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ECD ecdysoneless cell cycle regulator [ Homo sapiens (human) ]

Gene ID: 11319, updated on 27-Nov-2024

Summary

Official Symbol
ECDprovided by HGNC
Official Full Name
ecdysoneless cell cycle regulatorprovided by HGNC
Primary source
HGNC:HGNC:17029
See related
Ensembl:ENSG00000122882 MIM:616464; AllianceGenome:HGNC:17029
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
GCR2; SGT1; HSGT1
Summary
Enables histone acetyltransferase binding activity. Involved in positive regulation of transcription by RNA polymerase II. Located in cytosol and nucleoplasm. [provided by Alliance of Genome Resources, Nov 2024]
Expression
Ubiquitous expression in testis (RPKM 14.0), thyroid (RPKM 12.4) and 25 other tissues See more
Orthologs
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Genomic context

See ECD in Genome Data Viewer
Location:
10q22.2
Exon count:
15
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 10 NC_000010.11 (73133668..73168095, complement)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 10 NC_060934.1 (74005060..74039488, complement)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 10 NC_000010.10 (74893426..74927853, complement)

Chromosome 10 - NC_000010.11Genomic Context describing neighboring genes Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr10:74778077-74778636 Neighboring gene prolyl 4-hydroxylase subunit alpha 1 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 3554 Neighboring gene H3K27ac hESC enhancer GRCh37_chr10:74856005-74856760 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 3555 Neighboring gene ReSE screen-validated silencer GRCh37_chr10:74866945-74867185 Neighboring gene nudix hydrolase 13 Neighboring gene small nucleolar RNA, H/ACA box 11F Neighboring gene uncharacterized LOC124902452 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr10:74927585-74928184 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr10:74928785-74929383 Neighboring gene family with sequence similarity 149 member B1 Neighboring gene uncharacterized LOC105378358 Neighboring gene eukaryotic translation initiation factor 4A2 pseudogene 2

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Potential readthrough

Included gene: P4HA1

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables histone acetyltransferase binding IDA
Inferred from Direct Assay
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
involved_in RNA splicing IEA
Inferred from Electronic Annotation
more info
 
involved_in fibroblast proliferation IEA
Inferred from Electronic Annotation
more info
 
involved_in mRNA processing IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of transcription by RNA polymerase II IDA
Inferred from Direct Assay
more info
PubMed 
involved_in regulation of G1/S transition of mitotic cell cycle IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
located_in cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytosol IDA
Inferred from Direct Assay
more info
 
located_in nucleoplasm IDA
Inferred from Direct Assay
more info
 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in nucleus IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
protein ecdysoneless homolog
Names
ecdysoneless homolog
human suppressor of GCR two
protein SGT1
suppressor of GCR2
suppressor of S. cerevisiae gcr2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001135752.1NP_001129224.1  protein ecdysoneless homolog isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) omits an in-frame coding exon compared to variant 1 resulting in a shorter protein isoform (2).
    Source sequence(s)
    AK225519, AK315711, BC103720, BM763002
    Consensus CDS
    CCDS44434.1
    UniProtKB/TrEMBL
    B3KMT5
    Related
    ENSP00000401566.1, ENST00000430082.6
    Conserved Domains (1) summary
    pfam07093
    Location:14630
    SGT1; SGT1 protein
  2. NM_001135753.1NP_001129225.1  protein ecdysoneless homolog isoform 3

    Status: VALIDATED

    Description
    Transcript Variant: This variant includes an additional in-frame coding exon compared to variant 1 resulting in a longer protein isoform (3).
    Source sequence(s)
    AK225519, BC000721, BC103720, BM763002
    Consensus CDS
    CCDS44433.1
    UniProtKB/TrEMBL
    B3KMT5
    Related
    ENSP00000395786.1, ENST00000454759.6
    Conserved Domains (1) summary
    pfam07093
    Location:14554
    SGT1; SGT1 protein
  3. NM_007265.3NP_009196.1  protein ecdysoneless homolog isoform 1

    See identical proteins and their annotated locations for NP_009196.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents a more abundant transcript and encodes isoform 1.
    Source sequence(s)
    AC016394, BC103720, D88208
    Consensus CDS
    CCDS7321.1
    UniProtKB/Swiss-Prot
    C9JX46, E9PAW8, O95905
    UniProtKB/TrEMBL
    B3KMT5
    Related
    ENSP00000362070.4, ENST00000372979.9
    Conserved Domains (1) summary
    pfam07093
    Location:14597
    SGT1; SGT1 protein

RNA

  1. NR_024203.1 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) omits the first coding exon and an additional coding exon compared to variant 1. The transcript is a candidate for nonsense-mediated decay (NMD).
    Source sequence(s)
    BC000721, BC103720, BM763002
    Related
    ENST00000484976.6

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000010.11 Reference GRCh38.p14 Primary Assembly

    Range
    73133668..73168095 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060934.1 Alternate T2T-CHM13v2.0

    Range
    74005060..74039488 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)