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PDCD10 programmed cell death 10 [ Homo sapiens (human) ]

Gene ID: 11235, updated on 30-Dec-2018

Summary

Official Symbol
PDCD10provided by HGNC
Official Full Name
programmed cell death 10provided by HGNC
Primary source
HGNC:HGNC:8761
See related
Ensembl:ENSG00000114209 MIM:609118
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
CCM3; TFAR15
Summary
This gene encodes an evolutionarily conserved protein associated with cell apoptosis. The protein interacts with the serine/threonine protein kinase MST4 to modulate the extracellular signal-regulated kinase (ERK) pathway. It also interacts with and is phosphoryated by serine/threonine kinase 25, and is thought to function in a signaling pathway essential for vascular developent. Mutations in this gene are one cause of cerebral cavernous malformations, which are vascular malformations that cause seizures and cerebral hemorrhages. Multiple alternatively spliced variants, encoding the same protein, have been identified. [provided by RefSeq, Jul 2008]
Expression
Ubiquitous expression in colon (RPKM 13.1), lymph node (RPKM 11.6) and 25 other tissues See more
Orthologs

Genomic context

See PDCD10 in Genome Data Viewer
Location:
3q26.1
Exon count:
12
Annotation release Status Assembly Chr Location
109 current GRCh38.p12 (GCF_000001405.38) 3 NC_000003.12 (167683893..167735810, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 3 NC_000003.11 (167401692..167452693, complement)

Chromosome 3 - NC_000003.12Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105374197 Neighboring gene serpin family I member 2 Neighboring gene WD repeat domain 49 Neighboring gene high mobility group nucleosome binding domain 1 pseudogene 8 Neighboring gene serpin family I member 1 Neighboring gene mediator of cell motility 1 pseudogene 3 Neighboring gene leucine rich repeat containing 77, pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Pathways from BioSystems

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC1212, MGC24477

Gene Ontology Provided by GOA

Function Evidence Code Pubs
protein N-terminus binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein homodimerization activity IPI
Inferred from Physical Interaction
more info
PubMed 
protein kinase binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
Golgi reassembly IMP
Inferred from Mutant Phenotype
more info
PubMed 
angiogenesis IEA
Inferred from Electronic Annotation
more info
 
cellular response to leukemia inhibitory factor IEA
Inferred from Electronic Annotation
more info
 
establishment of Golgi localization IMP
Inferred from Mutant Phenotype
more info
PubMed 
intrinsic apoptotic signaling pathway in response to hydrogen peroxide IGI
Inferred from Genetic Interaction
more info
PubMed 
negative regulation of apoptotic process IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of cell migration involved in sprouting angiogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of gene expression IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of MAP kinase activity IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of Notch signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of cell migration IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of cell migration IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of cell proliferation IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of gene expression IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of intracellular protein transport IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of peptidyl-serine phosphorylation IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of protein serine/threonine kinase activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of stress-activated MAPK cascade IDA
Inferred from Direct Assay
more info
PubMed 
protein stabilization IMP
Inferred from Mutant Phenotype
more info
PubMed 
NOT regulation of Rho protein signal transduction IMP
Inferred from Mutant Phenotype
more info
PubMed 
response to hydrogen peroxide IDA
Inferred from Direct Assay
more info
PubMed 
NOT stress fiber assembly IMP
Inferred from Mutant Phenotype
more info
PubMed 
wound healing, spreading of cells IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
Golgi apparatus IDA
Inferred from Direct Assay
more info
PubMed 
colocalizes_with Golgi apparatus IDA
Inferred from Direct Assay
more info
PubMed 
Golgi membrane IEA
Inferred from Electronic Annotation
more info
 
cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
cytosol IDA
Inferred from Direct Assay
more info
PubMed 
extracellular exosome HDA PubMed 
plasma membrane IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
programmed cell death protein 10
Names
TF-1 cell apoptosis-related protein 15
apoptosis-related protein 15
cerebral cavernous malformations 3 protein

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_008158.1 RefSeqGene

    Range
    5058..55958
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_007217.4NP_009148.2  programmed cell death protein 10

    See identical proteins and their annotated locations for NP_009148.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longest transcript. Variants 1, 2, and 3 encode the same isoform.
    Source sequence(s)
    AC079822
    Consensus CDS
    CCDS3202.1
    UniProtKB/Swiss-Prot
    Q9BUL8
    Related
    ENSP00000376506.2, ENST00000392750.6
    Conserved Domains (1) summary
    pfam06840
    Location:14161
    DUF1241; Protein of unknown function (DUF1241)
  2. NM_145859.1NP_665858.1  programmed cell death protein 10

