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DUSP10 dual specificity phosphatase 10 [ Homo sapiens (human) ]

Gene ID: 11221, updated on 3-May-2020

Summary

Official Symbol
DUSP10provided by HGNC
Official Full Name
dual specificity phosphatase 10provided by HGNC
Primary source
HGNC:HGNC:3065
See related
Ensembl:ENSG00000143507 MIM:608867
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
MKP5; MKP-5
Summary
Dual specificity protein phosphatases inactivate their target kinases by dephosphorylating both the phosphoserine/threonine and phosphotyrosine residues. They negatively regulate members of the MAP kinase superfamily, which is associated with cellular proliferation and differentiation. Different members of this family of dual specificity phosphatases show distinct substrate specificities for MAP kinases, different tissue distribution and subcellular localization, and different modes of expression induction by extracellular stimuli. This gene product binds to and inactivates p38 and SAPK/JNK. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2014]
Expression
Broad expression in liver (RPKM 11.1), bone marrow (RPKM 10.7) and 22 other tissues See more
Orthologs

Genomic context

See DUSP10 in Genome Data Viewer
Location:
1q41
Exon count:
5
Annotation release Status Assembly Chr Location
109.20200228 current GRCh38.p13 (GCF_000001405.39) 1 NC_000001.11 (221701420..221742176, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (221874764..221916204, complement)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC107985462 Neighboring gene solute carrier family 35 member E3 pseudogene Neighboring gene uncharacterized LOC105372937 Neighboring gene uncharacterized LOC105372945 Neighboring gene FOXA motif-containing MPRA enhancer 201 Neighboring gene uncharacterized LOC107985300 Neighboring gene long intergenic non-protein coding RNA 1655 Neighboring gene RNA, U6 small nuclear 403, pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

NHGRI GWAS Catalog

Description
Genetic Variants Associated with Serum Thyroid Stimulating Hormone (TSH) Levels in European Americans and African Americans from the eMERGE Network.
NHGRI GWA Catalog
Large-scale genetic study in East Asians identifies six new loci associated with colorectal cancer risk.
NHGRI GWA Catalog
Meta-analysis of three genome-wide association studies identifies susceptibility loci for colorectal cancer at 1q41, 3q26.2, 12q13.13 and 20q13.33.
NHGRI GWA Catalog

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
JUN kinase binding IDA
Inferred from Direct Assay
more info
PubMed 
MAP kinase phosphatase activity IDA
Inferred from Direct Assay
more info
PubMed 
MAP kinase phosphatase activity ISS
Inferred from Sequence or Structural Similarity
more info
 
MAP kinase tyrosine phosphatase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
MAP kinase tyrosine/serine/threonine phosphatase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
MAP kinase tyrosine/serine/threonine phosphatase activity IEA
Inferred from Electronic Annotation
more info
 
mitogen-activated protein kinase binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
mitogen-activated protein kinase p38 binding IPI
Inferred from Physical Interaction
more info
PubMed 
phosphatase activity IDA
Inferred from Direct Assay
more info
PubMed 
phosphoprotein phosphatase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein tyrosine phosphatase activity IEA
Inferred from Electronic Annotation
more info
 
protein tyrosine/threonine phosphatase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
protein tyrosine/threonine phosphatase activity IDA
Inferred from Direct Assay
more info
PubMed 
Process Evidence Code Pubs
dephosphorylation IDA
Inferred from Direct Assay
more info
PubMed 
inactivation of MAPK activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
inactivation of MAPK activity IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of ERK1 and ERK2 cascade ISS
Inferred from Sequence or Structural Similarity
more info
 
negative regulation of JNK cascade IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
negative regulation of JNK cascade IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of JUN kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
negative regulation of JUN kinase activity IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of cell migration NAS
Non-traceable Author Statement
more info
PubMed 
negative regulation of epithelial cell migration ISS
Inferred from Sequence or Structural Similarity
more info
 
negative regulation of epithelial cell proliferation ISS
Inferred from Sequence or Structural Similarity
more info
 
