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WWP1 WW domain containing E3 ubiquitin protein ligase 1 [ Homo sapiens (human) ]

Gene ID: 11059, updated on 4-Jul-2021

Summary

Official Symbol
WWP1provided by HGNC
Official Full Name
WW domain containing E3 ubiquitin protein ligase 1provided by HGNC
Primary source
HGNC:HGNC:17004
See related
Ensembl:ENSG00000123124 MIM:602307
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
AIP5; Tiul1; hSDRP1
Summary
WW domain-containing proteins are found in all eukaryotes and play an important role in the regulation of a wide variety of cellular functions such as protein degradation, transcription, and RNA splicing. This gene encodes a protein which contains 4 tandem WW domains and a HECT (homologous to the E6-associated protein carboxyl terminus) domain. The encoded protein belongs to a family of NEDD4-like proteins, which are E3 ubiquitin-ligase molecules and regulate key trafficking decisions, including targeting of proteins to proteosomes or lysosomes. Alternative splicing of this gene generates at least 6 transcript variants; however, the full length nature of these transcripts has not been defined. [provided by RefSeq, Jul 2008]
Expression
Ubiquitous expression in liver (RPKM 24.3), gall bladder (RPKM 23.0) and 25 other tissues See more
Orthologs
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Genomic context

See WWP1 in Genome Data Viewer
Location:
8q21.3
Exon count:
25
Annotation release Status Assembly Chr Location
109.20210514 current GRCh38.p13 (GCF_000001405.39) 8 NC_000008.11 (86342547..86468503)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 8 NC_000008.10 (87354776..87480732)

Chromosome 8 - NC_000008.11Genomic Context describing neighboring genes Neighboring gene solute carrier family 7 member 13 Neighboring gene HNF4 motif-containing MPRA enhancer 29 Neighboring gene WWP1 antisense RNA 1 Neighboring gene regulator of microtubule dynamics 1 Neighboring gene N-terminal asparagine amidase pseudogene 2 Neighboring gene solute carrier family 2 member 3 pseudogene 4

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • DKFZp434D2111

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables ubiquitin protein ligase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables ubiquitin-protein transferase activity TAS
Traceable Author Statement
more info
PubMed 
Process Evidence Code Pubs
involved_in central nervous system development NAS
Non-traceable Author Statement
more info
PubMed 
involved_in ion transmembrane transport TAS
Traceable Author Statement
more info
 
involved_in negative regulation of transcription, DNA-templated ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in positive regulation of protein catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in proteasome-mediated ubiquitin-dependent protein catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in protein polyubiquitination IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in protein ubiquitination IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in protein ubiquitination TAS
Traceable Author Statement
more info
PubMed 
involved_in signal transduction NAS
Non-traceable Author Statement
more info
PubMed 
involved_in viral entry into host cell TAS
Traceable Author Statement
more info
PubMed 
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in cytosol TAS
Traceable Author Statement
more info
 
located_in extracellular exosome HDA PubMed 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
 
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
 
part_of ubiquitin ligase complex NAS
Non-traceable Author Statement
more info
PubMed 

General protein information

Preferred Names
NEDD4-like E3 ubiquitin-protein ligase WWP1
Names
HECT-type E3 ubiquitin transferase WWP1
Nedd-4-like ubiquitin-protein ligase
TGIF-interacting ubiquitin ligase 1
WW domain-containing protein 1
atrophin-1 interacting protein 5
NP_008944.1
XP_005250817.1
XP_005250818.1
XP_016868482.1
XP_016868483.1
XP_016868484.1
XP_016868485.1
XP_016868486.1
XP_024302824.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_007013.4NP_008944.1  NEDD4-like E3 ubiquitin-protein ligase WWP1

    See identical proteins and their annotated locations for NP_008944.1

    Status: VALIDATED

    Source sequence(s)
    AC103760, AC103817, AW137654, AY043361, BC036065, BM664090
    Consensus CDS
    CCDS6242.1
    UniProtKB/Swiss-Prot
    Q9H0M0
    Related
    ENSP00000427793.1, ENST00000517970.6
    Conserved Domains (2) summary
    cd04021
    Location:17140
    C2_E3_ubiquitin_ligase; C2 domain present in E3 ubiquitin ligase
    COG5021
    Location:307922
    HUL4; Ubiquitin-protein ligase [Posttranslational modification, protein turnover, chaperones]

