Abl1 c-abl oncogene 1, non-receptor tyrosine kinase [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Abl1provided by MGI
Official Full Name: c-abl oncogene 1, non-receptor tyrosine kinaseprovided by MGI
Primary source: MGI:MGI:87859
See related: Ensembl:ENSMUSG00000026842
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Abl; c-A; c-Abl; AI325092; E430008G22Rik
Expression: Ubiquitous expression in ovary adult (RPKM 24.4), limb E14.5 (RPKM 24.2) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 2 21.86 cM; 2 B

Exon count:: 16

Annotation release	Status	Assembly	Chr	Location
109	current	GRCm39 (GCF_000001635.27)	2	NC_000068.8 (31578256..31697105)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	2	NC_000068.7 (31688244..31807093)
Build 37.2	previous assembly	MGSCv37 (GCF_000001635.18)	2	NC_000068.6 (31544076..31659747)

Chromosome 2 - NC_000068.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Timely Inhibitory Circuit Formation Controlled by Abl1 Regulates Innate Olfactory Behaviors in Mouse.
Title: Timely Inhibitory Circuit Formation Controlled by Abl1 Regulates Innate Olfactory Behaviors in Mouse.
Role of c-Abl in Ang II-induced aortic dissection formation: Potential regulatory efficacy on phenotypic transformation and apoptosis of VSMCs.
Title: Role of c-Abl in Ang II-induced aortic dissection formation: Potential regulatory efficacy on phenotypic transformation and apoptosis of VSMCs.
These findings reveal a critical BCR signal-enhancing function of FcRL1 through its intrinsic recruitment to B cell immunological synapses and subsequent recruitment of c-Abl upon BCR cross-linking.
Title: Fc receptor-like 1 intrinsically recruits c-Abl to enhance B cell activation and function.
The c-Abl/YAPY357 pathway serves as a mechanism for the activation of integrin alpha5beta1 and the atherogenic phenotype of ECs in response to OSS, and provides a potential therapeutic strategy for atherogenesis.
Title: c-Abl regulates YAPY357 phosphorylation to activate endothelial atherogenic responses to disturbed flow.
Nonreceptor Tyrosine Kinase c-Abl- and Arg-Mediated IRF3 Phosphorylation Regulates Innate Immune Responses by Promoting Type I IFN Production.
Title: Nonreceptor Tyrosine Kinase c-Abl- and Arg-Mediated IRF3 Phosphorylation Regulates Innate Immune Responses by Promoting Type I IFN Production.
IL-4 amplifies IgE- and histamine-induced vascular endothelium (VE) dysfunction, fluid extravasation, and the severity of anaphylaxis through a VE IL-4Ralpha/ABL1-dependent mechanism.
Title: The vascular endothelial specific IL-4 receptor alpha-ABL1 kinase signaling axis regulates the severity of IgE-mediated anaphylactic reactions.
These results reveal a role for c-Abl-regulated smooth muscle proliferation in the pathogenesis of rectal prolapse, and imply that long-term use of imatinib mesylate may cause gastrointestinal problems in patients while ERK inhibitor may be effective in treating rectal prolapse.
Title: c-Abl regulates gastrointestinal muscularis propria homeostasis via ERKs.
Radotinib HCl protects the alpha-synuclein preformed fibrils (PFF)-induced neuronal toxicity, reduces the alpha-synuclein PFF-induced Lewy bodies (LB)/Lewy neurites (LN)-like pathology and inhibits the alpha-synuclein PFF-induced c-Abl activation in primary cortical neurons.
Title: The c-Abl inhibitor, Radotinib HCl, is neuroprotective in a preclinical Parkinson's disease mouse model.
WAVE2/c-Abl survival signal required at the hematopoietic stem cell (HSC) fetal liver to marrow transition that confers fitness to the HSC for marrow hematopoiesis
Title: The Wave2 scaffold Hem-1 is required for transition of fetal liver hematopoiesis to bone marrow.
Results indicate that c-Abl may play roles in preimplantation embryo development, especially in TE formation and differentiation.
Title: The Abelson tyrosine kinase (c-Abl) localization in preimplantation mouse development.

