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Abl1 c-abl oncogene 1, non-receptor tyrosine kinase [ Mus musculus (house mouse) ]

Gene ID: 11350, updated on 5-Jan-2023

Summary

Official Symbol
Abl1provided by MGI
Official Full Name
c-abl oncogene 1, non-receptor tyrosine kinaseprovided by MGI
Primary source
MGI:MGI:87859
See related
Ensembl:ENSMUSG00000026842 AllianceGenome:MGI:87859
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Abl; c-Abl; E430008G22Rik
Summary
Enables several functions, including ATP binding activity; metal ion binding activity; and signaling receptor binding activity. Involved in several processes, including negative regulation of long-term synaptic potentiation; positive regulation of blood vessel branching; and positive regulation of cell migration involved in sprouting angiogenesis. Acts upstream of or within several processes, including cell surface receptor signaling pathway; hematopoietic or lymphoid organ development; and regulation of signal transduction. Located in several cellular components, including actin cytoskeleton; cell leading edge; and nucleus. Is expressed in several structures, including alimentary system; brain; genitourinary system; heart; and sensory organ. Human ortholog(s) of this gene implicated in gastrointestinal system cancer (multiple); leukemia (multiple); and lung non-small cell carcinoma. Orthologous to human ABL1 (ABL proto-oncogene 1, non-receptor tyrosine kinase). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in ovary adult (RPKM 24.4), limb E14.5 (RPKM 24.2) and 28 other tissues See more
Orthologs
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Genomic context

See Abl1 in Genome Data Viewer
Location:
2 21.86 cM; 2 B
Exon count:
16
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (31578256..31697105)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (31688244..31807093)

Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene PR domain containing 12 Neighboring gene uncharacterized LOC118568509 Neighboring gene exosome component 2 Neighboring gene predicted gene 13427 Neighboring gene fibrinogen C domain containing 1 Neighboring gene pyroglutamylated RFamide peptide Neighboring gene laminin gamma 3

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (10)  1 citation
  • Endonuclease-mediated (2) 

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC117749

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables ATP binding IDA
Inferred from Direct Assay
more info
PubMed 
enables ATP binding ISO
Inferred from Sequence Orthology
more info
 
enables DNA binding IEA
Inferred from Electronic Annotation
more info
 
enables SH2 domain binding ISO
Inferred from Sequence Orthology
more info
 
enables SH3 domain binding ISO
Inferred from Sequence Orthology
more info
 
enables actin filament binding IDA
Inferred from Direct Assay
more info
PubMed 
enables bubble DNA binding ISO
Inferred from Sequence Orthology
more info
 
enables delta-catenin binding ISO
Inferred from Sequence Orthology
more info
 
enables ephrin receptor binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables four-way junction DNA binding ISO
Inferred from Sequence Orthology
more info
 
enables kinase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables kinase activity ISO
Inferred from Sequence Orthology
more info
 
enables magnesium ion binding IDA
Inferred from Direct Assay
more info
PubMed 
enables magnesium ion binding ISO
Inferred from Sequence Orthology
more info
 
enables manganese ion binding IDA
Inferred from Direct Assay
more info
PubMed 
enables manganese ion binding ISO
Inferred from Sequence Orthology
more info
 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables mitogen-activated protein kinase binding ISO
Inferred from Sequence Orthology
more info
 
enables neuropilin binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables neuropilin binding ISO
Inferred from Sequence Orthology
more info
 
enables non-membrane spanning protein tyrosine kinase activity ISO
Inferred from Sequence Orthology
more info
 
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
 
enables phosphotyrosine residue binding ISO
Inferred from Sequence Orthology
more info
 
enables proline-rich region binding ISO
Inferred from Sequence Orthology
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein domain specific binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein kinase C binding ISO
Inferred from Sequence Orthology
more info
 
enables protein kinase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables protein kinase activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
enables protein kinase activity ISO
Inferred from Sequence Orthology
more info
 
enables protein kinase binding ISO
Inferred from Sequence Orthology
more info
 
enables protein self-association ISO
Inferred from Sequence Orthology
more info
 
enables protein tyrosine kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables protein tyrosine kinase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables protein tyrosine kinase activity IGI
Inferred from Genetic Interaction
more info
PubMed 
enables protein tyrosine kinase activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
enables protein tyrosine kinase activity ISO
Inferred from Sequence Orthology
more info
 
enables sequence-specific double-stranded DNA binding ISO
Inferred from Sequence Orthology
more info
 
