Abl1 c-abl oncogene 1, non-receptor tyrosine kinase [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Abl1provided by MGI
Official Full Name: c-abl oncogene 1, non-receptor tyrosine kinaseprovided by MGI
Primary source: MGI:MGI:87859
See related: Ensembl:ENSMUSG00000026842 Vega:OTTMUSG00000012077
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Abl; c-Abl; AI325092; E430008G22Rik
Expression: Ubiquitous expression in ovary adult (RPKM 24.4), limb E14.5 (RPKM 24.2) and 28 other tissues See more
Orthologs: human all

Genomic context

Location:: 2 21.86 cM; 2 B

Exon count:: 16

Annotation release	Status	Assembly	Chr	Location
106	current	GRCm38.p4 (GCF_000001635.24)	2	NC_000068.7 (31688354..31807093)
Build 37.2	previous assembly	MGSCv37 (GCF_000001635.18)	2	NC_000068.6 (31544076..31659747)

Chromosome 2 - NC_000068.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Results indicate that c-Abl may play roles in preimplantation embryo development, especially in TE formation and differentiation.
Title: The Abelson tyrosine kinase (c-Abl) localization in preimplantation mouse development.
c-Abl phosphorylated Drp1 at tyrosine 266, 368 and 449 in vitro and in vivo, which augmented the GTPase activity of Drp1 and promoted Drp1-mediated mitochondrial fragmentation.
Title: c-Abl-mediated Drp1 phosphorylation promotes oxidative stress-induced mitochondrial fragmentation and neuronal cell death.
c-Abl phosphorylation of Mdm2 has a role in regulation of p53 tumor suppression and bone marrow failure
Title: Phosphorylation of the Mdm2 oncoprotein by the c-Abl tyrosine kinase regulates p53 tumor suppression and the radiosensitivity of mice.
BOC interacts with ABL and activates JNK thereby promoting neuronal differentiation and neurite outgrowth.
Title: A Sonic hedgehog coreceptor, BOC regulates neuronal differentiation and neurite outgrowth via interaction with ABL and JNK activation.
These results uncover a murine hepatic steatosis regulatory axis consisting of ABL1-PPARgamma2-MLL4, which may serve as a target of anti-steatosis drug development.
Title: Critical Roles of the Histone Methyltransferase MLL4/KMT2D in Murine Hepatic Steatosis Directed by ABL1 and PPARγ2.
this study shows that signaling downstream of murine inhibitory receptors does not involve c-Abl and that c-Abl plays no major role in NK cell education in the mouse
Title: The Abl-1 Kinase is Dispensable for NK Cell Inhibitory Signalling and is not Involved in Murine NK Cell Education.
ABL potentiated the assembly and activation of the RUNX2-TAZ master transcription factor complex that is required for osteoblastogenesis, while antagonizing PPARgamma-mediated adipogenesis.
Title: Reciprocal stabilization of ABL and TAZ regulates osteoblastogenesis through transcription factor RUNX2.
Normal ABL1 is a tumor suppressor in BCR-ABL1-induced leukemia. ABL1 inhibits expansion and proliferation of BCR-ABL1-expressing leukemic stem cells. Allosteric stimulation of the normal ABL1 kinase activity enhanced the antileukemia effect of ABL1 tyrosine kinase inhibitors.
Title: Normal ABL1 is a tumor suppressor and therapeutic target in human and mouse leukemias expressing oncogenic ABL1 kinases.
the ABL family of tyrosine kinases rheostatically enhances IRE1alpha's enzymatic activities, thereby potentiating endoplasmic reticulum stress-induced apoptosis.
Title: Targeting ABL-IRE1α Signaling Spares ER-Stressed Pancreatic β Cells to Reverse Autoimmune Diabetes.
p38a as a major substrate of c-Abl both in vitro and in vivo and c-Abl-mediated phosphorylation is critical for the dimerization of p38a.
Title: c-Abl-p38α signaling plays an important role in MPTP-induced neuronal death.

