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Abcb7 ATP-binding cassette, sub-family B member 7 [ Mus musculus (house mouse) ]

Gene ID: 11306, updated on 7-May-2024

Summary

Official Symbol
Abcb7provided by MGI
Official Full Name
ATP-binding cassette, sub-family B member 7provided by MGI
Primary source
MGI:MGI:109533
See related
Ensembl:ENSMUSG00000031333 AllianceGenome:MGI:109533
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Abc7
Summary
Predicted to enable ABC-type iron-sulfur cluster transporter activity and protein homodimerization activity. Involved in iron-sulfur cluster assembly; positive regulation of heme biosynthetic process; and positive regulation of iron-sulfur cluster assembly. Acts upstream of or within cellular iron ion homeostasis. Located in mitochondrial inner membrane. Is expressed in several structures, including adrenal gland; central nervous system; gut; hemolymphoid system gland; and retina. Human ortholog(s) of this gene implicated in X-linked sideroblastic anemia with ataxia. Orthologous to human ABCB7 (ATP binding cassette subfamily B member 7). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in liver E14 (RPKM 4.5), cerebellum adult (RPKM 4.1) and 27 other tissues See more
Orthologs
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Genomic context

See Abcb7 in Genome Data Viewer
Location:
X D; X 46.58 cM
Exon count:
16
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) X NC_000086.8 (103324171..103457452, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) X NC_000086.7 (104280565..104413846, complement)

Chromosome X - NC_000086.8Genomic Context describing neighboring genes Neighboring gene predicted gene, 22266 Neighboring gene neurite extension and migration factor Neighboring gene microRNA 672 Neighboring gene STARR-seq mESC enhancer starr_47705 Neighboring gene STARR-seq mESC enhancer starr_47706 Neighboring gene STARR-seq mESC enhancer starr_47707 Neighboring gene STARR-seq mESC enhancer starr_47708 Neighboring gene STARR-seq mESC enhancer starr_47709 Neighboring gene valosin containing protein, related sequence Neighboring gene STARR-seq mESC enhancer starr_47712 Neighboring gene 39S ribosomal protein L30, mitochondrial pseudogene Neighboring gene uracil phosphoribosyltransferase Neighboring gene ribosomal protein 10 pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables ABC-type iron-sulfur cluster transporter activity ISO
Inferred from Sequence Orthology
more info
 
enables ABC-type transporter activity IEA
Inferred from Electronic Annotation
more info
 
enables ATP binding IEA
Inferred from Electronic Annotation
more info
 
enables ATP hydrolysis activity IEA
Inferred from Electronic Annotation
more info
 
enables ATPase-coupled transmembrane transporter activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
 
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein homodimerization activity ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
located_in membrane IEA
Inferred from Electronic Annotation
more info
 
located_in mitochondrial inner membrane HDA PubMed 
is_active_in mitochondrial inner membrane IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in mitochondrial inner membrane ISO
Inferred from Sequence Orthology
more info
 
located_in mitochondrion HDA PubMed 
located_in mitochondrion ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
iron-sulfur clusters transporter ABCB7, mitochondrial
Names
ABC transporter 7 protein
ATP-binding cassette 7
ATP-binding cassette sub-family B member 7, mitochondrial
ATP-binding cassette transporter 7
ATP-binding cassette, sub-family B (MDR/TAP), member 7

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_009592.1NP_033722.1  iron-sulfur clusters transporter ABCB7, mitochondrial

    See identical proteins and their annotated locations for NP_033722.1

    Status: VALIDATED

    Source sequence(s)
    AK040069, AK152535, AL663052, BB612154
    Consensus CDS
    CCDS53167.1
    UniProtKB/Swiss-Prot
    A2AC46, Q3U7S8, Q61102
    Related
    ENSMUSP00000033695.6, ENSMUST00000033695.6
    Conserved Domains (3) summary
    cd03253
    Location:472708
    ABCC_ATM1_transporter; ATP-binding cassette domain of iron-sulfur clusters transporter, subfamily C
    COG5265
    Location:210705
    ATM1; ABC-type transport system involved in Fe-S cluster assembly, permease and ATPase components [Posttranslational modification, protein turnover, chaperones]
    pfam00664
    Location:150424
    ABC_membrane; ABC transporter transmembrane region

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000086.8 Reference GRCm39 C57BL/6J

    Range
    103324171..103457452 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)