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WWP1 WW domain containing E3 ubiquitin protein ligase 1 [ Homo sapiens (human) ]

Gene ID: 11059, updated on 6-Jan-2019

Summary

Official Symbol
WWP1provided by HGNC
Official Full Name
WW domain containing E3 ubiquitin protein ligase 1provided by HGNC
Primary source
HGNC:HGNC:17004
See related
Ensembl:ENSG00000123124 MIM:602307
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
AIP5; Tiul1; hSDRP1
Summary
WW domain-containing proteins are found in all eukaryotes and play an important role in the regulation of a wide variety of cellular functions such as protein degradation, transcription, and RNA splicing. This gene encodes a protein which contains 4 tandem WW domains and a HECT (homologous to the E6-associated protein carboxyl terminus) domain. The encoded protein belongs to a family of NEDD4-like proteins, which are E3 ubiquitin-ligase molecules and regulate key trafficking decisions, including targeting of proteins to proteosomes or lysosomes. Alternative splicing of this gene generates at least 6 transcript variants; however, the full length nature of these transcripts has not been defined. [provided by RefSeq, Jul 2008]
Expression
Ubiquitous expression in liver (RPKM 24.3), gall bladder (RPKM 23.0) and 25 other tissues See more
Orthologs

Genomic context

See WWP1 in Genome Data Viewer
Location:
8q21.3
Exon count:
25
Annotation release Status Assembly Chr Location
109 current GRCh38.p12 (GCF_000001405.38) 8 NC_000008.11 (86342660..86468354)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 8 NC_000008.10 (87354965..87480181)

Chromosome 8 - NC_000008.11Genomic Context describing neighboring genes Neighboring gene solute carrier family 7 member 13 Neighboring gene HNF4 motif-containing MPRA enhancer 29 Neighboring gene uncharacterized LOC105375624 Neighboring gene regulator of microtubule dynamics 1 Neighboring gene N-terminal asparagine amidase pseudogene 2 Neighboring gene solute carrier family 2 member 3 pseudogene 4

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Pathways from BioSystems

  • Adaptive Immune System, organism-specific biosystem (from REACTOME)
    Adaptive Immune System, organism-specific biosystemAdaptive immunity refers to antigen-specific immune response efficiently involved in clearing the pathogens. The adaptive immune system is comprised of B and T lymphocytes that express receptors with...
  • Antigen processing: Ubiquitination & Proteasome degradation, organism-specific biosystem (from REACTOME)
    Antigen processing: Ubiquitination & Proteasome degradation, organism-specific biosystemIntracellular foreign or aberrant host proteins are cleaved into peptide fragments of a precise size, such that they can be loaded on to class I MHC molecules and presented externally to cytotoxic T ...
  • Class I MHC mediated antigen processing & presentation, organism-specific biosystem (from REACTOME)
    Class I MHC mediated antigen processing & presentation, organism-specific biosystemMajor histocompatibility complex (MHC) class I molecules play an important role in cell mediated immunity by reporting on intracellular events such as viral infection, the presence of intracellular b...
  • Downregulation of ERBB4 signaling, organism-specific biosystem (from REACTOME)
    Downregulation of ERBB4 signaling, organism-specific biosystemWW-domain binding motifs in the C-tail of ERBB4 play an important role in the downregulation of ERBB4 receptor signaling, enabling the interaction of intact ERBB4, ERBB4 m80 and ERBB4 s80 with NEDD4 ...
  • Endocytosis, organism-specific biosystem (from KEGG)
    Endocytosis, organism-specific biosystemEndocytosis is a mechanism for cells to remove ligands, nutrients, and plasma membrane (PM) proteins, and lipids from the cell surface, bringing them into the cell interior. Transmembrane proteins en...
  • Endocytosis, conserved biosystem (from KEGG)
    Endocytosis, conserved biosystemEndocytosis is a mechanism for cells to remove ligands, nutrients, and plasma membrane (PM) proteins, and lipids from the cell surface, bringing them into the cell interior. Transmembrane proteins en...
  • ErbB4 signaling events, organism-specific biosystem (from Pathway Interaction Database)
    ErbB4 signaling events, organism-specific biosystem
    ErbB4 signaling events
  • Immune System, organism-specific biosystem (from REACTOME)
    Immune System, organism-specific biosystemHumans are exposed to millions of potential pathogens daily, through contact, ingestion, and inhalation. Our ability to avoid infection depends on the adaptive immune system and during the first crit...
  • Ion channel transport, organism-specific biosystem (from REACTOME)
    Ion channel transport, organism-specific biosystemIon channels mediate the flow of ions across the plasma membrane of cells. They are integral membrane proteins, typically a multimer of proteins, which, when arranged in the membrane, create a pore f...
  • Signal Transduction, organism-specific biosystem (from REACTOME)
    Signal Transduction, organism-specific biosystemSignal transduction is a process in which extracellular signals elicit changes in cell state and activity. Transmembrane receptors sense changes in the cellular environment by binding ligands, such a...
  • Signaling by ERBB4, organism-specific biosystem (from REACTOME)
    Signaling by ERBB4, organism-specific biosystemERBB4, also known as HER4, belongs to the ERBB family of receptors, which also includes ERBB1 (EGFR i.e. HER1), ERBB2 (HER2 i.e. NEU) and ERBB3 (HER3). Similar to EGFR, ERBB4 has an extracellular lig...
  • Stimuli-sensing channels, organism-specific biosystem (from REACTOME)
    Stimuli-sensing channels, organism-specific biosystemIon channels that mediate sensations such as pain, warmth, cold, taste pressure and vision. Channels that mediate these sensations include acid-sensing ion channels (ASICs) (Wang & Xu 2011, Qadri et ...
  • TGF-beta Signaling Pathway, organism-specific biosystem (from WikiPathways)
    TGF-beta Signaling Pathway, organism-specific biosystemThe signal transduction mechanisms underlying the pathophysiological activities of transforming growth factor-? (TGF-?) have been extensively studied since its discovery nearly 30 years ago. TGF-? li...
  • TGF-beta receptor signaling, organism-specific biosystem (from Pathway Interaction Database)
    TGF-beta receptor signaling, organism-specific biosystem
    TGF-beta receptor signaling
  • Transmembrane transport of small molecules, organism-specific biosystem (from REACTOME)
    Transmembrane transport of small molecules, organism-specific biosystem
    Transmembrane transport of small molecules
  • Ubiquitin mediated proteolysis, organism-specific biosystem (from KEGG)
    Ubiquitin mediated proteolysis, organism-specific biosystemProtein ubiquitination plays an important role in eukaryotic cellular processes. It mainly functions as a signal for 26S proteasome dependent protein degradation. The addition of ubiquitin to protein...
  • Ubiquitin mediated proteolysis, conserved biosystem (from KEGG)
    Ubiquitin mediated proteolysis, conserved biosystemProtein ubiquitination plays an important role in eukaryotic cellular processes. It mainly functions as a signal for 26S proteasome dependent protein degradation. The addition of ubiquitin to protein...

