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SCRG1 stimulator of chondrogenesis 1 [ Homo sapiens (human) ]

Gene ID: 11341, updated on 7-Jun-2020

Summary

Official Symbol
SCRG1provided by HGNC
Official Full Name
stimulator of chondrogenesis 1provided by HGNC
Primary source
HGNC:HGNC:17036
See related
Ensembl:ENSG00000164106 MIM:603163
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
SCRG-1
Summary
Scrapie-responsive gene 1 is associated with neurodegenerative changes observed in transmissible spongiform encephalopathies. It may play a role in host response to prion-associated infections. The scrapie responsive protein 1 may be partly included in the membrane or secreted by the cells due to its hydrophobic N-terminus. In addition, the encoded protein can interact with bone marrow stromal cell antigen 1 (BST1) to enhance the differentiation potentials of human mesenchymal stem cells during tissue and bone regeneration. [provided by RefSeq, Jul 2016]
Expression
Biased expression in brain (RPKM 46.0), testis (RPKM 30.3) and 3 other tissues See more
Orthologs

Genomic context

See SCRG1 in Genome Data Viewer
Location:
4q34.1
Exon count:
5
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 4 NC_000004.12 (173384701..173519144, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 4 NC_000004.11 (174309299..174320617, complement)

Chromosome 4 - NC_000004.12Genomic Context describing neighboring genes Neighboring gene SAP30 divergent transcript Neighboring gene uncharacterized LOC101928383 Neighboring gene uncharacterized LOC112268474 Neighboring gene Sin3A associated protein 30 Neighboring gene 60S ribosomal protein L38 pseudogene Neighboring gene ribosomal protein L5 pseudogene 11 Neighboring gene VISTA enhancer hs2501 Neighboring gene RNA, U6 small nuclear 1096, pseudogene Neighboring gene uncharacterized LOC112267917 Neighboring gene uncharacterized LOC101928409 Neighboring gene HAND2 antisense RNA 1 Neighboring gene heart and neural crest derivatives expressed 2 Neighboring gene mortality factor 4 (pseudogene)

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC26468

Gene Ontology Provided by GOA

Function Evidence Code Pubs
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
nervous system development TAS
Traceable Author Statement
more info
PubMed 
Component Evidence Code Pubs
Golgi apparatus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
extracellular space TAS
Traceable Author Statement
more info
PubMed 
neuron projection terminus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
scrapie-responsive protein 1
Names
scrapie responsive gene 1
scrapie-responsive gene 1 protein

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001329597.2NP_001316526.1  scrapie-responsive protein 1 precursor

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longer transcript. Variants 1 and 2 both encode the same protein.
    Source sequence(s)
    AC093849, AC097534
    Consensus CDS
    CCDS3818.1
    UniProtKB/Swiss-Prot
    O75711
    UniProtKB/TrEMBL
    Q6FGG5
    Conserved Domains (1) summary
    pfam15224
    Location:2297
    SCRG1; Scrapie-responsive protein 1
  2. NM_007281.4NP_009212.1  scrapie-responsive protein 1 precursor

    See identical proteins and their annotated locations for NP_009212.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1 and 2 both encode the same protein.
    Source sequence(s)
    AC097534, AJ224677
    Consensus CDS
    CCDS3818.1
    UniProtKB/Swiss-Prot
    O75711
    UniProtKB/TrEMBL
    Q6FGG5
    Related
    ENSP00000296506.2, ENST00000296506.8
    Conserved Domains (1) summary
    pfam15224
    Location:2297
    SCRG1; Scrapie-responsive protein 1

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000004.12 Reference GRCh38.p13 Primary Assembly

    Range
    173384701..173519144 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_024453882.1XP_024309650.1  scrapie-responsive protein 1 isoform X1

    Conserved Domains (1) summary
    pfam15224
    Location:2297
    SCRG1; Scrapie-responsive protein 1
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