Submit: New GeneRIF Correction See all GeneRIFs (124)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (10) 1 citation

Pathways from BioSystems

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Alpha6-Beta4 Integrin Signaling Pathway, organism-specific biosystem (from WikiPathways)
Alpha6-Beta4 Integrin Signaling Pathway, organism-specific biosystemIntegrins are cell surface heterodimeric protein complex consisting of one alpha and one beta chain. Integrins act as cell adhesion molecules as well as participate in cellular signaling. The ligands...
Axon guidance, organism-specific biosystem (from KEGG)
Axon guidance, organism-specific biosystemAxon guidance represents a key stage in the formation of neuronal network. Axons are guided by a variety of guidance factors, such as netrins, ephrins, Slits, and semaphorins. These guidance cues are...
Axon guidance, conserved biosystem (from KEGG)
Axon guidance, conserved biosystemAxon guidance represents a key stage in the formation of neuronal network. Axons are guided by a variety of guidance factors, such as netrins, ephrins, Slits, and semaphorins. These guidance cues are...
Axon guidance, organism-specific biosystem (from REACTOME)
Axon guidance, organism-specific biosystemcomputationally inferred pathway (not manually curated)
CDO in myogenesis, organism-specific biosystem (from REACTOME)
CDO in myogenesis, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Cell cycle, organism-specific biosystem (from KEGG)
Cell cycle, organism-specific biosystemMitotic cell cycle progression is accomplished through a reproducible sequence of events, DNA replication (S phase) and mitosis (M phase) separated temporally by gaps known as G1 and G2 phases. Cycli...
Cell cycle, conserved biosystem (from KEGG)
Cell cycle, conserved biosystemMitotic cell cycle progression is accomplished through a reproducible sequence of events, DNA replication (S phase) and mitosis (M phase) separated temporally by gaps known as G1 and G2 phases. Cycli...
Cell cycle signaling pathway, organism-specific biosystem (from LIPID MAPS)
Cell cycle signaling pathway, organism-specific biosystem
Cell cycle signaling pathway
Chronic myeloid leukemia, organism-specific biosystem (from KEGG)
Chronic myeloid leukemia, organism-specific biosystemChronic myeloid leukemia (CML) is a clonal myeloproliferative disorder of a pluripotent stem cell. The natural history of CML has a triphasic clinical course comprising of an initial chronic phase (C...
Chronic myeloid leukemia, conserved biosystem (from KEGG)
Chronic myeloid leukemia, conserved biosystemChronic myeloid leukemia (CML) is a clonal myeloproliferative disorder of a pluripotent stem cell. The natural history of CML has a triphasic clinical course comprising of an initial chronic phase (C...
DNA Double Strand Break Response, organism-specific biosystem (from REACTOME)
DNA Double Strand Break Response, organism-specific biosystemcomputationally inferred pathway (not manually curated)
DNA Double-Strand Break Repair, organism-specific biosystem (from REACTOME)
DNA Double-Strand Break Repair, organism-specific biosystemcomputationally inferred pathway (not manually curated)
DNA Repair, organism-specific biosystem (from REACTOME)
DNA Repair, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Developmental Biology, organism-specific biosystem (from REACTOME)
Developmental Biology, organism-specific biosystemcomputationally inferred pathway (not manually curated)
ErbB signaling pathway, organism-specific biosystem (from KEGG)
ErbB signaling pathway, organism-specific biosystemThe ErbB family of receptor tyrosine kinases (RTKs) couples binding of extracellular growth factor ligands to intracellular signaling pathways regulating diverse biologic responses, including prolife...
ErbB signaling pathway, conserved biosystem (from KEGG)
ErbB signaling pathway, conserved biosystemThe ErbB family of receptor tyrosine kinases (RTKs) couples binding of extracellular growth factor ligands to intracellular signaling pathways regulating diverse biologic responses, including prolife...
ErbB signaling pathway, organism-specific biosystem (from WikiPathways)
ErbB signaling pathway, organism-specific biosystemThe ErbB protein family or epidermal growth factor receptor (EGFR) family is a family of four structurally related receptor tyrosine kinases. Insufficient ErbB signaling in humans is associated with ...
Factors involved in megakaryocyte development and platelet production, organism-specific biosystem (from REACTOME)
Factors involved in megakaryocyte development and platelet production, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Fcgamma receptor (FCGR) dependent phagocytosis, organism-specific biosystem (from REACTOME)
Fcgamma receptor (FCGR) dependent phagocytosis, organism-specific biosystemcomputationally inferred pathway (not manually curated)
HDR through Homologous Recombination (HR) or Single Strand Annealing (SSA), organism-specific biosystem (from REACTOME)
HDR through Homologous Recombination (HR) or Single Strand Annealing (SSA), organism-specific biosystemcomputationally inferred pathway (not manually curated)
HDR through Single Strand Annealing (SSA), organism-specific biosystem (from REACTOME)
