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TMEM106A transmembrane protein 106A [ Homo sapiens (human) ]

Gene ID: 113277, updated on 13-Mar-2020

Summary

Official Symbol
TMEM106Aprovided by HGNC
Official Full Name
transmembrane protein 106Aprovided by HGNC
Primary source
HGNC:HGNC:28288
See related
Ensembl:ENSG00000184988
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Expression
Broad expression in kidney (RPKM 9.2), appendix (RPKM 4.7) and 23 other tissues See more
Orthologs

Genomic context

See TMEM106A in Genome Data Viewer
Location:
17q21.31
Exon count:
9
Annotation release Status Assembly Chr Location
109.20200228 current GRCh38.p13 (GCF_000001405.39) 17 NC_000017.11 (43211875..43220041)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 17 NC_000017.10 (41363865..41372061)

Chromosome 17 - NC_000017.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC101929767 Neighboring gene BRCA1 pseudogene 1 Neighboring gene NBR1 autophagy cargo receptor Neighboring gene Sharpr-MPRA regulatory region 10579 Neighboring gene coiled-coil domain containing 200 Neighboring gene RNA, U2 small nuclear 1

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ50420, FLJ50717, FLJ77644, MGC20235, MGC182077, MGC182126

Gene Ontology Provided by GOA

Function Evidence Code Pubs
molecular_function ND
No biological Data available
more info
 
Process Evidence Code Pubs
CD80 biosynthetic process ISS
Inferred from Sequence or Structural Similarity
more info
 
CD86 biosynthetic process ISS
Inferred from Sequence or Structural Similarity
more info
 
biological_process ND
No biological Data available
more info
 
innate immune response IEA
Inferred from Electronic Annotation
more info
 
interleukin-1 beta secretion ISS
Inferred from Sequence or Structural Similarity
more info
 
interleukin-6 secretion ISS
Inferred from Sequence or Structural Similarity
more info
 
macrophage activation ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of I-kappaB kinase/NF-kappaB signaling ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of MAPK cascade ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of MHC class II biosynthetic process ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of nitric oxide metabolic process ISS
Inferred from Sequence or Structural Similarity
more info
 
tumor necrosis factor secretion ISS
Inferred from Sequence or Structural Similarity
more info
 
Component Evidence Code Pubs
integral component of membrane IEA
Inferred from Electronic Annotation
more info
 
plasma membrane ISS
Inferred from Sequence or Structural Similarity
more info
 

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001291586.2NP_001278515.1  transmembrane protein 106A isoform a

    See identical proteins and their annotated locations for NP_001278515.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (a). Both variants 1 and 2 encode isoform a.
    Source sequence(s)
    AC024051, AK290387, BQ013276
    Consensus CDS
    CCDS11462.1
    UniProtKB/Swiss-Prot
    Q96A25
    Related
    ENSP00000466820.1, ENST00000588659.5
    Conserved Domains (1) summary
    pfam07092
    Location:25252
    DUF1356; Protein of unknown function (DUF1356)
  2. NM_001291587.2NP_001278516.1  transmembrane protein 106A isoform b

    See identical proteins and their annotated locations for NP_001278516.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR and lacks an alternate in-frame segment in the 5' coding region, compared to variant 1, resulting in an isoform (b) that is shorter than isoform a.
    Source sequence(s)
    AC024051, AK299974, BQ013276
    Consensus CDS
    CCDS74073.1
    UniProtKB/Swiss-Prot
    Q96A25
    Related
    ENSP00000439844.1, ENST00000541594.5
    Conserved Domains (1) summary
    pfam07092
    Location:2204
    DUF1356; Protein of unknown function (DUF1356)
  3. NM_001291588.2NP_001278517.1  transmembrane protein 106A isoform c

    See identical proteins and their annotated locations for NP_001278517.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) differs in the 5' UTR and lacks an alternate in-frame exon in the central coding region, compared to variant 1, resulting in an isoform (c) that is shorter than isoform a.
    Source sequence(s)
    AC024051, AK301571, BQ013276
    Consensus CDS
    CCDS77039.1
    UniProtKB/TrEMBL
    B7Z779
    Related
    ENSP00000439835.1, ENST00000536052.5
    Conserved Domains (1) summary
    pfam07092
    Location:25205
    DUF1356; Protein of unknown function (DUF1356)
  4. NM_145041.4NP_659478.1  transmembrane protein 106A isoform a

    See identical proteins and their annotated locations for NP_659478.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Both variants 1 and 2 encode the same isoform (a).
    Source sequence(s)
    AC024051, AK056132, BQ013276
    Consensus CDS
    CCDS11462.1
    UniProtKB/Swiss-Prot
    Q96A25
    Related
    ENSP00000483246.1, ENST00000612339.4
    Conserved Domains (1) summary
    pfam07092
    Location:25252
    DUF1356; Protein of unknown function (DUF1356)

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000017.11 Reference GRCh38.p13 Primary Assembly

    Range
    43211875..43220041
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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