Submit: New GeneRIF Correction See all GeneRIFs (133)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (10) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Abl1 (e-PCR), detects polymorphism
- UniSTS:527228

AI325092 (e-PCR)
- UniSTS:178600

Homology

Homologs of the Abl1 gene: The Abl1 gene is conserved in human, chimpanzee, dog, cow, rat, chicken, zebrafish, and frog.
Orthologs from Annotation Pipeline: 342 organisms have orthologs with human gene Abl1
Orthologs

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
ATP binding	IDA Inferred from Direct Assay more info	PubMed
ATP binding	ISO Inferred from Sequence Orthology more info
DNA binding	IEA Inferred from Electronic Annotation more info
SH2 domain binding	ISO Inferred from Sequence Orthology more info
SH3 domain binding	ISO Inferred from Sequence Orthology more info
actin filament binding	IDA Inferred from Direct Assay more info	PubMed
bubble DNA binding	ISO Inferred from Sequence Orthology more info
delta-catenin binding	ISO Inferred from Sequence Orthology more info
ephrin receptor binding	IPI Inferred from Physical Interaction more info	PubMed
four-way junction DNA binding	ISO Inferred from Sequence Orthology more info
kinase activity	IDA Inferred from Direct Assay more info	PubMed
kinase activity	ISO Inferred from Sequence Orthology more info
magnesium ion binding	IDA Inferred from Direct Assay more info	PubMed
magnesium ion binding	ISO Inferred from Sequence Orthology more info
manganese ion binding	IDA Inferred from Direct Assay more info	PubMed
manganese ion binding	ISO Inferred from Sequence Orthology more info
metal ion binding	IEA Inferred from Electronic Annotation more info
mitogen-activated protein kinase binding	ISO Inferred from Sequence Orthology more info
neuropilin binding	IPI Inferred from Physical Interaction more info	PubMed
neuropilin binding	ISO Inferred from Sequence Orthology more info
non-membrane spanning protein tyrosine kinase activity	ISO Inferred from Sequence Orthology more info
nucleotide binding	IEA Inferred from Electronic Annotation more info
phosphotyrosine residue binding	ISO Inferred from Sequence Orthology more info
proline-rich region binding	ISO Inferred from Sequence Orthology more info
protein C-terminus binding	ISO Inferred from Sequence Orthology more info
protein binding	IPI Inferred from Physical Interaction more info	PubMed
protein domain specific binding	IPI Inferred from Physical Interaction more info	PubMed
protein kinase C binding	ISO Inferred from Sequence Orthology more info
protein kinase activity	IDA Inferred from Direct Assay more info	PubMed
protein kinase activity	IMP Inferred from Mutant Phenotype more info	PubMed
protein kinase activity	ISO Inferred from Sequence Orthology more info
protein kinase binding	ISO Inferred from Sequence Orthology more info
protein tyrosine kinase activity	IDA Inferred from Direct Assay more info	PubMed
protein tyrosine kinase activity	IGI Inferred from Genetic Interaction more info	PubMed
protein tyrosine kinase activity	IMP Inferred from Mutant Phenotype more info	PubMed
protein tyrosine kinase activity	ISO Inferred from Sequence Orthology more info
sequence-specific double-stranded DNA binding	ISO Inferred from Sequence Orthology more info
syntaxin binding	ISO Inferred from Sequence Orthology more info
transferase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
B cell proliferation	IMP Inferred from Mutant Phenotype more info	PubMed
B cell proliferation involved in immune response	IGI Inferred from Genetic Interaction more info	PubMed
B cell proliferation involved in immune response	IMP Inferred from Mutant Phenotype more info	PubMed
B cell receptor signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
B-1 B cell homeostasis	IMP Inferred from Mutant Phenotype more info	PubMed
Bergmann glial cell differentiation	IGI Inferred from Genetic Interaction more info	PubMed
DNA conformation change	ISO Inferred from Sequence Orthology more info
DNA damage induced protein phosphorylation	ISO Inferred from Sequence Orthology more info
DNA repair	IEA Inferred from Electronic Annotation more info
T cell receptor signaling pathway	IDA Inferred from Direct Assay more info	PubMed
actin cytoskeleton organization	IDA Inferred from Direct Assay more info	PubMed
actin filament branching	IMP Inferred from Mutant Phenotype more info	PubMed
activated T cell proliferation	IMP Inferred from Mutant Phenotype more info	PubMed
activation of protein kinase C activity	ISO Inferred from Sequence Orthology more info
alpha-beta T cell differentiation	IGI Inferred from Genetic Interaction more info	PubMed
apoptotic process	IEA Inferred from Electronic Annotation more info
autophagy	IEA Inferred from Electronic Annotation more info