HDR through Single Strand Annealing (SSA), organism-specific biosystemcomputationally inferred pathway (not manually curated)
Hemostasis, organism-specific biosystem (from REACTOME)
Hemostasis, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Homology Directed Repair, organism-specific biosystem (from REACTOME)
Homology Directed Repair, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Immune System, organism-specific biosystem (from REACTOME)
Immune System, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Innate Immune System, organism-specific biosystem (from REACTOME)
Innate Immune System, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Kit Receptor Signaling Pathway, organism-specific biosystem (from WikiPathways)
Kit Receptor Signaling Pathway, organism-specific biosystemKit is a receptor protein tyrosine kinase, which is a receptor for stem cell factor or kit ligand. Signaling through Kit is important for formation of red cells, lymphocytes, mast cells and platelets...
MicroRNAs in cancer, organism-specific biosystem (from KEGG)
MicroRNAs in cancer, organism-specific biosystemMicroRNA (miRNA) is a cluster of small non-encoding RNA molecules of 21 - 23 nucleotides in length, which controls gene expression post-transcriptionally either via the degradation of target mRNAs or...
MicroRNAs in cancer, conserved biosystem (from KEGG)
MicroRNAs in cancer, conserved biosystemMicroRNA (miRNA) is a cluster of small non-encoding RNA molecules of 21 - 23 nucleotides in length, which controls gene expression post-transcriptionally either via the degradation of target mRNAs or...
Myogenesis, organism-specific biosystem (from REACTOME)
Myogenesis, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Neurotrophin signaling pathway, organism-specific biosystem (from KEGG)
Neurotrophin signaling pathway, organism-specific biosystemNeurotrophins are a family of trophic factors involved in differentiation and survival of neural cells. The neurotrophin family consists of nerve growth factor (NGF), brain derived neurotrophic facto...
Neurotrophin signaling pathway, conserved biosystem (from KEGG)
Neurotrophin signaling pathway, conserved biosystemNeurotrophins are a family of trophic factors involved in differentiation and survival of neural cells. The neurotrophin family consists of nerve growth factor (NGF), brain derived neurotrophic facto...
Pathways in cancer, organism-specific biosystem (from KEGG)
Pathways in cancer, organism-specific biosystem
Pathways in cancer
RHO GTPase Effectors, organism-specific biosystem (from REACTOME)
RHO GTPase Effectors, organism-specific biosystemcomputationally inferred pathway (not manually curated)
RHO GTPases Activate WASPs and WAVEs, organism-specific biosystem (from REACTOME)
RHO GTPases Activate WASPs and WAVEs, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Ras signaling pathway, organism-specific biosystem (from KEGG)
Ras signaling pathway, organism-specific biosystemThe Ras proteins are GTPases that function as molecular switches for signaling pathways regulating cell proliferation, survival, growth, migration, differentiation or cytoskeletal dynamism. Ras prote...
Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks, organism-specific biosystem (from REACTOME)
Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Regulation of actin dynamics for phagocytic cup formation, organism-specific biosystem (from REACTOME)
Regulation of actin dynamics for phagocytic cup formation, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Role of Abl in Robo-Slit signaling, organism-specific biosystem (from REACTOME)
Role of Abl in Robo-Slit signaling, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Signal Transduction, organism-specific biosystem (from REACTOME)
Signal Transduction, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Signaling by Rho GTPases, organism-specific biosystem (from REACTOME)
Signaling by Rho GTPases, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Signaling by Robo receptor, organism-specific biosystem (from REACTOME)
Signaling by Robo receptor, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Viral myocarditis, organism-specific biosystem (from KEGG)
Viral myocarditis, organism-specific biosystemMyocarditis is a cardiac disease associated with inflammation and injury of the myocardium. It results from various etiologies, both noninfectious and infectious, but coxsackievirus B3 (CVB3) is stil...
XPodNet - protein-protein interactions in the podocyte expanded by STRING, organism-specific biosystem (from WikiPathways)
XPodNet - protein-protein interactions in the podocyte expanded by STRING, organism-specific biosystemXPodNet is a larger version of PodNet. Interactions from STRING database have been added to PodNet to build XPodNet. Hence, not all interactions found in XPodNet do necessarily have to be curated.
miRNA regulation of DNA Damage Response, organism-specific biosystem (from WikiPathways)
miRNA regulation of DNA Damage Response, organism-specific biosystemThis is the first out of two pathways which deals with the DNA damage response. It is comprised of two central gene products (ATM and ATR) influenced by different sources of DNA damage (in blue). The...

