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SGF29 SAGA complex associated factor 29 [ Homo sapiens (human) ]

Gene ID: 112869, updated on 1-Mar-2024

Summary

Official Symbol
SGF29provided by HGNC
Official Full Name
SAGA complex associated factor 29provided by HGNC
Primary source
HGNC:HGNC:25156
See related
Ensembl:ENSG00000176476 MIM:613374; AllianceGenome:HGNC:25156
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
STAF36; TDRD29; CCDC101
Summary
CCDC101 is a subunit of 2 histone acetyltransferase complexes: the ADA2A (TADA2A; MIM 602276)-containing (ATAC) complex and the SPT3 (SUPT3H; MIM 602947)-TAF9 (MIM 600822)-GCN5 (KAT2A; MIM 602301)/PCAF (KAT2B; MIM 602303) acetylase (STAGA) complex. Both of these complexes contain either GCN5 or PCAF, which are paralogous acetyltransferases (Wang et al., 2008 [PubMed 18838386]).[supplied by OMIM, Apr 2010]
Expression
Ubiquitous expression in testis (RPKM 13.2), ovary (RPKM 12.9) and 25 other tissues See more
Orthologs
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Genomic context

See SGF29 in Genome Data Viewer
Location:
16p11.2
Exon count:
10
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 16 NC_000016.10 (28553920..28591790)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 16 NC_060940.1 (28803905..28857252, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 16 NC_000016.9 (28565241..28603111)

Chromosome 16 - NC_000016.10Genomic Context describing neighboring genes Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:28510584-28511084 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:28511085-28511585 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 7309 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 10641 Neighboring gene interleukin 27 Neighboring gene MED14-independent group 3 enhancer GRCh37_chr16:28549089-28550288 Neighboring gene nuclear protein 1, transcriptional regulator Neighboring gene ATAC-STARR-seq lymphoblastoid active region 10642 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 7310 Neighboring gene Sharpr-MPRA regulatory region 4245 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:28610237-28610771 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:28610772-28611305 Neighboring gene sulfotransferase family 1A member 2 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:28612139-28612653 Neighboring gene uncharacterized LOC107984835 Neighboring gene uncharacterized LOC124903674 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:28623750-28624250 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:28624498-28625048 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:28625049-28625598 Neighboring gene sulfotransferase family 1A member 1

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

EBI GWAS Catalog

Description
Common genetic variants associated with cognitive performance identified using the proxy-phenotype method.
EBI GWAS Catalog
Common variants at five new loci associated with early-onset inflammatory bowel disease.
EBI GWAS Catalog

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Clone Names

  • FLJ32446

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables methylated histone binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables methylated histone binding IDA
Inferred from Direct Assay
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
involved_in establishment of protein localization to chromatin TAS
Traceable Author Statement
more info
PubMed 
involved_in negative regulation of transcription by RNA polymerase II IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of DNA-templated transcription NAS
Non-traceable Author Statement
more info
PubMed 
involved_in regulation of DNA repair NAS
Non-traceable Author Statement
more info
PubMed 
involved_in regulation of DNA-templated transcription IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of DNA-templated transcription ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in regulation of RNA splicing NAS
Non-traceable Author Statement
more info
PubMed 
involved_in regulation of cell cycle IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of cell cycle ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in regulation of cell division IDA
Inferred from Direct Assay
more info
PubMed 
involved_in regulation of cell division ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in regulation of embryonic development ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of embryonic development ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in regulation of transcription by RNA polymerase II IDA
Inferred from Direct Assay
more info
PubMed 
involved_in regulation of transcription by RNA polymerase II ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in regulation of tubulin deacetylation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of tubulin deacetylation ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in response to endoplasmic reticulum stress IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in transcription initiation-coupled chromatin remodeling IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
part_of ATAC complex IDA
Inferred from Direct Assay
more info
PubMed 
part_of ATAC complex ISO
Inferred from Sequence Orthology
more info
 
part_of SAGA complex IBA
Inferred from Biological aspect of Ancestor
more info
 
part_of SAGA complex NAS
Non-traceable Author Statement
more info
PubMed 
part_of SAGA-type complex IDA
Inferred from Direct Assay
more info
PubMed 
located_in mitotic spindle NAS
Non-traceable Author Statement
more info
PubMed 
located_in nucleoplasm TAS
Traceable Author Statement
more info
 

General protein information

Preferred Names
SAGA-associated factor 29
Names
SAGA-associated factor 29 homolog
coiled-coil domain containing 101
coiled-coil domain-containing protein 101

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_138414.3NP_612423.1  SAGA-associated factor 29

    See identical proteins and their annotated locations for NP_612423.1

    Status: VALIDATED

    Source sequence(s)
    AA132314, AA132818, AC020765, BC011981
    Consensus CDS
    CCDS10635.1
    UniProtKB/Swiss-Prot
    Q96ES7, Q96MF5
    Related
    ENSP00000316114.3, ENST00000317058.8
    Conserved Domains (1) summary
    pfam07039
    Location:158288
    DUF1325; SGF29 tudor-like domain

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000016.10 Reference GRCh38.p14 Primary Assembly

    Range
    28553920..28591790
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017022894.2XP_016878383.1  SAGA-associated factor 29 isoform X1

RNA

  1. XR_001751821.2 RNA Sequence

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060940.1 Alternate T2T-CHM13v2.0

    Range
    28803905..28857252 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054379477.1XP_054235452.1  SAGA-associated factor 29 isoform X2

    UniProtKB/Swiss-Prot
    Q96ES7, Q96MF5

RNA

  1. XR_008489050.1 RNA Sequence