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CHGB chromogranin B [ Homo sapiens (human) ]

Gene ID: 1114, updated on 3-Jun-2018
Official Symbol
CHGBprovided by HGNC
Official Full Name
chromogranin Bprovided by HGNC
Primary source
HGNC:HGNC:1930
See related
Ensembl:ENSG00000089199 MIM:118920; Vega:OTTHUMG00000031821
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
SCG1
Summary
This gene encodes a tyrosine-sulfated secretory protein abundant in peptidergic endocrine cells and neurons. This protein may serve as a precursor for regulatory peptides. [provided by RefSeq, Jan 2009]
Expression
Biased expression in adrenal (RPKM 1898.3) and stomach (RPKM 91.0) See more
Orthologs
See CHGB in Genome Data Viewer
Location:
20p12.3
Exon count:
5
Annotation release Status Assembly Chr Location
109 current GRCh38.p12 (GCF_000001405.38) 20 NC_000020.11 (5911328..5925361)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 20 NC_000020.10 (5891974..5906007)

Chromosome 20 - NC_000020.11Genomic Context describing neighboring genes Neighboring gene shieldin complex subunit 1 Neighboring gene RNA, U1 small nuclear 55, pseudogene Neighboring gene KN motif and ankyrin repeat domains 1 pseudogene 1 Neighboring gene tRNA methyltransferase 6

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Jun 15 11:32:44 2016

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
hormone activity TAS
Traceable Author Statement
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
cellular protein metabolic process TAS
Traceable Author Statement
more info
 
post-translational protein modification TAS
Traceable Author Statement
more info
 
regulation of signaling receptor activity IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
endoplasmic reticulum lumen TAS
Traceable Author Statement
more info
 
extracellular region IEA
Inferred from Electronic Annotation
more info
 
extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
secretory granule IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
secretory granule IEA
Inferred from Electronic Annotation
more info
 
Preferred Names
secretogranin-1
Names
cgB
secretogranin B
secretogranin I
sgI

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_042285.1 RefSeqGene

    Range
    5001..19034
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001819.2NP_001810.2  secretogranin-1 precursor

    See identical proteins and their annotated locations for NP_001810.2

    Status: REVIEWED

    Source sequence(s)
    BC000375, BM681923, BP422638, DC312240
    Consensus CDS
    CCDS13092.1
    UniProtKB/Swiss-Prot
    P05060
    Related
    ENSP00000368244.4, OTTHUMP00000030215, ENST00000378961.8, OTTHUMT00000077897
    Conserved Domains (1) summary
    pfam01271
    Location:26674
    Granin; Granin (chromogranin or secretogranin)

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p12 Primary Assembly

Genomic

  1. NC_000020.11 Reference GRCh38.p12 Primary Assembly

    Range
    5911328..5925361
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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