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Abl1 (e-PCR), detects polymorphism
- UniSTS:527228

AI325092 (e-PCR)
- UniSTS:178600

Homology

Homologs of the Abl1 gene: The Abl1 gene is conserved in human, chimpanzee, dog, cow, rat, chicken, zebrafish, and frog.
Orthologs from Annotation Pipeline: 236 organisms have orthologs with human gene Abl1
The Hierarchical Catalog of Orthologs

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
ATP binding	IDA Inferred from Direct Assay more info	PubMed
ATP binding	ISO Inferred from Sequence Orthology more info
DNA binding	IEA Inferred from Electronic Annotation more info
SH2 domain binding	ISO Inferred from Sequence Orthology more info
SH3 domain binding	ISO Inferred from Sequence Orthology more info
actin filament binding	IDA Inferred from Direct Assay more info	PubMed
delta-catenin binding	ISO Inferred from Sequence Orthology more info
ephrin receptor binding	IPI Inferred from Physical Interaction more info	PubMed
kinase activity	IDA Inferred from Direct Assay more info	PubMed
kinase activity	ISO Inferred from Sequence Orthology more info
magnesium ion binding	IDA Inferred from Direct Assay more info	PubMed
magnesium ion binding	ISO Inferred from Sequence Orthology more info
manganese ion binding	IDA Inferred from Direct Assay more info	PubMed
manganese ion binding	ISO Inferred from Sequence Orthology more info
metal ion binding	IEA Inferred from Electronic Annotation more info
mitogen-activated protein kinase binding	ISO Inferred from Sequence Orthology more info
neuropilin binding	IPI Inferred from Physical Interaction more info	PubMed
neuropilin binding	ISO Inferred from Sequence Orthology more info
non-membrane spanning protein tyrosine kinase activity	IBA Inferred from Biological aspect of Ancestor more info	PubMed
non-membrane spanning protein tyrosine kinase activity	ISO Inferred from Sequence Orthology more info
nucleotide binding	IEA Inferred from Electronic Annotation more info
phosphotyrosine residue binding	ISO Inferred from Sequence Orthology more info
proline-rich region binding	ISO Inferred from Sequence Orthology more info
protein C-terminus binding	ISO Inferred from Sequence Orthology more info
protein binding	IPI Inferred from Physical Interaction more info	PubMed
protein domain specific binding	IPI Inferred from Physical Interaction more info	PubMed
protein kinase C binding	ISO Inferred from Sequence Orthology more info
protein kinase activity	IDA Inferred from Direct Assay more info	PubMed
protein kinase activity	IMP Inferred from Mutant Phenotype more info	PubMed
protein kinase activity	ISO Inferred from Sequence Orthology more info
protein kinase binding	ISO Inferred from Sequence Orthology more info
protein tyrosine kinase activity	IDA Inferred from Direct Assay more info	PubMed
protein tyrosine kinase activity	IGI Inferred from Genetic Interaction more info	PubMed
protein tyrosine kinase activity	IMP Inferred from Mutant Phenotype more info	PubMed
protein tyrosine kinase activity	ISO Inferred from Sequence Orthology more info
syntaxin binding	ISO Inferred from Sequence Orthology more info
transferase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
B cell proliferation	IMP Inferred from Mutant Phenotype more info	PubMed
B cell proliferation involved in immune response	IGI Inferred from Genetic Interaction more info	PubMed
B cell proliferation involved in immune response	IMP Inferred from Mutant Phenotype more info	PubMed
B cell receptor signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
B-1 B cell homeostasis	IMP Inferred from Mutant Phenotype more info	PubMed
Bergmann glial cell differentiation	IGI Inferred from Genetic Interaction more info	PubMed
DNA damage induced protein phosphorylation	ISO Inferred from Sequence Orthology more info
DNA repair	IEA Inferred from Electronic Annotation more info
actin cytoskeleton organization	IDA Inferred from Direct Assay more info	PubMed
actin cytoskeleton organization	IGI Inferred from Genetic Interaction more info	PubMed
actin filament branching	IMP Inferred from Mutant Phenotype more info	PubMed
activated T cell proliferation	IMP Inferred from Mutant Phenotype more info	PubMed
activation of protein kinase C activity	ISO Inferred from Sequence Orthology more info
alpha-beta T cell differentiation	IGI Inferred from Genetic Interaction more info	PubMed
apoptotic process	IEA Inferred from Electronic Annotation more info
autophagy	IEA Inferred from Electronic Annotation more info
cardiovascular system development	IGI Inferred from Genetic Interaction more info	PubMed
cell adhesion	IEA Inferred from Electronic Annotation more info
cell differentiation	IBA Inferred from Biological aspect of Ancestor more info	PubMed
