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RASSF8 Ras association domain family member 8 [ Homo sapiens (human) ]

Gene ID: 11228, updated on 25-Nov-2025
Official Symbol
RASSF8provided by HGNC
Official Full Name
Ras association domain family member 8provided by HGNC
Primary source
HGNC:HGNC:13232
See related
Ensembl:ENSG00000123094 MIM:608231; AllianceGenome:HGNC:13232
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
HOJ1; C12orf2
Summary
This gene encodes a member of the Ras-assocation domain family (RASSF) of tumor suppressor proteins. This gene is essential for maintaining adherens junction function in epithelial cells and has a role in epithelial cell migration. It is a lung tumor suppressor gene candidate. A chromosomal translocation t(12;22)(p11.2;q13.3) leading to the fusion of this gene and the FBLN1 gene is found in a complex type of synpolydactyly. Multiple alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2011]
Expression
Broad expression in testis (RPKM 13.9), endometrium (RPKM 13.0) and 23 other tissues See more
Orthologs
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See RASSF8 in Genome Data Viewer
Location:
12p12.1
Exon count:
15
Annotation release Status Assembly Chr Location
RS_2025_08 current GRCh38.p14 (GCF_000001405.40) 12 NC_000012.12 (25958232..26079889)
RS_2025_08 current T2T-CHM13v2.0 (GCF_009914755.1) 12 NC_060936.1 (25830796..25952417)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 12 NC_000012.11 (26111165..26232822)

Chromosome 12 - NC_000012.12Genomic Context describing neighboring genes Neighboring gene thymine-DNA glycosylase pseudogene 1 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr12:26038654-26039197 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr12:26040173-26040831 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_26717 Neighboring gene microRNA 4302 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 4295 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 4296 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 4297 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 4298 Neighboring gene RASSF8 antisense RNA 1 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr12:26150508-26151264 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr12:26151265-26152021 Neighboring gene uncharacterized LOC107984501 Neighboring gene uncharacterized LOC124902901 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr12:26200376-26200975 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 4299 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 4300 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 4301 Neighboring gene basic helix-loop-helix family member e41 Neighboring gene sarcospan Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_26866 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr12:26379181-26379816 Neighboring gene SSPN antisense RNA 1 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 6118 Neighboring gene MED14-independent group 3 enhancer GRCh37_chr12:26398995-26400194 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_26902 Neighboring gene uncharacterized LOC105369705

  • Project title: Tissue-specific circular RNA induction during human fetal development
  • Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
  • BioProject: PRJNA270632
  • Publication: PMID 26076956
  • Analysis date: Mon Apr 2 22:54:59 2018

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
Products Interactant Other Gene Complex Source Pubs Description

Markers

Clone Names

  • FLJ11542, DKFZp434O0227

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
involved_in signal transduction IEA
Inferred from Electronic Annotation
more info
 
Preferred Names
ras association domain-containing protein 8
Names
Ras association (RalGDS/AF-6) domain family (N-terminal) member 8
carcinoma-associated protein HOJ-1

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_029077.1 RefSeqGene

    Range
    4652..118839
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001164746.2NP_001158218.1  ras association domain-containing protein 8 isoform a

    See identical proteins and their annotated locations for NP_001158218.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longer isoform (a). Variants 1, 2 and 3 encode the same isoform.
    Source sequence(s)
    AC055707, AK292333, AY665468, BE440096, DB055998
    Consensus CDS
    CCDS53765.1
    UniProtKB/Swiss-Prot
    A8K1Z0, O95647, Q5SCI2, Q76KB6, Q8NHQ8
    UniProtKB/TrEMBL
    A8K8G8
    Related
    ENSP00000282884.9, ENST00000282884.13
    Conserved Domains (2) summary
    COG1196
    Location:160351
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    cd16134
    Location:283
    RA_RASSF8; Ras-associating (RA) domain found in N-terminal Ras-association domain family 8 (RASSF8)
  2. NM_001164747.2NP_001158219.1  ras association domain-containing protein 8 isoform a

    See identical proteins and their annotated locations for NP_001158219.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1, 2 and 3 encode the same isoform (a).
    Source sequence(s)
    AC055707, AK290055, AY665468, BE440096
    Consensus CDS
    CCDS53765.1
    UniProtKB/Swiss-Prot
    A8K1Z0, O95647, Q5SCI2, Q76KB6, Q8NHQ8
    UniProtKB/TrEMBL
    A8K8G8
    Related
    ENSP00000439839.1, ENST00000542865.5
    Conserved Domains (2) summary
    COG1196
    Location:160351
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    cd16134
    Location:283
    RA_RASSF8; Ras-associating (RA) domain found in N-terminal Ras-association domain family 8 (RASSF8)
  3. NM_001164748.2NP_001158220.1  ras association domain-containing protein 8 isoform a

