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CHGA chromogranin A [ Homo sapiens (human) ]

Gene ID: 1113, updated on 5-Jul-2025
Official Symbol
CHGAprovided by HGNC
Official Full Name
chromogranin Aprovided by HGNC
Primary source
HGNC:HGNC:1929
See related
Ensembl:ENSG00000100604 MIM:118910; AllianceGenome:HGNC:1929
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
CGA; PHE5; PHES
Summary
The protein encoded by this gene is a member of the chromogranin/secretogranin family of neuroendocrine secretory proteins. It is found in secretory vesicles of neurons and endocrine cells. This gene product is a precursor to three biologically active peptides; vasostatin, pancreastatin, and parastatin. These peptides act as autocrine or paracrine negative modulators of the neuroendocrine system. Two other peptides, catestatin and chromofungin, have antimicrobial activity and antifungal activity, respectively. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2014]
Expression
Biased expression in adrenal (RPKM 574.1), stomach (RPKM 148.9) and 5 other tissues See more
Orthologs
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See CHGA in Genome Data Viewer
Location:
14q32.12
Exon count:
9
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 14 NC_000014.9 (92922664..92935285)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 14 NC_060938.1 (87154582..87167278)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 14 NC_000014.8 (93389495..93401630)

Chromosome 14 - NC_000014.9Genomic Context describing neighboring genes Neighboring gene long intergenic non-protein coding RNA 2833 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr14:93369186-93370385 Neighboring gene NANOG-H3K27ac hESC enhancer GRCh37_chr14:93377003-93377546 Neighboring gene long intergenic non-protein coding RNA 2287 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr14:93403665-93404166 Neighboring gene uncharacterized LOC124903366 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr14:93418215-93418715 Neighboring gene inositol-tetrakisphosphate 1-kinase Neighboring gene H3K4me1 hESC enhancer GRCh37_chr14:93428049-93428613 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr14:93439689-93440278 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr14:93440279-93440866 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr14:93440867-93441454 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr14:93459858-93460540 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr14:93465116-93465630 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr14:93472927-93473838 Neighboring gene Sharpr-MPRA regulatory region 15213 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr14:93475437-93475938 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr14:93477163-93477664 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr14:93477665-93478164 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr14:93480925-93481426 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr14:93481427-93481926 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr14:93482386-93482886 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr14:93484819-93485602 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr14:93485603-93486386 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr14:93500760-93501455 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr14:93506655-93507584 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr14:93511809-93512368 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr14:93515290-93515917 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr14:93516545-93517172 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr14:93522559-93523246 Neighboring gene ITPK1 antisense RNA 1

  • Project title: Tissue-specific circular RNA induction during human fetal development
  • Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
  • BioProject: PRJNA270632
  • Publication: PMID 26076956
  • Analysis date: Mon Apr 2 22:54:59 2018

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
Products Interactant Other Gene Complex Source Pubs Description

Markers

Gene Ontology Provided by GOA

Process Evidence Code Pubs
involved_in adenylate cyclase-activating adrenergic receptor signaling pathway TAS
Traceable Author Statement
more info
PubMed 
involved_in defense response to Gram-negative bacterium IDA
Inferred from Direct Assay
more info
PubMed 
involved_in defense response to Gram-positive bacterium IDA
Inferred from Direct Assay
more info
PubMed 
involved_in defense response to bacterium IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in defense response to bacterium IEA
Inferred from Electronic Annotation
more info
 
involved_in defense response to fungus IEA
Inferred from Electronic Annotation
more info
 
involved_in innate immune response NAS
Non-traceable Author Statement
more info
PubMed 
involved_in killing of cells of another organism IEA
Inferred from Electronic Annotation
more info
 
involved_in mast cell activation IDA
Inferred from Direct Assay
more info
PubMed 
involved_in mast cell chemotaxis IDA
Inferred from Direct Assay
more info
PubMed 
involved_in mast cell degranulation IDA
Inferred from Direct Assay
more info
PubMed 
involved_in negative regulation of catecholamine secretion IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in negative regulation of catecholamine secretion IDA
Inferred from Direct Assay
more info
PubMed 
involved_in negative regulation of insulin secretion IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in positive regulation of cardiac muscle contraction ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in positive regulation of dense core granule biogenesis IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of dense core granule biogenesis ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in positive regulation of phospholipase C-activating G protein-coupled receptor signaling pathway ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in positive regulation of relaxation of cardiac muscle ISS
Inferred from Sequence or Structural Similarity
more info
 
acts_upstream_of_or_within protein localization to secretory granule IEA
Inferred from Electronic Annotation
more info
 
involved_in regulation of blood pressure TAS
Traceable Author Statement
more info
PubMed 
involved_in regulation of the force of heart contraction ISS
Inferred from Sequence or Structural Similarity
more info
 