enables syntaxin binding ISO
Inferred from Sequence Orthology
more info
 
enables transferase activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
acts_upstream_of_or_within B cell proliferation IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within B cell proliferation involved in immune response IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within B cell proliferation involved in immune response IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within B cell receptor signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within B-1 B cell homeostasis IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of BMP signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within Bergmann glial cell differentiation IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within DN4 thymocyte differentiation IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in DNA conformation change ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within DNA repair IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of ERK1 and ERK2 cascade IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of I-kappaB kinase/NF-kappaB signaling IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within T cell receptor signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
involved_in actin cytoskeleton organization IDA
Inferred from Direct Assay
more info
PubMed 
involved_in actin filament polymerization ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within activated T cell proliferation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in activation of protein kinase C activity ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within alpha-beta T cell differentiation IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within apoptotic process IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within autophagy IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within cell adhesion IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of cell-cell adhesion IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in cellular response to DNA damage stimulus ISO
Inferred from Sequence Orthology
more info
 
involved_in cellular response to hydrogen peroxide ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within cellular response to lipopolysaccharide IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of cellular senescence IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within cerebellum morphogenesis IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within circulatory system development IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within endocytosis IEA
Inferred from Electronic Annotation
more info
 
involved_in endothelial cell migration ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within epidermal growth factor receptor signaling pathway IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within establishment of localization in cell IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within establishment of localization in cell IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in integrin-mediated signaling pathway ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of interleukin-2 production IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in learning or memory ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within microspike assembly IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within negative regulation of BMP signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within negative regulation of ERK1 and ERK2 cascade IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within negative regulation of I-kappaB kinase/NF-kappaB signaling IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within negative regulation of cell-cell adhesion IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within negative regulation of cellular senescence IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within negative regulation of endothelial cell apoptotic process IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in negative regulation of long-term synaptic potentiation IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within negative regulation of mitotic cell cycle IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within negative regulation of mitotic cell cycle IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within negative regulation of phospholipase C activity ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of protein serine/threonine kinase activity ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within negative regulation of ubiquitin-protein transferase activity ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within neural tube closure IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within neuroepithelial cell differentiation IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within neuromuscular process controlling balance IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of neuron death IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within neuron differentiation IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in neuropilin signaling pathway ISO
Inferred from Sequence Orthology
more info
 
involved_in peptidyl-tyrosine autophosphorylation ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within peptidyl-tyrosine phosphorylation IDA
Inferred from Direct Assay
more info
PubMed 
involved_in peptidyl-tyrosine phosphorylation IDA
Inferred from Direct Assay
more info
PubMed 
involved_in peptidyl-tyrosine phosphorylation ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within phagocytosis IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within phagocytosis IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within phosphorylation IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within platelet-derived growth factor receptor signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within platelet-derived growth factor receptor signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in platelet-derived growth factor receptor-beta signaling pathway ISO
Inferred from Sequence Orthology
more info
 
involved_in podocyte apoptotic process ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within positive regulation of ERK1 and ERK2 cascade IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within positive regulation of I-kappaB kinase/NF-kappaB signaling IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in positive regulation of T cell migration IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within positive regulation of Wnt signaling pathway, planar cell polarity pathway IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in positive regulation of actin cytoskeleton reorganization ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of actin filament binding ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within positive regulation of apoptotic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of apoptotic process ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of blood vessel branching IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of cell migration involved in sprouting angiogenesis IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within positive regulation of cytosolic calcium ion concentration ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of dendrite development ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of endothelial cell migration ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of establishment of T cell polarity IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of extracellular matrix organization ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of fibroblast proliferation ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of focal adhesion assembly ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of hydrogen peroxide-mediated programmed cell death ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within positive regulation of interleukin-2 production IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in positive regulation of microtubule binding ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within positive regulation of mitotic cell cycle IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in positive regulation of neuron apoptotic process ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within positive regulation of neuron death IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of neuron death ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within positive regulation of osteoblast proliferation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of oxidoreductase activity ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of peptidyl-tyrosine phosphorylation ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of protein phosphorylation ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within positive regulation of release of sequestered calcium ion into cytosol IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in positive regulation of stress fiber assembly ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of substrate adhesion-dependent cell spreading ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within positive regulation of type II interferon production IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in positive regulation of vasoconstriction ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within post-embryonic development IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in protein autophosphorylation ISO
Inferred from Sequence Orthology
more info
 
involved_in protein localization to cytoplasmic microtubule plus-end ISO
Inferred from Sequence Orthology
more info
 
