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PTGDR2 prostaglandin D2 receptor 2 [ Homo sapiens (human) ]

Gene ID: 11251, updated on 13-Mar-2020

Summary

Official Symbol
PTGDR2provided by HGNC
Official Full Name
prostaglandin D2 receptor 2provided by HGNC
Primary source
HGNC:HGNC:4502
See related
Ensembl:ENSG00000183134 MIM:604837
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
DP2; DL1R; CD294; CRTH2; GPR44
Summary
This gene encodes a G-protein-coupled receptor that is preferentially expressed in CD4+ effector T helper 2 (Th2) cells. This protein is a prostaglandin D2 receptor that mediates the pro-inflammatory chemotaxis of eosinophils, basophils, and Th2 lymphocytes generated during allergic inflammation. Single nucleotide polymorphisms in the 3' UTR of this gene have been associated with asthma susceptibility.[provided by RefSeq, Mar 2011]
Expression
Broad expression in stomach (RPKM 4.7), colon (RPKM 3.6) and 21 other tissues See more
Orthologs

Genomic context

See PTGDR2 in Genome Data Viewer
Location:
11q12.2
Exon count:
2
Annotation release Status Assembly Chr Location
109.20200228 current GRCh38.p13 (GCF_000001405.39) 11 NC_000011.10 (60850933..60855950, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 11 NC_000011.9 (60618398..60623444, complement)

Chromosome 11 - NC_000011.10Genomic Context describing neighboring genes Neighboring gene membrane spanning 4-domains A15 Neighboring gene uncharacterized LOC105369322 Neighboring gene membrane spanning 4-domains A10 Neighboring gene coiled-coil domain containing 86 Neighboring gene zona pellucida glycoprotein 1 Neighboring gene pre-mRNA processing factor 19

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

NHGRI GWAS Catalog

Description
Host-microbe interactions have shaped the genetic architecture of inflammatory bowel disease.
NHGRI GWA Catalog

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
G protein-coupled receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
G protein-coupled receptor activity IDA
Inferred from Direct Assay
more info
PubMed 
neuropeptide binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
peptide binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
prostaglandin D receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
prostaglandin D receptor activity IDA
Inferred from Direct Assay
more info
PubMed 
prostaglandin F receptor activity IEA
Inferred from Electronic Annotation
more info
 
prostaglandin J receptor activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
G protein-coupled receptor signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
G protein-coupled receptor signaling pathway TAS
Traceable Author Statement
more info
 
adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
 
calcium-mediated signaling IDA
Inferred from Direct Assay
more info
PubMed 
chemotaxis IDA
Inferred from Direct Assay
more info
PubMed 
immune response TAS
Traceable Author Statement
more info
PubMed 
negative regulation of male germ cell proliferation IEA
Inferred from Electronic Annotation
more info
 
neuropeptide signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
positive regulation of G protein-coupled receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
integral component of plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
neuron projection IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
plasma membrane TAS
Traceable Author Statement
more info
 

General protein information

Preferred Names
prostaglandin D2 receptor 2
Names
G-protein coupled receptor 44
chemoattractant receptor homologous molecule expressed on T helper type 2 cells
chemoattractant receptor-homologous molecule expressed on TH2 cells
putative G-protein coupled receptor 44

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_016170.1 RefSeqGene

    Range
    5022..10039
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_004778.3NP_004769.2  prostaglandin D2 receptor 2

    See identical proteins and their annotated locations for NP_004769.2

    Status: REVIEWED

    Source sequence(s)
    AP000777
    Consensus CDS
    CCDS7994.1
    UniProtKB/Swiss-Prot
    Q9Y5Y4
    Related
    ENSP00000332812.4, ENST00000332539.5
    Conserved Domains (1) summary
    pfam00001
    Location:49304
    7tm_1; 7 transmembrane receptor (rhodopsin family)

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000011.10 Reference GRCh38.p13 Primary Assembly

    Range
    60850933..60855950 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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