Component Evidence Code Pubs
is_active_in chromaffin granule IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in chromaffin granule ISS
Inferred from Sequence or Structural Similarity
more info
 
located_in cytoplasmic vesicle IEA
Inferred from Electronic Annotation
more info
 
located_in extracellular region IEA
Inferred from Electronic Annotation
more info
 
located_in extracellular region TAS
Traceable Author Statement
more info
 
is_active_in extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in extracellular space ISS
Inferred from Sequence or Structural Similarity
more info
 
located_in neuronal dense core vesicle IEA
Inferred from Electronic Annotation
more info
 
located_in neuronal dense core vesicle ISS
Inferred from Sequence or Structural Similarity
more info
 
located_in perinuclear region of cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
located_in secretory granule IEA
Inferred from Electronic Annotation
more info
 
located_in secretory granule ISS
Inferred from Sequence or Structural Similarity
more info
 
located_in transport vesicle IEA
Inferred from Electronic Annotation
more info
 
Preferred Names
chromogranin-A
Names
SP-I
betagranin (N-terminal fragment of chromogranin A)
catestatin
chromofungin
parathyroid secretory protein 1
pituitary secretory protein I

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001275.4NP_001266.1  chromogranin-A isoform 1 preproprotein

    See identical proteins and their annotated locations for NP_001266.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    BC001059, BC009384, BX248263, DA201149
    Consensus CDS
    CCDS9906.1
    UniProtKB/Swiss-Prot
    B2R9E9, P10645, Q53FA8, Q6NR84, Q96E84, Q96GL7, Q9BQB5
    Related
    ENSP00000216492.5, ENST00000216492.10
    Conserved Domains (1) summary
    pfam01271
    Location:25457
    Granin; Granin (chromogranin or secretogranin)
  2. NM_001301690.2NP_001288619.1  chromogranin-A isoform 2 preproprotein

    See identical proteins and their annotated locations for NP_001288619.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) lacks an alternate in-frame exon compared to variant 1. The resulting isoform (2) has the same N- and C-termini but is shorter compared to isoform 1.
    Source sequence(s)
    BC009384, BX248263, DA201149
    Consensus CDS
    CCDS76718.1
    UniProtKB/TrEMBL
    G5E968, Q86T07
    Related
    ENSP00000334023.4, ENST00000334654.4
    Conserved Domains (1) summary
    pfam01271
    Location:116306
    Granin; Granin (chromogranin or secretogranin)

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000014.9 Reference GRCh38.p14 Primary Assembly

    Range
    92922664..92935285
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011536370.3XP_011534672.1  chromogranin-A isoform X1

    See identical proteins and their annotated locations for XP_011534672.1

    UniProtKB/Swiss-Prot
    B2R9E9, P10645, Q53FA8, Q6NR84, Q96E84, Q96GL7, Q9BQB5
    Conserved Domains (1) summary
    pfam01271
    Location:25457
    Granin; Granin (chromogranin or secretogranin)

Reference GRCh38.p14 ALT_REF_LOCI_1

Genomic

  1. NT_187601.1 Reference GRCh38.p14 ALT_REF_LOCI_1

    Range
    37150..49847
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054328954.1XP_054184929.1  chromogranin-A isoform X1

    UniProtKB/Swiss-Prot
    B2R9E9, P10645, Q53FA8, Q6NR84, Q96E84, Q96GL7, Q9BQB5

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060938.1 Alternate T2T-CHM13v2.0

    Range
    87154582..87167278
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054375290.1XP_054231265.1  chromogranin-A isoform X1

    UniProtKB/Swiss-Prot
    B2R9E9, P10645, Q53FA8, Q6NR84, Q96E84, Q96GL7, Q9BQB5