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PTH2 parathyroid hormone 2 [ Homo sapiens (human) ]

Gene ID: 113091, updated on 13-Mar-2020

Summary

Official Symbol
PTH2provided by HGNC
Official Full Name
parathyroid hormone 2provided by HGNC
Primary source
HGNC:HGNC:30828
See related
Ensembl:ENSG00000142538 MIM:608386
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
TIP39
Summary
This gene encodes the precursor of a peptide hormone that shares sequence similarity with the parathyroid hormone. This gene is expressed in various regions of the brain where it plays a role in the release of pituitary hormones, anxiety and nociception. The encoded precursor protein is proteolytically processed to generate the biologically active neuropeptide. [provided by RefSeq, Jul 2015]
Orthologs

Genomic context

See PTH2 in Genome Data Viewer
Location:
19q13.33
Exon count:
2
Annotation release Status Assembly Chr Location
109.20200228 current GRCh38.p13 (GCF_000001405.39) 19 NC_000019.10 (49422419..49423441, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (49925671..49926698, complement)

Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene dickkopf like acrosomal protein 1 Neighboring gene uncharacterized LOC101928295 Neighboring gene KASH domain containing 5 Neighboring gene solute carrier family 17 member 7 Neighboring gene golgi associated olfactory signaling regulator

Genomic regions, transcripts, and products

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Process Evidence Code Pubs
G protein-coupled receptor signaling pathway TAS
Traceable Author Statement
more info
 
neuropeptide signaling pathway IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
extracellular region TAS
Traceable Author Statement
more info
 

General protein information

Preferred Names
tuberoinfundibular peptide of 39 residues
Names
tuberoinfundibular 39 residue protein

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_178449.4NP_848544.1  tuberoinfundibular peptide of 39 residues preproprotein

    See identical proteins and their annotated locations for NP_848544.1

    Status: REVIEWED

    Source sequence(s)
    AY037555, BC093997
    Consensus CDS
    CCDS12763.1
    UniProtKB/Swiss-Prot
    Q96A98
    Related
    ENSP00000270631.1, ENST00000270631.2
    Conserved Domains (1) summary
    pfam14980
    Location:4999
    TIP39; TIP39 peptide

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000019.10 Reference GRCh38.p13 Primary Assembly

    Range
    49422419..49423441 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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