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ECD ecdysoneless cell cycle regulator [ Homo sapiens (human) ]

Gene ID: 11319, updated on 1-Jun-2020

Summary

Official Symbol
ECDprovided by HGNC
Official Full Name
ecdysoneless cell cycle regulatorprovided by HGNC
Primary source
HGNC:HGNC:17029
See related
Ensembl:ENSG00000122882 MIM:616464
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
GCR2; SGT1; HSGT1
Expression
Ubiquitous expression in testis (RPKM 14.0), thyroid (RPKM 12.4) and 25 other tissues See more
Orthologs

Genomic context

See ECD in Genome Data Viewer
Location:
10q22.2
Exon count:
15
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 10 NC_000010.11 (73133668..73168095, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 10 NC_000010.10 (74894282..74927853, complement)

Chromosome 10 - NC_000010.11Genomic Context describing neighboring genes Neighboring gene prolyl 4-hydroxylase subunit alpha 1 Neighboring gene nudix hydrolase 13 Neighboring gene small nucleolar RNA, H/ACA box 11F Neighboring gene family with sequence similarity 149 member B1 Neighboring gene uncharacterized LOC105378358 Neighboring gene eukaryotic translation initiation factor 4A2 pseudogene 2

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Potential readthrough

Included gene: P4HA1

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
histone acetyltransferase binding IDA
Inferred from Direct Assay
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
RNA splicing IEA
Inferred from Electronic Annotation
more info
 
cell proliferation IEA
Inferred from Electronic Annotation
more info
 
mRNA processing IEA
Inferred from Electronic Annotation
more info
 
positive regulation of transcription by RNA polymerase II IDA
Inferred from Direct Assay
more info
PubMed 
regulation of G1/S transition of mitotic cell cycle IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
cytosol IDA
Inferred from Direct Assay
more info
 
nucleoplasm IDA
Inferred from Direct Assay
more info
 
nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
nucleus IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
protein ecdysoneless homolog
Names
ecdysoneless homolog
human suppressor of GCR two
protein SGT1
suppressor of GCR2
suppressor of S. cerevisiae gcr2

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001135752.1NP_001129224.1  protein ecdysoneless homolog isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) omits an in-frame coding exon compared to variant 1 resulting in a shorter protein isoform (2).
    Source sequence(s)
    AK225519, AK315711, BC103720, BM763002
    Consensus CDS
    CCDS44434.1
    UniProtKB/Swiss-Prot
    O95905
    Related
    ENSP00000401566.1, ENST00000430082.6
    Conserved Domains (1) summary
    pfam07093
    Location:14630
    SGT1; SGT1 protein
  2. NM_001135753.1NP_001129225.1  protein ecdysoneless homolog isoform 3

    Status: VALIDATED

    Description
    Transcript Variant: This variant includes an additional in-frame coding exon compared to variant 1 resulting in a longer protein isoform (3).
    Source sequence(s)
    AK225519, BC000721, BC103720, BM763002
    Consensus CDS
    CCDS44433.1
    UniProtKB/Swiss-Prot
    O95905
    Related
    ENSP00000395786.1, ENST00000454759.6
    Conserved Domains (1) summary
    pfam07093
    Location:14554
    SGT1; SGT1 protein
  3. NM_007265.3NP_009196.1  protein ecdysoneless homolog isoform 1

    See identical proteins and their annotated locations for NP_009196.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents a more abundant transcript and encodes isoform 1.
    Source sequence(s)
    AC016394, BC103720, D88208
    Consensus CDS
    CCDS7321.1
    UniProtKB/Swiss-Prot
    O95905
    Related
    ENSP00000362070.4, ENST00000372979.9
    Conserved Domains (1) summary
    pfam07093
    Location:14597
    SGT1; SGT1 protein

RNA

  1. NR_024203.1 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) omits the first coding exon and an additional coding exon compared to variant 1. The transcript is a candidate for nonsense-mediated decay (NMD).
    Source sequence(s)
    BC000721, BC103720, BM763002
    Related
    ENST00000484976.6

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000010.11 Reference GRCh38.p13 Primary Assembly

    Range
    73133668..73168095 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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