cellular response to DNA damage stimulus	ISO Inferred from Sequence Orthology more info
cellular response to hydrogen peroxide	ISO Inferred from Sequence Orthology more info
cellular response to lipopolysaccharide	IMP Inferred from Mutant Phenotype more info	PubMed
cerebellum morphogenesis	IGI Inferred from Genetic Interaction more info	PubMed
collateral sprouting	IMP Inferred from Mutant Phenotype more info	PubMed
endocytosis	IEA Inferred from Electronic Annotation more info
endothelial cell migration	ISO Inferred from Sequence Orthology more info
epidermal growth factor receptor signaling pathway	IGI Inferred from Genetic Interaction more info	PubMed
establishment of protein localization	ISO Inferred from Sequence Orthology more info
integrin-mediated signaling pathway	ISO Inferred from Sequence Orthology more info
microspike assembly	IDA Inferred from Direct Assay more info	PubMed
negative regulation of BMP signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
negative regulation of ERK1 and ERK2 cascade	IMP Inferred from Mutant Phenotype more info	PubMed
negative regulation of I-kappaB kinase/NF-kappaB signaling	IMP Inferred from Mutant Phenotype more info	PubMed
negative regulation of cell-cell adhesion	IGI Inferred from Genetic Interaction more info	PubMed
negative regulation of cellular senescence	IGI Inferred from Genetic Interaction more info	PubMed
negative regulation of endothelial cell apoptotic process	IGI Inferred from Genetic Interaction more info	PubMed
negative regulation of long-term synaptic potentiation	IGI Inferred from Genetic Interaction more info	PubMed
negative regulation of mitotic cell cycle	IDA Inferred from Direct Assay more info	PubMed
negative regulation of mitotic cell cycle	IGI Inferred from Genetic Interaction more info	PubMed
negative regulation of phospholipase C activity	ISO Inferred from Sequence Orthology more info
negative regulation of protein serine/threonine kinase activity	ISO Inferred from Sequence Orthology more info
negative regulation of ubiquitin-protein transferase activity	ISO Inferred from Sequence Orthology more info
neural tube closure	IGI Inferred from Genetic Interaction more info	PubMed
neuroepithelial cell differentiation	IGI Inferred from Genetic Interaction more info	PubMed
neuromuscular process controlling balance	IGI Inferred from Genetic Interaction more info	PubMed
neuron differentiation	IGI Inferred from Genetic Interaction more info	PubMed
neuropilin signaling pathway	ISO Inferred from Sequence Orthology more info
peptidyl-tyrosine autophosphorylation	IBA Inferred from Biological aspect of Ancestor more info	PubMed
peptidyl-tyrosine autophosphorylation	ISO Inferred from Sequence Orthology more info
peptidyl-tyrosine phosphorylation	IDA Inferred from Direct Assay more info	PubMed
peptidyl-tyrosine phosphorylation	ISO Inferred from Sequence Orthology more info
phagocytosis	IGI Inferred from Genetic Interaction more info	PubMed
phagocytosis	IMP Inferred from Mutant Phenotype more info	PubMed
phosphorylation	IEA Inferred from Electronic Annotation more info
platelet-derived growth factor receptor signaling pathway	IDA Inferred from Direct Assay more info	PubMed
platelet-derived growth factor receptor signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
platelet-derived growth factor receptor-beta signaling pathway	ISO Inferred from Sequence Orthology more info
positive regulation blood vessel branching	IMP Inferred from Mutant Phenotype more info	PubMed
positive regulation of ERK1 and ERK2 cascade	IMP Inferred from Mutant Phenotype more info	PubMed
positive regulation of I-kappaB kinase/NF-kappaB signaling	IGI Inferred from Genetic Interaction more info	PubMed
positive regulation of Wnt signaling pathway, planar cell polarity pathway	IGI Inferred from Genetic Interaction more info	PubMed
positive regulation of actin cytoskeleton reorganization	ISO Inferred from Sequence Orthology more info
positive regulation of actin filament binding	ISO Inferred from Sequence Orthology more info
positive regulation of apoptotic process	IMP Inferred from Mutant Phenotype more info	PubMed
positive regulation of apoptotic process	ISO Inferred from Sequence Orthology more info
positive regulation of cell migration involved in sprouting angiogenesis	IDA Inferred from Direct Assay more info	PubMed
positive regulation of cytosolic calcium ion concentration	ISO Inferred from Sequence Orthology more info
positive regulation of endothelial cell migration	ISO Inferred from Sequence Orthology more info
positive regulation of focal adhesion assembly	ISO Inferred from Sequence Orthology more info