involved_in protein phosphorylation IDA
Inferred from Direct Assay
more info
PubMed 
involved_in protein phosphorylation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in protein phosphorylation ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of Cdc42 protein signal transduction ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of T cell differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within regulation of actin cytoskeleton organization IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in regulation of actin cytoskeleton organization ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of apoptotic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in regulation of axon extension ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within regulation of cell cycle IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within regulation of cell population proliferation IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within regulation of cellular senescence IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within regulation of extracellular matrix organization IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in regulation of microtubule polymerization ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of modification of synaptic structure IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in regulation of modification of synaptic structure ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of response to DNA damage stimulus ISO
Inferred from Sequence Orthology
more info
 
involved_in response to endoplasmic reticulum stress ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within response to oxidative stress IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within response to oxidative stress ISO
Inferred from Sequence Orthology
more info
 
involved_in signal transduction in response to DNA damage ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within spleen development IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within substrate adhesion-dependent cell spreading IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within thymus development IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within transitional one stage B cell differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of type II interferon production IGI
Inferred from Genetic Interaction
more info
PubMed 
Component Evidence Code Pubs
located_in actin cytoskeleton IDA
Inferred from Direct Assay
more info
PubMed 
located_in cell leading edge IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in cytoskeleton IEA
Inferred from Electronic Annotation
more info
 
located_in cytosol ISA
Inferred from Sequence Alignment
more info
PubMed 
located_in cytosol ISO
Inferred from Sequence Orthology
more info
 
located_in cytosol TAS
Traceable Author Statement
more info
 
located_in dendrite ISO
Inferred from Sequence Orthology
more info
 
located_in endoplasmic reticulum ISO
Inferred from Sequence Orthology
more info
 
located_in growth cone ISO
Inferred from Sequence Orthology
more info
 
located_in mitochondrion ISO
Inferred from Sequence Orthology
more info
 
located_in neuron projection ISO
Inferred from Sequence Orthology
more info
 
located_in neuronal cell body ISO
Inferred from Sequence Orthology
more info
 
located_in nuclear body ISO
Inferred from Sequence Orthology
more info
 
located_in nucleolus ISO
Inferred from Sequence Orthology
more info
 
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in nucleus IDA
Inferred from Direct Assay
more info
PubMed 
located_in nucleus ISO
Inferred from Sequence Orthology
more info
 
located_in perinuclear region of cytoplasm ISO
Inferred from Sequence Orthology
more info
 
part_of protein-containing complex ISO
Inferred from Sequence Orthology
more info
 
located_in ruffle ISO
Inferred from Sequence Orthology
more info
 
located_in synapse ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
tyrosine-protein kinase ABL1
Names
Abelson murine leukemia oncogene
Abelson tyrosine-protein kinase 1
abelson murine leukemia viral oncogene homolog 1
c-abl oncogene 1, receptor tyrosine kinase
c-abl protein, type I
c-abl protein, type II
c-abl protein, type III
p150
proto-oncogene c-Abl
proto-oncogene tyrosine-protein kinase ABL1
v-abl Abelson murine leukemia oncogene 1
NP_001106174.1
NP_001269974.1
NP_001269975.1
NP_001269976.1
NP_033724.2
XP_006497684.1

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001112703.2NP_001106174.1  tyrosine-protein kinase ABL1 isoform a

    See identical proteins and their annotated locations for NP_001106174.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longest protein (isoform a).
    Source sequence(s)
    AK166028, AL929275, BC103770
    Consensus CDS
    CCDS50563.1
    UniProtKB/Swiss-Prot
    P00520
    UniProtKB/TrEMBL
    Q3SYK5
    Related
    ENSMUSP00000075167.7, ENSMUST00000075759.13
    Conserved Domains (5) summary
    smart00808
    Location:10181142
    FABD; F-actin binding domain (FABD)
    cd09935
    Location:142235
    SH2_ABL; Src homology 2 (SH2) domain found in Abelson murine lymphosarcoma virus (ABL) proteins
    cd11850
    Location:84137
    SH3_Abl; Src homology 3 domain of the Protein Tyrosine Kinase, Abelson kinase
    cd05052
    Location:254516
    PTKc_Abl; Catalytic domain of the Protein Tyrosine Kinase, Abelson kinase
    pfam07714
    Location:261512
    Pkinase_Tyr; Protein tyrosine kinase
  2. NM_001283045.1NP_001269974.1  tyrosine-protein kinase ABL1 isoform c