    See identical proteins and their annotated locations for NP_001158220.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR compared to variant 1. Variants 1, 2 and 3 encode the same isoform (a).
    Source sequence(s)
    AB093206, AC055707, BE440096, DB044325
    Consensus CDS
    CCDS53765.1
    UniProtKB/Swiss-Prot
    A8K1Z0, O95647, Q5SCI2, Q76KB6, Q8NHQ8
    UniProtKB/TrEMBL
    A8K8G8
    Related
    ENSP00000384491.1, ENST00000405154.6
    Conserved Domains (2) summary
    COG1196
    Location:160351
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    cd16134
    Location:283
    RA_RASSF8; Ras-associating (RA) domain found in N-terminal Ras-association domain family 8 (RASSF8)
  4. NM_001394094.1NP_001381023.1  ras association domain-containing protein 8 isoform a

    Status: REVIEWED

    Source sequence(s)
    AC055707
    Consensus CDS
    CCDS53765.1
    UniProtKB/Swiss-Prot
    A8K1Z0, O95647, Q5SCI2, Q76KB6, Q8NHQ8
    UniProtKB/TrEMBL
    A8K8G8
    Related
    ENSP00000509001.1, ENST00000688511.1
    Conserved Domains (2) summary
    COG1196
    Location:160351
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    cd16134
    Location:283
    RA_RASSF8; Ras-associating (RA) domain found in N-terminal Ras-association domain family 8 (RASSF8)
  5. NM_001394095.1NP_001381024.1  ras association domain-containing protein 8 isoform a

    Status: REVIEWED

    Source sequence(s)
    AC055707
    Consensus CDS
    CCDS53765.1
    UniProtKB/Swiss-Prot
    A8K1Z0, O95647, Q5SCI2, Q76KB6, Q8NHQ8
    UniProtKB/TrEMBL
    A8K8G8
    Related
    ENSP00000509645.1, ENST00000689434.1
    Conserved Domains (2) summary
    COG1196
    Location:160351
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    cd16134
    Location:283
    RA_RASSF8; Ras-associating (RA) domain found in N-terminal Ras-association domain family 8 (RASSF8)
  6. NM_001394096.1NP_001381025.1  ras association domain-containing protein 8 isoform a

    Status: REVIEWED

    Source sequence(s)
    AC055707
    Consensus CDS
    CCDS53765.1
    UniProtKB/Swiss-Prot
    A8K1Z0, O95647, Q5SCI2, Q76KB6, Q8NHQ8
    UniProtKB/TrEMBL
    A8K8G8
    Related
    ENSP00000623863.1, ENST00000953804.1
    Conserved Domains (2) summary
    COG1196
    Location:160351
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    cd16134
    Location:283
    RA_RASSF8; Ras-associating (RA) domain found in N-terminal Ras-association domain family 8 (RASSF8)
  7. NM_001394097.1NP_001381026.1  ras association domain-containing protein 8 isoform a

    Status: REVIEWED

    Source sequence(s)
    AC055707
    Consensus CDS
    CCDS53765.1
    UniProtKB/Swiss-Prot
    A8K1Z0, O95647, Q5SCI2, Q76KB6, Q8NHQ8
    UniProtKB/TrEMBL
    A8K8G8
    Related
    ENSP00000623866.1, ENST00000953807.1
    Conserved Domains (2) summary
    COG1196
    Location:160351
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    cd16134
    Location:283
    RA_RASSF8; Ras-associating (RA) domain found in N-terminal Ras-association domain family 8 (RASSF8)
  8. NM_001394098.1NP_001381027.1  ras association domain-containing protein 8 isoform a

    Status: REVIEWED

    Source sequence(s)
    AC055707
    Consensus CDS
    CCDS53765.1
    UniProtKB/Swiss-Prot
    A8K1Z0, O95647, Q5SCI2, Q76KB6, Q8NHQ8
    UniProtKB/TrEMBL
    A8K8G8
    Related
    ENSP00000510086.1, ENST00000689635.1
    Conserved Domains (2) summary
    COG1196
    Location:160351
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    cd16134
    Location:283
    RA_RASSF8; Ras-associating (RA) domain found in N-terminal Ras-association domain family 8 (RASSF8)
  9. NM_001394099.1NP_001381028.1  ras association domain-containing protein 8 isoform a

