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GLCCI1 glucocorticoid induced 1 [ Homo sapiens (human) ]

Gene ID: 113263, updated on 12-Oct-2019

Summary

Official Symbol
GLCCI1provided by HGNC
Official Full Name
glucocorticoid induced 1provided by HGNC
Primary source
HGNC:HGNC:18713
See related
Ensembl:ENSG00000106415 MIM:614283
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
GCTR; GIG18; TSSN1; FAM117C
Summary
This gene encodes a protein of unknown function. Expression of this gene is induced by glucocorticoids and may be an early marker for glucocorticoid-induced apoptosis. Single nucleotide polymorphisms in this gene are associated with a decreased response to inhaled glucocorticoids in asthmatic patients. [provided by RefSeq, Feb 2012]
Expression
Broad expression in thyroid (RPKM 12.0), testis (RPKM 9.8) and 24 other tissues See more
Orthologs

Genomic context

See GLCCI1 in Genome Data Viewer
Location:
7p21.3
Exon count:
8
Annotation release Status Assembly Chr Location
109.20190905 current GRCh38.p13 (GCF_000001405.39) 7 NC_000007.14 (7968796..8089080)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 7 NC_000007.13 (8008374..8128710)

Chromosome 7 - NC_000007.14Genomic Context describing neighboring genes Neighboring gene cyclin B2 pseudogene 1 Neighboring gene GLCCI1 divergent transcript Neighboring gene peptidylprolyl isomerase like 4 pseudogene Neighboring gene uncharacterized LOC105375142 Neighboring gene islet cell autoantigen 1 Neighboring gene uncharacterized LOC100505938

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

Associated conditions

Description Tests
Glucocorticoid therapy, response to
MedGen: C3280689 OMIM: 614400 GeneReviews: Not available
Compare labs

NHGRI GWAS Catalog

Description
Genome-wide association study of intraocular pressure identifies the GLCCI1/ICA1 region as a glaucoma susceptibility locus.
NHGRI GWA Catalog
Heritability and genetic association analysis of cognition in the Diabetes Heart Study.
NHGRI GWA Catalog

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Potential readthrough

Included gene: UMAD1

Homology

Gene Ontology Provided by GOA

Component Evidence Code Pubs
cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
glucocorticoid-induced transcript 1 protein
Names
glucocorticoid induced transcript 1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_032073.1 RefSeqGene

    Range
    5054..125337
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_138426.4NP_612435.1  glucocorticoid-induced transcript 1 protein

    See identical proteins and their annotated locations for NP_612435.1

    Status: REVIEWED

    Source sequence(s)
    AL832860, AL833694, BC050291
    Consensus CDS
    CCDS34601.1
    UniProtKB/Swiss-Prot
    Q86VQ1
    Related
    ENSP00000223145.5, ENST00000223145.10
    Conserved Domains (1) summary
    pfam15388
    Location:167477
    FAM117; Protein Family FAM117

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109.20190905

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000007.14 Reference GRCh38.p13 Primary Assembly

    Range
    7968796..8089080
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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