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210514

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000008.11 Reference GRCh38.p13 Primary Assembly

    Range
    86342547..86468503
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005250760.4XP_005250817.1  NEDD4-like E3 ubiquitin-protein ligase WWP1 isoform X1

    See identical proteins and their annotated locations for XP_005250817.1

    UniProtKB/Swiss-Prot
    Q9H0M0
    Related
    ENSP00000265428.4, ENST00000265428.4
    Conserved Domains (2) summary
    cd04021
    Location:17140
    C2_E3_ubiquitin_ligase; C2 domain present in E3 ubiquitin ligase
    COG5021
    Location:307922
    HUL4; Ubiquitin-protein ligase [Posttranslational modification, protein turnover, chaperones]
  2. XM_017012993.1XP_016868482.1  NEDD4-like E3 ubiquitin-protein ligase WWP1 isoform X2

    Conserved Domains (6) summary
    cd04021
    Location:17140
    C2_E3_ubiquitin_ligase; C2 domain present in E3 ubiquitin ligase
    smart00119
    Location:590918
    HECTc; Domain Homologous to E6-AP Carboxyl Terminus with
    cd00078
    Location:567919
    HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
    cd00201
    Location:498527
    WW; Two conserved tryptophans domain; also known as the WWP or rsp5 domain; around 40 amino acids; functions as an interaction module in a diverse set of signalling proteins; binds specific proline-rich sequences but at low affinities compared to other ...
    pfam00397
    Location:350379
    WW; WW domain
    pfam07010
    Location:201326
    Endomucin; Endomucin
  3. XM_017012994.2XP_016868483.1  NEDD4-like E3 ubiquitin-protein ligase WWP1 isoform X3

    Conserved Domains (4) summary
    cd04021
    Location:17140
    C2_E3_ubiquitin_ligase; C2 domain present in E3 ubiquitin ligase
    cd00078
    Location:559896
    HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
    cd00201
    Location:499528
    WW; Two conserved tryptophans domain; also known as the WWP or rsp5 domain; around 40 amino acids; functions as an interaction module in a diverse set of signalling proteins; binds specific proline-rich sequences but at low affinities compared to other ...
    pfam00397
    Location:351380
    WW; WW domain
  4. XM_017012996.1XP_016868485.1  NEDD4-like E3 ubiquitin-protein ligase WWP1 isoform X4

  5. XM_017012997.2XP_016868486.1  NEDD4-like E3 ubiquitin-protein ligase WWP1 isoform X5

  6. XM_005250761.4XP_005250818.1  NEDD4-like E3 ubiquitin-protein ligase WWP1 isoform X2

    Conserved Domains (6) summary
    cd04021
    Location:17140
    C2_E3_ubiquitin_ligase; C2 domain present in E3 ubiquitin ligase
    smart00119
    Location:590918
    HECTc; Domain Homologous to E6-AP Carboxyl Terminus with
    cd00078
    Location:567919
    HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
    cd00201
    Location:498527
    WW; Two conserved tryptophans domain; also known as the WWP or rsp5 domain; around 40 amino acids; functions as an interaction module in a diverse set of signalling proteins; binds specific proline-rich sequences but at low affinities compared to other ...
    pfam00397
    Location:350379
    WW; WW domain
    pfam07010
    Location:201326
    Endomucin; Endomucin
  7. XM_017012995.2XP_016868484.1  NEDD4-like E3 ubiquitin-protein ligase WWP1 isoform X4

  8. XM_024447056.1XP_024302824.1  NEDD4-like E3 ubiquitin-protein ligase WWP1 isoform X3

    Conserved Domains (4) summary
    cd04021
    Location:17140
    C2_E3_ubiquitin_ligase; C2 domain present in E3 ubiquitin ligase
    cd00078
    Location:559896
    HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
    cd00201
    Location:499528
    WW; Two conserved tryptophans domain; also known as the WWP or rsp5 domain; around 40 amino acids; functions as an interaction module in a diverse set of signalling proteins; binds specific proline-rich sequences but at low affinities compared to other ...
    pfam00397
    Location:351380
    WW; WW domain

RNA

  1. XR_001745464.2 RNA Sequence

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