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CHGA chromogranin A [ Homo sapiens (human) ]

Gene ID: 1113, updated on 12-Aug-2018
Official Symbol
CHGAprovided by HGNC
Official Full Name
chromogranin Aprovided by HGNC
Primary source
HGNC:HGNC:1929
See related
Ensembl:ENSG00000100604 MIM:118910; Vega:OTTHUMG00000171225
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
CGA
Summary
The protein encoded by this gene is a member of the chromogranin/secretogranin family of neuroendocrine secretory proteins. It is found in secretory vesicles of neurons and endocrine cells. This gene product is a precursor to three biologically active peptides; vasostatin, pancreastatin, and parastatin. These peptides act as autocrine or paracrine negative modulators of the neuroendocrine system. Two other peptides, catestatin and chromofungin, have antimicrobial activity and antifungal activity, respectively. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2014]
Expression
Biased expression in adrenal (RPKM 574.1), stomach (RPKM 148.9) and 5 other tissues See more
Orthologs
See CHGA in Genome Data Viewer
Location:
14q32.12
Exon count:
9
Annotation release Status Assembly Chr Location
109 current GRCh38.p12 (GCF_000001405.38) 14 NC_000014.9 (92922594..92935293)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 14 NC_000014.8 (93389445..93401638)

Chromosome 14 - NC_000014.9Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105370629 Neighboring gene long intergenic non-protein coding RNA 2287 Neighboring gene inositol-tetrakisphosphate 1-kinase Neighboring gene ITPK1 antisense RNA 1 Neighboring gene cytochrome b5 type A pseudogene 3

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Jun 15 11:32:44 2016

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

  • Antimicrobial peptides, organism-specific biosystem (from REACTOME)
    Antimicrobial peptides, organism-specific biosystemAntimicrobial peptides (AMPs) are small molecular weight proteins with broad spectrum of antimicrobial activity against bacteria, viruses, and fungi (Zasloff M 2002; Radek K & Gallo R 2007). The majo...
  • Immune System, organism-specific biosystem (from REACTOME)
    Immune System, organism-specific biosystemHumans are exposed to millions of potential pathogens daily, through contact, ingestion, and inhalation. Our ability to avoid infection depends on the adaptive immune system and during the first crit...
  • Innate Immune System, organism-specific biosystem (from REACTOME)
    Innate Immune System, organism-specific biosystemInnate immunity encompases the nonspecific part of immunity tha are part of an individual's natural biologic makeup
Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Gene Ontology Provided by GOA

Process Evidence Code Pubs
adenylate cyclase-activating adrenergic receptor signaling pathway involved in cardiac muscle relaxation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
adenylate cyclase-activating adrenergic receptor signaling pathway involved in cardiac muscle relaxation ISS
Inferred from Sequence or Structural Similarity
more info
 
antimicrobial humoral response TAS
Traceable Author Statement
more info
 
defense response to Gram-negative bacterium IDA
Inferred from Direct Assay
more info
PubMed 
defense response to Gram-positive bacterium IDA
Inferred from Direct Assay
more info
PubMed 
defense response to fungus IEA
Inferred from Electronic Annotation
more info
 
innate immune response NAS
Non-traceable Author Statement
more info
PubMed 
killing of cells of other organism IEA
Inferred from Electronic Annotation
more info
 
mast cell activation IDA
Inferred from Direct Assay
more info
PubMed 
mast cell chemotaxis IDA
Inferred from Direct Assay
more info
PubMed 
mast cell cytokine production IDA
Inferred from Direct Assay
more info
PubMed 
mast cell degranulation IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of blood vessel diameter ISS
Inferred from Sequence or Structural Similarity
more info
 
negative regulation of catecholamine secretion IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
negative regulation of catecholamine secretion IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of hormone secretion IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
negative regulation of insulin secretion IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
negative regulation of neuron death ISS
Inferred from Sequence or Structural Similarity
more info
 
organelle organization ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of cardiac muscle contraction ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of dense core granule biogenesis ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of phospholipase C-activating G-protein coupled receptor signaling pathway ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of relaxation of cardiac muscle ISS
Inferred from Sequence or Structural Similarity
more info
 
regulation of blood pressure TAS
Traceable Author Statement
more info
PubMed 
regulation of the force of heart contraction ISS
Inferred from Sequence or Structural Similarity
more info
 
Component Evidence Code Pubs
chromaffin granule IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
chromaffin granule ISS
Inferred from Sequence or Structural Similarity
more info
 
extracellular region TAS
Traceable Author Statement
more info
 
extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
extracellular space ISS
Inferred from Sequence or Structural Similarity
more info
 
mast cell granule IEA
Inferred from Electronic Annotation
more info
 
perinuclear region of cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
secretory granule IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
secretory granule ISS
Inferred from Sequence or Structural Similarity
more info
 
transport vesicle membrane IEA
Inferred from Electronic Annotation
more info
 
Preferred Names
chromogranin-A
Names
SP-I
betagranin (N-terminal fragment of chromogranin A)
catestatin
chromofungin
parathyroid secretory protein 1
pituitary secretory protein I

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001275.3NP_001266.1  chromogranin-A isoform 1 preproprotein

    See identical proteins and their annotated locations for NP_001266.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    BC001059, BC009384, BX248263, DA201149
    Consensus CDS
    CCDS9906.1
    UniProtKB/Swiss-Prot
    P10645
    UniProtKB/TrEMBL
    Q86T07
    Related
    ENSP00000216492.5, OTTHUMP00000245492, ENST00000216492.9, OTTHUMT00000412411
    Conserved Domains (1) summary
    pfam01271
    Location:25457
    Granin; Granin (chromogranin or secretogranin)
  2. NM_001301690.1NP_001288619.1  chromogranin-A isoform 2 preproprotein

    See identical proteins and their annotated locations for NP_001288619.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) lacks an alternate in-frame exon compared to variant 1. The resulting isoform (2) has the same N- and C-termini but is shorter compared to isoform 1.
    Source sequence(s)
    BC009384, BX248263, DA201149
    Consensus CDS
    CCDS76718.1
    UniProtKB/Swiss-Prot
    P10645
    UniProtKB/TrEMBL
    G5E968, Q86T07
    Related
    ENSP00000334023.4, OTTHUMP00000245495, ENST00000334654.4, OTTHUMT00000412414
    Conserved Domains (1) summary
    pfam01271
    Location:116306
    Granin; Granin (chromogranin or secretogranin)

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p12 Primary Assembly

Genomic

  1. NC_000014.9 Reference GRCh38.p12 Primary Assembly

    Range
    92922594..92935293
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011536370.2XP_011534672.1  chromogranin-A isoform X1

    See identical proteins and their annotated locations for XP_011534672.1

    UniProtKB/Swiss-Prot
    P10645
    Conserved Domains (1) summary
    pfam01271
    Location:25457
    Granin; Granin (chromogranin or secretogranin)

Reference GRCh38.p12 ALT_REF_LOCI_1

Genomic

  1. NT_187601.1 Reference GRCh38.p12 ALT_REF_LOCI_1

    Range
    37662..49855
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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