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • DKFZp434D2111

Gene Ontology Provided by GOA

Function Evidence Code Pubs
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
ubiquitin protein ligase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
ubiquitin-protein transferase activity TAS
Traceable Author Statement
more info
PubMed 
Process Evidence Code Pubs
central nervous system development NAS
Non-traceable Author Statement
more info
PubMed 
ion transmembrane transport TAS
Traceable Author Statement
more info
 
negative regulation of transcription, DNA-templated ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of protein catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
proteasome-mediated ubiquitin-dependent protein catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
protein polyubiquitination IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
protein ubiquitination IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
protein ubiquitination TAS
Traceable Author Statement
more info
PubMed 
signal transduction NAS
Non-traceable Author Statement
more info
PubMed 
ubiquitin-dependent protein catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
viral entry into host cell TAS
Traceable Author Statement
more info
PubMed 
Component Evidence Code Pubs
cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cytosol TAS
Traceable Author Statement
more info
 
extracellular exosome HDA PubMed 
nucleus IEA
Inferred from Electronic Annotation
more info
 
plasma membrane IEA
Inferred from Electronic Annotation
more info
 
ubiquitin ligase complex NAS
Non-traceable Author Statement
more info
PubMed 

General protein information

Preferred Names
NEDD4-like E3 ubiquitin-protein ligase WWP1
Names
HECT-type E3 ubiquitin transferase WWP1
Nedd-4-like ubiquitin-protein ligase
TGIF-interacting ubiquitin ligase 1
WW domain-containing protein 1
atrophin-1 interacting protein 5
NP_008944.1
XP_005250817.1
XP_005250818.1
XP_016868482.1
XP_016868483.1
XP_016868484.1
XP_016868485.1
XP_016868486.1
XP_024302824.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_007013.3NP_008944.1  NEDD4-like E3 ubiquitin-protein ligase WWP1

