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CAVIN3 caveolae associated protein 3 [ Homo sapiens (human) ]

Gene ID: 112464, updated on 1-Jun-2020

Summary

Official Symbol
CAVIN3provided by HGNC
Official Full Name
caveolae associated protein 3provided by HGNC
Primary source
HGNC:HGNC:9400
See related
Ensembl:ENSG00000170955 MIM:618303
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
SRBC; HSRBC; PRKCDBP; cavin-3
Summary
The protein encoded by this gene was identified as a binding protein of the protein kinase C, delta (PRKCD). The expression of this gene in cultured cell lines is strongly induced by serum starvation. The expression of this protein was found to be down-regulated in various cancer cell lines, suggesting the possible tumor suppressor function of this protein. [provided by RefSeq, Jul 2008]
Expression
Broad expression in fat (RPKM 24.8), testis (RPKM 13.9) and 19 other tissues See more
Orthologs

Genomic context

See CAVIN3 in Genome Data Viewer
Location:
11p15.4
Exon count:
2
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 11 NC_000011.10 (6318946..6320501, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 11 NC_000011.9 (6340176..6341740, complement)

Chromosome 11 - NC_000011.10Genomic Context describing neighboring genes Neighboring gene cyclic nucleotide gated channel subunit alpha 4 Neighboring gene cholecystokinin B receptor Neighboring gene uncharacterized LOC101927825 Neighboring gene Sharpr-MPRA regulatory region 8482 Neighboring gene sphingomyelin phosphodiesterase 1 Neighboring gene amyloid beta precursor protein binding family B member 1

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

NHGRI GWAS Catalog

Description
Genome-wide association study of primary dentition pit-and-fissure and smooth surface caries.
NHGRI GWA Catalog

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC20400

Gene Ontology Provided by GOA

Function Evidence Code Pubs
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein kinase C binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Process Evidence Code Pubs
circadian regulation of gene expression ISS
Inferred from Sequence or Structural Similarity
more info
 
cortical actin cytoskeleton organization IEA
Inferred from Electronic Annotation
more info
 
negative regulation of fermentation IEA
Inferred from Electronic Annotation
more info
 
negative regulation of protein kinase B signaling IEA
Inferred from Electronic Annotation
more info
 
positive regulation of ERK1 and ERK2 cascade IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
caveola IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
caveola IDA
Inferred from Direct Assay
more info
PubMed 
cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cytoplasm ISS
Inferred from Sequence or Structural Similarity
more info
 
cytosol IEA
Inferred from Electronic Annotation
more info
 
protein-containing complex IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
caveolae-associated protein 3
Names
protein kinase C delta binding protein
sdr-related gene product that binds to c-kinase
serum deprivation response factor-related gene product that binds to C-kinase

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_145040.3NP_659477.2  caveolae-associated protein 3

    See identical proteins and their annotated locations for NP_659477.2

    Status: REVIEWED

    Source sequence(s)
    BC011585, BQ434360
    Consensus CDS
    CCDS7762.1
    UniProtKB/Swiss-Prot
    Q969G5
    Related
    ENSP00000307292.3, ENST00000303927.4
    Conserved Domains (1) summary
    pfam15237
    Location:20194
    PTRF_SDPR; PTRF/SDPR family

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000011.10 Reference GRCh38.p13 Primary Assembly

    Range
    6318946..6320501 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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