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CAVIN3 caveolae associated protein 3 [ Homo sapiens (human) ]

Gene ID: 112464, updated on 23-Nov-2023

Summary

Official Symbol
CAVIN3provided by HGNC
Official Full Name
caveolae associated protein 3provided by HGNC
Primary source
HGNC:HGNC:9400
See related
Ensembl:ENSG00000170955 MIM:618303; AllianceGenome:HGNC:9400
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
SRBC; HSRBC; PRKCDBP; cavin-3
Summary
The protein encoded by this gene was identified as a binding protein of the protein kinase C, delta (PRKCD). The expression of this gene in cultured cell lines is strongly induced by serum starvation. The expression of this protein was found to be down-regulated in various cancer cell lines, suggesting the possible tumor suppressor function of this protein. [provided by RefSeq, Jul 2008]
Expression
Broad expression in fat (RPKM 24.8), testis (RPKM 13.9) and 19 other tissues See more
Orthologs
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Genomic context

See CAVIN3 in Genome Data Viewer
Location:
11p15.4
Exon count:
2
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 11 NC_000011.10 (6318946..6320501, complement)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 11 NC_060935.1 (6377369..6378924, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 11 NC_000011.9 (6340176..6341731, complement)

Chromosome 11 - NC_000011.10Genomic Context describing neighboring genes Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3098 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:6256113-6256803 Neighboring gene MPRA-validated peak1186 silencer Neighboring gene cyclic nucleotide gated channel subunit alpha 4 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr11:6291386-6292585 Neighboring gene cholecystokinin B receptor Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr11:6324771-6325489 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:6340407-6341144 Neighboring gene uncharacterized LOC101927825 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4336 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4337 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4338 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4339 Neighboring gene uncharacterized LOC124902623 Neighboring gene Sharpr-MPRA regulatory region 11421 Neighboring gene uncharacterized LOC124902624 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3099

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

EBI GWAS Catalog

Description
Genome-wide association study of primary dentition pit-and-fissure and smooth surface caries.
EBI GWAS Catalog

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Clone Names

  • MGC20400

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein kinase C binding IBA
Inferred from Biological aspect of Ancestor
more info
 
Component Evidence Code Pubs
is_active_in caveola IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in caveola IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in cytoplasm ISS
Inferred from Sequence or Structural Similarity
more info
 
located_in cytosol IEA
Inferred from Electronic Annotation
more info
 
part_of protein-containing complex IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
caveolae-associated protein 3
Names
protein kinase C delta binding protein
sdr-related gene product that binds to c-kinase
serum deprivation response factor-related gene product that binds to C-kinase

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_145040.3NP_659477.2  caveolae-associated protein 3

    See identical proteins and their annotated locations for NP_659477.2

    Status: REVIEWED

    Source sequence(s)
    BC011585, BQ434360
    Consensus CDS
    CCDS7762.1
    UniProtKB/Swiss-Prot
    Q969G5
    UniProtKB/TrEMBL
    E9PIE3
    Related
    ENSP00000307292.3, ENST00000303927.4
    Conserved Domains (1) summary
    pfam15237
    Location:20194
    PTRF_SDPR; PTRF/SDPR family

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000011.10 Reference GRCh38.p14 Primary Assembly

    Range
    6318946..6320501 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060935.1 Alternate T2T-CHM13v2.0

    Range
    6377369..6378924 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)