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CHGA chromogranin A [ Homo sapiens (human) ]

Gene ID: 1113, updated on 19-Jun-2022

Summary

Official Symbol
CHGAprovided by HGNC
Official Full Name
chromogranin Aprovided by HGNC
Primary source
HGNC:HGNC:1929
See related
Ensembl:ENSG00000100604 MIM:118910; AllianceGenome:HGNC:1929
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
CGA; PHE5; PHES
Summary
The protein encoded by this gene is a member of the chromogranin/secretogranin family of neuroendocrine secretory proteins. It is found in secretory vesicles of neurons and endocrine cells. This gene product is a precursor to three biologically active peptides; vasostatin, pancreastatin, and parastatin. These peptides act as autocrine or paracrine negative modulators of the neuroendocrine system. Two other peptides, catestatin and chromofungin, have antimicrobial activity and antifungal activity, respectively. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2014]
Expression
Biased expression in adrenal (RPKM 574.1), stomach (RPKM 148.9) and 5 other tissues See more
Orthologs
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Genomic context

See CHGA in Genome Data Viewer
Location:
14q32.12
Exon count:
9
Annotation release Status Assembly Chr Location
110 current GRCh38.p14 (GCF_000001405.40) 14 NC_000014.9 (92922664..92935285)
110 current T2T-CHM13v2.0 (GCF_009914755.1) 14 NC_060938.1 (87155144..87167278)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 14 NC_000014.8 (93389495..93401630)

Chromosome 14 - NC_000014.9Genomic Context describing neighboring genes Neighboring gene long intergenic non-protein coding RNA 2833 Neighboring gene long intergenic non-protein coding RNA 2287 Neighboring gene uncharacterized LOC124903366 Neighboring gene inositol-tetrakisphosphate 1-kinase Neighboring gene ITPK1 antisense RNA 1

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Process Evidence Code Pubs
involved_in adenylate cyclase-activating adrenergic receptor signaling pathway involved in cardiac muscle relaxation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in adenylate cyclase-activating adrenergic receptor signaling pathway involved in cardiac muscle relaxation ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in defense response to Gram-negative bacterium IDA
Inferred from Direct Assay
more info
PubMed 
involved_in defense response to Gram-positive bacterium IDA
Inferred from Direct Assay
more info
PubMed 
involved_in defense response to bacterium IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in defense response to fungus IEA
Inferred from Electronic Annotation
more info
 
involved_in innate immune response NAS
Non-traceable Author Statement
more info
PubMed 
involved_in killing of cells of another organism IEA
Inferred from Electronic Annotation
more info
 
involved_in mast cell activation IDA
Inferred from Direct Assay
more info
PubMed 
involved_in mast cell chemotaxis IDA
Inferred from Direct Assay
more info
PubMed 
involved_in mast cell degranulation IDA
Inferred from Direct Assay
more info
PubMed 
involved_in negative regulation of catecholamine secretion IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in negative regulation of catecholamine secretion IDA
Inferred from Direct Assay
more info
PubMed 
involved_in negative regulation of insulin secretion IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in negative regulation of neuron death ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in organelle organization ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in positive regulation of cardiac muscle contraction ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in positive regulation of dense core granule biogenesis ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in positive regulation of phospholipase C-activating G protein-coupled receptor signaling pathway ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in positive regulation of relaxation of cardiac muscle ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in protein localization to secretory granule IEA
Inferred from Electronic Annotation
more info
 
involved_in regulation of blood pressure TAS
Traceable Author Statement
more info
PubMed 
involved_in regulation of the force of heart contraction ISS
Inferred from Sequence or Structural Similarity
more info
 
Component Evidence Code Pubs
is_active_in chromaffin granule IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in chromaffin granule ISS
Inferred from Sequence or Structural Similarity
more info
 
located_in extracellular region TAS
Traceable Author Statement
more info
 
is_active_in extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in extracellular space ISS
Inferred from Sequence or Structural Similarity
more info
 
located_in neuronal dense core vesicle ISS
Inferred from Sequence or Structural Similarity
more info
 
located_in perinuclear region of cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in secretory granule IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in secretory granule ISS
Inferred from Sequence or Structural Similarity
more info
 
located_in transport vesicle IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
chromogranin-A
Names
SP-I
betagranin (N-terminal fragment of chromogranin A)
catestatin
chromofungin
parathyroid secretory protein 1
pituitary secretory protein I

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001275.4NP_001266.1  chromogranin-A isoform 1 preproprotein

    See identical proteins and their annotated locations for NP_001266.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    BC001059, BC009384, BX248263, DA201149
    Consensus CDS
    CCDS9906.1
    UniProtKB/Swiss-Prot
    P10645
    UniProtKB/TrEMBL
    Q86T07
    Related
    ENSP00000216492.5, ENST00000216492.10
    Conserved Domains (1) summary
    pfam01271
    Location:25457
    Granin; Granin (chromogranin or secretogranin)
  2. NM_001301690.2NP_001288619.1  chromogranin-A isoform 2 preproprotein

    See identical proteins and their annotated locations for NP_001288619.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) lacks an alternate in-frame exon compared to variant 1. The resulting isoform (2) has the same N- and C-termini but is shorter compared to isoform 1.
    Source sequence(s)
    BC009384, BX248263, DA201149
    Consensus CDS
    CCDS76718.1
    UniProtKB/Swiss-Prot
    P10645
    UniProtKB/TrEMBL
    G5E968, Q86T07
    Related
    ENSP00000334023.4, ENST00000334654.4
    Conserved Domains (1) summary
    pfam01271
    Location:116306
    Granin; Granin (chromogranin or secretogranin)

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 110 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000014.9 Reference GRCh38.p14 Primary Assembly

    Range
    92922664..92935285
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011536370.3XP_011534672.1  chromogranin-A isoform X1

    See identical proteins and their annotated locations for XP_011534672.1

    UniProtKB/Swiss-Prot
    P10645
    Conserved Domains (1) summary
    pfam01271
    Location:25457
    Granin; Granin (chromogranin or secretogranin)

Reference GRCh38.p14 ALT_REF_LOCI_1

Genomic

  1. NT_187601.1 Reference GRCh38.p14 ALT_REF_LOCI_1

    Range
    37712..49847
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060938.1 Alternate T2T-CHM13v2.0

    Range
    87155144..87167278
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)