cell adhesion	IEA Inferred from Electronic Annotation more info
cellular response to DNA damage stimulus	ISO Inferred from Sequence Orthology more info
cellular response to hydrogen peroxide	ISO Inferred from Sequence Orthology more info
cellular response to lipopolysaccharide	IMP Inferred from Mutant Phenotype more info	PubMed
cerebellum morphogenesis	IGI Inferred from Genetic Interaction more info	PubMed
circulatory system development	IGI Inferred from Genetic Interaction more info	PubMed
collateral sprouting	IMP Inferred from Mutant Phenotype more info	PubMed
endocytosis	IEA Inferred from Electronic Annotation more info
endothelial cell migration	ISO Inferred from Sequence Orthology more info
epidermal growth factor receptor signaling pathway	IGI Inferred from Genetic Interaction more info	PubMed
establishment of protein localization	ISO Inferred from Sequence Orthology more info
integrin-mediated signaling pathway	ISO Inferred from Sequence Orthology more info
microspike assembly	IDA Inferred from Direct Assay more info	PubMed
negative regulation of BMP signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
negative regulation of ERK1 and ERK2 cascade	IMP Inferred from Mutant Phenotype more info	PubMed
negative regulation of I-kappaB kinase/NF-kappaB signaling	IMP Inferred from Mutant Phenotype more info	PubMed
negative regulation of cell-cell adhesion	IGI Inferred from Genetic Interaction more info	PubMed
negative regulation of cellular senescence	IGI Inferred from Genetic Interaction more info	PubMed
negative regulation of endothelial cell apoptotic process	IGI Inferred from Genetic Interaction more info	PubMed
negative regulation of long-term synaptic potentiation	IGI Inferred from Genetic Interaction more info	PubMed
negative regulation of mitotic cell cycle	IDA Inferred from Direct Assay more info	PubMed
negative regulation of mitotic cell cycle	IGI Inferred from Genetic Interaction more info	PubMed
negative regulation of phospholipase C activity	ISO Inferred from Sequence Orthology more info
negative regulation of protein serine/threonine kinase activity	ISO Inferred from Sequence Orthology more info
negative regulation of ubiquitin-protein transferase activity	ISO Inferred from Sequence Orthology more info
neural tube closure	IGI Inferred from Genetic Interaction more info	PubMed
neuroepithelial cell differentiation	IGI Inferred from Genetic Interaction more info	PubMed
neuromuscular process controlling balance	IGI Inferred from Genetic Interaction more info	PubMed
neuron differentiation	IGI Inferred from Genetic Interaction more info	PubMed
neuropilin signaling pathway	ISO Inferred from Sequence Orthology more info
peptidyl-tyrosine autophosphorylation	ISO Inferred from Sequence Orthology more info
peptidyl-tyrosine phosphorylation	IDA Inferred from Direct Assay more info	PubMed
peptidyl-tyrosine phosphorylation	ISO Inferred from Sequence Orthology more info
phagocytosis	IGI Inferred from Genetic Interaction more info	PubMed
phagocytosis	IMP Inferred from Mutant Phenotype more info	PubMed
phosphorylation	IEA Inferred from Electronic Annotation more info
platelet-derived growth factor receptor signaling pathway	IDA Inferred from Direct Assay more info	PubMed
platelet-derived growth factor receptor signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
platelet-derived growth factor receptor-beta signaling pathway	ISO Inferred from Sequence Orthology more info
positive regulation of ERK1 and ERK2 cascade	IMP Inferred from Mutant Phenotype more info	PubMed
positive regulation of I-kappaB kinase/NF-kappaB signaling	IGI Inferred from Genetic Interaction more info	PubMed
positive regulation of Wnt signaling pathway, planar cell polarity pathway	IGI Inferred from Genetic Interaction more info	PubMed
positive regulation of actin cytoskeleton reorganization	ISO Inferred from Sequence Orthology more info
positive regulation of actin filament binding	ISO Inferred from Sequence Orthology more info
positive regulation of apoptotic process	IMP Inferred from Mutant Phenotype more info	PubMed
positive regulation of apoptotic process	ISO Inferred from Sequence Orthology more info
positive regulation of blood vessel branching	IMP Inferred from Mutant Phenotype more info	PubMed
positive regulation of cell migration involved in sprouting angiogenesis	IDA Inferred from Direct Assay more info	PubMed
positive regulation of cytosolic calcium ion concentration	ISO Inferred from Sequence Orthology more info
positive regulation of endothelial cell migration	ISO Inferred from Sequence Orthology more info
positive regulation of focal adhesion assembly	ISO Inferred from Sequence Orthology more info
positive regulation of interferon-gamma production	IGI Inferred from Genetic Interaction more info	PubMed