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR and coding region, and uses an alternate downstream start codon compared to variant 1. The resulting protein (isoform c) has a shorter and distinct N-terminus compared to isoform a.
    Source sequence(s)
    AL929275, BQ769074, CF536749, CF726668, CF727094
    UniProtKB/Swiss-Prot
    P00520
    Conserved Domains (5) summary
    smart00808
    Location:9941118
    FABD; F-actin binding domain (FABD)
    cd09935
    Location:118211
    SH2_ABL; Src homology 2 (SH2) domain found in Abelson murine lymphosarcoma virus (ABL) proteins
    cd11850
    Location:60113
    SH3_Abl; Src homology 3 domain of the Protein Tyrosine Kinase, Abelson kinase
    cd05052
    Location:230492
    PTKc_Abl; Catalytic domain of the Protein Tyrosine Kinase, Abelson kinase
    pfam07714
    Location:237488
    Pkinase_Tyr; Protein tyrosine kinase
  3. NM_001283046.1NP_001269975.1  tyrosine-protein kinase ABL1 isoform d

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) contains an alternate 5' exon compared to variant 1, and uses an alternate downstream start codon compared to variant 1. The resulting protein (isoform d) has a shorter and distinct N-terminus compared to isoform a.
    Source sequence(s)
    AL929275
    UniProtKB/Swiss-Prot
    P00520
    Conserved Domains (5) summary
    smart00808
    Location:9931117
    FABD; F-actin binding domain (FABD)
    cd09935
    Location:117210
    SH2_ABL; Src homology 2 (SH2) domain found in Abelson murine lymphosarcoma virus (ABL) proteins
    cd11850
    Location:59112
    SH3_Abl; Src homology 3 domain of the Protein Tyrosine Kinase, Abelson kinase
    cd05052
    Location:229491
    PTKc_Abl; Catalytic domain of the Protein Tyrosine Kinase, Abelson kinase
    pfam07714
    Location:236487
    Pkinase_Tyr; Protein tyrosine kinase
  4. NM_001283047.1NP_001269976.1  tyrosine-protein kinase ABL1 isoform e

    See identical proteins and their annotated locations for NP_001269976.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (5) contains an alternate 5' exon and uses a downstream start codon compared to variant 1. The resulting protein (isoform e) has a shorter and distinct N-terminus compared to isoform a.
    Source sequence(s)
    AL929275
    Conserved Domains (3) summary
    smart00808
    Location:763887
    FABD; F-actin binding domain (FABD)
    cd05052
    Location:1261
    PTKc_Abl; Catalytic domain of the Protein Tyrosine Kinase, Abelson kinase
    pfam07714
    Location:6257
    Pkinase_Tyr; Protein tyrosine kinase
  5. NM_009594.4NP_033724.2  tyrosine-protein kinase ABL1 isoform b

    See identical proteins and their annotated locations for NP_033724.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR and coding region, and uses an alternate downstream start codon compared to variant 1. The resulting protein (isoform b) has a shorter and distinct N-terminus compared to isoform a.
    Source sequence(s)
    AL929275, BM949741, BU053120, CA752052, CF726668, CF727248, CJ099623, CJ101520, CJ128107, CK626997, CN663033
    Consensus CDS
    CCDS15901.1
    UniProtKB/Swiss-Prot
    P00520, Q8C1X4
    Related
    ENSMUSP00000028190.7, ENSMUST00000028190.13
    Conserved Domains (4) summary
    smart00808
    Location:9991123
    FABD; F-actin binding domain (FABD)
    cd09935
    Location:123216
    SH2_ABL; Src homology 2 (SH2) domain found in Abelson murine lymphosarcoma virus (ABL) proteins
    cd11850
    Location:65118
    SH3_Abl; Src homology 3 domain of the Protein Tyrosine Kinase, Abelson kinase
    cd05052
    Location:235497
    PTKc_Abl; Catalytic domain of the Protein Tyrosine Kinase, Abelson kinase

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000068.8 Reference GRCm39 C57BL/6J

    Range
    31578256..31697105
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006497621.4XP_006497684.1  tyrosine-protein kinase ABL1 isoform X1

    Conserved Domains (3) summary
    cd09935
    Location:142235
    SH2_ABL; Src homology 2 (SH2) domain found in Abelson murine lymphosarcoma virus (ABL) proteins
    cd11850
    Location:84137
    SH3_Abl; Src homology 3 domain of the Protein Tyrosine Kinase, Abelson kinase
    cd05052
    Location:254516
    PTKc_Abl; Catalytic domain of the Protein Tyrosine Kinase, Abelson kinase