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MIRLET7A1HG miRlet-7a-1/let-7f-1/let-7d cluster host gene [ Homo sapiens (human) ]

Gene ID: 112903833, updated on 7-Apr-2025

Summary

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Official Symbol
MIRLET7A1HGprovided by HGNC
Official Full Name
miRlet-7a-1/let-7f-1/let-7d cluster host geneprovided by HGNC
Primary source
HGNC:HGNC:53970
See related
Ensembl:ENSG00000269929 AllianceGenome:HGNC:53970
Gene type
ncRNA
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
Predicted to be involved in miRNA-mediated post-transcriptional gene silencing. Predicted to be part of RISC complex. [provided by Alliance of Genome Resources, Apr 2025]
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Genomic context

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See MIRLET7A1HG in Genome Data Viewer
Location:
9q22.32
Exon count:
5
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 9 NC_000009.12 (94166258..94200905)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 9 NC_060933.1 (106334316..106368968)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 9 NC_000009.11 (96928540..96963187)

Chromosome 9 - NC_000009.12Genomic Context describing neighboring genes Neighboring gene protein tyrosine phosphatase domain containing 1 Neighboring gene CYCS pseudogene 24 Neighboring gene Sharpr-MPRA regulatory region 768 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr9:96856496-96857248 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr9:96880956-96881652 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_110048 Neighboring gene tripartite motif-containing protein 54-like Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_110072 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_110085 Neighboring gene PTPDC1-MIRLET7DHG intergenic CAGE-defined high expression enhancer Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 20053 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 20054 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 28628 Neighboring gene microRNA let-7a-1 Neighboring gene microRNA let-7f-1 Neighboring gene long intergenic non-protein coding RNA 2603 Neighboring gene microRNA let-7d Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr9:96974681-96975243 Neighboring gene small nucleolar RNA U13 Neighboring gene uncharacterized LOC124902332

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. SNORD11B-mediated 2'-O-methylation of primary let-7a in colorectal carcinogenesis. Bian Z, et al. Oncogene, 2023 Oct. PMID 37620450

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. SNORD11B-mediated 2'-O-methylation of primary let-7a in colorectal carcinogenesis.
    Title: SNORD11B-mediated 2'-O-methylation of primary let-7a in colorectal carcinogenesis.
Submit: New GeneRIF Correction

Phenotypes

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Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See Variation Viewer (GRCh37.p13)

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

RNA

  1. NR_170274.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AL158152

  2. NR_170275.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AL158152
    Related
    ENST00000602703.2

  3. NR_170276.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AL158152
    Related
    ENST00000710611.1

  4. NR_170277.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AL158152
    Related
    ENST00000803408.1

  5. NR_170278.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AL158152
    Related
    ENST00000652620.1

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000009.12 Reference GRCh38.p14 Primary Assembly

    Range
    94166258..94200905
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060933.1 Alternate T2T-CHM13v2.0

    Range
    106334316..106368968
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version

Gene LinkOut

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