positive regulation of interleukin-2 production	IGI Inferred from Genetic Interaction more info	PubMed
positive regulation of microtubule binding	ISO Inferred from Sequence Orthology more info
positive regulation of mitotic cell cycle	IGI Inferred from Genetic Interaction more info	PubMed
positive regulation of neuron death	IMP Inferred from Mutant Phenotype more info	PubMed
positive regulation of osteoblast proliferation	IMP Inferred from Mutant Phenotype more info	PubMed
positive regulation of oxidoreductase activity	ISO Inferred from Sequence Orthology more info
positive regulation of peptidyl-tyrosine phosphorylation	ISO Inferred from Sequence Orthology more info
positive regulation of protein phosphorylation	ISO Inferred from Sequence Orthology more info
positive regulation of release of sequestered calcium ion into cytosol	IGI Inferred from Genetic Interaction more info	PubMed
positive regulation of stress fiber assembly	ISO Inferred from Sequence Orthology more info
positive regulation of substrate adhesion-dependent cell spreading	ISO Inferred from Sequence Orthology more info
post-embryonic development	IGI Inferred from Genetic Interaction more info	PubMed
protein autophosphorylation	ISO Inferred from Sequence Orthology more info
protein phosphorylation	IDA Inferred from Direct Assay more info	PubMed
protein phosphorylation	IMP Inferred from Mutant Phenotype more info	PubMed
protein phosphorylation	ISO Inferred from Sequence Orthology more info
regulation of Cdc42 protein signal transduction	ISO Inferred from Sequence Orthology more info
regulation of T cell differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
regulation of actin cytoskeleton organization	IGI Inferred from Genetic Interaction more info	PubMed
regulation of actin cytoskeleton organization	ISO Inferred from Sequence Orthology more info
regulation of apoptotic process	IBA Inferred from Biological aspect of Ancestor more info	PubMed
regulation of axon extension	ISO Inferred from Sequence Orthology more info
regulation of cell cycle	IDA Inferred from Direct Assay more info	PubMed
regulation of cell population proliferation	IGI Inferred from Genetic Interaction more info	PubMed
regulation of cellular senescence	IGI Inferred from Genetic Interaction more info	PubMed
regulation of extracellular matrix organization	IGI Inferred from Genetic Interaction more info	PubMed
regulation of microtubule polymerization	ISO Inferred from Sequence Orthology more info
regulation of modification of synaptic structure	IGI Inferred from Genetic Interaction more info	PubMed
regulation of response to DNA damage stimulus	ISO Inferred from Sequence Orthology more info
response to oxidative stress	IMP Inferred from Mutant Phenotype more info	PubMed
response to oxidative stress	ISO Inferred from Sequence Orthology more info
signal transduction in response to DNA damage	ISO Inferred from Sequence Orthology more info
spleen development	IMP Inferred from Mutant Phenotype more info	PubMed
substrate adhesion-dependent cell spreading	IDA Inferred from Direct Assay more info	PubMed
thymus development	IMP Inferred from Mutant Phenotype more info	PubMed
transitional one stage B cell differentiation	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
actin cytoskeleton	IDA Inferred from Direct Assay more info	PubMed
cell leading edge	IDA Inferred from Direct Assay more info	PubMed
cytoplasm	IDA Inferred from Direct Assay more info	PubMed
cytoplasm	ISO Inferred from Sequence Orthology more info
cytoskeleton	IEA Inferred from Electronic Annotation more info
cytosol	ISA Inferred from Sequence Alignment more info	PubMed
cytosol	ISO Inferred from Sequence Orthology more info
cytosol	TAS Traceable Author Statement more info
dendrite	ISO Inferred from Sequence Orthology more info
endoplasmic reticulum	ISO Inferred from Sequence Orthology more info
growth cone	ISO Inferred from Sequence Orthology more info
mitochondrion	ISO Inferred from Sequence Orthology more info
neuron projection	ISO Inferred from Sequence Orthology more info
neuronal cell body	ISO Inferred from Sequence Orthology more info
nuclear body	ISO Inferred from Sequence Orthology more info
nucleolus	ISO Inferred from Sequence Orthology more info
nucleoplasm	ISO Inferred from Sequence Orthology more info
nucleus	IDA Inferred from Direct Assay more info	PubMed
nucleus	ISO Inferred from Sequence Orthology more info
perinuclear region of cytoplasm	ISO Inferred from Sequence Orthology more info
protein-containing complex	ISO Inferred from Sequence Orthology more info
ruffle	ISO Inferred from Sequence Orthology more info
synapse	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: tyrosine-protein kinase ABL1

