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TREH trehalase [ Homo sapiens (human) ]

Gene ID: 11181, updated on 11-Sep-2019

Summary

Official Symbol
TREHprovided by HGNC
Official Full Name
trehalaseprovided by HGNC
Primary source
HGNC:HGNC:12266
See related
Ensembl:ENSG00000118094 MIM:275360
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
TRE; TREA; TREHD
Summary
This gene encodes an enzyme that hydrolyses trehalose, a disaccharide formed from two glucose molecules found mainly in fungi, plants, and insects. A partial duplication of this gene is located adjacent to this locus on chromosome 11. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2014]
Expression
Biased expression in duodenum (RPKM 44.4), small intestine (RPKM 43.7) and 1 other tissue See more
Orthologs

Genomic context

See TREH in Genome Data Viewer
Location:
11q23.3
Exon count:
15
Annotation release Status Assembly Chr Location
109.20190905 current GRCh38.p13 (GCF_000001405.39) 11 NC_000011.10 (118657316..118679650, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 11 NC_000011.9 (118528942..118550381, complement)

Chromosome 11 - NC_000011.10Genomic Context describing neighboring genes Neighboring gene archain 1 Neighboring gene RNA, U6 small nuclear 1157, pseudogene Neighboring gene pleckstrin homology like domain family B member 1 Neighboring gene microRNA 6716 Neighboring gene Sharpr-MPRA regulatory region 11464 Neighboring gene uncharacterized LOC105369519 Neighboring gene trehalase pseudogene 1 Neighboring gene RNA, U6 small nuclear 376, pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

Associated conditions

Description Tests
alpha, alpha-Trehalase deficiency
MedGen: C0268187 OMIM: 612119 GeneReviews: Not available
not available

NHGRI GWAS Catalog

Description
Association analyses identify three susceptibility Loci for vitiligo in the Chinese Han population.
NHGRI GWA Catalog
Genetic determinants influencing human serum metabolome among African Americans.
NHGRI GWA Catalog
Hundreds of variants clustered in genomic loci and biological pathways affect human height.
NHGRI GWA Catalog

Pathways from BioSystems

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC129621

Gene Ontology Provided by GOA

Function Evidence Code Pubs
alpha,alpha-trehalase activity IDA
Inferred from Direct Assay
more info
PubMed 
Process Evidence Code Pubs
animal organ morphogenesis IEA
Inferred from Electronic Annotation
more info
 
trehalose catabolic process IDA
Inferred from Direct Assay
more info
PubMed 
trehalose metabolic process NAS
Non-traceable Author Statement
more info
PubMed 
Component Evidence Code Pubs
anchored component of membrane ISS
Inferred from Sequence or Structural Similarity
more info
 
anchored component of plasma membrane TAS
Traceable Author Statement
more info
PubMed 
extracellular exosome HDA PubMed 

General protein information

Preferred Names
trehalase
Names
alpha,alpha-trehalose glucohydrolase
trehalase (brush-border membrane glycoprotein)
NP_001287994.1
NP_009111.2

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_023321.1 RefSeqGene

    Range
    5023..27357
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001301065.2NP_001287994.1  trehalase isoform 2 precursor

    See identical proteins and their annotated locations for NP_001287994.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) lacks an alternate in-frame exon compared to variant 1. The resulting isoform (2) has the same N- and C-termini but is shorter compared to isoform 1.
    Source sequence(s)
    AK223140, AP000941, BC109206
    Consensus CDS
    CCDS73401.1
    UniProtKB/Swiss-Prot
    O43280
    Related
    ENSP00000381020.2, ENST00000397925.2
    Conserved Domains (1) summary
    pfam01204
    Location:46519
    Trehalase; Trehalase
  2. NM_007180.3NP_009111.2  trehalase isoform 1 precursor

    See identical proteins and their annotated locations for NP_009111.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AK223140, AK223143, AP000941
    Consensus CDS
    CCDS73402.1
    UniProtKB/Swiss-Prot
    O43280
    Related
    ENSP00000264029.5, ENST00000264029.8
    Conserved Domains (2) summary
    COG1626
    Location:22552
    TreA; Neutral trehalase [Carbohydrate transport and metabolism]
    pfam01204
    Location:46550
    Trehalase; Trehalase

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000011.10 Reference GRCh38.p13 Primary Assembly

    Range
    118657316..118679650 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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