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NRM nurim [ Homo sapiens (human) ]

Gene ID: 11270, updated on 18-Jun-2020

Summary

Official Symbol
NRMprovided by HGNC
Official Full Name
nurimprovided by HGNC
Primary source
HGNC:HGNC:8003
See related
Ensembl:ENSG00000137404
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
NRM29
Summary
The protein encoded by this gene contains transmembrane domains and resides within the inner nuclear membrane, where it is tightly associated with the nucleus. This protein shares homology with isoprenylcysteine carboxymethyltransferase enzymes. Alternative splicing results in multiple transcript variants that encode different protein isoforms. [provided by RefSeq, Jul 2012]
Expression
Ubiquitous expression in skin (RPKM 5.3), bone marrow (RPKM 5.1) and 25 other tissues See more
Orthologs

Genomic context

See NRM in Genome Data Viewer
Location:
6p21.33
Exon count:
7
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 6 NC_000006.12 (30688047..30691420, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 6 NC_000006.11 (30655824..30659197, complement)

Chromosome 6 - NC_000006.12Genomic Context describing neighboring genes Neighboring gene chromosome 6 open reading frame 136 Neighboring gene DEAH-box helicase 16 Neighboring gene protein phosphatase 1 regulatory subunit 18 Neighboring gene Sharpr-MPRA regulatory region 567 Neighboring gene ribosomal protein L7 pseudogene 4 Neighboring gene MDC1 antisense RNA 1 Neighboring gene mediator of DNA damage checkpoint 1

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
molecular_function ND
No biological Data available
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
biological_process ND
No biological Data available
more info
 
Component Evidence Code Pubs
integral component of membrane IEA
Inferred from Electronic Annotation
more info
 
membrane HDA PubMed 
nuclear envelope IDA
Inferred from Direct Assay
more info
PubMed 
nuclear inner membrane IEA
Inferred from Electronic Annotation
more info
 
nuclear membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
nuclear membrane IDA
Inferred from Direct Assay
more info
 

General protein information

Preferred Names
nurim
Names
nuclear rim protein
nurim (nuclear envelope membrane protein)

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001270707.2NP_001257636.1  nurim isoform 2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR and uses an alternate in-frame splice site in the coding region compared to variant 1. It encodes isoform 2 which is longer than isoform 1.
    Source sequence(s)
    AK075509, BC039865, BU159435
    UniProtKB/Swiss-Prot
    Q8IXM6
    UniProtKB/TrEMBL
    B3KQU6
  2. NM_001270708.2NP_001257637.1  nurim isoform 3

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) differs in the 5' and 3' UTR and uses an alternate in-frame splice site in the coding region compared to variant 1. It terminates translation at an alternate stop codon resulting in an isoform (3) that is shorter than isoform 1.
    Source sequence(s)
    AI521967, BC039865, BM917173
    UniProtKB/Swiss-Prot
    Q8IXM6
    UniProtKB/TrEMBL
    B3KQU6
    Related
    ENST00000462857.5
  3. NM_001270709.2NP_001257638.1  nurim isoform 4

    See identical proteins and their annotated locations for NP_001257638.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) differs in the 5' UTR and lacks an alternate in-frame exon in the coding region compared to variant 1. It encodes isoform 4 which is shorter than isoform 1.
    Source sequence(s)
    JQ798186
    Consensus CDS
    CCDS59498.1
    UniProtKB/Swiss-Prot
    Q8IXM6
    UniProtKB/TrEMBL
    B3KQU6
    Related
    ENSP00000365602.5, ENST00000376420.9
  4. NM_001270710.2NP_001257639.1  nurim isoform 5

    See identical proteins and their annotated locations for NP_001257639.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (5) lacks two alternate in-frame exons in the coding region compared to variant 1. The resulting isoform (5) has a distinct C-terminus, compared to isoform 1.
    Source sequence(s)
    JQ798187
    UniProtKB/Swiss-Prot
    Q8IXM6
    UniProtKB/TrEMBL
    B3KQU6
    Related
    ENST00000474864.5
  5. NM_001384369.1NP_001371298.1  nurim isoform 1

    Status: REVIEWED

    Source sequence(s)
    AL662797
  6. NM_007243.3NP_009174.1  nurim isoform 1

    See identical proteins and their annotated locations for NP_009174.1

    Status: REVIEWED

    Source sequence(s)
    AL662797
    Consensus CDS
    CCDS4686.1
    UniProtKB/Swiss-Prot
    Q8IXM6
    UniProtKB/TrEMBL
    A0A1U9X845, B3KQU6
    Related
    ENSP00000259953.4, ENST00000259953.8

RNA

  1. NR_073065.2 RNA Sequence

    Status: REVIEWED

    Description
    Transcript Variant: This variant (7) uses an alternate splice site compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AI521967, BC039865, BM847576
    Related
    ENST00000470733.1
  2. NR_073066.2 RNA Sequence

    Status: REVIEWED

    Description
    Transcript Variant: This variant (8) lacks an alternate internal exon compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AI521967, AK075509, AK298152
    Related
    ENST00000482141.5
  3. NR_073072.2 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AL662797
    Related
    ENST00000444096.5

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000006.12 Reference GRCh38.p13 Primary Assembly

    Range
    30688047..30691420 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017010225.2XP_016865714.1  nurim isoform X1

  2. XM_017010224.2XP_016865713.1  nurim isoform X1

Reference GRCh38.p13 ALT_REF_LOCI_1

Genomic

  1. NT_167244.2 Reference GRCh38.p13 ALT_REF_LOCI_1

    Range
    2017554..2020927 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Reference GRCh38.p13 ALT_REF_LOCI_2

Genomic

  1. NT_113891.3 Reference GRCh38.p13 ALT_REF_LOCI_2

    Range
    2167791..2171164 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Reference GRCh38.p13 ALT_REF_LOCI_3

Genomic

  1. NT_167245.2 Reference GRCh38.p13 ALT_REF_LOCI_3

    Range
    1943901..1947274 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Reference GRCh38.p13 ALT_REF_LOCI_4

Genomic

  1. NT_167246.2 Reference GRCh38.p13 ALT_REF_LOCI_4

    Range
    1998300..2001673 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Reference GRCh38.p13 ALT_REF_LOCI_5

Genomic

  1. NT_167247.2 Reference GRCh38.p13 ALT_REF_LOCI_5

    Range
    2032124..2035497 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Reference GRCh38.p13 ALT_REF_LOCI_6

Genomic

  1. NT_167248.2 Reference GRCh38.p13 ALT_REF_LOCI_6

    Range
    1943161..1946534 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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