    Status: REVIEWED

    Source sequence(s)
    AC055707
    Consensus CDS
    CCDS53765.1
    UniProtKB/Swiss-Prot
    A8K1Z0, O95647, Q5SCI2, Q76KB6, Q8NHQ8
    UniProtKB/TrEMBL
    A8K8G8
    Related
    ENSP00000586421.1, ENST00000916362.1
    Conserved Domains (2) summary
    COG1196
    Location:160351
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    cd16134
    Location:283
    RA_RASSF8; Ras-associating (RA) domain found in N-terminal Ras-association domain family 8 (RASSF8)
  10. NM_001394100.1NP_001381029.1  ras association domain-containing protein 8 isoform a

    Status: REVIEWED

    Source sequence(s)
    AC055707
    Consensus CDS
    CCDS53765.1
    UniProtKB/Swiss-Prot
    A8K1Z0, O95647, Q5SCI2, Q76KB6, Q8NHQ8
    UniProtKB/TrEMBL
    A8K8G8
    Conserved Domains (2) summary
    COG1196
    Location:160351
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    cd16134
    Location:283
    RA_RASSF8; Ras-associating (RA) domain found in N-terminal Ras-association domain family 8 (RASSF8)
  11. NM_001394101.1NP_001381030.1  ras association domain-containing protein 8 isoform a

    Status: REVIEWED

    Source sequence(s)
    AC055707
    Consensus CDS
    CCDS53765.1
    UniProtKB/Swiss-Prot
    A8K1Z0, O95647, Q5SCI2, Q76KB6, Q8NHQ8
    UniProtKB/TrEMBL
    A8K8G8
    Conserved Domains (2) summary
    COG1196
    Location:160351
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    cd16134
    Location:283
    RA_RASSF8; Ras-associating (RA) domain found in N-terminal Ras-association domain family 8 (RASSF8)
  12. NM_001394102.1NP_001381031.1  ras association domain-containing protein 8 isoform a

    Status: REVIEWED

    Source sequence(s)
    AC055707
    Consensus CDS
    CCDS53765.1
    UniProtKB/Swiss-Prot
    A8K1Z0, O95647, Q5SCI2, Q76KB6, Q8NHQ8
    UniProtKB/TrEMBL
    A8K8G8
    Related
    ENSP00000536687.1, ENST00000866628.1
    Conserved Domains (2) summary
    COG1196
    Location:160351
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    cd16134
    Location:283
    RA_RASSF8; Ras-associating (RA) domain found in N-terminal Ras-association domain family 8 (RASSF8)
  13. NM_007211.5NP_009142.2  ras association domain-containing protein 8 isoform b

    See identical proteins and their annotated locations for NP_009142.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) differs in both UTRs and in the 3' coding region, compared to variant 1. The encoded isoform (b) has a distinct C-terminus and is shorter than isoform a.
    Source sequence(s)
    AC055707, BC030021
    Consensus CDS
    CCDS8705.1
    UniProtKB/TrEMBL
    A8K8G8
    Related
    ENSP00000370756.3, ENST00000381352.7
    Conserved Domains (2) summary
    COG1196
    Location:160351
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    cd16134
    Location:283
    RA_RASSF8; Ras-associating (RA) domain found in N-terminal Ras-association domain family 8 (RASSF8)

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2025_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000012.12 Reference GRCh38.p14 Primary Assembly

    Range
    25958232..26079889
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047428189.1XP_047284145.1  ras association domain-containing protein 8 isoform X1

    UniProtKB/Swiss-Prot
    A8K1Z0, O95647, Q5SCI2, Q76KB6, Q8NHQ8
    UniProtKB/TrEMBL
    A8K8G8
  2. XM_047428188.1XP_047284144.1  ras association domain-containing protein 8 isoform X1

    UniProtKB/Swiss-Prot
    A8K1Z0, O95647, Q5SCI2, Q76KB6, Q8NHQ8
    UniProtKB/TrEMBL
    A8K8G8
    Related
    ENSP00000623867.1, ENST00000953808.1
  3. XM_047428187.1XP_047284143.1  ras association domain-containing protein 8 isoform X1

    UniProtKB/Swiss-Prot
    A8K1Z0, O95647, Q5SCI2, Q76KB6, Q8NHQ8
    UniProtKB/TrEMBL
    A8K8G8
  4. XM_047428191.1XP_047284147.1  ras association domain-containing protein 8 isoform X1

    UniProtKB/Swiss-Prot
    A8K1Z0, O95647, Q5SCI2, Q76KB6, Q8NHQ8
    UniProtKB/TrEMBL
    A8K8G8
  5. XM_047428192.1XP_047284148.1  ras association domain-containing protein 8 isoform X1

    UniProtKB/Swiss-Prot
    A8K1Z0, O95647, Q5SCI2, Q76KB6, Q8NHQ8
    UniProtKB/TrEMBL
    A8K8G8
  6. XM_047428190.1XP_047284146.1  ras association domain-containing protein 8 isoform X1