    See identical proteins and their annotated locations for NP_008944.1

    Status: VALIDATED

    Source sequence(s)
    AW137654, AY043361, BC036065, BM664090
    Consensus CDS
    CCDS6242.1
    UniProtKB/Swiss-Prot
    Q9H0M0
    Related
    ENSP00000427793.1, ENST00000517970.5
    Conserved Domains (2) summary
    cd04021
    Location:17140
    C2_E3_ubiquitin_ligase; C2 domain present in E3 ubiquitin ligase
    COG5021
    Location:307922
    HUL4; Ubiquitin-protein ligase [Posttranslational modification, protein turnover, chaperones]

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p12 Primary Assembly

Genomic

  1. NC_000008.11 Reference GRCh38.p12 Primary Assembly

    Range
    86342660..86468354
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005250760.4XP_005250817.1  NEDD4-like E3 ubiquitin-protein ligase WWP1 isoform X1

    See identical proteins and their annotated locations for XP_005250817.1

    UniProtKB/Swiss-Prot
    Q9H0M0
    Related
    ENSP00000265428.4, ENST00000265428.4
    Conserved Domains (2) summary
    cd04021
    Location:17140
    C2_E3_ubiquitin_ligase; C2 domain present in E3 ubiquitin ligase
    COG5021
    Location:307922
    HUL4; Ubiquitin-protein ligase [Posttranslational modification, protein turnover, chaperones]
  2. XM_017012993.1XP_016868482.1  NEDD4-like E3 ubiquitin-protein ligase WWP1 isoform X2

    Conserved Domains (6) summary
    cd04021
    Location:17140
    C2_E3_ubiquitin_ligase; C2 domain present in E3 ubiquitin ligase
    smart00119
    Location:590918
    HECTc; Domain Homologous to E6-AP Carboxyl Terminus with
    cd00078
    Location:567919
    HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
    cd00201
    Location:498527
    WW; Two conserved tryptophans domain; also known as the WWP or rsp5 domain; around 40 amino acids; functions as an interaction module in a diverse set of signalling proteins; binds specific proline-rich sequences but at low affinities compared to other ...
    pfam00397
    Location:350379
    WW; WW domain
    pfam07010
    Location:201326
    Endomucin; Endomucin
  3. XM_017012994.2XP_016868483.1  NEDD4-like E3 ubiquitin-protein ligase WWP1 isoform X3

    Conserved Domains (4) summary
    cd04021
    Location:17140
    C2_E3_ubiquitin_ligase; C2 domain present in E3 ubiquitin ligase
    cd00078
    Location:559896
    HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
    cd00201
    Location:499528
    WW; Two conserved tryptophans domain; also known as the WWP or rsp5 domain; around 40 amino acids; functions as an interaction module in a diverse set of signalling proteins; binds specific proline-rich sequences but at low affinities compared to other ...
    pfam00397
    Location:351380
    WW; WW domain
  4. XM_017012996.1XP_016868485.1  NEDD4-like E3 ubiquitin-protein ligase WWP1 isoform X4

  5. XM_017012997.2XP_016868486.1  NEDD4-like E3 ubiquitin-protein ligase WWP1 isoform X5

  6. XM_005250761.4XP_005250818.1  NEDD4-like E3 ubiquitin-protein ligase WWP1 isoform X2

    Conserved Domains (6) summary
    cd04021
    Location:17140
    C2_E3_ubiquitin_ligase; C2 domain present in E3 ubiquitin ligase
    smart00119
    Location:590918
    HECTc; Domain Homologous to E6-AP Carboxyl Terminus with
    cd00078
    Location:567919
    HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
    cd00201
    Location:498527
    WW; Two conserved tryptophans domain; also known as the WWP or rsp5 domain; around 40 amino acids; functions as an interaction module in a diverse set of signalling proteins; binds specific proline-rich sequences but at low affinities compared to other ...
    pfam00397
    Location:350379
    WW; WW domain
    pfam07010
    Location:201326
    Endomucin; Endomucin
  7. XM_017012995.2XP_016868484.1  NEDD4-like E3 ubiquitin-protein ligase WWP1 isoform X4

  8. XM_024447056.1XP_024302824.1  NEDD4-like E3 ubiquitin-protein ligase WWP1 isoform X3

    Conserved Domains (4) summary
    cd04021
    Location:17140
    C2_E3_ubiquitin_ligase; C2 domain present in E3 ubiquitin ligase
    cd00078
    Location:559896
    HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
    cd00201
    Location:499528
    WW; Two conserved tryptophans domain; also known as the WWP or rsp5 domain; around 40 amino acids; functions as an interaction module in a diverse set of signalling proteins; binds specific proline-rich sequences but at low affinities compared to other ...
    pfam00397
    Location:351380
    WW; WW domain

RNA

  1. XR_001745464.2 RNA Sequence

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