positive regulation of interferon-gamma secretion	IGI Inferred from Genetic Interaction more info	PubMed
positive regulation of interleukin-2 secretion	IGI Inferred from Genetic Interaction more info	PubMed
positive regulation of microtubule binding	ISO Inferred from Sequence Orthology more info
positive regulation of mitotic cell cycle	IGI Inferred from Genetic Interaction more info	PubMed
positive regulation of neuron death	IMP Inferred from Mutant Phenotype more info	PubMed
positive regulation of osteoblast proliferation	IMP Inferred from Mutant Phenotype more info	PubMed
positive regulation of oxidoreductase activity	ISO Inferred from Sequence Orthology more info
positive regulation of peptidyl-tyrosine phosphorylation	ISO Inferred from Sequence Orthology more info
positive regulation of protein phosphorylation	ISO Inferred from Sequence Orthology more info
positive regulation of release of sequestered calcium ion into cytosol	IGI Inferred from Genetic Interaction more info	PubMed
positive regulation of stress fiber assembly	ISO Inferred from Sequence Orthology more info
positive regulation of substrate adhesion-dependent cell spreading	ISO Inferred from Sequence Orthology more info
post-embryonic development	IGI Inferred from Genetic Interaction more info	PubMed
protein autophosphorylation	ISO Inferred from Sequence Orthology more info
protein phosphorylation	IDA Inferred from Direct Assay more info	PubMed
protein phosphorylation	IMP Inferred from Mutant Phenotype more info	PubMed
protein phosphorylation	ISO Inferred from Sequence Orthology more info
regulation of Cdc42 protein signal transduction	ISO Inferred from Sequence Orthology more info
regulation of T cell differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
regulation of actin cytoskeleton organization	IGI Inferred from Genetic Interaction more info	PubMed
regulation of actin cytoskeleton organization	ISO Inferred from Sequence Orthology more info
regulation of axon extension	ISO Inferred from Sequence Orthology more info
regulation of cell cycle	IDA Inferred from Direct Assay more info	PubMed
regulation of cell proliferation	IBA Inferred from Biological aspect of Ancestor more info	PubMed
regulation of cell proliferation	IGI Inferred from Genetic Interaction more info	PubMed
regulation of cellular senescence	IGI Inferred from Genetic Interaction more info	PubMed
regulation of extracellular matrix organization	IGI Inferred from Genetic Interaction more info	PubMed
regulation of microtubule polymerization	ISO Inferred from Sequence Orthology more info
regulation of modification of synaptic structure	IGI Inferred from Genetic Interaction more info	PubMed
regulation of response to DNA damage stimulus	ISO Inferred from Sequence Orthology more info
response to oxidative stress	IMP Inferred from Mutant Phenotype more info	PubMed
response to oxidative stress	ISO Inferred from Sequence Orthology more info
signal transduction in response to DNA damage	ISO Inferred from Sequence Orthology more info
spleen development	IMP Inferred from Mutant Phenotype more info	PubMed
substrate adhesion-dependent cell spreading	IDA Inferred from Direct Assay more info	PubMed
thymus development	IMP Inferred from Mutant Phenotype more info	PubMed
transitional one stage B cell differentiation	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
actin cytoskeleton	IDA Inferred from Direct Assay more info	PubMed
cell leading edge	IDA Inferred from Direct Assay more info	PubMed
cytoplasm	IDA Inferred from Direct Assay more info	PubMed
cytoplasm	ISO Inferred from Sequence Orthology more info
cytoskeleton	IEA Inferred from Electronic Annotation more info
cytosol	ISA Inferred from Sequence Alignment more info	PubMed
cytosol	ISO Inferred from Sequence Orthology more info
dendrite	ISO Inferred from Sequence Orthology more info
endoplasmic reticulum	ISO Inferred from Sequence Orthology more info
growth cone	ISO Inferred from Sequence Orthology more info
mitochondrion	ISO Inferred from Sequence Orthology more info
neuron projection	ISO Inferred from Sequence Orthology more info
neuronal cell body	ISO Inferred from Sequence Orthology more info
nuclear body	ISO Inferred from Sequence Orthology more info
nucleolus	ISO Inferred from Sequence Orthology more info
nucleoplasm	ISO Inferred from Sequence Orthology more info
nucleus	IDA Inferred from Direct Assay more info	PubMed
nucleus	ISO Inferred from Sequence Orthology more info
perinuclear region of cytoplasm	ISO Inferred from Sequence Orthology more info
protein-containing complex	ISO Inferred from Sequence Orthology more info
ruffle	ISO Inferred from Sequence Orthology more info
synapse	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: tyrosine-protein kinase ABL1

