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ZHX1 zinc fingers and homeoboxes 1 [ Homo sapiens (human) ]

Gene ID: 11244, updated on 7-Dec-2018

Summary

Official Symbol
ZHX1provided by HGNC
Official Full Name
zinc fingers and homeoboxes 1provided by HGNC
Primary source
HGNC:HGNC:12871
See related
Ensembl:ENSG00000165156 MIM:604764
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
The members of the zinc fingers and homeoboxes gene family are nuclear homodimeric transcriptional repressors that interact with the A subunit of nuclear factor-Y (NF-YA) and contain two C2H2-type zinc fingers and five homeobox DNA-binding domains. This gene encodes member 1 of this gene family. In addition to forming homodimers, this protein heterodimerizes with members 2 and 3 of the zinc fingers and homeoboxes family. Alternative splicing results in multiple transcript variants. Read-through transcription also exists between this gene and the downstream chromosome 8 open reading frame 76 (C8orf76) gene. [provided by RefSeq, Feb 2011]
Expression
Ubiquitous expression in thyroid (RPKM 19.7), esophagus (RPKM 16.5) and 25 other tissues See more
Orthologs

Genomic context

See ZHX1 in Genome Data Viewer
Location:
8q24.13
Exon count:
5
Annotation release Status Assembly Chr Location
109 current GRCh38.p12 (GCF_000001405.38) 8 NC_000008.11 (123248450..123275541, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 8 NC_000008.10 (124260690..124287781, complement)

Chromosome 8 - NC_000008.11Genomic Context describing neighboring genes Neighboring gene ZHX1-C8orf76 readthrough Neighboring gene microRNA 4663 Neighboring gene chromosome 8 open reading frame 76 Neighboring gene ubiquitin A-52 residue ribosomal protein fusion product 1 pseudogene 5 Neighboring gene transfer RNA-Phe (GAA) 12-1 Neighboring gene RNA, U6 small nuclear 628, pseudogene Neighboring gene hydroxysteroid 17-beta dehydrogenase 4 pseudogene Neighboring gene ATPase family AAA domain containing 2 Neighboring gene RNA, U6 small nuclear 875, pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Readthrough ZHX1-C8orf76

Readthrough gene: ZHX1-C8orf76, Included gene: C8orf76

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
DNA binding IEA
Inferred from Electronic Annotation
more info
 
DNA-binding transcription factor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
DNA-binding transcription factor activity IDA
Inferred from Direct Assay
more info
PubMed 
DNA-binding transcription factor activity, RNA polymerase II-specific ISA
Inferred from Sequence Alignment
more info
 
DNA-binding transcription factor activity, RNA polymerase II-specific ISM
Inferred from Sequence Model
more info
PubMed 
DNA-binding transcription factor activity, RNA polymerase II-specific NAS
Non-traceable Author Statement
more info
PubMed 
metal ion binding IEA
Inferred from Electronic Annotation
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein heterodimerization activity IDA
Inferred from Direct Assay
more info
PubMed 
transcription corepressor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
transcription corepressor activity IDA
Inferred from Direct Assay
more info
PubMed 
Process Evidence Code Pubs
cell differentiation IEA
Inferred from Electronic Annotation
more info
 
negative regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
negative regulation of transcription by RNA polymerase II IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of transcription, DNA-templated IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
nucleoplasm IDA
Inferred from Direct Assay
more info
 
nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
nucleus IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
zinc fingers and homeoboxes protein 1
Names
zinc finger and homeodomain protein 1
zinc fingers and homeobox 1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001017926.2NP_001017926.1  zinc fingers and homeoboxes protein 1

    See identical proteins and their annotated locations for NP_001017926.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longest transcript. Both variants 1 and 2 encode the same protein.
    Source sequence(s)
    AF106862, AK025236, BC040481, CA776642, CN352595, DA238313
    Consensus CDS
    CCDS6342.1
    UniProtKB/Swiss-Prot
    Q9UKY1
    UniProtKB/TrEMBL
    A0A024R9F1
    Related
    ENSP00000297857.2, ENST00000297857.3
    Conserved Domains (3) summary
    smart00389
    Location:665716
    HOX; Homeodomain
    cd00086
    Location:468523
    homeodomain; Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner.
    pfam11569
    Location:785821
    Homez; Homeodomain leucine-zipper encoding, Homez
  2. NM_007222.5NP_009153.3  zinc fingers and homeoboxes protein 1

    See identical proteins and their annotated locations for NP_009153.3

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) uses an alternate splice site in the 5' UTR, compared to variant 1. Both variants 1 and 2 encode the same protein.
    Source sequence(s)
    AF195766, AK025236, BC040481, CA776642, DA238313
    Consensus CDS
    CCDS6342.1
    UniProtKB/Swiss-Prot
    Q9UKY1
    UniProtKB/TrEMBL
    A0A024R9F1
    Related
    ENSP00000378938.2, ENST00000395571.7
    Conserved Domains (3) summary
    smart00389
    Location:665716
    HOX; Homeodomain
    cd00086
    Location:468523
    homeodomain; Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner.
    pfam11569
    Location:785821
    Homez; Homeodomain leucine-zipper encoding, Homez

RNA

  1. NR_037873.1 RNA Sequence

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) contains an alternate first exon, compared to variant 1. This variant is represented as non-coding due to the presence of an upstream ORF that is predicted to interfere with translation of the downstream ORF, as found in variant 1. Translation of the upstream ORF would render the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AF106862, AK025236, AK289532, BC040481, CA776642
  2. NR_037874.1 RNA Sequence

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) lacks an internal coding exon, compared to variant 1. This variant is represented as non-coding because it lacks the entire coding region, as found in variant 1.
    Source sequence(s)
    AK025236, AK094451, BC040481, CA776642, DA238313

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p12 Primary Assembly

Genomic

  1. NC_000008.11 Reference GRCh38.p12 Primary Assembly

    Range
    123248450..123275541 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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