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Acat2 acetyl-Coenzyme A acetyltransferase 2 [ Mus musculus (house mouse) ]

Gene ID: 110460, updated on 8-Feb-2024

Summary

Official Symbol
Acat2provided by MGI
Official Full Name
acetyl-Coenzyme A acetyltransferase 2provided by MGI
Primary source
MGI:MGI:87871
See related
Ensembl:ENSMUSG00000023832 AllianceGenome:MGI:87871
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Tcp-1x; Tcp1-rs1
Summary
Predicted to enable acetyl-CoA C-acetyltransferase activity. Involved in positive regulation of intestinal cholesterol absorption. Located in mitochondrion. Is expressed in several structures, including alimentary system; genitourinary system; integumental system; nervous system; and sensory organ. Human ortholog(s) of this gene implicated in coronary artery disease. Orthologous to human ACAT2 (acetyl-CoA acetyltransferase 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in CNS E11.5 (RPKM 65.2), liver adult (RPKM 62.8) and 28 other tissues See more
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Genomic context

See Acat2 in Genome Data Viewer
Location:
17 A1; 17 8.73 cM
Exon count:
9
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 17 NC_000083.7 (13161929..13179612, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 17 NC_000083.6 (12943042..12960725, complement)

Chromosome 17 - NC_000083.7Genomic Context describing neighboring genes Neighboring gene t-complex protein 1 Neighboring gene small nucleolar RNA, H/ACA box 20 Neighboring gene acetyl-Coenzyme A acetyltransferase 3 Neighboring gene t-complex protein 1, pseudogene 2 Neighboring gene predicted gene 15946 Neighboring gene WT1 associating protein

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (2) 
  • Endonuclease-mediated (1) 

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables acetyl-CoA C-acetyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables acetyl-CoA C-acetyltransferase activity ISO
Inferred from Sequence Orthology
more info
 
enables acyltransferase activity IEA
Inferred from Electronic Annotation
more info
 
enables acyltransferase activity, transferring groups other than amino-acyl groups IEA
Inferred from Electronic Annotation
more info
 
enables transferase activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
involved_in fatty acid beta-oxidation IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in positive regulation of intestinal cholesterol absorption IDA
Inferred from Direct Assay
more info
 
Component Evidence Code Pubs
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in mitochondrion HDA PubMed 
is_active_in mitochondrion IBA
Inferred from Biological aspect of Ancestor
more info
 

General protein information

Preferred Names
acetyl-CoA acetyltransferase, cytosolic
Names
cytosolic acetoacetyl-CoA thiolase
t-complex protein 1, related sequence 1
NP_033364.2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_009338.3NP_033364.2  acetyl-CoA acetyltransferase, cytosolic

    See identical proteins and their annotated locations for NP_033364.2

    Status: PROVISIONAL

    Source sequence(s)
    AK167234
    Consensus CDS
    CCDS37437.1
    UniProtKB/Swiss-Prot
    Q3TJY7, Q62292, Q8CAY6, Q96EB7, Q99K88, Q9CYV2
    UniProtKB/TrEMBL
    Q8R4V3
    Related
    ENSMUSP00000007005.8, ENSMUST00000007005.14
    Conserved Domains (2) summary
    PRK05790
    Location:8396
    PRK05790; putative acyltransferase; Provisional
    cd00751
    Location:9396
    thiolase; Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and ...

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000083.7 Reference GRCm39 C57BL/6J

    Range
    13161929..13179612 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)