Names: Abelson murine leukemia oncogene; Abelson tyrosine-protein kinase 1; abelson murine leukemia viral oncogene homolog 1; c-abl oncogene 1, receptor tyrosine kinase; c-abl protein, type I; c-abl protein, type II; c-abl protein, type III; p150; proto-oncogene c-Abl; proto-oncogene tyrosine-protein kinase ABL1; v-abl Abelson murine leukemia oncogene 1

NP_001106174.1

EC 2.7.10.2

NP_001269974.1

EC 2.7.10.2

NP_001269975.1

EC 2.7.10.2

NP_001269976.1

EC 2.7.10.2

NP_033724.2

EC 2.7.10.2

XP_006497684.1

EC 2.7.10.2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001112703.2 → NP_001106174.1 tyrosine-protein kinase ABL1 isoform a

See identical proteins and their annotated locations for NP_001106174.1

Status: VALIDATED

Description

Transcript Variant: This variant (1) encodes the longest protein (isoform a).

Source sequence(s)

AK166028, AL929275, BC103770

Consensus CDS

CCDS50563.1

UniProtKB/Swiss-Prot

P00520

UniProtKB/TrEMBL

Q3SYK5

Related

ENSMUSP00000075167.6, OTTMUSP00000013004, ENSMUST00000075759.12, OTTMUST00000028740

Conserved Domains (5) summary

smart00808
Location:1018 → 1142

FABD; F-actin binding domain (FABD)

cd09935
Location:142 → 235

SH2_ABL; Src homology 2 (SH2) domain found in Abelson murine lymphosarcoma virus (ABL) proteins

cd11850
Location:84 → 137

SH3_Abl; Src homology 3 domain of the Protein Tyrosine Kinase, Abelson kinase

cd05052
Location:254 → 516

PTKc_Abl; Catalytic domain of the Protein Tyrosine Kinase, Abelson kinase

pfam07714
Location:261 → 512

Pkinase_Tyr; Protein tyrosine kinase
NM_001283045.1 → NP_001269974.1 tyrosine-protein kinase ABL1 isoform c

Status: VALIDATED

Description

Transcript Variant: This variant (3) differs in the 5' UTR and coding region, and uses an alternate downstream start codon compared to variant 1. The resulting protein (isoform c) has a shorter and distinct N-terminus compared to isoform a.