negative regulation of epithelium regeneration ISS
Inferred from Sequence or Structural Similarity
more info
 
negative regulation of oligodendrocyte differentiation IEA
Inferred from Electronic Annotation
more info
 
negative regulation of p38MAPK cascade IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of p38MAPK cascade NAS
Non-traceable Author Statement
more info
PubMed 
negative regulation of protein kinase activity by regulation of protein phosphorylation IEA
Inferred from Electronic Annotation
more info
 
negative regulation of respiratory burst involved in inflammatory response IEA
Inferred from Electronic Annotation
more info
 
oligodendrocyte differentiation IEA
Inferred from Electronic Annotation
more info
 
peptidyl-threonine dephosphorylation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
peptidyl-threonine dephosphorylation IDA
Inferred from Direct Assay
more info
PubMed 
peptidyl-tyrosine dephosphorylation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
peptidyl-tyrosine dephosphorylation involved in inactivation of protein kinase activity IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of regulatory T cell differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
protein dephosphorylation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
protein dephosphorylation IDA
Inferred from Direct Assay
more info
PubMed 
regulation of adaptive immune response IEA
Inferred from Electronic Annotation
more info
 
regulation of brown fat cell differentiation IEA
Inferred from Electronic Annotation
more info
 
response to lipopolysaccharide IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
Golgi apparatus IDA
Inferred from Direct Assay
more info
 
cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
cytosol IDA
Inferred from Direct Assay
more info
 
nuclear speck IDA
Inferred from Direct Assay
more info
 
nucleoplasm IDA
Inferred from Direct Assay
more info
 
nucleus IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
dual specificity protein phosphatase 10
Names
dual specificity phosphatase MKP-5
map kinase phosphatase 5
mitogen-activated protein kinase phosphatase 5
serine/threonine specific protein phosphatase
NP_009138.1
XP_016855636.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_007207.6NP_009138.1  dual specificity protein phosphatase 10

    See identical proteins and their annotated locations for NP_009138.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the functional protein.
    Source sequence(s)
    AI261880, BC031405, BC063826, BG720911
    Consensus CDS
    CCDS1528.1
    UniProtKB/Swiss-Prot
    Q9Y6W6
    Related
    ENSP00000355866.3, ENST00000366899.4
    Conserved Domains (2) summary
    cd00127
    Location:321459
    DSPc; Dual specificity phosphatases (DSP); Ser/Thr and Tyr protein phosphatases. Structurally similar to tyrosine-specific phosphatases but with a shallower active site cleft and a distinctive active site signature motif, HCxxGxxR. Characterized as VHR- or ...
    cd01446
    Location:149284
    DSP_MapKP; N-terminal regulatory rhodanese domain of dual specificity phosphatases (DSP), such as Mapk Phosphatase. This domain is believed to determine substrate specificity by binding the substrate, such as ERK2, and activating the C-terminal catalytic domain by ...

RNA

  1. NR_111939.1 RNA Sequence

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) lacks two 5' exons, and contains an alternate 5'-terminal exon, compared to variant 1. This variant is represented as non-coding because the predicted protein does not meet RefSeq quality criteria.
    Source sequence(s)
    AI261880, BC020608, BC063826
    Related
    ENST00000468085.5
  2. NR_111940.1 RNA Sequence

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) lacks an internal exon, compared to variant 1. This variant is represented as non-coding because the predicted protein does not meet RefSeq quality criteria.
    Source sequence(s)
    AI261880, BC031405, BC063826, BG720911

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p13 Primary Assembly

    Range
    221701420..221742176 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017000147.2XP_016855636.1  dual specificity protein phosphatase 10 isoform X1

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_144728.2: Suppressed sequence

    Description
    NM_144728.2: This RefSeq was permanently suppressed because currently there is support for the transcript but not for the protein.
  2. NM_144729.2: Suppressed sequence

    Description
    NM_144729.2: This RefSeq was permanently suppressed because currently there is support for the transcript but not for the protein.
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