrion IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in mitochondrion IDA
Inferred from Direct Assay
more info
PubMed 
located_in mitochondrion ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
medium-chain specific acyl-CoA dehydrogenase, mitochondrial
NP_031408.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_007382.5NP_031408.1  medium-chain specific acyl-CoA dehydrogenase, mitochondrial precursor

    See identical proteins and their annotated locations for NP_031408.1

    Status: REVIEWED

    Source sequence(s)
    AC087184, AK146444, BB745012, CX232934
    Consensus CDS
    CCDS17924.1
    UniProtKB/Swiss-Prot
    P45952, Q64235
    UniProtKB/TrEMBL
    Q91WS8
    Related
    ENSMUSP00000072483.7, ENSMUST00000072697.13
    Conserved Domains (2) summary
    cd01157
    Location:41418
    MCAD; Medium chain acyl-CoA dehydrogenase
    COG1960
    Location:39420
    CaiA; Acyl-CoA dehydrogenase related to the alkylation response protein AidB [Lipid transport and metabolism]

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000069.7 Reference GRCm39 C57BL/6J

    Range
    153627990..153650280 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)