    UniProtKB/Swiss-Prot
    A8K1Z0, O95647, Q5SCI2, Q76KB6, Q8NHQ8
    UniProtKB/TrEMBL
    A8K8G8
  7. XM_047428186.1XP_047284142.1  ras association domain-containing protein 8 isoform X1

    UniProtKB/Swiss-Prot
    A8K1Z0, O95647, Q5SCI2, Q76KB6, Q8NHQ8
    UniProtKB/TrEMBL
    A8K8G8
  8. XM_006719028.1XP_006719091.1  ras association domain-containing protein 8 isoform X1

    See identical proteins and their annotated locations for XP_006719091.1

    UniProtKB/Swiss-Prot
    A8K1Z0, O95647, Q5SCI2, Q76KB6, Q8NHQ8
    UniProtKB/TrEMBL
    A8K8G8
    Conserved Domains (2) summary
    COG1196
    Location:160351
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    cd16134
    Location:283
    RA_RASSF8; Ras-associating (RA) domain found in N-terminal Ras-association domain family 8 (RASSF8)
  9. XM_024448820.2XP_024304588.1  ras association domain-containing protein 8 isoform X1

    UniProtKB/Swiss-Prot
    A8K1Z0, O95647, Q5SCI2, Q76KB6, Q8NHQ8
    UniProtKB/TrEMBL
    A8K8G8
    Conserved Domains (2) summary
    COG1196
    Location:160351
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    cd16134
    Location:283
    RA_RASSF8; Ras-associating (RA) domain found in N-terminal Ras-association domain family 8 (RASSF8)
  10. XM_006719027.3XP_006719090.1  ras association domain-containing protein 8 isoform X1

    See identical proteins and their annotated locations for XP_006719090.1

    UniProtKB/Swiss-Prot
    A8K1Z0, O95647, Q5SCI2, Q76KB6, Q8NHQ8
    UniProtKB/TrEMBL
    A8K8G8
    Conserved Domains (2) summary
    COG1196
    Location:160351
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    cd16134
    Location:283
    RA_RASSF8; Ras-associating (RA) domain found in N-terminal Ras-association domain family 8 (RASSF8)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060936.1 Alternate T2T-CHM13v2.0

    Range
    25830796..25952417
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054370930.1XP_054226905.1  ras association domain-containing protein 8 isoform X1

    UniProtKB/Swiss-Prot
    A8K1Z0, O95647, Q5SCI2, Q76KB6, Q8NHQ8
    UniProtKB/TrEMBL
    A8K8G8
  2. XM_054370931.1XP_054226906.1  ras association domain-containing protein 8 isoform X1

    UniProtKB/Swiss-Prot
    A8K1Z0, O95647, Q5SCI2, Q76KB6, Q8NHQ8
    UniProtKB/TrEMBL
    A8K8G8
  3. XM_054370932.1XP_054226907.1  ras association domain-containing protein 8 isoform X1

    UniProtKB/Swiss-Prot
    A8K1Z0, O95647, Q5SCI2, Q76KB6, Q8NHQ8
    UniProtKB/TrEMBL
    A8K8G8
  4. XM_054370925.1XP_054226900.1  ras association domain-containing protein 8 isoform X1

    UniProtKB/Swiss-Prot
    A8K1Z0, O95647, Q5SCI2, Q76KB6, Q8NHQ8
    UniProtKB/TrEMBL
    A8K8G8
  5. XM_054370929.1XP_054226904.1  ras association domain-containing protein 8 isoform X1

    UniProtKB/Swiss-Prot
    A8K1Z0, O95647, Q5SCI2, Q76KB6, Q8NHQ8
    UniProtKB/TrEMBL
    A8K8G8
  6. XM_054370926.1XP_054226901.1  ras association domain-containing protein 8 isoform X1

    UniProtKB/Swiss-Prot
    A8K1Z0, O95647, Q5SCI2, Q76KB6, Q8NHQ8
    UniProtKB/TrEMBL
    A8K8G8
  7. XM_054370927.1XP_054226902.1  ras association domain-containing protein 8 isoform X1

    UniProtKB/Swiss-Prot
    A8K1Z0, O95647, Q5SCI2, Q76KB6, Q8NHQ8
    UniProtKB/TrEMBL
    A8K8G8
  8. XM_054370928.1XP_054226903.1  ras association domain-containing protein 8 isoform X1

    UniProtKB/Swiss-Prot
    A8K1Z0, O95647, Q5SCI2, Q76KB6, Q8NHQ8
    UniProtKB/TrEMBL
    A8K8G8