    See identical proteins and their annotated locations for NP_665858.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1, 2, and 3 encode the same isoform.
    Source sequence(s)
    BC016353
    Consensus CDS
    CCDS3202.1
    UniProtKB/Swiss-Prot
    Q9BUL8
    Related
    ENSP00000418317.2, ENST00000473645.6
    Conserved Domains (1) summary
    pfam06840
    Location:14161
    DUF1241; Protein of unknown function (DUF1241)
  3. NM_145860.1NP_665859.1  programmed cell death protein 10

    See identical proteins and their annotated locations for NP_665859.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR compared to variant 1. Variants 1, 2, and 3 encode the same isoform.
    Source sequence(s)
    AF022385
    Consensus CDS
    CCDS3202.1
    UniProtKB/Swiss-Prot
    Q9BUL8
    Related
    ENSP00000420553.2, ENST00000497056.6
    Conserved Domains (1) summary
    pfam06840
    Location:14161
    DUF1241; Protein of unknown function (DUF1241)

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p12 Primary Assembly

Genomic

  1. NC_000003.12 Reference GRCh38.p12 Primary Assembly

    Range
    167683893..167735810 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017005645.2XP_016861134.1  programmed cell death protein 10 isoform X2

    UniProtKB/TrEMBL
    C9J363
    Conserved Domains (1) summary
    pfam06840
    Location:198
    DUF1241; Protein of unknown function (DUF1241)
  2. XM_024453329.1XP_024309097.1  programmed cell death protein 10 isoform X2

    Related
    ENSP00000417309.1, ENST00000492396.5
    Conserved Domains (1) summary
    pfam06840
    Location:198
    DUF1241; Protein of unknown function (DUF1241)
  3. XM_024453331.1XP_024309099.1  programmed cell death protein 10 isoform X2

    Conserved Domains (1) summary
    pfam06840
    Location:198
    DUF1241; Protein of unknown function (DUF1241)
  4. XM_024453330.1XP_024309098.1  programmed cell death protein 10 isoform X2

    Conserved Domains (1) summary
    pfam06840
    Location:198
    DUF1241; Protein of unknown function (DUF1241)
  5. XM_005247086.5XP_005247143.1  programmed cell death protein 10 isoform X1

    See identical proteins and their annotated locations for XP_005247143.1

    UniProtKB/Swiss-Prot
    Q9BUL8
    Related
    ENSP00000417202.1, ENST00000470131.5
    Conserved Domains (1) summary
    pfam06840
    Location:14161
    DUF1241; Protein of unknown function (DUF1241)
  6. XM_011512368.3XP_011510670.1  programmed cell death protein 10 isoform X1

    See identical proteins and their annotated locations for XP_011510670.1

    UniProtKB/Swiss-Prot
    Q9BUL8
    Conserved Domains (1) summary
    pfam06840
    Location:14161
    DUF1241; Protein of unknown function (DUF1241)
  7. XM_005247087.5XP_005247144.1  programmed cell death protein 10 isoform X1

    See identical proteins and their annotated locations for XP_005247144.1

    UniProtKB/Swiss-Prot
    Q9BUL8
    Conserved Domains (1) summary
    pfam06840
    Location:14161
    DUF1241; Protein of unknown function (DUF1241)
  8. XM_011512369.3XP_011510671.1  programmed cell death protein 10 isoform X1

    See identical proteins and their annotated locations for XP_011510671.1

    UniProtKB/Swiss-Prot
    Q9BUL8
    Conserved Domains (1) summary
    pfam06840
    Location:14161
    DUF1241; Protein of unknown function (DUF1241)
  9. XM_006713485.4XP_006713548.1  programmed cell death protein 10 isoform X1

    See identical proteins and their annotated locations for XP_006713548.1

    UniProtKB/Swiss-Prot
    Q9BUL8
    Related
    ENSP00000417118.2, ENST00000475915.6
    Conserved Domains (1) summary
    pfam06840
    Location:14161
    DUF1241; Protein of unknown function (DUF1241)
  10. XM_017005644.2XP_016861133.1  programmed cell death protein 10 isoform X1

    UniProtKB/Swiss-Prot
    Q9BUL8
    Conserved Domains (1) summary
    pfam06840
    Location:14161
    DUF1241; Protein of unknown function (DUF1241)
  11. XM_005247088.4XP_005247145.1  programmed cell death protein 10 isoform X1

    See identical proteins and their annotated locations for XP_005247145.1

    UniProtKB/Swiss-Prot
    Q9BUL8
    Related
    ENSP00000420021.1, ENST00000461494.5
    Conserved Domains (1) summary
    pfam06840
    Location:14161
    DUF1241; Protein of unknown function (DUF1241)
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