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RWDD2A RWD domain containing 2A [ Homo sapiens (human) ]

Gene ID: 112611, updated on 3-Apr-2024

Summary

Official Symbol
RWDD2Aprovided by HGNC
Official Full Name
RWD domain containing 2Aprovided by HGNC
Primary source
HGNC:HGNC:21385
See related
Ensembl:ENSG00000013392 AllianceGenome:HGNC:21385
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
RWDD2; dJ747H23.2
Expression
Broad expression in prostate (RPKM 6.9), testis (RPKM 5.4) and 24 other tissues See more
Orthologs
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Genomic context

See RWDD2A in Genome Data Viewer
Location:
6q14.1
Exon count:
3
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 6 NC_000006.12 (83193357..83198935)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 6 NC_060930.1 (84416598..84422177)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 6 NC_000006.11 (83903076..83908654)

Chromosome 6 - NC_000006.12Genomic Context describing neighboring genes Neighboring gene ubiquitin protein ligase E3D Neighboring gene leucine aminopeptidase 3 pseudogene 1 Neighboring gene ReSE screen-validated silencer GRCh37_chr6:83710771-83710962 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr6:83747652-83748851 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 24780 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 24781 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 17355 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 24782 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 24783 Neighboring gene NANOG hESC enhancer GRCh37_chr6:83821047-83821571 Neighboring gene DOP1 leucine zipper like protein A Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 17356 Neighboring gene H3K27ac hESC enhancer GRCh37_chr6:83902947-83903446 Neighboring gene phosphoglucomutase 3 Neighboring gene MPRA-validated peak5928 silencer Neighboring gene malic enzyme 1 Neighboring gene ReSE screen-validated silencer GRCh37_chr6:84004031-84004257 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 24784 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 17358 Neighboring gene MED14-independent group 3 enhancer GRCh37_chr6:84140986-84142185 Neighboring gene serine protease 35

Genomic regions, transcripts, and products

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General protein information

Preferred Names
RWD domain-containing protein 2A
Names
RWD domain containing 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001322335.2NP_001309264.1  RWD domain-containing protein 2A isoform b

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses an alternate splice site in the 5' region, and it thus differs in its 5' UTR and initiates translation from a downstream in-frame start codon, compared to variant 1. The encoded isoform (b) is shorter at the N-terminus, compared to isoform a.
    Source sequence(s)
    AJ420581, AK302978, AW197622, BC104816, CN414510, DA032938, DC377982
    UniProtKB/TrEMBL
    B4DZK9
    Conserved Domains (2) summary
    pfam06544
    Location:85206
    DUF1115; Protein of unknown function (DUF1115)
    cl02687
    Location:159
    RWD; RWD domain
  2. NM_001322336.2NP_001309265.1  RWD domain-containing protein 2A isoform c

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) contains an additional internal exon and thus differs in its 5' UTR and initiates translation from an alternate start codon, compared to variant 1. The encoded isoform (c) has a distinct N-terminus and is shorter than isoform a. Variants 3, 4 and 5 all encode isoform c.
    Source sequence(s)
    AJ420581, AW197622, BC104816, CD108545, CN414510, DA032938, DC377982
    UniProtKB/TrEMBL
    B4DZK9
    Conserved Domains (2) summary
    pfam06544
    Location:94215
    DUF1115; Protein of unknown function (DUF1115)
    cl02687
    Location:268
    RWD; RWD domain
  3. NM_001322337.2NP_001309266.1  RWD domain-containing protein 2A isoform c

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) contains an additional internal exon and thus differs in its 5' UTR and initiates translation from an alternate start codon, compared to variant 1. The encoded isoform (c) has a distinct N-terminus and is shorter than isoform a. Variants 3, 4 and 5 all encode isoform c.
    Source sequence(s)
    AJ420581, AW197622, BC104816, BG676907, CN414510, DA032938, DC377982
    UniProtKB/TrEMBL
    B4DZK9
    Conserved Domains (2) summary
    pfam06544
    Location:94215
    DUF1115; Protein of unknown function (DUF1115)
    cl02687
    Location:268
    RWD; RWD domain
  4. NM_001322339.2NP_001309268.1  RWD domain-containing protein 2A isoform c

    Status: VALIDATED

    Description
    Transcript Variant: This variant (5) uses an alternate splice site in the 5' region and contains an additional internal exon, and it thus differs in its 5' UTR and initiates translation from an alternate start codon, compared to variant 1. The encoded isoform (c) has a distinct N-terminus and is shorter than isoform a. Variants 3, 4 and 5 all encode isoform c.
    Source sequence(s)
    AJ420581, AW197622, BC104816, CD108545, CN414510, DA032938, DC377982
    UniProtKB/TrEMBL
    B4DZK9
    Conserved Domains (2) summary
    pfam06544
    Location:94215
    DUF1115; Protein of unknown function (DUF1115)
    cl02687
    Location:268
    RWD; RWD domain
  5. NM_033411.5NP_219479.2  RWD domain-containing protein 2A isoform a

    See identical proteins and their annotated locations for NP_219479.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longest isoform (a).
    Source sequence(s)
    AJ420581, AK313083, AW197622, BC104816, CN414510, DA032938, DC377982
    Consensus CDS
    CCDS4998.1
    UniProtKB/Swiss-Prot
    B4DIQ3, E1P548, Q2M3R3, Q96FH1, Q9UIY3
    UniProtKB/TrEMBL
    B2R7R2
    Related
    ENSP00000358739.3, ENST00000369724.5
    Conserved Domains (2) summary
    smart00591
    Location:15134
    RWD; domain in RING finger and WD repeat containing proteins and DEXDc-like helicases subfamily related to the UBCc domain
    pfam06544
    Location:160281
    DUF1115; Protein of unknown function (DUF1115)

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000006.12 Reference GRCh38.p14 Primary Assembly

    Range
    83193357..83198935
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047418135.1XP_047274091.1  RWD domain-containing protein 2A isoform X2

  2. XM_047418134.1XP_047274090.1  RWD domain-containing protein 2A isoform X1

    UniProtKB/Swiss-Prot
    B4DIQ3, E1P548, Q2M3R3, Q96FH1, Q9UIY3
  3. XM_017010222.3XP_016865711.1  RWD domain-containing protein 2A isoform X2

    UniProtKB/TrEMBL
    B4DZK9
    Conserved Domains (2) summary
    pfam06544
    Location:94215
    DUF1115; Protein of unknown function (DUF1115)
    cl02687
    Location:268
    RWD; RWD domain
  4. XM_017010223.2XP_016865712.1  RWD domain-containing protein 2A isoform X2

    UniProtKB/TrEMBL
    B4DZK9
    Conserved Domains (2) summary
    pfam06544
    Location:94215
    DUF1115; Protein of unknown function (DUF1115)
    cl02687
    Location:268
    RWD; RWD domain
  5. XM_047418136.1XP_047274092.1  RWD domain-containing protein 2A isoform X2

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060930.1 Alternate T2T-CHM13v2.0

    Range
    84416598..84422177
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054354137.1XP_054210112.1  RWD domain-containing protein 2A isoform X2

  2. XM_054354138.1XP_054210113.1  RWD domain-containing protein 2A isoform X2

  3. XM_054354139.1XP_054210114.1  RWD domain-containing protein 2A isoform X2

  4. XM_054354135.1XP_054210110.1  RWD domain-containing protein 2A isoform X1

    UniProtKB/Swiss-Prot
    B4DIQ3, E1P548, Q2M3R3, Q96FH1, Q9UIY3
  5. XM_054354136.1XP_054210111.1  RWD domain-containing protein 2A isoform X2