Names: Abelson murine leukemia oncogene; Abelson tyrosine-protein kinase 1; abelson murine leukemia viral oncogene homolog 1; c-abl oncogene 1, receptor tyrosine kinase; c-abl protein, type I; c-abl protein, type II; c-abl protein, type III; p150; proto-oncogene c-Abl; proto-oncogene tyrosine-protein kinase ABL1; v-abl Abelson murine leukemia oncogene 1

NP_001106174.1

EC 2.7.10.2

NP_001269974.1

EC 2.7.10.2

NP_001269975.1

EC 2.7.10.2

NP_001269976.1

EC 2.7.10.2

NP_033724.2

EC 2.7.10.2

XP_006497684.1

EC 2.7.10.2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001112703.2 → NP_001106174.1 tyrosine-protein kinase ABL1 isoform a

See identical proteins and their annotated locations for NP_001106174.1

Status: VALIDATED

Description

Transcript Variant: This variant (1) encodes the longest protein (isoform a).

Source sequence(s)

AK166028, AL929275, BC103770

Consensus CDS

CCDS50563.1

UniProtKB/Swiss-Prot

P00520

UniProtKB/TrEMBL

Q3SYK5

Related

ENSMUSP00000075167.6, ENSMUST00000075759.12

Conserved Domains (5) summary

smart00808
Location:1018 → 1142

FABD; F-actin binding domain (FABD)

cd09935
Location:142 → 235

SH2_ABL; Src homology 2 (SH2) domain found in Abelson murine lymphosarcoma virus (ABL) proteins

cd11850
Location:84 → 137

SH3_Abl; Src homology 3 domain of the Protein Tyrosine Kinase, Abelson kinase

cd05052
Location:254 → 516

PTKc_Abl; Catalytic domain of the Protein Tyrosine Kinase, Abelson kinase

pfam07714
Location:261 → 512

Pkinase_Tyr; Protein tyrosine kinase
NM_001283045.1 → NP_001269974.1 tyrosine-protein kinase ABL1 isoform c

Status: VALIDATED

Description

Transcript Variant: This variant (3) differs in the 5' UTR and coding region, and uses an alternate downstream start codon compared to variant 1. The resulting protein (isoform c) has a shorter and distinct N-terminus compared to isoform a.

