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Pgd phosphogluconate dehydrogenase [ Mus musculus (house mouse) ]

Gene ID: 110208, updated on 8-Feb-2024

Summary

Official Symbol
Pgdprovided by MGI
Official Full Name
phosphogluconate dehydrogenaseprovided by MGI
Primary source
MGI:MGI:97553
See related
Ensembl:ENSMUSG00000028961 AllianceGenome:MGI:97553
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
0610042A05Rik
Summary
Enables phosphogluconate dehydrogenase (decarboxylating) activity. Acts upstream of or within pentose biosynthetic process. Predicted to be located in intracellular membrane-bounded organelle. Predicted to be active in cytosol. Is expressed in several structures, including adrenal gland; alimentary system; axial musculature; liver; and orbito-sphenoid. Orthologous to human PGD (phosphogluconate dehydrogenase). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in subcutaneous fat pad adult (RPKM 156.7), mammary gland adult (RPKM 135.7) and 28 other tissues See more
Orthologs
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Genomic context

See Pgd in Genome Data Viewer
Location:
4 E2; 4 78.96 cM
Exon count:
13
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 4 NC_000070.7 (149234448..149251162, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 4 NC_000070.6 (149149991..149166705, complement)

Chromosome 4 - NC_000070.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E4730 Neighboring gene STARR-positive B cell enhancer ABC_E11279 Neighboring gene STARR-positive B cell enhancer ABC_E4731 Neighboring gene ribosomal protein SA, pseudogene 12 Neighboring gene STARR-seq mESC enhancer starr_12104 Neighboring gene centromere protein S Neighboring gene STARR-positive B cell enhancer ABC_E3554 Neighboring gene kinesin family member 1B Neighboring gene STARR-positive B cell enhancer ABC_E845 Neighboring gene ubiquitination factor E4B, opposite strand 3 Neighboring gene ubiquitination factor E4B

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables NADP binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables NADP binding ISO
Inferred from Sequence Orthology
more info
 
enables carbohydrate binding ISO
Inferred from Sequence Orthology
more info
 
enables carboxylic acid binding ISO
Inferred from Sequence Orthology
more info
 
enables oxidoreductase activity IEA
Inferred from Electronic Annotation
more info
 
enables phosphogluconate 2-dehydrogenase activity IEA
Inferred from Electronic Annotation
more info
 
enables phosphogluconate dehydrogenase (decarboxylating) activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables phosphogluconate dehydrogenase (decarboxylating) activity IDA
Inferred from Direct Assay
more info
PubMed 
enables phosphogluconate dehydrogenase (decarboxylating) activity ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
involved_in D-gluconate catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in D-gluconate metabolic process ISO
Inferred from Sequence Orthology
more info
 
involved_in NADP metabolic process ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within pentose biosynthetic process IDA
Inferred from Direct Assay
more info
PubMed 
involved_in pentose-phosphate shunt ISO
Inferred from Sequence Orthology
more info
 
involved_in pentose-phosphate shunt, oxidative branch IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in pentose-phosphate shunt, oxidative branch IDA
Inferred from Direct Assay
more info
PubMed 
involved_in pentose-phosphate shunt, oxidative branch ISO
Inferred from Sequence Orthology
more info
PubMed 
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
 
is_active_in cytosol IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
6-phosphogluconate dehydrogenase, decarboxylating
NP_001074743.1
NP_001343261.1
XP_006538535.1
XP_030108942.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001081274.2NP_001074743.1  6-phosphogluconate dehydrogenase, decarboxylating isoform 1

    See identical proteins and their annotated locations for NP_001074743.1

    Status: VALIDATED

    Source sequence(s)
    AI834806, AK145602, CX212251, CX215938
    Consensus CDS
    CCDS38974.1
    UniProtKB/Swiss-Prot
    Q3UD80, Q9DCD0
    UniProtKB/TrEMBL
    Q91V28
    Related
    ENSMUSP00000081141.7, ENSMUST00000084124.7
    Conserved Domains (3) summary
    PRK09287
    Location:14470
    PRK09287; 6-phosphogluconate dehydrogenase; Validated
    pfam00393
    Location:180469
    6PGD; 6-phosphogluconate dehydrogenase, C-terminal domain
    pfam03446
    Location:3176
    NAD_binding_2; NAD binding domain of 6-phosphogluconate dehydrogenase
  2. NM_001356332.1NP_001343261.1  6-phosphogluconate dehydrogenase, decarboxylating isoform 2

    Status: VALIDATED

    Source sequence(s)
    AI834806, AK145602, AL731655, CX212251
    Conserved Domains (1) summary
    pfam00393
    Location:1285
    6PGD; 6-phosphogluconate dehydrogenase, C-terminal domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000070.7 Reference GRCm39 C57BL/6J

    Range
    149234448..149251162 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_030253082.2XP_030108942.1  6-phosphogluconate dehydrogenase, decarboxylating isoform X1

    Conserved Domains (1) summary
    pfam00393
    Location:1285
    6PGD; 6-phosphogluconate dehydrogenase, C-terminal domain
  2. XM_006538472.4XP_006538535.1  6-phosphogluconate dehydrogenase, decarboxylating isoform X1

    Conserved Domains (1) summary
    pfam00393
    Location:1285
    6PGD; 6-phosphogluconate dehydrogenase, C-terminal domain

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_025801.1: Suppressed sequence

    Description
    NM_025801.1: This RefSeq was suppressed temporarily based on the calculation that the annotated protein was shorter than a protein or proteins from a putative ortholog.