Source sequence(s)

AL929275, BQ769074, CF536749, CF726668, CF727094

UniProtKB/Swiss-Prot

P00520

Conserved Domains (5) summary

smart00808
Location:994 → 1118

FABD; F-actin binding domain (FABD)

cd09935
Location:118 → 211

SH2_ABL; Src homology 2 (SH2) domain found in Abelson murine lymphosarcoma virus (ABL) proteins

cd11850
Location:60 → 113

SH3_Abl; Src homology 3 domain of the Protein Tyrosine Kinase, Abelson kinase

cd05052
Location:230 → 492

PTKc_Abl; Catalytic domain of the Protein Tyrosine Kinase, Abelson kinase

pfam07714
Location:237 → 488

Pkinase_Tyr; Protein tyrosine kinase
NM_001283046.1 → NP_001269975.1 tyrosine-protein kinase ABL1 isoform d

Status: VALIDATED

Description

Transcript Variant: This variant (4) contains an alternate 5' exon compared to variant 1, and uses an alternate downstream start codon compared to variant 1. The resulting protein (isoform d) has a shorter and distinct N-terminus compared to isoform a.

Source sequence(s)

AL929275

UniProtKB/Swiss-Prot

P00520

Conserved Domains (5) summary

smart00808
Location:993 → 1117

FABD; F-actin binding domain (FABD)

cd09935
Location:117 → 210

SH2_ABL; Src homology 2 (SH2) domain found in Abelson murine lymphosarcoma virus (ABL) proteins

cd11850
Location:59 → 112

SH3_Abl; Src homology 3 domain of the Protein Tyrosine Kinase, Abelson kinase

cd05052
Location:229 → 491

PTKc_Abl; Catalytic domain of the Protein Tyrosine Kinase, Abelson kinase

pfam07714
Location:236 → 487

Pkinase_Tyr; Protein tyrosine kinase
NM_001283047.1 → NP_001269976.1 tyrosine-protein kinase ABL1 isoform e

See identical proteins and their annotated locations for NP_001269976.1

Status: VALIDATED

Description

Transcript Variant: This variant (5) contains an alternate 5' exon and uses a downstream start codon compared to variant 1. The resulting protein (isoform e) has a shorter and distinct N-terminus compared to isoform a.

Source sequence(s)

AL929275

Conserved Domains (3) summary

smart00808
Location:763 → 887

FABD; F-actin binding domain (FABD)

cd05052
Location:1 → 261

PTKc_Abl; Catalytic domain of the Protein Tyrosine Kinase, Abelson kinase

pfam07714
Location:6 → 257

Pkinase_Tyr; Protein tyrosine kinase
NM_009594.4 → NP_033724.2 tyrosine-protein kinase ABL1 isoform b

See identical proteins and their annotated locations for NP_033724.2

Status: VALIDATED

Description

Transcript Variant: This variant (2) differs in the 5' UTR and coding region, and uses an alternate downstream start codon compared to variant 1. The resulting protein (isoform b) has a shorter and distinct N-terminus compared to isoform a.

Source sequence(s)

AL929275, BM949741, BU053120, CA752052, CF726668, CF727248, CJ099623, CJ101520, CJ128107, CK626997, CN663033

Consensus CDS

CCDS15901.1

UniProtKB/Swiss-Prot

P00520

Related

ENSMUSP00000028190.6, OTTMUSP00000013005, ENSMUST00000028190.12, OTTMUST00000028747

Conserved Domains (5) summary

smart00808
Location:999 → 1123

FABD; F-actin binding domain (FABD)

cd09935
Location:123 → 216

SH2_ABL; Src homology 2 (SH2) domain found in Abelson murine lymphosarcoma virus (ABL) proteins

cd11850
Location:65 → 118

SH3_Abl; Src homology 3 domain of the Protein Tyrosine Kinase, Abelson kinase

cd05052
Location:235 → 497

PTKc_Abl; Catalytic domain of the Protein Tyrosine Kinase, Abelson kinase

pfam07714
Location:242 → 493

Pkinase_Tyr; Protein tyrosine kinase

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm38.p4 C57BL/6J

Genomic

NC_000068.7 Reference GRCm38.p4 C57BL/6J

Range

31688354..31807093

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006497621.3 → XP_006497684.1 tyrosine-protein kinase ABL1 isoform X1

Conserved Domains (4) summary

cd09935
Location:142 → 235

SH2_ABL; Src homology 2 (SH2) domain found in Abelson murine lymphosarcoma virus (ABL) proteins

cd11850
Location:84 → 137

SH3_Abl; Src homology 3 domain of the Protein Tyrosine Kinase, Abelson kinase

cd05052
Location:254 → 516

PTKc_Abl; Catalytic domain of the Protein Tyrosine Kinase, Abelson kinase

pfam07714
Location:261 → 512

Pkinase_Tyr; Protein tyrosine kinase