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Gabra5 gamma-aminobutyric acid type A receptor subunit alpha 5 [ Mus musculus (house mouse) ]

Gene ID: 110886, updated on 8-Feb-2024

Summary

Official Symbol
Gabra5provided by MGI
Official Full Name
gamma-aminobutyric acid type A receptor subunit alpha 5provided by MGI
Primary source
MGI:MGI:95617
See related
Ensembl:ENSMUSG00000055078 AllianceGenome:MGI:95617
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
A230018I05Rik
Summary
Predicted to enable GABA receptor binding activity and extracellular ligand-gated ion channel activity. Predicted to contribute to GABA-A receptor activity; benzodiazepine receptor activity; and chloride channel activity. Involved in several processes, including inner ear development; innervation; and sensory perception of sound. Acts upstream of or within associative learning and behavioral fear response. Located in cell body and dendrite. Is expressed in brain. Human ortholog(s) of this gene implicated in bipolar disorder; developmental and epileptic encephalopathy 79; and mental depression. Orthologous to human GABRA5 (gamma-aminobutyric acid type A receptor subunit alpha5). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in CNS E18 (RPKM 18.3), frontal lobe adult (RPKM 16.8) and 4 other tissues See more
Orthologs
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Genomic context

See Gabra5 in Genome Data Viewer
Location:
7 B5; 7 33.52 cM
Exon count:
13
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (57057417..57240808, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (57407669..57591016, complement)

Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene gamma-aminobutyric acid type A receptor, subunit gamma 3 Neighboring gene STARR-seq mESC enhancer starr_18970 Neighboring gene vaccinia related kinase 3 pseudogene Neighboring gene STARR-seq mESC enhancer starr_18971 Neighboring gene STARR-seq mESC enhancer starr_18972 Neighboring gene predicted gene, 39017 Neighboring gene predicted gene 9962 Neighboring gene STARR-seq mESC enhancer starr_18974 Neighboring gene STARR-seq mESC enhancer starr_18975 Neighboring gene STARR-seq mESC enhancer starr_18976 Neighboring gene microRNA 6389 Neighboring gene GABRB3, gamma-aminobutyric acid type A receptor subunit beta 3 Neighboring gene STARR-seq mESC enhancer starr_18977 Neighboring gene predicted gene, 34272 Neighboring gene DEP domain containing 1a pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (7)  1 citation
  • Endonuclease-mediated (4) 

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables GABA receptor binding ISO
Inferred from Sequence Orthology
more info
 
contributes_to GABA-A receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables GABA-A receptor activity ISO
Inferred from Sequence Orthology
more info
 
enables GABA-gated chloride ion channel activity IBA
Inferred from Biological aspect of Ancestor
more info
 
contributes_to benzodiazepine receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
 
contributes_to chloride channel activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables chloride channel activity IEA
Inferred from Electronic Annotation
more info
 
enables extracellular ligand-gated monoatomic ion channel activity IEA
Inferred from Electronic Annotation
more info
 
enables ligand-gated monoatomic ion channel activity involved in regulation of presynaptic membrane potential ISO
Inferred from Sequence Orthology
more info
 
enables monoatomic ion channel activity IEA
Inferred from Electronic Annotation
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables transmembrane signaling receptor activity IEA
Inferred from Electronic Annotation
more info
 
enables transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
acts_upstream_of_or_within associative learning IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within behavioral fear response IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in chemical synaptic transmission ISO
Inferred from Sequence Orthology
more info
 
involved_in chloride transmembrane transport IBA
Inferred from Biological aspect of Ancestor
more info
 
acts_upstream_of_or_within chloride transport IEA
Inferred from Electronic Annotation
more info
 
involved_in chloride transport IEA
Inferred from Electronic Annotation
more info
 
involved_in cochlea development IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in gamma-aminobutyric acid signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in gamma-aminobutyric acid signaling pathway IEA
Inferred from Electronic Annotation
more info
 
involved_in inhibitory synapse assembly IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in inner ear receptor cell development IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in innervation IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within monoatomic ion transmembrane transport IEA
Inferred from Electronic Annotation
more info
 
involved_in monoatomic ion transmembrane transport IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within monoatomic ion transport IEA
Inferred from Electronic Annotation
more info
 
involved_in monoatomic ion transport IEA
Inferred from Electronic Annotation
more info
 
involved_in nervous system process IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in neuron development IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of postsynaptic membrane potential IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in synaptic transmission, GABAergic IBA
Inferred from Biological aspect of Ancestor
more info
 
Component Evidence Code Pubs
part_of GABA-A receptor complex IBA
Inferred from Biological aspect of Ancestor
more info
 
is_active_in GABA-ergic synapse ISO
Inferred from Sequence Orthology
more info
 
located_in cell body IDA
Inferred from Direct Assay
more info
PubMed 
part_of chloride channel complex IEA
Inferred from Electronic Annotation
more info
 
located_in cytosol ISO
Inferred from Sequence Orthology
more info
 
located_in dendrite IDA
Inferred from Direct Assay
more info
PubMed 
located_in dendrite ISO
Inferred from Sequence Orthology
more info
 
is_active_in dendrite membrane IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 
is_active_in neuron projection IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in neuronal cell body membrane ISO
Inferred from Sequence Orthology
more info
 