Source sequence(s)

AL929275, BQ769074, CF536749, CF726668, CF727094

UniProtKB/Swiss-Prot

P00520

Conserved Domains (5) summary

smart00808
Location:994 → 1118

FABD; F-actin binding domain (FABD)

cd09935
Location:118 → 211

SH2_ABL; Src homology 2 (SH2) domain found in Abelson murine lymphosarcoma virus (ABL) proteins

cd11850
Location:60 → 113

SH3_Abl; Src homology 3 domain of the Protein Tyrosine Kinase, Abelson kinase

cd05052
Location:230 → 492

PTKc_Abl; Catalytic domain of the Protein Tyrosine Kinase, Abelson kinase

pfam07714
Location:237 → 488

Pkinase_Tyr; Protein tyrosine kinase
NM_001283046.1 → NP_001269975.1 tyrosine-protein kinase ABL1 isoform d

Status: VALIDATED

Description

Transcript Variant: This variant (4) contains an alternate 5' exon compared to variant 1, and uses an alternate downstream start codon compared to variant 1. The resulting protein (isoform d) has a shorter and distinct N-terminus compared to isoform a.

Source sequence(s)

AL929275

UniProtKB/Swiss-Prot

P00520

Conserved Domains (5) summary

smart00808
Location:993 → 1117

FABD; F-actin binding domain (FABD)

cd09935
Location:117 → 210

SH2_ABL; Src homology 2 (SH2) domain found in Abelson murine lymphosarcoma virus (ABL) proteins

cd11850
Location:59 → 112

SH3_Abl; Src homology 3 domain of the Protein Tyrosine Kinase, Abelson kinase

cd05052
Location:229 → 491

PTKc_Abl; Catalytic domain of the Protein Tyrosine Kinase, Abelson kinase

pfam07714
Location:236 → 487

Pkinase_Tyr; Protein tyrosine kinase
NM_001283047.1 → NP_001269976.1 tyrosine-protein kinase ABL1 isoform e

See identical proteins and their annotated locations for NP_001269976.1

Status: VALIDATED

Description

Transcript Variant: This variant (5) contains an alternate 5' exon and uses a downstream start codon compared to variant 1. The resulting protein (isoform e) has a shorter and distinct N-terminus compared to isoform a.

Source sequence(s)

AL929275

Conserved Domains (3) summary

smart00808
Location:763 → 887

FABD; F-actin binding domain (FABD)

cd05052
Location:1 → 261

PTKc_Abl; Catalytic domain of the Protein Tyrosine Kinase, Abelson kinase

pfam07714
Location:6 → 257

Pkinase_Tyr; Protein tyrosine kinase
NM_009594.4 → NP_033724.2 tyrosine-protein kinase ABL1 isoform b

See identical proteins and their annotated locations for NP_033724.2

Status: VALIDATED

Description

Transcript Variant: This variant (2) differs in the 5' UTR and coding region, and uses an alternate downstream start codon compared to variant 1. The resulting protein (isoform b) has a shorter and distinct N-terminus compared to isoform a.

Source sequence(s)

AL929275, BM949741, BU053120, CA752052, CF726668, CF727248, CJ099623, CJ101520, CJ128107, CK626997, CN663033

Consensus CDS

CCDS15901.1

UniProtKB/Swiss-Prot

P00520

Related

ENSMUSP00000028190.6, ENSMUST00000028190.12

Conserved Domains (5) summary

smart00808
Location:999 → 1123

FABD; F-actin binding domain (FABD)

cd09935
Location:123 → 216

SH2_ABL; Src homology 2 (SH2) domain found in Abelson murine lymphosarcoma virus (ABL) proteins

cd11850
Location:65 → 118

SH3_Abl; Src homology 3 domain of the Protein Tyrosine Kinase, Abelson kinase

cd05052
Location:235 → 497

PTKc_Abl; Catalytic domain of the Protein Tyrosine Kinase, Abelson kinase

pfam07714
Location:242 → 493

Pkinase_Tyr; Protein tyrosine kinase

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000068.8 Reference GRCm39 C57BL/6J

Range

31578256..31697105

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006497621.4 → XP_006497684.1 tyrosine-protein kinase ABL1 isoform X1

Conserved Domains (3) summary

cd09935
Location:142 → 235

SH2_ABL; Src homology 2 (SH2) domain found in Abelson murine lymphosarcoma virus (ABL) proteins

cd11850
Location:84 → 137

SH3_Abl; Src homology 3 domain of the Protein Tyrosine Kinase, Abelson kinase

cd05052
Location:254 → 516

PTKc_Abl; Catalytic domain of the Protein Tyrosine Kinase, Abelson kinase