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PLAAT3 phospholipase A and acyltransferase 3 [ Homo sapiens (human) ]

Gene ID: 11145, updated on 22-Aug-2021

Summary

Official Symbol
PLAAT3provided by HGNC
Official Full Name
phospholipase A and acyltransferase 3provided by HGNC
Primary source
HGNC:HGNC:17825
See related
Ensembl:ENSG00000176485 MIM:613867
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
AdPLA; HRSL3; HRASLS3; HREV107; PLA2G16; PLAAT-3; H-REV107; HREV107-1; HREV107-3; H-REV107-1
Expression
Biased expression in fat (RPKM 173.9), testis (RPKM 32.8) and 11 other tissues See more
Orthologs
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Genomic context

See PLAAT3 in Genome Data Viewer
Location:
11q12.3-q13.1
Exon count:
6
Annotation release Status Assembly Chr Location
109.20210514 current GRCh38.p13 (GCF_000001405.39) 11 NC_000011.10 (63574462..63616926, complement)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 11 NC_000011.9 (63341934..63381909, complement)

Chromosome 11 - NC_000011.10Genomic Context describing neighboring genes Neighboring gene CRISPRi-validated cis-regulatory element chr11.2897 Neighboring gene phospholipase A and acyltransferase 2 Neighboring gene uncharacterized LOC105369335 Neighboring gene uncharacterized LOC107984336 Neighboring gene inner mitochondrial membrane peptidase subunit 1 pseudogene 1 Neighboring gene atlastin GTPase 3 Neighboring gene reticulon 3

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC118754

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables 1-acyl-2-lysophosphatidylserine acylhydrolase activity IEA
Inferred from Electronic Annotation
more info
 
enables N-acyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables N-acyltransferase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables acyltransferase activity TAS
Traceable Author Statement
more info
 
enables phosphatidylserine 1-acylhydrolase activity IEA
Inferred from Electronic Annotation
more info
 
enables phospholipase A1 activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables phospholipase A1 activity IDA
Inferred from Direct Assay
more info
PubMed 
enables phospholipase A2 activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables phospholipase A2 activity IDA
Inferred from Direct Assay
more info
PubMed 
enables phospholipase A2 activity IEA
Inferred from Electronic Annotation
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
involved_in N-acylphosphatidylethanolamine metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in N-acylphosphatidylethanolamine metabolic process IDA
Inferred from Direct Assay
more info
PubMed 
involved_in ether lipid metabolic process ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in lens fiber cell differentiation ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in lipid catabolic process ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in membrane disassembly ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in negative regulation of cell cycle IEA
Inferred from Electronic Annotation
more info
 
involved_in organelle disassembly ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in peroxisome organization ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in phosphatidylethanolamine acyl-chain remodeling TAS
Traceable Author Statement
more info
 
involved_in phospholipid biosynthetic process IEA
Inferred from Electronic Annotation
more info
 
involved_in phospholipid metabolic process IDA
Inferred from Direct Assay
more info
PubMed 
involved_in regulation of adipose tissue development ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in response to bacterium IEA
Inferred from Electronic Annotation
more info
 
involved_in triglyceride metabolic process ISS
Inferred from Sequence or Structural Similarity
more info
 
Component Evidence Code Pubs
is_active_in cellular_component ND
No biological Data available
more info
 
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in cytosol ISS
Inferred from Sequence or Structural Similarity
more info
 
located_in cytosol TAS
Traceable Author Statement
more info
 
located_in endoplasmic reticulum ISS
Inferred from Sequence or Structural Similarity
more info
 
located_in integral component of membrane IEA
Inferred from Electronic Annotation
more info
 
located_in lysosome ISS
Inferred from Sequence or Structural Similarity
more info
 
located_in mitochondrion ISS
Inferred from Sequence or Structural Similarity
more info
 
located_in nuclear envelope ISS
Inferred from Sequence or Structural Similarity
more info
 
located_in perinuclear region of cytoplasm IEA
Inferred from Electronic Annotation
more info
 
located_in peroxisomal membrane IEA
Inferred from Electronic Annotation
more info
 
located_in peroxisome ISS
Inferred from Sequence or Structural Similarity
more info
 
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
phospholipase A and acyltransferase 3
Names
Ca-independent phospholipase A1/2
H-rev 107 protein homolog
HRAS-like suppressor 1
HRAS-like suppressor 3
adipose-specific PLA2
adipose-specific phospholipase A2
group XVI phospholipase A1/A2
group XVI phospholipase A2
phospholipase A/acyltransferase-3
phospholipase A2 group XVI
renal carcinoma antigen NY-REN-65
NP_001121675.1
NP_009000.2
XP_006718489.1
XP_011543043.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001128203.2NP_001121675.1  phospholipase A and acyltransferase 3

    See identical proteins and their annotated locations for NP_001121675.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1 and 2 encode the same isoform.
    Source sequence(s)
    AI374456, AI590735, BG719903, CK003948
    Consensus CDS
    CCDS8047.1
    UniProtKB/Swiss-Prot
    P53816
    UniProtKB/TrEMBL
    A0A024R561
    Related
    ENSP00000389124.1, ENST00000415826.3
    Conserved Domains (1) summary
    pfam04970
    Location:19125
    LRAT; Lecithin retinol acyltransferase
  2. NM_007069.3NP_009000.2  phospholipase A and acyltransferase 3

    See identical proteins and their annotated locations for NP_009000.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript. Variants 1 and 2 encode the same isoform.
    Source sequence(s)
    AI374456, AI590735, AK313075, AU099540
    Consensus CDS
    CCDS8047.1
    UniProtKB/Swiss-Prot
    P53816
    UniProtKB/TrEMBL
    A0A024R561
    Related
    ENSP00000320337.5, ENST00000323646.9
    Conserved Domains (1) summary
    pfam04970
    Location:19125
    LRAT; Lecithin retinol acyltransferase

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210514

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000011.10 Reference GRCh38.p13 Primary Assembly

    Range
    63574462..63616926 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011544741.1XP_011543043.1  phospholipase A and acyltransferase 3 isoform X1

    See identical proteins and their annotated locations for XP_011543043.1

    Conserved Domains (1) summary
    pfam04970
    Location:35140
    LRAT; Lecithin retinol acyltransferase
  2. XM_006718426.1XP_006718489.1  phospholipase A and acyltransferase 3 isoform X2

    See identical proteins and their annotated locations for XP_006718489.1

    UniProtKB/Swiss-Prot
    P53816
    UniProtKB/TrEMBL
    A0A024R561
    Conserved Domains (1) summary
    pfam04970
    Location:19125
    LRAT; Lecithin retinol acyltransferase
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