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
 
is_active_in postsynapse IBA
Inferred from Biological aspect of Ancestor
more info
 
is_active_in postsynaptic membrane ISO
Inferred from Sequence Orthology
more info
 
is_active_in postsynaptic specialization membrane ISO
Inferred from Sequence Orthology
more info
 
is_active_in presynaptic membrane ISO
Inferred from Sequence Orthology
more info
 
part_of receptor complex ISO
Inferred from Sequence Orthology
more info
 
is_active_in synapse IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in synapse IEA
Inferred from Electronic Annotation
more info
 
part_of transmembrane transporter complex IBA
Inferred from Biological aspect of Ancestor
more info
 

General protein information

Preferred Names
gamma-aminobutyric acid receptor subunit alpha-5
Names
GABA(A) receptor subunit alpha-5
gamma-aminobutyric acid (GABA) A receptor, subunit alpha 5
ligand-gated ion channel subunit

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001362161.1NP_001349090.1  gamma-aminobutyric acid receptor subunit alpha-5 precursor

    Status: VALIDATED

    Source sequence(s)
    AK038476, AK083185
    Consensus CDS
    CCDS21322.1
    UniProtKB/Swiss-Prot
    Q8BHJ7
    Related
    ENSMUSP00000145685.2, ENSMUST00000206734.2
    Conserved Domains (2) summary
    TIGR00860
    Location:15449
    LIC; Cation transporter family protein
    cd19038
    Location:58256
    LGIC_ECD_GABAAR_A5; extracellular domain of gamma-aminobutyric acid receptor subunit alpha-5 (GABAAR-A5 or GABRA5)
  2. NM_001362162.1NP_001349091.1  gamma-aminobutyric acid receptor subunit alpha-5 precursor

    Status: VALIDATED

    Source sequence(s)
    AC102129, AC160553
    Consensus CDS
    CCDS21322.1
    UniProtKB/Swiss-Prot
    Q8BHJ7
    Conserved Domains (2) summary
    TIGR00860
    Location:15449
    LIC; Cation transporter family protein
    cd19038
    Location:58256
    LGIC_ECD_GABAAR_A5; extracellular domain of gamma-aminobutyric acid receptor subunit alpha-5 (GABAAR-A5 or GABRA5)
  3. NM_176942.4NP_795916.1  gamma-aminobutyric acid receptor subunit alpha-5 precursor

    See identical proteins and their annotated locations for NP_795916.1

    Status: VALIDATED

    Source sequence(s)
    AC102129, AC160553
    Consensus CDS
    CCDS21322.1
    UniProtKB/Swiss-Prot
    Q8BHJ7
    Related
    ENSMUSP00000063276.7, ENSMUST00000068456.8
    Conserved Domains (2) summary
    TIGR00860
    Location:15449
    LIC; Cation transporter family protein
    cd19038
    Location:58256
    LGIC_ECD_GABAAR_A5; extracellular domain of gamma-aminobutyric acid receptor subunit alpha-5 (GABAAR-A5 or GABRA5)

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000073.7 Reference GRCm39 C57BL/6J

    Range
    57057417..57240808 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_030241988.2XP_030097848.1  gamma-aminobutyric acid receptor subunit alpha-5 isoform X1

    UniProtKB/Swiss-Prot
    Q8BHJ7
    Conserved Domains (2) summary
    TIGR00860
    Location:15449
    LIC; Cation transporter family protein
    cd19038
    Location:58256
    LGIC_ECD_GABAAR_A5; extracellular domain of gamma-aminobutyric acid receptor subunit alpha-5 (GABAAR-A5 or GABRA5)
  2. XM_006540560.5XP_006540623.1  gamma-aminobutyric acid receptor subunit alpha-5 isoform X1

    See identical proteins and their annotated locations for XP_006540623.1

    UniProtKB/Swiss-Prot
    Q8BHJ7
    Conserved Domains (2) summary
    TIGR00860
    Location:15449
    LIC; Cation transporter family protein
    cd19038
    Location:58256
    LGIC_ECD_GABAAR_A5; extracellular domain of gamma-aminobutyric acid receptor subunit alpha-5 (GABAAR-A5 or GABRA5)
  3. XM_006540557.5XP_006540620.1  gamma-aminobutyric acid receptor subunit alpha-5 isoform X1

    See identical proteins and their annotated locations for XP_006540620.1

    UniProtKB/Swiss-Prot
    Q8BHJ7
    Conserved Domains (2) summary
    TIGR00860
    Location:15449
    LIC; Cation transporter family protein
    cd19038
    Location:58256
    LGIC_ECD_GABAAR_A5; extracellular domain of gamma-aminobutyric acid receptor subunit alpha-5 (GABAAR-A5 or GABRA5)
  4. XM_006540556.5XP_006540619.1  gamma-aminobutyric acid receptor subunit alpha-5 isoform X1

    See identical proteins and their annotated locations for XP_006540619.1

    UniProtKB/Swiss-Prot
    Q8BHJ7
    Related
    ENSMUSP00000146238.2, ENSMUST00000206382.2
    Conserved Domains (2) summary
    TIGR00860
    Location:15449
    LIC; Cation transporter family protein
    cd19038
    Location:58256
    LGIC_ECD_GABAAR_A5; extracellular domain of gamma-aminobutyric acid receptor subunit alpha-5 (GABAAR-A5 or GABRA5)